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阿奇霉素致药物性肝损伤临床误诊探析

临床误诊误治 2024年第13期37卷 23-27页

作者：林赫妍熊昊三亚哈尔滨医科大学鸿森医院重症医学科海南三亚572000

目的探讨阿奇霉素致药物性肝损伤(DILI)的临床特点、误诊原因及防范措施。方法回顾分析2020年2月至2022年10月阿奇霉素致DILI误诊患者11例的临床病例资料。结果11例中男5例、女6例;年龄6~58岁。2例以发热、咳嗽、胸闷,初步诊断为肺炎收... 详细信息

目的探讨阿奇霉素致药物性肝损伤(DILI)的临床特点、误诊原因及防范措施。方法回顾分析2020年2月至2022年10月阿奇霉素致DILI误诊患者11例的临床病例资料。结果11例中男5例、女6例;年龄6~58岁。2例以发热、咳嗽、胸闷,初步诊断为肺炎收入院。1例以发热、关节酸痛,初步诊断为类风湿关节炎收入院。3例以皮肤瘙痒、皮疹,初步诊断为过敏性皮疹收入院。5例以食欲减退、乏力、恶心、上腹部不适,初步诊断为胃炎收入院。对应治疗后首诊症状未见好转,6例出现不同程度黄疸、肝区不适。11例行肝功能检查异常。肝脏超声显示:1例未见明显异常;8例肝脏轮廓正常,肝实质回声减低,呈细颗粒状,密度较稀疏;2例肝脏略增大,肝实质光点增亮、增粗,高回声,分布不均。追溯病史患者均有急性上呼吸道感染史及阿奇霉素服用史。遂确诊为阿奇霉素致DILI。误诊时间1~2 d。11例予以保肝、解毒、降酶对症治疗,首诊症状显著缓解,肝功能逐步恢复正常,复查肝脏超声肝脏受损程度明显改善,预后良好。结论DILI临床表现各异,且缺乏特异性,首发症状可以是多种肝外表现,易引起误诊。大部分患者停药后可恢复。因此临床医师应提高对DILI的诊断能力,临床药师应积极参与临床查房、药学会诊等,加强用药指导,减少DILI的发生。

关键词：药物性肝损伤阿奇霉素误诊肺炎类风湿关节炎过敏性皮疹胃炎肝功能

Computer Simulation of Carbide Transformation in Die Steel for Plastic

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Journal of Iron and Steel Research International 2005年第4期12卷 44-49页

作者： heyan-lin LIlin PatrickWOLLANTS ShanghaiUniversity Shanghai200072China KatholiekeUniversiteitLeuven B-3001HeverleeBelgium

Thermo-Calc software package (TCP+DICTRA) was used to simulate the carbide transformation process in die steel for plastic. Combined with TEM analysis, the calculated result confirms that the carbide in equilibrium state is M_7C_3 carbide. The dissolution of M_7C_3 carbide in steel is predicted by DICTRA program. It was shown that the temperature remarkably affects the dissolution process of M_7C_3 carbide, but the influence of alloy elements such as manganese and molybdenum can be neglected in this steel.

关键词： Thermo-Calc software package die steel for plastic M_7C_3 carbide TEM analysis

Computer Aided Design of Heat Treatment for AISI P20+Ni Mold Steel with Good Machinability

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材料热处理学报 2004年第5期25卷 627-630页

作者： HUXin-bin GAOWen heyan-lin LIlin Dept.Mater.Sci.＆Eng. ShanghaiUniversity149YanchangRoadShanghai200072China Dept.Mater.Sci.＆Eng. ShanghaiUniversity149YanchangRoadShanghai200072China／Dept.MechanicalEngineeringHubeiPolytechnicUniversityWuhan430068China ShanghaiNo.5steelCo. LTDofShanghaiBaosteelGroupCo.Shanghai200940China

Computer aided design of heat treatment for AISI P20 mold steel with good machinability is attempted to proceed by the commercial software package Thermo-Calc (TCP+DICTRA). Through experimental and theoretical analysis of phase transformation during heat treatment, further knowledge of designing proper heat treatment is obtained. Then the machinability of AISI P20+Ni steel under given heat treatment condition is studied and the influencing factors to their machinability are analyzed. It is shown that heat treatment designed by computer simulation of carbide transformation is applicable to AISI P20+Ni steel with good machinability; AISI P20+Ni steel with tempered sorbite treated by quenching & tempering has optimal machinability; normalizing at the temperature of 910°C & tempering can avoid cracking and result in acceptable machinability in small thickness module.

