检索结果-南通市图书馆

Role of cD97^(stalk) and cD55 as molecular markers for prognosis and therapy of gastric carcinoma patients

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2005年第9期6卷 913-918页

作者：柳咏陈力彭淑牖陈周浔 hoang-vu c Department of Surgery Second Affiliated Hospital School of Medicine Yangzhou University Yangzhou 225001 China Department of Surgery Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Surgery Second Affiliated Hospital School of Medicine Zhejiang UniversityHangzhou 310009 China Department of Surgery University of Halle-WittenbergHalle Germany

Objectives： To explore the mechanism of development and aggressiveness in gastric carcinomas by investigating the expression and role of cD97 and its cellular ligand cD55 in gastric carcinomas. Methods： Tumor and corresponding normal mucosal tissue, collected from 39 gastric carcinoma patients, were examined by immunohistochemistry and RT-PcR for the expression of cD97 and cD55. Results： cD97^stalk was strongly stained on scattered tumor cells or small tumor cell clusters at the invasion front of gastric carcinomas. The expression of cD97^stalk was frequently observed in tumors of stage Ⅰ and T1 gastric carcinoma patients. The expression of cD97^stalk between Stage Ⅰ and Stage Ⅱ, Ⅲ, Ⅳ specimens showed significant difference （P〈0.05）, between T1 and T2, T3, T4 specimens also showed significant difference （P〈0.05）. Specimens with tumor invasion depth limited in mucosa of T1 specimens showed higher positive cD55 expression than specimens with the same tumor invasion depth in T2, T3, T4 specimens, the expression of cD55 between T1 and T2, T3, T4 specimens was significantly different （P〈0.05）. There was strong correlation between the distribution patterns of cD97^stalk and cD55 on tumor tissues （r=0.73, P〈0.05）. Signet ring cell carcinomas frequently contained strong cD97^stalk and cD55-staining. conclusions： Our results suggest that cD97^stalk is probably involved in the growth, invasion and aggressiveness of gastric carcinomas by binding its cellular ligand cD55. cD97^stalk and cD55 could be useful as molecular markers for prognosis and therapy of gastric carcinoma patients.

关键词： cD97^stalk cD55 Gastric carcinoma Molecular markers

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Generating highly active oxide-phosphide heterostructure through interfacial engineering to break the energy scaling relation toward urea-assisted natural seawater electrolysis

引用

Journal of Energy chemistry 2024年第10期97卷 687-699页

作者： Ngoc Quang Tran Nam hoang vu Jianmin Yu Khanh Vy Pham Nguyen Thuy Tien Nguyen Tran Thuy-Kieu Truong Lishan Peng Thi Anh Le Yoshiyuki Kawazoe center for Innovative Materials and Architectures Vietnam National University Faculty of Materials Science and Technology University of Science Key Laboratory of Rare Earths Ganjiang Innovation Academy Chinese Academy of Sciences Department of Mechanical Engineering Hanbat National University (HBNU) School of chemical Engineering-Hanoi University of Science and Technology New Industry creation Hatchery center Tohoku University

Urea-assisted natural seawater electrolysis is an emerging technology that is effective for grid-scale carbon-neutral hydrogen mass production yet *** scaling relations is an effective strategy to break through the bottleneck of natural seawater ***,by DFT calculation,we demonstrated that the interface boundaries between Ni2P and MoO2play an essential role in the selfrelaxation of the Ni-O interfacial bond,effectively modulating a coordination number of intermediates to control independently their adsorption-free energy,thus circumventing the adsorption-energy scaling *** this conceptual model,a well-defined 3D F-doped Ni2P-MoO2heterostructure microrod array was rationally designed via an interfacial engineering strategy toward urea-assisted natural seawater *** a result,the F-Ni2P-MoO2exhibits eminently active and durable bifunctional catalysts for both HER and OER in acid,alkaline,and alkaline sea water-based *** in-situ analysis,we found that a thin amorphous layer of NiOOH,which is evolved from the Ni2P during anodic reaction,is real catalytic active sites for the OER and UOR ***,such electrode-assembled urea-assisted natural seawater electrolyzer requires low voltages of 1.29 and 1.75 V to drive 10 and600 mA cm-2and demonstrates superior durability by operating continuously for 100 h at 100 mA cm-2,beyond commercial Pt/c || RuO2and most previous reports.

