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非变性Ⅱ型胶原蛋白对老年db/db小鼠运动机能的改善作用

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中国食品学报 2021年第5期21卷 125-132页

作者：樊蕊郝云涛康佳伟胡佳妮徐美虹李勇北京大学公共卫生学院营养与食品卫生学系北京100191

目的:探讨非变性Ⅱ型胶原蛋白(UCⅡ)对增龄导致的db/db小鼠运动机能下降的改善作用。方法:将正常喂养至老年的db/db小鼠随机分为模型对照组、UCⅡ干预组、阳性对照组,以同周龄的db/m小鼠为正常对照组,喂养至25周的db/db小鼠作为青年对照... 详细信息

目的:探讨非变性Ⅱ型胶原蛋白(UCⅡ)对增龄导致的db/db小鼠运动机能下降的改善作用。方法:将正常喂养至老年的db/db小鼠随机分为模型对照组、UCⅡ干预组、阳性对照组,以同周龄的db/m小鼠为正常对照组,喂养至25周的db/db小鼠作为青年对照组,干预12周后评估其爬网时间和步态特征,继续干预4周后评价其骨形态计量学特征,计算腓肠肌指数。结果:UCⅡ干预组腓肠肌指数明显大于模型对照组(P0.5),小鼠骨密度与爬网时间、支撑相时长、摆动速度呈现一定正相关(系数>0.5),表明UCⅡ可以改善db/db小鼠由于增龄带来的腓肠肌质量、骨密度的下降,提高其运动能力。

关键词：老年db/db小鼠非变性Ⅱ型胶原蛋白骨胳肌肉运动机能

S-equol,a Secondary Metabolite of Natural Anticancer Isoflavone Daidzein,Inhibits Prostate Cancer Growth in vitro and in vivo,through Activating the Akt/FOXO3a Pathway

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S-equol,a Secondary Metabolite of Natural Anticancer Isoflav...

“鲟龙1号”含肉率及肌肉营养成分分析与评价

第六届全国中西医结合营养学术会议

作者： Zongliang Lu Rui Zhou Wanyuan Xia Ya Kong Jiajia Wang Jing Guo Jie Liu Hailan Sun Kai Liu yong Zhou Jian Yang Mantian Mi Hongxia xu Department of nutrition Daping Hospital and Research Institute of SurgeryThird Military Medical University Research Center for nutrition and food Safety Third Military Medical University

Objective:The present study aimed at testing the hypothesis that AKT/FOXO3 pathway is critical for S-equol to exert its anticancer ***:The MTT assay was used to detect the inhibitory efficacy of S-equol in prostate cancer cells in comparison with normal prostate epithelial cells to demonstrate its activity and *** cytometric analysis was used to detect the effects of S-equol on cell cycle and apoptosis in prostate cancer *** assay was used to detect the effects of S-equol on FOXO3 protein nuclear *** blotting analysis was used to determine the expression levels and the phosphorylation levels of FOXO3 a and AKT and the expression levels of p21,p27,FasL,and *** nude mouse xenograft tumor model of human prostate cancer PC3 cells was used to demonstrate the in vivo efficacy of S-equol as an anti-prostate cancer ***:S-equol inhibited cell survival in three prostate cancer cell lines,LnCaP,DU145,and PC3,with half-maximal inhibitory concentrations(IC) values ranging froml 19.2μM to 169.13μM.S-equol had minimal effect on the survival of RWPE-1,a human non-malignant prostate epithelial cell *** S-equol treatment,the three prostate cancer cell lines exhibited a significant increase in apoptosis(p<0.05)in a concentration-dependent manner;compared with the DMSO control cells,following exposure to 200μM of S-equol,the apoptotic indices were increased by 1.88,1.54,and 3.3-fold in LnCaP,DU145,and PC3 cells,separately,.S-equol induced cell cycle arrest at the G0/G1 phase in LnCaP cells(p53 wt) and DU145cells(p53 mt) and induced cell cycle arrest in the G2/M phase in PC3 cells(p53 null),indicating that its cell cycle arrest effects may be associated with the p53 status of the prostate cancer *** results of Western blot analyses indicated that S-equol increased the FOXO3 a protein expression and decreased the MDM2 protein *** PC3 cells,S-equol exposure decreased the expression p-AKT a

