检索结果-南通市图书馆

World Journal of Gastroenterology 2018年第2期24卷 211-215页

作者： Hirohito Mori hideki Kobara Noriko Nishiyama Tsutomu Masaki Departments of Gastroenterology and Neurology Kagawa University

AIM To evaluate appropriate and rapid polyglycolic acid sheet(PGAs) covering time using device delivery station system(DDSS).METHODS This pilot basic study was conducted to evaluate the potential of accurate and rapid PGAs delivery using DDSS. Three 11-month-old female Beagle dogs were used in this study. Two endoscopic submucosal dissections(ESDs) 4 cm in diameter were performed in lesser curvature of middle gastric body and greater curvature of antrum(total 6 ESDs performed). DDSS(3 cm length, 12 mm in outer diameter) has 2 chambers which 16 cm^2 large 2 PGAs were stored, and DDSS was attached post ESD ulcers, respectively. Beriplast P?(CSL Behring K.K., Tokyo, Japan)(combination of fibringlue and thrombin) was applied equally to the artificial ulcer, and tight attachment of 2 PGAs with DDSS were completed. The evaluation items were covering times, post ESD bleeding and perforation during *** The covering time of PGAs(defined as the duration from the beginning of endoscope insertion into the mouth to the end of the fibrin glue coating process) was 6.07(4.86-8.29) min. There was no postESD bleeding(1-7 d after ESD), and there was no perforation during *** DDSS was very useful for rapid delivering and tight attachment of PGAs, and has potentials of multipurpose delivery station system.

关键词： Post-endoscopic submucosal dissection ulcers Bleeding Polyglycolic acid sheet Rapidly delivery Tightly attachment

Bayesian optimization with experimental failure for high-throughput materials growth

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2022年第1期8卷 1746-1754页

作者： Yuki K.Wakabayashi Takuma Otsuka Yoshiharu Krockenberger Hiroshi Sawada Yoshitaka Taniyasu hideki Yamamoto NTT Basic Research Laboratories NTT CorporationAtsugiKanagawa243-0198Japan NTT Communication Science Laboratories NTT CorporationSoraku-gunKyoto619-0237Japan

A crucial problem in achieving innovative high-throughput materials growth with machine learning,such as Bayesian optimization(BO),and automation techniques has been a lack of an appropriate way to handle missing data due to experimental ***,we propose a BO algorithm that complements the missing data in optimizing materials growth *** proposed method provides a flexible optimization algorithm that searches a wide multi-dimensional parameter *** demonstrate the effectiveness of the method with simulated data as well as in its implementation for actual materials growth,namely machine-learning-assisted molecular beam epitaxy(ML-MBE)of SrRuO_(3),which is widely used as a metallic electrode in oxide *** the exploitation and exploration in a wide three-dimensional parameter space,while complementing the missing data,we attained tensile-strained SrRuO3 film with a high residual resistivity ratio of 80.1,the highest among tensile-strained SrRuO3 films ever reported,in only 35 MBE growth runs.

关键词： optimization strained resistivity

Demonstration of Optical Isolator with CeY_2Fe_5O_(12) Guiding Layer Employing Nonreciprocal Phase Shift

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

光学学报 2003年第S1期23卷 169-170页

作者： Kazumasa Sakurai hideki Yokoi Tetsuya Mizumoto Department of Electrical and Electronic Engineering Tokyo Institute of Technology Japan 2-12-1 Ookayama Meguro-ku Tokyo 152-B552 JapanDepartment of Electrical and Electronic Engineering Tokyo Institute of Technology Japan 2-12-1 Ookayama Meguro-ku Tokyo 152-B552 JapanDepartment of Electrical and Electronic Engineering Tokyo Institute of Technology Japan 2-12-1 Ookayama Meguro-ku Tokyo 152-B552 Japan

A waveguide optical isolator with a CeY2Fe5O12 guiding layer employing a nonreciprocal phase shift was studied. The isolation ratio of more than 12.2 dB was achieved at a wavelength of 1.55μm.

关键词： of on as by YIG Guiding Layer Employing Nonreciprocal Phase Shift Demonstration of Optical Isolator with CeY2Fe5O with

Patients with early recurrence of hepatocellular carcinoma have poor prognosis

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2017年第3期16卷 279-288页

作者： Tomoki Kobayashi Hiroshi Aikata Tsuyoshi Kobayashi hideki Ohdan Koji Arihiro Kazuaki Chayama Department of Gastroenterology and Metabolism Hiroshima University Hospital Hiroshima Japan Department of Anatomical Pathology Hiroshima University Hospital Hiroshima Japan Department of Gastroenterological and Transplant Surgery Applied Life Sciences Institute of Biomedical and Health Sciences Hiroshima University Hiroshima Japan Liver Research Project Center Hiroshima University Hiroshima Japan

BACKGROUND： Early recurrence （ER） after hepatic resection （HR） is a poor prognostic factor for patients with hepatocellular carcinoma （HCC）. This study aimed to identify the clinico- pathological features, outcomes, and risk factors for ER after HR for small HCC in order to clarify the reasons why ER is a worse recurrence pattern. METHODS： We retrospectively examined 130 patients who underwent HR for small HCC （___30 mm）. Recurrence was clas- sifted into ER （〈2 years） and late recurrence （LR）（_〉2 years）. The clinicopathological features, outcomes, and risk factors for ER were analyzed by multivariate analysis. RESULTS： ER was observed in 39 patients （30.0%）. The sur- vival rate of the ER group was significantly lower than that of the LR group （P〈0.005）, and ER was an independent prognos- tic factor for poor survival （P=0.0001）. The ER group had a significantly higher frequency （P=0.0039） and shorter interval （P=0.027） of development to carcinoma beyond the Milan criteria （DBMC） compared with the LR group, and ER was an independent risk factor for DBMC （P〈0.0001）. Multi-nodularity, non-simple nodular type, and microvascular invasion were independent predictors for ER （P=0.012, 0.010, and 0.019, respectively）.CONCLUSIONS： ER was a highly malignant recurrence pattern associated with DBMC and subsequent poor survival after HR for small HCC. Multi-nodularity, non-simple nodular type, and microvascular invasion predict ER, and taking these factors into consideration may be useful for the decision of the treatment strategy for small HCC after HR.

关键词： early recurrence small hepatocellular carcinoma risk factors beyond the Milan criteria

Primary hepatic leiomyosarcoma with liver metastasis of rectal cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第38期18卷 5479-5484页

作者： Kiyoto Takehara hideki Aoki Yuko Takehara Rie Yamasaki Kohji Tanakaya Hitoshi Takeuchi Department of Gastroenterological Surgery Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan Department of Surgery National Hospital Organization Iwakuni Clinical Center Yamaguchi 740-8510 Japan Department of Clinical Examination National Hospital Organization Iwakuni Clinical Center Yamaguchi 740-8510 Japan

Primary hepatic leiomyosarcoma is a particularly rare tumor with a poor prognosis. Curative resection is currently the only effective treatment, and the efficacy of chemotherapy is unclear. This represents the first case report of a patient with primary hepatic leiomyosarcoma co-existing with metastatic liver carcinoma. We present a 59-year-old man who was diagnosed preoperatively with rectal cancer with multiple liver metastases. He underwent a curative hepatectomy after a series of chemotherapy regimens with modified FOLFOX6 consisting of 5-fluorouracil, leucovorin and oxaliplatin plus bevacizumab, FOLFIRI consisting of 5-fluorouracil, leucovorin and irinotecan plus bevacizumab, and irinotecan plus cetuximab. One of the liver tumors showed a different response to chemotherapy and was diag-nosed as a leiomyosarcoma following histopathological examination. This case suggests that irinotecan has the potential to inhibit the growth of hepatic leiomyosarcomas. The possibility of comorbid different histological types of tumors should be suspected when considering the treatment of multiple liver tumors.

关键词： Leiomyosarcoma Rectal cancer Metastasis Chemotherapy Surgery

Design and evaluation of an extended-release matrix tablet formulation; the combination of hypromellose acetate succinate and hydroxypropylcellulose

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2017年第2期12卷 149-156页

作者： Sachiko Fukui hideki Yano Shuichi Yada Tsuyoshi Mikkaichi Hidemi Minami Formulation Technology Research Laboratories Daiichi Sankyo Co.Ltd.1-2-58HiromachiShinagawa-kuTokyo 140-8710Japan Drug Metabolism&Pharmacokinetics Research Laboratories Daiichi Sankyo Co.Ltd.1-2-58HiromachiShinagawa-kuTokyo 140-8710Japan

The purpose of this study was to develop an extended-release(ER) matrix tablet that shows robust dissolution properties able to account for the variability of pH and mechanical stress in the GI tract using a combination of enteric polymer and hydrophilic polymer. Hypromellose acetate succinate(HPMCAS) and hydroxypropylcellulose(HPC) were selected as ER polymers for the ER matrix tablet(HPMCAS/HPC ER matrix tablet). Oxycodone hydrochloride was employed as a model drug. Dissolution properties of the HPMCAS/HPC ER matrix tablets were evaluated and were not affected by the pH of the test medium or paddle rotating *** a USP apparatus 3(bio-relevant dissolution method), dissolution profiles of the HPMCAS/HPC ER matrix tablets containing oxycodone hydrochloride were similar to that of the reference product(OxyC ontin). Moreover, in vivo performance after oral administration of the HPMCAS/HPC ER matrix tablets to humans was simulated by GastroP lus based on dissolution profiles from the USP apparatus 3. The plasma concentration-time profile simulated was similar to that of the reference product. These results suggest that the combination of HPMCAS and HPC shows a robust dissolution profile against pH and paddle rotating speed and indicates the appropriate extended-release profile in humans.

关键词： Extended-release matrix tablet Hypromellose acetate succinate Hydroxypropylcellulose Robust dissolution USP apparatus 3

Application of highwall mining system in weak geological condition

在线全文

学校读者我要写书评

暂无评论

International Journal of Coal Science & Technology 2016年第3期3卷 311-321页

作者： Takashi Sasaoka Tri Karian Akihiro Hamanaka hideki Shimada Kikuo Matsui Department of Earth Resources Engineering KyushuUniversity Fukuoka 819-0395 Japan

Almost all the coal is produced from open cut mines in Indonesia. As a consequence of open cut mine application, a great deal of coal is left out in the highwalls of the mined-out pits. Highwall mining systems can be used to recover this coal. The use of highwall mining systems has increasingly come into play in the US and Australia. However, it is not common in Indonesia. Moreover, Indonesia coal measure is categorized as weak geological condition. Some problems are likely to arise during the application of the highwall mining system for example instability of openings and highwalls due to the roof and pillar failures. Therefore, study of highwall mining system application in Indonesia is needed in order to increase the recovery rate of coal mining in Indonesia. This paper described the characteristics of the highwa!l mining system and discussed the appropriate highwall mining system application in weak geological condition, Indonesia. From the results of a series of laboratory tests and numerical analyses, it can be concluded that the stability of pillars and mine openings in auger mining systems is much higher than that in CHM and an auger mining system is suitable for such as very weak/poor strata conditions. Moreover, the application of backfilling system is very effective for improvement of the stability of pillar and openings.

关键词： Open cut mine Left out coal Highwall mining systems Weak geological condition

Hepatic reconstruction from fetal porcine liver cells using a radial flow bioreactor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第17期14卷 2740-2747页

作者： Yuji Ishii Ryota Saito hideki Marushima Ryusuke Ito Taro Sakamoto Katsuhiko Yanaga Department of Surgery the Jikei University School of Medicine

AIM： To examine the efficacy of the radial flow bioreactor （RFB） as an extracorporeal bioartificial liver （BAL） and the reconstruction of liver organoids using embryonic pig liver cells. METHODS： We reconstructed the liver organoids using embryonic porcine liver cells in the RFB. We also determined the gestational time window for the optimum growth of embryonic porcine liver cells. Five weeks of gestation was designated as embryonic day （E） 35 and 8 wk of gestation was designated as E56. These cells were cultured for one week before morphological and functional examinations. Moreover, the efficacy of pulsed adminisbation of a high concentration hepatocyte growth factor （HGF） was examined. RESULTS： Both cell growth and function were excellent after harvesting on E35. The pulsed administration of a high concentration of HGF promoted the differentiation and maturation of these fetal hepatic cells. Microscopic examination of organoids in the RFB revealed palisading and showed that bile duct-like structures were well developed, indicating that the organoids were mini livers. Transmission electron microscopy revealed microvilli on the luminal surfaces of bile duct-like structures and junctional complexes, which form the basis of the cytoskeleton of epithelial tissues. Furthermore, strong expression of connexin （Cx） 32, which is the main protein of hepatocyte gap junctions, was observed. With respect to liver function, ammonia detoxification and urea synthesis were shown to be performed effectively. CONCLUSION： Our system can potentially be applied in the fields of BAL and transplantation medicine.