关键词： Break scaling relationships Doping Interfacial engineering Natural seawater splitting Urea electrolysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

胃癌组织中cD97^(STALK)和cD55的表达及其临床病理学意义

引用

实用肿瘤杂志 2005年第4期20卷 327-331页

作者：柳咏陈力彭淑牖陈周浔 hoang-vu c 浙江大学医学院附属第二医院普外科浙江杭州310009 德国马丁路德大学外科系

目的检测cD97STALK和其细胞配体cD55在胃癌组织及其相应的正常胃黏膜组织中的表达分布,分析这一对受体-配体分子与胃癌患者临床病理学特征之间的关系,探讨cD97STALK和cD55在胃癌发生、发展中的作用机制。方法选取39例经外科手术切除及... 详细信息

目的检测cD97STALK和其细胞配体cD55在胃癌组织及其相应的正常胃黏膜组织中的表达分布,分析这一对受体-配体分子与胃癌患者临床病理学特征之间的关系,探讨cD97STALK和cD55在胃癌发生、发展中的作用机制。方法选取39例经外科手术切除及组织病理学证实的胃癌患者的癌组织标本及相应的正常胃黏膜组织,应用RT-PcR技术和冰冻切片免疫组化染色方法,分别在mRNA和蛋白水平进行检测,并将两个分子的表达水平与患者临床病理学参数进行比较。结果大部分胃癌组织都有cD97STALK的阳性染色。cD97STALK强阳性染色位于胃肿块边沿散在分布的单个瘤细胞和小簇的肿瘤细胞。在临床Ⅰ期和Ⅱ、Ⅲ、Ⅳ期两组胃癌患者的癌组织中cD97STALK阳性表达差异有显著性(PcD55的阳性表达,在肿瘤浸润深度为T1与T2、T3、T4两组胃癌患者的癌组织之间,cD55的阳性表达差异有显著性(PcD97STALK和cD55在早期胃癌中呈现优势表达。胃印戒细胞癌胞浆频繁出现cD97STALK和cD55强阳性染色。胃癌组织cD55与cD97STALK表达高度相关(r=0.73)。结论cD97STALK通过与其细胞配体cD55直接的受体-配体作用,在胃癌发生、发展中发挥作用,cD97STALK和cD55有可能成为早期胃癌诊断、治疗和预后的分子标志。

关键词：胃肿瘤/诊断 cD97^STALK cD55 基因表达病理学免疫组织化学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

cD97EGF与配体分子cD55在胃癌中的表达及其临床意义

CD97EGF与配体分子CD55在胃癌中的表达及其临床意义

引用

2005年浙江省外科学术会议

作者：陈力田华李国刚陈周迅 hoang-vu c 浙江大学医学院附属第二医院外科德国Martin-Luther大学医学院外科

目的检测cD97EGF与配体分子cD55在胃癌中的表达特点及与胃癌患者临床病理特点相关性分析。方法收集本院2003年3月至2004年3月胃癌患者手术切除标本35例,应用RT-PcR、免疫组织化学及western blot等方法检测在胃癌组织、癌旁组织及正常胃...

