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P08 Comparing study in self-motivation learning： PBL vs LBL

中国药理通讯 2006年第2期23卷 18-19页

作者： hg nie JQ CAI MJ WEI ZG SONG WB JIN JM LI XS YU BZ SUN department of pharmacology medical education research center China Medical UniversityLN Shenyang 110001

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Evaluation of critical thinking skills in pharmacological PBL teaching

Evaluation of critical thinking skills in pharmacological PB...

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Satellite Meeting on Pharmacological Teaching & The 15th World Congress of Pharmacology

作者： Cai JQ nie hg Yu XS Sun BZ (School of pharmaceutical science medical education research center China Medical University LN Shenyang 10001 P.R. China)

＜正＞OBJECTIVE: Critical thinking is regarded as purposeful, self-regulatory judgment, which is a composite of skills linked to problem-based learning （PBL）. Because rigorous evaluation of critical thinking had not been formally undertaken, the purpose of this study was to evaluate how the PBL in pharmacology was developing students’ critical thinking skills. METHOD: 3rd year medical students were initially randomized to participate in a PBL （n =30）, or a lecture-based learning （LBL, n =30） course in basic pharmacology. Data was collected quantitatively according to the modified CTDI-CV （California critical thinking disposition inventory-Chinese version） over a ten-hour period. RESULTS: The modified CTDI-CV score indicated that students using PBL teaching method scored overall higher than those using LBL mode （P＜0.001）, especially at truth seeking, open mindedness, analyticity, systematicity, inquisitiveness. CONCLUSION: The modified CTDI-CV is not only useful for the students to think through their appearance in critical thinking, but the teachers to evaluate the students’ critical thinking skills which will be very beneficial to the students by enhancing the practice according to their results.

关键词： critical thinking problem-based learning pharmacology medical education

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Study on the element geochemical charactersitics of the Shazi large-sized anatase ore deposit in Qinglong, Guizhou Province

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Chinese Journal Of Geochemistry 2014年第3期33卷 316-323页

作者： ZHANG Min nie Aiguo XIE Fei ZHU Mingjin ZHANG Zhuru Guizhou University Guizhou Coal Mine Design and Research Institute Guizhou Institute of Technology

The Shazi anatase ore deposit in Qinglong, Guizhou Province, is a large-sized anatase deposit that has been recently explored. The characteristics of major oxides in the ore are similar to those of modern laterite weathering crust and laterite in the laterite-type gold deposits in the western part of Guizhou Province. Studies on the REE characteristics of basalts and anatase ores in the study region showed that both of them do have extremely strong affinities. There are two groups of trace elements in the ores, i.e., Au-Ag-As-Sb-hg-Tl association and Sc-TiO2-Cu-Fe-Mn association, reflecting that the formation of anatase ore is related to the formation of siliceous claystone at the early stage of eruption of the Emeishan basaltic magma. The siliceous claystones are the major country rocks for the formation of laterite-type gold ores and anatase ores. In the region anatase ores are rich in Sc and the basalts enriched in Fe, Mn, Ti and Sc are the material source of metallogenesis.

关键词：地球化学特性稀土元素锐钛矿贵州省矿床峨眉山玄武岩红土型金矿作者

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Late Paleozoic Element Migration and Accumulation under Intracontinental Sinistral Strike-slip Faulting in the West Junggar Orogenic Belt, NW China

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Acta Geologica Sinica(English Edition) 2020年第6期94卷 2012-2030页

作者： WANG Ye CHEN Xuanhua nie Lanshi DING Weicui WANG Xueqiu XU Shenglin MA Feizhou HAN Lele SinoProbe Center Chinese Academy of Geological Sciences and China Geological SurveyBeijing 100037China Institute of Geophysical and Geochemical Exploration Chinese Academy of Geological SciencesLangfangHebei 065000China China University of Geosciences Beijing 100083China

The migration,accumulation and dispersion of elements caused by tectonic dynamics have always been a focus of attention,and become the basis of ***,the effects of faulting,especially strike-slip faulting,on the adjustment of geochemical element distribution,are still not *** this paper,we select the West Junggar Orogenic Belt(WJOB),NW China,as a case study to test the migration behavior of elements under tectonic *** WJOB is dominated by NE-trending large-scale sinistral strike-slip faults such as the Darabut Fault,the Mayile Fault,and the Baerluke Fault,which formed during the intracontinental adjustment under N-S compression during ocean-continental conversion in the Late *** maps of 13 elements,Al,W,Sn,Mo,Cu,Pb,Zn,As,Sb,hg,Fe,Ni,and Au,are analyzed for the effects of faulting and folding on element distribution at the regional *** results show that the element distribution in the WJOB is controlled mainly by two mechanisms during tectonic deformation:first is the material transporting mechanism,where the movement of geological units is consistent with the direction of tectonic movement;second is the diffusion mechanism,especially by tectonic pressure dissolution driven by tectonic dynamics,where the migration of elements is approximately perpendicular or opposite to the direction of tectonic *** conclude that the adjustment of element distributions has been determined by the combined actions of transporting and diffusion mechanisms,and that the diffusion mechanism plays an important role in the formation of geochemical Au blocks in the WJOB.