关键词： S-equol Akt FOXO3a MDM2 prostate cancer

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水产学杂志 2019年第4期32卷 31-37页

作者：高雪张颖纪锋许式见张永旺中国水产科学研究院黑龙江水产研究所黑龙江哈尔滨150070 上海海洋大学水产与生命学院上海201306 新疆伊河鲟业科技股份有限公司新疆伊宁835000 杭州千岛湖鲟龙科技股份有限公司浙江杭州311701

用常规测定和评价方法测定鲟新品种'鲟龙1号'(Huso dauricus♀×Acipenser schrenckii♂)的含肉率及肌肉营养成分,评价其营养价值。结果表明:'鲟龙1号'含肉率达63.25%;肌肉中水分、粗蛋白、粗脂肪、灰分和无氮浸出物的含量分别为(72.10... 详细信息

用常规测定和评价方法测定鲟新品种'鲟龙1号'(Huso dauricus♀×Acipenser schrenckii♂)的含肉率及肌肉营养成分,评价其营养价值。结果表明:'鲟龙1号'含肉率达63.25%;肌肉中水分、粗蛋白、粗脂肪、灰分和无氮浸出物的含量分别为(72.10±1.13)%、(19.90±0.95)%、(6.47±0.50)%、(0.98±0.02)%和(0.5±0.44)%。其肌肉中富含钙、镁、磷等多种人体所需矿物元素。检测出18种常见氨基酸,其中8种必需氨基酸占总氨基酸含量的48.88%,4种鲜味氨基酸含量占总氨基酸含量的36.53%,必需氨基酸指数(EAAI)为82.51,必需氨基酸总量及其占总氨基酸含量的百分比均高于FAO/WHO制定的标准。'鲟龙1号'肌肉中共检测出21种脂肪酸,其中多不饱和脂肪酸(PUFAs)为(3.06±0.43)g/100g,二十碳五稀酸EPA+二十二碳六稀酸DHA含量为0.49g/100g。测定结果表明:'鲟龙1号'营养价值高,是理想的蛋白质源。

关键词：杂交鲟 “鲟龙1号” 肌肉含肉率营养评价

玉米肽对乙醇氧化损伤模型小鼠的抗氧化作用研究

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食品研究与开发 2019年第15期40卷 31-35页

作者：李雍林峰秦勇刘伟周雅琳李睿珺于兰兰许雅君北京大学公共卫生学院营养与食品卫生学系北京100191 北京中医药大学中药学院北京100029 正生营养研究院新疆昌吉830000 食品安全毒理学研究与评价北京市重点实验室北京100191

为探讨玉米肽对乙醇氧化损伤模型小鼠的抗氧化作用,将实验动物依据其体重随机分为5组:正常对照组、模型对照组、玉米肽低剂量组、中剂量组和高剂量组,除玉米肽的各剂量组外均灌胃给药酪蛋白。30 d后玉米肽各剂量组及模型组均灌胃50 %乙... 详细信息

为探讨玉米肽对乙醇氧化损伤模型小鼠的抗氧化作用,将实验动物依据其体重随机分为5组:正常对照组、模型对照组、玉米肽低剂量组、中剂量组和高剂量组,除玉米肽的各剂量组外均灌胃给药酪蛋白。30 d后玉米肽各剂量组及模型组均灌胃50 %乙醇以造模氧化损伤小鼠模型,并摘取肝脏及摘眼球取血以测定各指标:丙二醛(malondialdehyde,MDA)含量、超氧化物歧化酶(superoxide dismutase,SOD)活力、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)活力、谷胱甘肽(glutathione,GSH)含量和肝组织蛋白质羰基(protein carbonyl,PC)含量。实验结果显示受试样品能显著提升实验动物机体内SOD、GSH-Px抗氧化酶的活力和抗氧化物质GSH的含量(p<0.01),并显著降低MDA和肝组织中PC含量(p<0.05)。研究结果表明玉米肽对乙醇氧化损伤模型小鼠具有抗氧化作用。

