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Multistep hepatocarcinogenesis from a dysplastic nodule to well-differentiated hepatocellular carcinoma in a patient with alcohol-related liver cirrhosis

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World Journal of Gastroenterology 2007年第8期13卷 1271-1274页

作者： Soo Ryang Kim Hirotsugu Ikawa Kenji Ando Keiji Mita Shuichi Fuki Michiie sakamoto Yoshihiro Kanbara Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi Department of Gastroenterology Kobe Asahi Hospital Japan Department of Pathology Keio University School of Medicine Japan Department of Surgery Hyogo Medical Center for Adults Japan Department of Radiology Osaka City University Medical School Japan Department of Gastroenterology Kinki University School of Medicine Japan Division of Molecular Medicine & Medical Genetics International Center for Medical Research and Treatment Kobe University Graduate School of Medicine Japan

We describe a rare case of the transformation of a dysplastic nodule into well-differentiated hepato- cellular carcinoma (HCC) in a 56-year-old man with alcoholrelated liver cirrhosis. Ultrasound (US) disclosed a 10 mm hypoechoic nodule and contrast enhanced US revealed a hypovascular nodule, both in segment seven. US-guided biopsy revealed a high-grade dysplastic nodule characterized by enhanced cellularity with a high N/C ratio, increased cytoplasmic eosinophilia, and slight cell atypia. One year later, the US pattern of the nodule changed from hypoechoic to hyperechoic without any change in size or hypovascularity. US-guided biopsy revealed well-differentiated HCC of the same features as shown in the first biopsy, but with additional pseudoglandular formation and moderate cell atypia. Moreover, immunohistochemical staining of cyclase- associated protein 2, a new molecular marker of well- differentiated HCC, turned positive. This is the first case of multistep hepatocarcinogenesis from a dysplastic nodule to well-differentiated HCC within one year in alcohol-related liver cirrhosis.

关键词： Multistep hepatocarcinogenesis Dysplastic nodule Well-differentiated hepatocellular carcinoma Alcohol-related liver cirrhosis Cyclase-associated protein 2

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Density Modulation Experiments to Determine Particle Transport Coefficients on HT-7 Tokamak

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Plasma Science and Technology 2006年第2期8卷 129-132页

作者：揭银先高翔 K.TANAKA R.sakamoto K.TOI 刘海庆高丽 M.ASIF 刘瑾徐强童兴德程永飞 Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 China National Institute for Fusion Science 322-6 Oroshi-cho Toki Japan Huazhong University of Science and Technology Wuhan 430074China

The particle diffusion coefficient and the convection velocity were studied based on the density modulation using D2 gas puffing on the HT-7 tokamak. The density was measured by a five-channel FIR interferometer. The density modulation amplitude was 10% of the central chord averaged background density and the modulation frequency was 10 Hz in the experiments. The particle diffusion coefficient （D） and the convection velocity （V） were obtained for different background plasmas with the central chord averaged density 〈ne〉 = 1.5×10^19m^-3 and 3.0×10^19 m^-3 respectively. It was observed that the influence of density modulation on the main plasma parameters was very weak. This technology is expected to be useful for the analysis of LHW and IBW heated plasmas on HT-7 tokamak in the near future.

关键词： electron density density modulation particle transport coefficient

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Preliminary study of automatic gastric cancer risk classification from photofluorography

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World Journal of Gastrointestinal Oncology 2018年第2期10卷 62-70页

作者： Ren Togo Kenta Ishihara Katsuhiro Mabe Harufumi Oizumi Takahiro Ogawa Mototsugu Kato Naoya sakamoto Shigemi Nakajima Masahiro Asaka Miki Haseyama Graduate School of Information Science and Technology Hokkaido UniversityHokkaido 060-0814Japan Department of Gastroenterology National Hospital Organization Hakodate HospitalHokkaido 041-8512Japan Medical Examination Center of the Yamagata City Medical Association Yamagata 990-2473Japan Department of Gastroenterology Hokkaido University Graduate School of MedicineHokkaido 060-8648Japan Department of General Medicine Japan Community Healthcare Organization Shiga HospitalShiga 520-0846Japan Health Sciences University of Hokkaido Hokkaido 061-0293Japan