关键词： tectono-geochemistry strike-slip fault system element distribution gold West Junggar Central Asian Orogenic Belt

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Mechanical behaviors and rupture processes of a typical granitic stratum

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第10期16卷 4247-4260页

作者： Xiaofang nie Dong Wang Song Yuan Liangpu Li Zhilong Zhang Zidong Fan Qin Zhou Meng Wang Li Ren MOE Key Laboratory of Deep Earth Science and Engineering College of Architecture and EnvironmentSichuan UniversityChengdu610065China College of Water Resources and Hydropower Sichuan UniversityChengdu610065China Sichuan Communication Surveying&Design Institute Co. Ltd.Chengdu610065China

Granitic veins(GVs)have a significant influence on the mechanical responses of tunnels excavated in granitic *** the mechanical properties of host granites(hgs),GVs and vein-granite interfaces(VGIs)is *** this,this paper analyzed the mechanical behaviors and rupture processes of typical hg,GV,and VGI samples under uniaxial compression *** the rocks studied,although the linear axial stress‒strain relation can be identified and the deformation modulus can be determined,the transverse deformation developed nonlinearly with axial *** a result,the instantaneous Poisson’s ratio increases continuously and may even exceed 0.5,making it extremely difficult to accurately determine the Poisson’s *** addition,the studied GV samples were found to be significantly brittle,indicating that large-scale GVs cannot be ignored when assessing rockburst hazards in granitic strata with brittle *** terms of the rupture process,the hg and GV samples were gradually damaged by the formation of small-scale cracks and then ruptured by large cracks formed from smallscale cracks,whereas the VGI samples ruptured along large cracks with significant energy *** examining the characteristic stress thresholds of these three granites,it is noted that the crack closure stress scc exceeds both the crack initiation stress sci and the crack damage stress scd for the hg and VGI *** transverse damage to a tested sample appears to be significantly greater than the axial damage,which is essentially related to the rock grain size and grain size distribution.

关键词： Tunnel Granite Granitic vein Uniaxial compression Acoustic emission

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Systemic changes and adverse effects induced by retinopathy of prematurity screening

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1148-1155页

作者： Jing-Bo Jiang Zhi-Wei Zhang Jia-Wen Zhang Yan-Li Wang Chuan nie Xian-Qiong Luo Department of Neonatology Guangdong Province Women and Children's Hospital Department of Pediatric Cardiology Guangdong Cardiovascular Institute Guangdong General HospitalGuangdong Academy of Medical Sciences

AIM: To estimate the potential systemic events during and after retinopathy of prematurity (ROP) screening. ' METHODS: A prospective and descriptive designed study was conducted to detect the physiologic and pathological changes 24h before, during, and 72h after ROP screening. Control blood pressure (BP), saturation, pulse rate, and body temperature were routinely taken at various time internals before and after screening. Adverse effects pertain to cardiovascular system, respiratory system, gastric system, urinary system and nervous system were retrospect 0-72h after ROP screening at a 24-hour interval. RESULTS: Totally 1254 prematurity babies receiving ROP screening during Jan. 1st 2013 to Dec. 31th 2013 were enrolled in our survey. Compared to control vital sign data taken before the examination, there was a fluctuation in the diastolic BP with the increased 3.03 mm hg (P=0.04) after 3 doses of mydriatic drops. Immediately after the examination, there was a further 12.64 mm hg (Phg (P<0.01) in diastolic BP. The mean pulse rate during examination was 22.4 bpm (P<0.01) higher than the 133.3 +/- 9.0 bpm control level. The oxygen saturation shared an average drop of 5% (P<0.01) during screening. In prematurity with postconceptional age less than 31wk, the incidence of apnea (23.5%), necrotizing enterocolitis (NEC) (8.7%), gastric residual (25.4%) and upper digestive tract hemorrhage (6.4%) also demonstrated a significant rise (P<0.01). CONCLUSION: In our study sample, ROP screening was associated with NEC, gastric residual and upper digestive tract hemorrhage. These gastrointestinal side effects, along with breath activity pattern change and vital signs indicators fluctuation, may be results of additional stress responses.