关键词：热处理 AISI P20+Ni模具钢可加工性计算机设计

Quantum dot-enabled infrared hyperspectral imaging with single-pixel detection

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Light(Science & Applications) 2024年第6期13卷 1112-1121页

作者： heyan Meng Yuan Gao Xuhong Wang Xianye Li Lili Wang Xian Zhao Baoqing Sun School of Information Sciences and Engineering Shandong UniversityQingdaoChina Center for Optics Research and Engineering(CORE) Key Laboratory of Laser&Infrared System(Shandong University)Ministry of EducationShandong UniversityQingdaoChina School of Mechanical Electrical and Information EngineeringShandong UniversityWeihaiChina

Near-infrared(NIR)hyperspectral imaging is a powerful technique that enables the capture of three-dimensional(3D)spectra-spatial information within the NIR spectral range,offering a wide array of ***,the high cost associated with InGaAs focal plane array(FPA)has impeded the widespread adoption of NIR hyperspectral *** this challenge,in this study,we adopt an alternative approach—single-pixel detection for NIR hyperspectral *** investigation reveals that single-pixel detection outperforms conventional FPA,delivering a superior signal-to-noise ratio(SNR)for both spectral and imaging *** implement this strategy,we leverage self-assembled colloidal quantum dots(CQDs)and a digital micromirror device(DMD)for NIR spectral and spatial information multiplexing,complemented by single-pixel detection for simultaneous spectral and image *** experimental results demonstrate successful NIR hyperspectral imaging with a detection window about 600 nm and an average spectral resolution of 8.6 nm with a pixel resolution of 128×*** resulting spectral and spatial data align well with reference instruments,which validates the effectiveness of our *** circumventing the need for expensive and bulky FPA and wavelength selection components,our solution shows promise in advancing affordable and accessible NIR hyperspectral imaging technologies,thereby expanding the range of potential applications.

关键词： spectral Quantum mirror

A fast forward computational method for nuclear measurement using volumetric detection constraints

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Nuclear Science and Techniques 2024年第2期35卷 47-63页

作者： Qiong Zhang lin-Lv lin University of Electronic Science and Technology of China Chengdu 610000China

Owing to the complex lithology of unconventional reservoirs,field interpreters usually need to provide a basis for interpretation using logging simulation *** the various detection tools that use nuclear sources,the detector response can reflect various types of information of the *** Monte Carlo method is one of the primary methods used to obtain nuclear detection responses in complex ***,this requires a computational process with extensive random sampling,consumes considerable resources,and does not provide real-time response ***,a novel fast forward computational method(FFCM)for nuclear measurement that uses volumetric detection constraints to rapidly calculate the detector response in various complex environments is ***,the data library required for the FFCM is built by collecting the detection volume,detector counts,and flux sensitivity functions through a Monte Carlo ***,based on perturbation theory and the Rytov approximation,a model for the detector response is derived using the flux sensitivity function method and a one-group diffusion *** environmental perturbation is constrained to optimize the model according to the tool structure and the impact of the formation and borehole within the effective detection ***,the method is applied to a neutron porosity tool for *** various complex simulation environments,the maximum relative error between the calculated porosity results of Monte Carlo and FFCM was 6.80%,with a rootmean-square error of 0.62 *** field well applications,the formation porosity model obtained using FFCM was in good agreement with the model obtained by interpreters,which demonstrates the validity and accuracy of the proposed method.

关键词： Nuclear measurement Fast forward computation Volumetric constraints

Enhancing Safety in Autonomous Vehicle Navigation:An Optimized Path Planning Approach Leveraging Model Predictive Control

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Computers, Materials & Continua 2024年第9期80卷 3555-3572页

作者： Shih-lin lin Bo-Chen lin Graduate Institute of Vehicle Engineering National Changhua University of EducationChanghua50007TaiwanChina

This paper explores the application of Model Predictive Control(MPC)to enhance safety and efficiency in autonomous vehicle(AV)navigation through optimized path *** evolution of AV technology has progressed rapidly,moving from basic driver-assistance systems(Level 1)to fully autonomous capabilities(Level 5).Central to this advancement are two key functionalities:Lane-Change Maneuvers(LCM)and Adaptive Cruise Control(ACC).In this study,a detailed simulation environment is created to replicate the road network between Nantun andWuri on National Freeway No.1 in *** MPC controller is deployed to optimize vehicle trajectories,ensuring safe and efficient *** onboard sensors,including vehicle cameras and millimeterwave radar,are used to detect and respond to dynamic changes in the surrounding environment,enabling real-time decision-making for LCM and *** simulation resultshighlight the superiority of the MPC-based approach in maintaining safe distances,executing controlled lane changes,and optimizing fuel ***,the MPC controller effectively manages collision avoidance,reduces travel time,and contributes to smoother traffic flow compared to traditional path planning *** findings underscore the potential of MPC to enhance the reliability and safety of autonomous driving in complex traffic *** research will focus on validating these results through real-world testing,addressing computational challenges for real-time implementation,and exploring the adaptability of MPC under various environmental *** study provides a significant step towards achieving safer and more efficient autonomous vehicle navigation,paving the way for broader adoption of MPC in AV systems.

关键词： Autonomous driving model predictive control(MPC) lane change maneuver(LCM) adaptive cruise control(ACC)

The Existence of a Meridional Curve in Closed Incompressible Surfaces in Fully Alternating link Complements

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 73-80页

作者： Wei lin School of Mathematical Sciences Dalian University of TechnologyDalian 116024LiaoningChina

Menasco showed that a closed incompressible surface in the complement of a non-split prime alternating link in S^(3) contains a circle isotopic in the link complement to a meridian of the *** on this result,he was able to argue the hyperbolicity of non-split prime alternating links in *** et *** that if F■S×I\L is an essential torus,then F contains a circle which is isotopic in S×I\L to a meridian of *** author generalizes his result as follows:Let S be a closed orientable surface,L be a fully alternating link in S×I\If F ■ S×I\L is a closed essential surface,then F contains a circle which is isotopic in S×I\L to a meridian of L.

关键词： Fully alternating Incompressible surfaces Meridionally incompressible

无锡口岸进境木质包装中截获的两种伞滑刃线虫的形态鉴定

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植物检疫 2010年第3期24卷 29-31页

作者：林何燕刘亮山丁晓帆林茂松无锡出入境检验检疫局江苏无锡214028 深圳出入境检验检疫局南京农业大学植物保护学院

松材线虫病是林业上的一种毁灭性病害。在进境木质包装检疫中,除该病的病原物松材线虫(Bursaphelenchus xylophilus(steiner et buhrer)Nickel)外,还常常截获同属于伞滑刃线虫属(Bursaphelenchus spp.)的多种与之形态非常相似的线虫。... 详细信息

松材线虫病是林业上的一种毁灭性病害。在进境木质包装检疫中,除该病的病原物松材线虫(Bursaphelenchus xylophilus(steiner et buhrer)Nickel)外,还常常截获同属于伞滑刃线虫属(Bursaphelenchus spp.)的多种与之形态非常相似的线虫。本研究对进境木质包装检疫中截获的两种伞滑刃属线虫——***和***进行了形态描述和鉴定。

关键词：伞滑刃线虫属形态鉴定

Adaptive admittance tracking control for interactive robot with prescribed performance

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Journal of Systems Engineering and Electronics 2024年第2期35卷 444-450页

作者： MENG Qingrui lin Yan School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100190China College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China

An adaptive control approach is presented in this paper for tracking desired trajectories in interactive manipulators. The controller design incorporates prescribed performance functions (PPFs) to improve dynamic performance. Notably, the performance of the output error is confined in an envelope characterized by exponential convergence, leading to convergence to zero. This feature ensures a prompt response from admittance control and establishes a reliable safety framework for interactions. Simulation results provide practical insights,demonstrating the viability of the control scheme proposed in this paper.

关键词： prescribed performance admittance control adaptive control robots