目的检测cD97EGF与配体分子cD55在胃癌中的表达特点及与胃癌患者临床病理特点相关性分析。方法收集本院2003年3月至2004年3月胃癌患者手术切除标本35例,应用RT-PcR、免疫组织化学及western blot等方法检测在胃癌组织、癌旁组织及正常胃粘膜组织cD97EGF与配体分子 cD55表达。采用相关性方法分析cD97EGF和cD55在胃癌中的表达特点与临床病理特点的联系。结果

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Development of Extraction and Detection Method for a chemotherapeutic Drug with Phenytoin in Biological Samples

引用

Advances in Biological chemistry 2024年第4期14卷 103-110页

作者： Michael Arnot Nicolas Brice Adan Garcia Victor Lomeli My Phuong vu Karno Ng Department of chemistry & Biochemistry California State University San Marcos San Marcos CA U.S.A.

Dexamethasone is classified as a corticosteroid and is commonly used among cancer patients to decrease the amount of swelling around the tumor. Among patients with cancer, in particular brain tumors, seizures can become a daily routine in their everyday lives. To counteract the seizures, an antiepileptic drug such as phenytoin is administered to act as an anticonvulsant. Phenytoin and dexamethasone are frequently administrated concurrently to brain cancer patients. A previous study has shown that phenytoin serum concentration decreases when administrated concurrently with dexamethasone. Thus, it is important to monitor the concentration of these two drugs in biological samples to ensure that the proper dosages are administrated to the patients. This study aims to develop an effective extraction and detection method for dexamethasone and phenytoin. A reverse-phase high-performance liquid chromatography (HPLc) method with UV/Vis detection has been developed to separate phenytoin and dexamethasone at 219 nm and 241 nm respectively from urine samples. The mobile phase consists of a mixture of 0.01 M KH2PO4, acetonitrile, and methanol adjusted to pH 5.6 (48:32:20) and is pumped at a flow rate of 1.0 mL/min. calibration curves were prepared for phenytoin and dexamethasone (r2 > 0.99). An efficient solid-phase extraction (SPE) method for the extraction of dexamethasone and phenytoin from urine samples was developed with the use of c-18 cartridges. The percent recovery for phenytoin and dexamethasone is 95.4% (RSD = 1.15%) and 81.1% (RSD = 3.56%) respectively.

关键词： Dexamethasone Phenytoin cancer Drug Interaction Solid Phase Extraction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

α1-cOP modulates plasmodesmata function through sphingolipid enzyme regulation

引用

Journal of Integrative Plant Biology 2024年第8期66卷 1639-1657页

作者： Arya Bagus Boedi Iswanto Minh Huy vu Jong cheol Shon Ritesh Kumar Shuwei Wu Hobin Kang Da-Ran Kim Geon Hui Son Woe Yoen Kim Youn-Sig Kwak Kwang Hyeon Liu Sang Hee Kim Jae-Yean Kim Division of Applied Life Science(BK21 FOUR Program) Plant Molecular Biology and Biotechnology Research CenterGyeongsang National UniversityJinju 52828Korea college of Pharmacy and Research Institute of Pharmaceutical Sciences Kyungpook National UniversityDaegu 702-701Korea Departement of Plant Medicine Gyeongsang National UniversityJinju 52828Korea Division of Life Science Gyeongsang National UniversityJinju 52828Korea

callose,aβ-1,3-glucan plant cell wall polymer,regulates symplasmic channel size at plasmodesmata(PD)and plays a crucial role in a variety of plant ***,elucidating the molecular mechanism of PD callose homeostasis is *** screened and identified an Arabidopsis mutant plant with excessive callose deposition at PD and found that the mutated gene wasα1-cOP,a member of the coat protein I(cOPI)coatomer *** report that loss of function ofα1-cOP elevates the callose accumulation at PD by affecting subcellular protein localization of callose degradation enzyme Pd *** process is linked to the functions of ERH1,an inositol phosphoryl ceramide synthase,and glucosylceramide synthase through physical interactions with theα1-cOP ***,the loss of function ofα1-cOP alters the subcellular localization of ERH1 and GcS proteins,resulting in a reduction of Glc cers and Glc Hcers molecules,which are key sphingolipid(SL)species for lipid raft *** findings suggest thatα1-cOP protein,together with SL modifiers controlling lipid raft compositions,regulates the subcellular localization of GPI-anchored PDBG2 proteins,and hence the callose turnover at PD and symplasmic movement of *** findings provide the first key clue to link the cOPI-mediated intracellular trafficking pathway to the callose-mediated intercellular signaling pathway through PD.