AIM To perform automatic gastric cancer risk classificationusing photofluorography for realizing effective mass screening as a preliminary study. METHODS We used data for 2100 subjects including X-ray images, pepsinogen Ⅰ and Ⅱ levels, PGⅠ/PGⅡ ratio, Helicobacter pylori (H. pylori) antibody, H. pylori eradication history and interview sheets. We performed two-stage classification with our system. In the first stage, H. pylori infection status classification was performed, and H. pylori-infected subjects were automatically detected. In the second stage, we performed atrophic level classification to validate the effectiveness of our *** Sensitivity, specificity and Youden index(YI) of H. pylori infection status classification were 0.884, 0.895 and 0.779, respectively, in the first stage. In the second stage, sensitivity, specificity and YI of atrophic level classification for H. pylori-infected subjects were 0.777, 0.824 and 0.601, respectively. CONCLUSION Although further improvements of the system are needed, experimental results indicated the effectiveness of machine learning techniques for estimation of gastric cancer risk.

关键词： Gastric cancer Helicobacter pylori Mass screening Photofluorography Automatic data processing

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Endoscopic submucosal dissection for colorectal neoplasms:A review

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World Journal of Gastroenterology 2014年第43期20卷 16153-16158页

作者： Taku sakamoto Genki Mori Masayoshi Yamada Yuzuru Kinjo Eriko So Seiichiro Abe Yosuke Otake Takeshi Nakajima Takahisa Matsuda Yutaka Saito Endoscopy Division National Cancer Center Hospital

The introduction of colorectal endoscopic submucosal dissection(ESD)has expanded the application of endoscopic treatment,which can be used for lesions with a low metastatic potential regardless of their *** has the advantage of achieving en bloc resection with a lower local recurrence rate compared with that of piecemeal endoscopic mucosal ***,in the past,surgery was indicated in patients with large lesions spreading to almost the entire circumference of the rectum,regardless of the depth of invasion,as endoscopic resection of these lesions was technically ***,a prime benefit of ESD is significant improvement in the quality of life for patients who have large rectal *** the other hand,ESD is not as widely applied in the treatment of colorectal neoplasms as it is in gastric cancers owing to the associated technical difficulty,longer procedural duration,and increased risk of *** diversify the available endoscopic treatment strategies for superficial colorectal neoplasms,endoscopists performing ESD need torecognize its indications,the technical issues involved in its application,and the associated *** review outlines the methods and type of devices used for colorectal ESD,and the training required by endoscopists to perform this procedure.

关键词： Colorectum Endoscopic submucosal dissection Short-term outcomes Training indication for endoscopic treatment

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Fundamental Study of a Loop-Tube-Type Thermoacoustic Heating System

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Journal of Energy and Power Engineering 2013年第11期7卷 2096-2099页

作者： Shin-ichi sakamoto Yoshiaki Watanabe Department of Electronic Systems Engineering University of Shiga Prefecture Faculty of Life and Medical Sciences Doshisha University

This paper proposes a loop-tube type thermoacoustic heating system without any moving parts based on the thermoacoustic effect. In a thermoacoustic heating system, the supplied sound is converted to heat and the heating point is heated. A thermoacoustic heating system differs from a thermoacoustic cooling system： The location of the reference temperature section at the heat pump is upside down. The authors construct a prototype ofthermoacoustic heating system. The experimental results show that the heating point reaches 100 ~C. It must be emphasized that, using this simple and inexpensive thermoacoustic heating system, noise, waste heat and unused heat are useful as a renewable energy source.

关键词： Thermoacoustic heating system loop-tube-type thermoacoustic heating system.

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Visualization and Management Platform with Augmented Reality for Wireless Sensor Networks

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Wireless Sensor Network 2015年第1期7卷 1-11页

作者： Kenya Sato Naoya sakamoto Hideki Shimada Department of Information Systems Design Doshisha University Kyoto Japan

Recently a ubiquitous sensor network which collects our environmental information gets increasingly popular, a visualization application is necessary for users to manage complicated wireless networks, however, these applications are developed individually for wireless communication standard or a type of wireless device. Therefore, users are forced to adopt and use the application individually according to the target of the wireless network. In this paper, we propose a visualization platform for wireless network environments using augmented reality technology, and evaluate the effectiveness of the platform. From the result of the evaluation, we have confirmed the proposed platform has availability for visualization and management of wireless networks.

关键词： Network Management Visualization Augmented Reality

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System describing surgical field extension associated with flap reconstruction after resection of a superficial malignant soft tissue tumor

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World Journal of Clinical Oncology 2023年第11期14卷 471-478页

作者： Akio sakamoto Takashi Noguchi Shuichi Matsuda Department of Orthopaedic Surgery Graduate School of MedicineKyoto UniversityKyoto 606-8507Japan

BACKGROUND Flap reconstruction after resection of a superficial malignant soft tissue tumor extends the surgical field and is an indicator for potential recurrence *** To describe a grading system for surgical field extension of soft tissue *** Grading system:CD-grading is a description system consisting of C and D values in the surgical field extension,which are related to the compartmental position of the flap beyond the nearby large joint and deeper extension for the pedicle,respectively.C1/D1 are positive values and C0/D0 are *** a known location,1/0 values can be"p"(proximal),"d"(distal),and"b"(in the tumor bed),and the description method is as follows:flap type,CxDx[x=0,1,p,d or b].RESULTS Four representative patients with subcutaneous sarcomas who underwent reconstruction using fasciocutaneous flaps are *** cases involved a distal upper arm(elbow)synovial sarcoma reconstructed using a pedicled latissimus dorsi(pedicled flap:CpDp);a distal upper arm(elbow)pleomorphic rhabdomyosarcoma reconstructed using a transpositional flap from the forearm(transpositional flap:CdD0);an undifferentiated pleomorphic sarcoma in the buttocks reconstructed using a transpositional flap(transpositional flap:C0D0);and a myxofibrosarcoma in the buttocks reconstructed using a propeller flap from the thigh(pedicled flap:CdDd).CONCLUSION The reconstruction method is chosen by the surgeon based on size,location,and other tumor characteristics;however,the final surgical field cannot be determined based on preoperative images ***-grading is a description system consisting of C and D values in the surgical field extension that are related to the compartmental position of the flap beyond the nearby large joint and deeper extension for the pedicle,*** CD-grading system gives a new perspective to the flap reconstruction *** CD-grading system also provides important information for follow-up imaging of a possible recurrenc

关键词： Soft tissue Sarcoma Surgery Sarcoma Grading system Surgical flap

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(–)-Epigallocatechingallate Interferes RANKL/RANK Signal Pathway and Induces Apoptosis during Osteoclastogenesis in RAW264 Cell

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Food and Nutrition Sciences 2014年第2期5卷 107-116页

作者： Ran Zhao Masayoshi Kamon Kazuichi sakamoto Graduate School of Life and Environmental Sciences University of Tsukuba Tsukuba Japan Graduate School of Life and Environmental Sciences University of Tsukuba Tsukuba Japan Center for Genomic Medicine The Saitama Medical Research University Hidakashi Japan.

Green tea catechin, (–)-epigallocatechin-3-gallate [(–)-EGCG], was found to increase osteogenic functioning in mesenchymal stem cells. This study qualified EGCG, the strongest inhibitory efficiency for receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL)-activated osteoclastogenesis among other green tea catechins for RAW264, a murine preosteoclast cell line. Moreover, EGCG inhibited tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cell formation dose dependently in both single culture and co-culture systems, the expression of transcription factor, nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) and some osteoclastic genes. Especially, EGCG exhibited a strong inhibitory effect on the expression levels of RANK, the receptor of RANKL, and OSCAR, a key co-stimulator of the RANKL/RANK signal. Simultaneously, apoptotic genes expression and Hoechst staining revealed that EGCG induced apoptosis in RAW264. Taken together, these data suggest that the inhibitory effect of EGCG to osteoclastogenesis is associated with a down regulation of RANKL/RANK signal, and increased apoptosis of preosteoclasts.

关键词： (–)-Epigallocatechin-3-Gallate RANK Osteoclastogenesis Apoptosis

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Genetic Background Influences Brassinosteroid-Related Mutant Phenotypes in Rice

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American Journal of Plant Sciences 2013年第2期4卷 212-221页

作者： Tomoaki sakamoto Hidemi Kitano Shozo Fujioka Bioscience and Biotechnology Center Nagoya University Nagoya Japan Faculty of Bioresources and Environmental Sciences Ishikawa Prefectural University Nonoichi Japan RIKEN Advanced Science Institute Wako Japan

In two cases, mutations in the same brassinosteroid-related genes caused different phenotypes in japonica varieties Nipponbare and Taichung 65. The mutant phenotypes were less severe in the Taichung 65 background than in the Nipponbare background. Three newly isolated brassinosteroid-insensitive mutants (d61-1N, d61-11, and d61-12) derived from a Nipponbare mutant library were found to be alleles of d61, which represent defects in the OsBRI1 gene. Although the Nipponbare-derived mutant d61-1N had the same nucleotide substitution as the previously characterized Taichung 65-derived mutant d61-1T, these two mutants showed different phenotypes for plant stature, internode elongation pattern, and seed shape;in each case, d61-1N (in the Nipponbare genetic background) had the more severe mutant phenotype. Similar trends were seen for phenotypes caused by mutants of d2, a brassinosteroid biosynthesis gene. Consistent with these phenotypes, the expression of brassinosteroid-responsive genes was lower in the Nipponbare-derived mutants. These results can be explained by our findings that feed-forward up-regulation of OsBRI1 did not occur in the Nipponbare-derived mutants and that an mPing transposon is inserted into the promoter region of Nipponbare OsBRI1. Based on these results, we conclude that the expression of OsBRI1, especially its feed-forward up-regulation, is misregulated in wild-type Nipponbare and in brassinosteroid-related mutants in a Nipponbare genetic background. Although Nipponbare is a model rice genotype, it can be categorized as an OsBRI1 mutant that has reduced sensitivity to brassinosteroid.

关键词： Brassinosteroid Brassinosteroid Receptor Brassinosteroid Sensitivity miniature Ping (mPing) Mutant Nipponbare Rice

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Branched-chain amino acid treatment before transcatheter arterial chemoembolization for hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第12期18卷 1379-1384页

作者： Hiroki Nishikawa Yukio Osaki Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Shinichiro Henmi Azusa sakamoto Tetsuro Ishikawa Sumio Saito Ryuichi Kita Toru Kimura Department of Gastroenterology and Hepatology Osaka Red Cross Hospital

AIM： To examine the significance of branched-chain amino acid （BCAA） treatment before transcatheter arterial chemoembolization （rACE） for hepatocellular carcinoma （HCC）.METHODS： This study included 99 patients who underwent TACE therapy for HCC at our hospital and were followed up without treatment for at least 6 mo between January 2004 and January 2010. They were divided into 2 groups： those receiving BCAA granules （/7 = 40） or regular diet （n = 59, control）. Data obtained were retrospectively analyzed （prior to TACE, and 1 wk, 1, 3, and 6 mo after TACE） in terms of nutritional condition and clinical laboratory parameters （serum albumin level and Child-Pugh score）, both of which are determinants of hepatic functional reserve.RESULTS： The BCAA group comprised 27 males and 13 females with a mean age of 69,9 ：E 8,8 years, The patients of the BCAA group were classified as follows： Child-Pugh A/B/C in 22/15/3 patients, and Stage Ⅱ/Ⅲ/ /IVA HCC in 12/23/5 patients, respectively. The controlgroup comprised 32 males and 27 females with a mean age of 73.2 ± 10.1 years. In the control group, 9 patients had chronic hepatitis, Child-Pugh A/B/C in 39/10/1 patients, and Stage Ⅰ/Ⅱ/Ⅲ/IVA HCC in 1/11/35/12 patients, respectively. Overall, both serum albumin level and Child-Pugh score improved significantly in the BCAA group as compared with the control 3 and 6 mo after TACE （P 〈 0.05）. Further analysis was performed by the following categorization：（1） child-Pugh classification; （2） liver cirrhosis subgroup with a serum albumin level 〉 3.5 g/dL; and （3） epirubicin dose. A similar trend indicating a significant improvement of all variables in the BCAA group was noted （P 〈 0.05）.CONCLUSION： Treatment with BCAA granules in patients who have undergone TACE for HCC is considered useful to maintain their hepatic functional reserve.

关键词： Hepatocellular carcinoma Branched-chainamino acid granules Transcatheter arterial chemoembo-lization Liver function Improvement Cirrhosis Protein-energy malnutrition

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