关键词： retinopathy of prematurity prematurity screening apnea necrotizing enterocolitis stress response mydriatic drops

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ICP-MS法测定食品级壳聚糖中的微量杂质元素

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光谱学与光谱分析 2016年第8期36卷 2621-2624页

作者：聂西度符靓湖南工学院材料与化学工程系湖南衡阳421002 长江师范学院化学化工学院重庆408100

建立了电感耦合等离子体质谱(ICP-MS)法直接测定食品级壳聚糖中杂质元素的分析方法。壳聚糖用3%的柠檬酸溶解并加入低浓度盐酸后,采用ICP-MS法直接测定其中的Be,Na,Mg,K,Ca,Ti,V,Cr,Mn,Fe,Co,Ni,Cu,Zn,As,Cd,Sn,Sb,hg,Pb等20种杂质元素... 详细信息

建立了电感耦合等离子体质谱(ICP-MS)法直接测定食品级壳聚糖中杂质元素的分析方法。壳聚糖用3%的柠檬酸溶解并加入低浓度盐酸后,采用ICP-MS法直接测定其中的Be,Na,Mg,K,Ca,Ti,V,Cr,Mn,Fe,Co,Ni,Cu,Zn,As,Cd,Sn,Sb,hg,Pb等20种杂质元素。盐酸的使用有效地改善了元素的稳定性,尤其是hg和Sn。选择动态反应池(DRC)技术消除了氯离子干扰以及其他质谱干扰,采用基体匹配法并通过加入Sc,Y,In,Bi内标元素混合溶液补偿了样品传输效率的差异以及有机溶剂蒸发速率的影响。在选定的工作条件下,20种元素的标准曲线方程具有良好的线性关系,线性相关系数不小于0.999 7,各元素的检出限在0.64~19.01 ng·L^(-1)之间,加标回收率在89.50%~109.00%之间,相对标准偏差(RSD)在1.17%~4.05%之间,实际样品分析结果显示,食品级壳聚糖中杂质元素的含量较低,其中重金属元素的含量很低,食用安全。该方法能简便、灵敏、准确地测定食品级壳聚糖中的20种杂质元素。

关键词：壳聚糖电感耦合等离子体质谱柠檬酸盐酸杂质元素

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电感耦合等离子体质谱法测定硅藻土助滤剂中的重金属元素

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光谱学与光谱分析 2015年第11期35卷 3192-3195页

作者：聂西度符靓湖南工学院材料与化学工程学院湖南衡阳421002 长江师范学院化学化工学院重庆涪陵408100

建立了硅藻土助滤剂中多个重金属元素的分析方法。以氢氟酸、硝酸和磷酸为混合试剂采用微波消解法对硅藻土助滤剂进行密闭消解,应用电感耦合等离子体质谱（ICP-MS）法对消解液中的Be,Cr,Ni,As,Cd,Sb,Sn,Tl,hg,Pb等10个元素进行测定。研... 详细信息

建立了硅藻土助滤剂中多个重金属元素的分析方法。以氢氟酸、硝酸和磷酸为混合试剂采用微波消解法对硅藻土助滤剂进行密闭消解,应用电感耦合等离子体质谱（ICP-MS）法对消解液中的Be,Cr,Ni,As,Cd,Sb,Sn,Tl,hg,Pb等10个元素进行测定。研究了高硅基体存在时所产的质谱干扰,首先通过优化仪器工作参数以及待测元素同位素的选择,最大程度地避免了质谱分析过程中的多种干扰,然后选择动态反应（DRC）技术消除了其它质谱干扰,多元素（Li,Sc,Y,In,Bi）内标溶液的使用消除了基体效应,维持了分析信号的稳定。分析结果显示,10个待测元素的检出限在3.29~15.68ng·L^-1之间,相对标准偏差（RSD）≤4.62%,加标回收率为90.71%~107.22%。方法的灵敏度高,准确度和精密度好,可用于硅藻土助滤剂的质量控制和安全评价。

关键词：硅藻土助滤剂电感耦合等离子体质谱重金属内标动态反应池

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Geological and geochemical characteristics of the Baogudi Carlintype gold district(Southwest Guizhou, China) and their geological implications

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Acta Geochimica 2019年第4期38卷 587-609页

作者： Songtao Li Yong Xia Jianzhong Liu Zhuojun Xie Qinping Tan Yimeng Zhao Minghua Meng Lijin Tan Rong nie Zepeng Wang Guanghong Zhou Haiyan Guo State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China No.105 Geological Team Guizhou Bureau of Geology and Mineral Exploration and DevelopmentGuiyang 550018China Bureau of Geology and Mineral Exploration and Development Guizhou Province Guiyang 550004China Guizhou Education University Guiyang 550018China School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China