关键词： callose coatomer proteins membrane-bound vesicle plasmodesmata sphingolipid enzymes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Wing Kinematics Modulation on Aerodynamic Force Generation in Hovering Insect-mimicking Flapping-wing Micro Air Vehicle

引用

Journal of Bionic Engineering 2015年第4期12卷 539-554页

作者： hoang vu Phan Quang Tri Truong Thi Kim Loan Au Hoon cheol Park Artificial Muscle Research center Konkuk University Seoul 143-701 South Korea National Research Laboratory for Biomimetics and Intelligent Microsystems Konkuk University Seoul 143-701 South Korea Department of Advanced Technology Fusion Konkuk University Seoul 143-701 South Korea Laboratory of Applied Mechanics Faculty of Applied Science Ho Chi Minh City University of Technology Ho Chi Minh 740-128 Vietnam

We investigated the effect of wing kinematics modulation, which was achieved by adjusting the location of trailing-edge constraint at the wing-root, i.e., by adjusting the wing-root offset, on the generation of aerodynamic forces in a hovering in- sect-mimicking Flapping-Wing Micro Air Vehicle （FW-MAV） by numerical and experimental studies. Three-dimensional wing kinematics measured using three synchronized high-speed cameras revealed a clear difference in the wing rotation angle of a wing section for different wing-root offsets. The extrapolated wing kinematics were in good agreement with the measured ones for various wing-root offsets. The Unsteady Blade Element Theory （UBET） was used to estimate the forces generated by the flapping wings and validated by comparison with results of measurements performed using a load cell. Although the thrust produced by a flapping wing with a wing-root offset of 0.20 c was about 4% less, its force-to-input-power ratio was about 30% and 10% higher than those with the offsets of 0.10 c and 0.15 c, respectively. This result could be explained by analyzing the effective Angle of Attack （AoA） and the force components computed by the UBET. Thus, a flapping wing with a wing-root offset of 0.20 c can be regarded as an optimal twist configuration for the development of the FW-MAV.

关键词： wing kinematics flapping-wing MAV biomimetics beetle-mimicking insect flight linear extrapolation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Poly-Alkylene-Glycol Quenchant on the Distortion, Hardness, and Microstructure of 65Mn Steel

引用

computers, Materials & continua 2021年第6期67卷 3249-3264页

作者： Thi Xuan Tran Xuan Phuong Nguyen Duong Nam Nguyen Dinh Toai vu Minh Quang chau Osamah Ibrahim Khalaf Anh Tuan hoang Hanoi University of Science and Technology HanoiVietnam Ho chi Minh city University of Transport Ho Chi Minh CityVietnam Vietnam Maritime University HaiphongVietnam Industrial University of Ho chi Minh city(IUH) Ho Chi Minh CityVietnam Al-Nahrain Nanorenewable Energy Research center Al-Nahrain UniversityBaghdadIraq Ho chi Minh city University of Technology(HUTEcH) Ho Chi Minh CityVietnam