关键词：玉米肽氧化应激抗氧化酶系膜脂损伤抗氧化

短波紫外线处理对鲜切果蔬品质及抗氧化活性的影响研究进展

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食品工业科技 2020年第10期41卷 344-349页

作者：方晓彤陶永霞沈琦邵旭鹏王艳王成刘峰娟新疆农业科学院农业质量标准与检测技术研究所新疆乌鲁木齐830091 农业农村部农产品质量安全风险评估实验室新疆乌鲁木齐830091 新疆农产品质量安全重点实验室新疆乌鲁木齐830091 新疆农业科学院科研管理处新疆乌鲁木齐830091 新疆农业大学食品科学与药学学院新疆乌鲁木齐830052

鲜切果蔬因具有营养、便利、新鲜、可食率达100%等特点,越来越受到人们的关注。但鲜切果蔬由于受到机械损伤,其品质下降、易被微生物污染。短波紫外线作为一种非热力杀菌技术,近年来被研究者们用于鲜切果蔬保鲜,得到了良好的效果。本文... 详细信息

鲜切果蔬因具有营养、便利、新鲜、可食率达100%等特点,越来越受到人们的关注。但鲜切果蔬由于受到机械损伤,其品质下降、易被微生物污染。短波紫外线作为一种非热力杀菌技术,近年来被研究者们用于鲜切果蔬保鲜,得到了良好的效果。本文介绍了鲜切果蔬及短波紫外线技术的特点,综述了短波紫外线处理对鲜切果蔬安全品质、营养品质及感官品质的影响及短波紫外线处理对鲜切果蔬抗氧化物质及抗氧化活性的作用,并讨论短波紫外线技术在鲜切果蔬中的应用前景,为短波紫外线处理鲜切果蔬的深入研究和推广应用提供重要的理论依据和参考。

关键词：短波紫外线鲜切果蔬杀菌技术营养品质安全抗氧化活性

不同盐处理对乳化肉糜的流变性质和凝胶特性的影响

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食品与发酵工业 2018年第9期44卷 98-104页

作者：孙迪邓亚敏郑多多许帅强邵俊花刘登勇渤海大学食品科学与工程学院辽宁省食品安全重点实验室生鲜农产品贮藏加工及安全控制技术国家地方联合工程研究中心辽宁锦州121013 中国农业科学院合肥食品营养与健康创新研究院北京100193

以乳化猪肉糜为研究对象,结合乳化肉糜的色泽、保水性、流变学特性和质构特性,研究不同盐处理(空白组、食盐组、磷酸盐组、食盐+磷酸盐组)对乳化肉糜流变及凝胶特性的影响。结果表明,与空白组比较,食盐处理组的蒸煮损失显著(p 0. 05);... 详细信息

以乳化猪肉糜为研究对象,结合乳化肉糜的色泽、保水性、流变学特性和质构特性,研究不同盐处理(空白组、食盐组、磷酸盐组、食盐+磷酸盐组)对乳化肉糜流变及凝胶特性的影响。结果表明,与空白组比较,食盐处理组的蒸煮损失显著(p 0. 05);流变特性测试结果显示,磷酸盐组中的乳化肉糜蛋白发生变化的起始温度较低,凝结结束表现为较低的弹性模量;对于食盐+磷酸盐组,蒸煮损失显著(p <0. 05)降低,整体黏弹性较好且凝胶剖面结构紧凑。说明食盐与磷酸盐二者发挥协同作用使乳化肉糜整体黏弹性较好且加热凝胶呈现较好的保水性与质构特性,单独添加磷酸盐处理后,不能达到此效果。