The newly discovered Baogudi gold district is located in the southwestern Guizhou Province,China,where there are numerous Carlin-type gold *** better understand the geological and geochemical characteristics of the Baogudi gold district,we carried out petrographic observations,elemental analyses,and fluid inclusion and isotopic composition *** also compared the results with those of typical Carlin-type gold deposits in southwestern *** mineralization stages,namely,the sedimentation diagenesis,hydrothermal(main-ore and late-ore substages),and supergene stages,were identified based on field and petrographic *** main-ore and late-ore stages correspond to Au and Sb mineralization,respectively,which are similar to typical Carlin-type *** mass transfer associated with alteration and mineralization shows that a significant amount of Au,As,Sb,hg,Tl,Mo,and S were added to mineralized rocks during the main-ore ***,arsenic,Sb,and S were added to the mineralized rocks during the late-ore *** migration indicates that the sulfidation process was responsible for ore *** types of fluid inclusions were identified in ore-related quartz and *** main-ore stage fluids are characterized by an H2O–NaCl–CO2–CH4±N2system,with medium to low temperatures(180–260℃)and low salinity(0–9.08%NaCl equivalent).The late-ore stage fluids featured H2O–NaCl±CO2±CH4,with low temperature(120–200℃)and low salinity(0–7.48%Na Cl equivalent).The temperature,salinity,and CO2and CH4concentrations of ore-forming fluids decreased from the main-ore stage to the late-ore *** calculated δ^13C,d D,and δ^18O values of the ore-forming fluids range from-14.3 to-7.0%,-76 to-55.7%,and 4.5–15.0%,***-ore-stage stibnite had δ^34S values ranging from-0.6 to 1.9%.These stable isotopic compositions indicate that the ore-forming fluids originated mainly from deep magmatic hydrothermal fluids,with minor contribution

关键词： Elemental geochemistry Fluid inclusions Stable isotopes Carlin-type gold deposits Baogudi gold district Southwestern Guizhou

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Effects of Outdoor Temperature on Blood Pressure in a Prospective Cohort of Northwest China

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Biomedical and Environmental Sciences 2021年第2期34卷 89-100页

作者： ZHENG Shan WANG Min Zhen CHENG Zhi Yuan KANG Feng nie Yong Hong MI Xiu Ying LI Hai Yan JIN Lan ZHANG Ya Wei BAI Ya Na Institute of Epidemiology and Statistics School of Public HealthLanzhou UniversityLanzhou 73000GansuChina Department of Epidemiology School of Public HealthBrown UniversityProvidenceRhode Island 02903USA Workers'Hospital of Jinchuan Group Co. Ltd.Jinchang 737103GansuChina Jinchang Center for Disease Prevention and Control Jinchang 737100GansuChina Jinchang Meteorological Service Jinchang737100GansuChina Department of Surgery Yale School of MedicineNew Haven 06511USA Department of Environmental Health Sciences Yale School of Public HealthNew Haven 06511US

Objective The relationship between outdoor temperature and blood pressure(BP) has been inconclusive. We analyzed data from a prospective cohort study in northwestern China to investigate the effect of outdoor temperature on BP and effect modification by *** A total of 32,710 individuals who participated in both the baseline survey and the first follow-up in 2011–2015 were included in the study. A linear mixed-effect model and generalized additive mixed model(GAMM) were applied to estimate the association between outdoor temperature and BP after adjusting for confounding *** The mean differences in systolic blood pressure(SBP) and diastolic blood pressure(DBP)between summer and winter were 3.5 mm hg and 2.75 mm hg, respectively. After adjusting for individual characteristics, meteorological factors and air pollutants, a significant increase in SBP and DBP was observed for lag 06 day and lag 04 day, a 0.28 mm hg(95% CI: 0.27–0.30) per 1 °C decrease in average temperature for SBP and a 0.16 mm hg(95% CI: 0.15–0.17) per 1 °C decrease in average temperature for DBP, respectively. The effects of the average temperature on both SBP and DBP were stronger in summer than in other seasons. The effects of the average temperature on BP were also greater if individuals were older, male, overweight or obese, a smoker or drinker, or had cardiovascular diseases(CVDs), hypertension, and *** This study demonstrated a significant negative association between outdoor temperature and BP in a high-altitude environment of northwest China. Moreover, BP showed a significant seasonal variation. The association between BP and temperature differed by season and individuals' demographic characteristics(age, gender, BMI), unhealthy behaviors(smoking and alcohol consumption), and chronic disease status(CVDs, hypertension, and diabetes).

关键词： Outdoor temperature Season Blood pressure Jinchang cohort

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