currently,the 65Mn steel is quenched mainly by oil *** though the lower cooling rate of oil compared to water reduces the hardness of steel post quenching,the deforming and cracking of parts are often *** the other hand,the oil media also has the disadvantage of being ammable,creating smoke that adversely affects the *** poly alkylene glycol(PAG)polymer quenchant is commonly used for quenching a variety of steels based on its advantages such as non-ammability and exible cooling rate subjected to varying concentration and stirring *** article examines the effect of PAG polymer quenching solution(with concentrations of 10%and 20%)on deformation,hardness,and microstructure of c-ring samples made of 65Mn ***,the performance of PAG polymer quenchant is also compared with those of two common quenching solutions:Water and *** cooling in water,the c-ring samples had the largest deformation and 2 times higher than the results obtained when a 10%PAG solution was *** particular,similar levels of deformation on the c-ring samples were observed in both cases of 20%PAG solution and oil as the primary quenching ***,the hardness level measured between the sampled parts quenched in the 20%PAG solution appeared to be more uniform than that obtained from the oil-quenched *** study of the microscopic structure of steel by optical microscopy combined with X-ray diffraction showed that the water hardened sample exhibited cracks and comprised of two phases,martensite and retained *** to the results of Electron Back Scattering Diffraction(EBSD)analysis and backscattering electronic image(BSE),the content of austenite residue in the sample when the sample was cooled in PAG 10 and 20%solution was 3.21%and 4.73%,respectively and smaller than the measurements obtained from oil quenching ***,the 65Mn steel is cooled in 20%PAG solution for high hardness and more evenly distributed than when it is q

关键词： Polyethylene glycol electron backscattering diffraction quenching media cooling rate backscattering electronic image

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Feature mapping and state estimation for highly automated vehicles

引用

Journal of control and Decision 2015年第1期2卷 1-25页

作者： Anh vu Jay A.Farrell Department of Electrical and computer Engineering University of California-RiversideRiversideCAUSA

The past decade has witnessed an acceleration of autonomous vehicle research and development,with technological advances contributed by academia,government,and the industrial and consumer *** advancements hold the potential to improve society by enhancing transportation safety and throughput,where decreased congestion saves time and reduces vehicle *** of the key technologies to enable vehicle infrastructure interaction,advanced traffic management,and automated vehicles are automated roadway mapping and reliable vehicle state *** this paper,we present an overview and new methods for the problems automated roadway mapping plus a discussion of the extension of these methods to the problem of vehicle state *** from the application of these methods to feature mapping and state estimation are presented.

关键词： automated precise mapping vehicle state estimation Bayesian estimation vehicle infrastructure interaction advanced driver assistance systems autonomous driving

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polygonal Finite Element for Two-Dimensional Lid-Driven cavity Flow

引用

computers, Materials & continua 2022年第3期70卷 4217-4239页

作者： T.vu-Huu c.Le-Thanh H.Nguyen-Xuan M.Abdel-Wahab Faculty of civil Engineering Vietnam Maritime University484 Lach Tray Str.Hai PhongVietnam Faculty of civil Engineering and Electricity Ho Chi Minh City Open UniversityVietnam cIRTech Institute Ho ChiMinh City University of Technology(HUTECH)Ho Chi Minh CityVietnam Department of Architectural Engineering Sejong University209 NeungdongroGwangjinguSeoul05006Republic of Korea Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityTechnologiepark Zwijnaarde903B-9052ZwijnaardeBelgium

This paper investigates a polygonal finite element(PFE)to solve a two-dimensional(2D)incompressible steady fluid problem in a cavity *** is a well-known standard benchmark(i.e.,lid-driven cavity flow)-to evaluate the numerical methods in solving fluid problems controlled by the Navier-Stokes(N-S)equation *** approximation solutions provided in this research are based on our developed equal-order mixed PFE,called *** is an exciting development based on constructing the mixed scheme method of two equal-order discretisation spaces for both fluid pressure and velocity fields of flows and our proposed stabilisation *** this research,to handle the nonlinear problem of N-S,the Picard iteration scheme is *** proposed method’s performance and convergence are validated by several simulations coded by commercial software,i.e.,*** this research,the benchmark is executed with variousReynolds numbers up to the maximum Re=*** results then numerously compared to available sources in the literature.

关键词： Lid-driven cavity incompressible steady Navier-Stokes equations polygonal finite element method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：