关键词： Liver organoid Radial flow bioreactor Bioartificial liver Fetal porcine liver Hepatocyte growthfactor

A comparative study on crash-influencing factors by facility types on urban expressway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Transportation 2013年第4期21卷 224-235页

作者： Yong Wu hideki Nakamura Miho Asano Department of Civil Engineering Nagoya University

This study aims at identifying crash-influencing factors by facility type of Nagoya Urban Expressway, considering the interaction of geometry, traffic flow, and ambient conditions. Crash rate （CR） model is firstly developed separately at four facility types： basic, merge, and diverge segments and sharp curve. Traffic flows are thereby categorized, and based on the traffic categories, the significances of factors affecting crashes are analyzed by principal component analysis. The results reveal that, the CR at merge segment is significantly higher than those at basic and diverge segments in uncongested flow, while the value is not significantly different at the three facility types in congested flow. In both un- and congested flows, sharp curve has the worst safety performance in view of its highest CR. Regarding influencing factors, geometric design and traffic flow are most significant in un- and congested flows, respectively. As mainline flow increases, the effect of merging ratio affecting crash is on the rise at basic and merge segments as opposed to the decreasing significance of diverging ratio at diverge segment. Mean- while, longer acceleration and deceleration lanes are adverse to safety in uncongested flow, while shorter acceleration and deceleration lanes are adverse in congested flow. Due to its special geometric design, crashes at sharp curve are highly associated with the large centrifugal force and heavy restricted visibility.

关键词： Crash-influencing factors Crash rates Principal component analysis - Facility types Urbanexpressway

Niche Differentiation of Phenol-Degrading Microorganisms in UASB Granular Sludge as Revealed by Fluorescence in situ Hybridization

在线全文

学校读者我要写书评

暂无评论

Engineering 2022年第2期8卷 61-66页

作者： Kengo Kubota Kei Igarashi Masayoshi Yamada Yasuyuki Takemura Yu-You Li hideki Harada Department of Civil and Environmental Engineering Tohoku UniversitySendai 980-8579Japan Department of Urban Environmental Design and Engineering National Institute of TechnologyKagoshima CollegeKirishima 899-5193Japan New Industry Creation Hatchery Center Tohoku UniversitySendai 980-8579Japan

A microbial community structure of granules harvested from an anaerobic sludge blanket reactor treating phenolic wastewater was investigated using fluorescence in situ hybridization(FISH)and clone library *** of Syntrophorhabdaceae and Cryptanaerobacter were observed to be responsible for phenol *** accurate taxonomic assignment of Cryptanaerobacter clones,phylogenetic analysis using nearly full-length 16S ribosomal RNA(rRNA)gene sequences was *** oligonucleotide probes were designed to detect the following three taxonomic groups:Syntrophorhabdaceae,Cryptanaerobacter,and *** analysis of thin sections of anaerobic granules showed a random distribution of bacteria and ***,a well-defined distribution of Syntrophorhabdaceae,Cryptanaerobacter,and Syntrophus was *** and Syntrophus were found on the outer layer of the granules and were closely associated with each other,while Syntrophorhabdaceae was located in the deeper part of the *** specific distribution of the bacteria is most likely due to their metabolic association and affinity for the *** degradation in the granular sludge was observed to be carried out in the following ***,Cryptanaerobacter converts phenol to benzoate,which is then degraded by Syntrophus into *** syntrophic degradation of phenol occurs near the surface of the granule,where the phenol concen-tration is *** the deeper part of the granule,where the phenol concentration is lower,Syntrophorhabdaceae degrades phenol into *** observed that Syntrophorhabdaceae is less likely to produce benzoate as an intermediate to feed the neighboring organisms,which contradicts the theo-ries presented by previous studies.

关键词： Cryptanaerobacter Fluorescence in situ hybridization Anaerobic phenol degradation Syntrophorhabdaceae Syntrophus UASB granular sludge