关键词：乳化肉糜食盐磷酸盐流变

遥感植被指数和CASA模型估算山东省冬小麦单产

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光谱学与光谱分析 2021年第1期41卷 257-264页

作者：张莎白雲刘琦童德明徐振田赵娜王兆雪王霄鹏李咏沙张佳华青岛大学自动化学院山东青岛266071 青岛大学计算机科学技术学院遥感信息与数字地球研究中心山东青岛266071 中国科学院大学地球与行星科学学院北京100049 中国科学院空天信息创新研究院北京100094

准确估算区域尺度冬小麦单产对明确区域农业生产现状与保证国家粮食安全有重要意义。光能利用率模型是作物单产估算的常用模型之一,模型中最大光能利用率(ξmax)是准确估算作物单产的关键参数,作物的ξmax是否随时间发生变化需要深入探... 详细信息

准确估算区域尺度冬小麦单产对明确区域农业生产现状与保证国家粮食安全有重要意义。光能利用率模型是作物单产估算的常用模型之一,模型中最大光能利用率(ξmax)是准确估算作物单产的关键参数,作物的ξmax是否随时间发生变化需要深入探讨。首先使用Savitzky-Golay(S-G)对中分辨率成像光谱仪(MODIS)时序植被指数数据进行滤波,采用差分法结合光谱突变法提取了山东省2000年—2015年冬小麦种植面积,并使用市级尺度年鉴统计面积对提取面积进行验证,然后使用固定ξmax和变化ξmax分别驱动光能利用率模型(CASA),结合作物收获指数与冬小麦种植面积获取山东省2000年—2016年冬小麦单产时空分布特征,探讨最大光能利用率对作物单产模拟的影响。结果表明,滤波后的时序植被指数数据能够反映冬小麦生长的光谱特征,差分法与光谱突变法结合提取冬小麦面积具有较好的普适性,提取的多年冬小麦种植面积与年鉴统计冬小麦播种面积之间的决定系数(R^2)达0.71;变化ξmax情景下模拟的多年冬小麦单产与统计单产之间的决定系数更高,说明冬小麦ξmax是随时间变化的,可能与冬小麦品种更替有关。基于统计与模拟的结果均显示山东省冬小麦单产在2000年—2016年间呈现增加趋势,两者表现出来的增加速率分别为93.12和149.79 kg·hm^-2·a^-1。在空间上,山东省冬小麦单产呈现西部高于东部的分布特征。

关键词：时序遥感植被指数数据最大光能利用率冬小麦种植面积提取冬小麦单产估算山东省

COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,china,July 2020

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china CDC weekly 2021年第21期3卷 441-447页

作者： Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo xu chinese Center for Disease Control and Prevention BeijingChina Dalian Center for Disease Control and Prevention DalianLiaoningChina National institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Chengdu Center for Disease Control and Prevention ChengduSichuanChina Liaoning Center for Disease Control and Prevention ShenyangLiaoningChina china National Center for food Safety Risk Assessment BeijingChina Zhejiang Center for Disease Control and Prevention HangzhouZhejiangChina National Center for Rural Water Supply Technical Guidance Chinese Center for Disease Control and PreventionBeijingChina National institute of Occupational Health and Poison Control Chinese Center for Disease Control and PreventionBeijingChina Nanjing Center for Disease Control and Prevention NanjingJiangsuChina National institute for nutrition and Health Chinese Center for Disease Control and PreventionBeijingChina

Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in china after major nonpharmaceutical interventions and vaccines have been deployed and ***,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of china..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,*** investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel *** are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible *** with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported *** measures to prevent the introduction of the virus via cold-chain goods can be implemented.

关键词： introducing prevention maintain

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Biomarkers of aging

Science china(Life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan xu Yingying xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS Key Laboratory of Genomic and Precision medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Nuclear medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Maternal Fetal medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The Department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock