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FRACTi.NAL-STEP Fi.i.E ELEm.NT m.THOD FOR CALCULATi.N OF 3-D FREE SURFACE PROBLEm.USi.G LEVEL SET m.THOD

Journal of Hydrodynam.cs 2006年第6期18卷 742-747页

作者： ZHAO Lan-hao Li.Tong-chun WANG Li.g herreros m. i. PASTOR m. College of Water Conservancy and Hydropower Engi.eeri.g Hohai University Naniing 210098 China Anhui.Survey and Desi.n i.sti.ute of Water Conservancy and Hydropower Hefei 230022 China CEDEX and E.T.S. de Cam.nos Madrid Spain

A two-step Taylor-Galerki. fracti.nal-step fi.i.e elem.nt m.thod, whi.h i. of second order accuracy i. space and ti.0}, was proposed for the three-di.0}nsi.nal free surface problem. Wi.h thi. m.thod, the i.term.di.te veloci.y was expli.i.ly obtai.ed by neglecti.g pressure gradi.nt term. and then the veloci.y was corrected by addi.g the effects of pressure once the pressure fi.ld had been obtai.ed from.the pressure Poi.son equati.n. The level set approach was appli.d to track i.0}li.i.ly the free surface. i. order to track the free surface, the transport equati.n of the level set functi.n was solved at each ti.0} step and the level set functi.n i. rei.i.i.li.ed through i.erati.n to m.i.tai. i. as a di.tance functi.n. The governi.g equati.ns of the system.were di.creti.ed by the two- step Taylor-Galerki. m.thod, whi.h i. of hi.h-order accuracy and easy to be used. The vali.i.y and reli.bi.i.y of thi. m.thod i. thi. arti.le were proved by two num.ri.al exam.les.

关键词： level set free surface two steps Taylor-Galerki. fracti.nal step FEm

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Detecti.n of Gene Dosage i. Ci.culati.g Free Plasm. DNA as Bi.m.rker for Lung Cancer

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Journal of Cancer Therapy 2012年第4期3卷 343-351页

作者： Alba m.yerly Alvarez Sandra Janneth Perdom. Lara Di.na m. Palaci.s Edward Fabi.n Carri.lo Lui. Gerardo García herreros Fi.el Cam.cho Durán Pauli.a Ojeda León Fabi. A. Ari.ti.ábal 1Departam.nto de Farm.ci. Facultad de Ciencias Universidad Nacional de Colombia Bogotá Colombia Departam.nto de Farm.ci. Facultad de Ciencias Universidad Nacional de Colombia Bogotá Colombia Departam.nto de Patología Fundación Santa Fe de Bogotá (FSFB) Bogotá Colombia Departam.nto de Patología Hospital Santa Clara ESE Bogotá Colombia

The i.crease i. the num.er of gene copi.s at speci.i. loci.i. a geneti. alterati.n frequently associ.ted wi.h over expressi.n of the related protei. i. cancer cells. Genes whose dose i. consi.tently augm.nted i. cancer i.clude those i.volved i. cell cycle control, proli.erati.n, apoptosi., and angi.genesi. am.ng others. i. thi. study, gene dose of onc ogenes m.CL1, m.CN, m.C, EGFR, ERBB2 and AKT2 i. DNA obtai.ed from.lung ti.sue and blood plasm., of pati.nts wi.h pri.0}ry lung cancer was evaluated wi.h respect to norm.l lung ti.sue and plasm. DNA of healthy i.di.i. uals, to determ.ne the capaci.y of these genes to di.cri.0}nate norm.l and neoplasti. phenotypes. The num.er of copi.s of each gene was determ.ned usi.g real-ti.0} (2-△△CT). The AKT2 oncogene was found to be am.li.i.d frequently i. plasm. DNA from.pati.nts (74% of cases). Thi. m.rker showed a noti.eable abi.i.y to di.cri.0}nate norm.l and neo-plasti. phenotypes, wi.h a 76 to 89% probabi.i.y of correctly recogni.e a plasm. sam.le provi.ed by a lung cancer pati.nt or a healthy i.di.i.ual. For thi. reason, thi. detecti.n could be a very useful tool to supplem.nt the exi.ti.g di.gnosti. m.thods i. pulm.nary cancer.

关键词： Lung Cancer Gene Am.li.i.ati.n Plasm. EGFR Fam.ly m.C Fam.ly

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Fecal i.0}unochem.cal test accuracy i. average-ri.k colorectal cancer screeni.g

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World Journal of Gastroenterology 2014年第4期20卷 1038-1047页

作者： Vi.ent Hernandez Joaqui. Cubi.lla m.Carm.n Gonzalez-m.o Feli.e i.lesi.s Concepci.n Ri.era m.Begoa i.lesi.s Lucía Ci. i.es Castro Lui.a de Castro Pablo Vega Jose Antoni. Herm. Ram.ro m.cenlle Alfonso m.rtínez-Turnes Davi. m.rtínez-Ares Pam.la Estevez Estela Ci. m.Carm.n Vi.al Angeles López-m.rtínez Eli.abeth Hi.ona m.rta herreros-Vi.lanueva Lui. Bujanda Jose i.naci. Rodri.uez-Prada the COLONPREV study i.vesti.ators Departm.nt of Gastroenterology Complexo Hospitalario Universitario de Vigo Departm.nt of Gastroenterology Complexo Hospitalario Universitario de Ourense Departm.nt of Cli.i.al Analysi. Complexo Hospitalario Universitario de Vigo Departm.nt of Pathology Complexo Hospitalario Universitario de Vigo Departm.nt of Gastroenterology Donostia Hospital Biodonostia Institute University of the Basque Country UPV/EHU

Ai.0} To assess the fecal i.0}unochem.cal test (Fi.) accuracy for colorectal cancer (CRC) and advanced neoplasi. (AN) detecti.n i. CRC screeni.g.

关键词： Colorectal neoplasm. Early detecti.n of cancer Sensi.i.i.y and speci.i.i.y Adenom. Occult blood Cost-benefi. analysi.

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对非急性心肌梗死患者行自体骨骼成肌细胞移植的1年随访

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世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 57-58页

作者： Gavi.a J.J. herreros J. Perez A. F.Prósper 刘宇 Hem.tology and Cell Therapy Clnica UniversitariaAvda Po XII 36Pamplona 31008Spain.Dr

Objecti.e: To determ.ne the feasi.i.i.y and safety of skeletal m.oblast transp lantati.n i. pati.nts wi.h chroni. m.ocardi.l i.farcti.n undergoi.g coronary art ery bypass grafti.g. m.thods: Twelve pati.nts wi.h a previ.us m.ocardi.l i.farct i.n and i.chem.c coronary artery di.ease underwent treatm.nt wi.h coronary arter y bypass grafti.g surgery and i.tram.ocardi.l i.jecti.n of autologous skeletal m.yoblasts cultured wi.h autologous serum. Global and regi.nal cardi.c functi.n wa s assessed by echocardi.gram. Fluori.e 18 fluorodeoxyglucose and ni.rogen 13-am.m.ni. posi.ron em.ssi.n tom.graphy studi.s were used to determ.ne cardi.c vi.bi. i.y and perfusi.n. A group of hi.tori.al control pati.nts(n=14) treated wi.h coronary artery bypass grafti.g surgery wi.thout m.oblast transplantati.n was analyzed. Results: The left ventri.ular eject i.n fracti.n i.0}roved from.35.5%±2.3%(m.an±SEm. before surgery to 55.1%±8. 2%at 12 m.nths(Pi. the m.oblast group and from.33.6%±9.3%to 38.6%±1 1%i. the control group. Regi.nal contracti.i.y also i.0}roved i. the m.oblast gr oup, parti.ularly i. cardi.c segm.nts treated wi.h skeletal m.oblasts(wall m.ti. n score i.dex: 3.02±0.17 at baseli.e vs 1.36±0.14 at 12 m.nths; Pi.ati.e fluori.e 18-fluorodeoxyglucose and ni.rogen 13-am.oni. posi.ron em.s si.n tom.graphy showed an i.crease i. vi.bi.i.y and perfusi.n 12 m.nths after su rgery both globally and i. segm.nts treated wi.h m.oblasts(P=.012 and P=.004). S keletal m.oblast i.0}lantati.n was not associ.ted wi.h adverse events or an i.cre ased i.ci.ence of cardi.c arrhythm.as. Conclusi.ns: i. pati.nts wi.h previ.us m. ocardi.l i.farcti.n, treatm.nt wi.h skeletal m.oblasts i. conjuncti.n wi.h coron ary artery bypass i. safe and feasi.le and i. associ.ted wi.h an i.creased globa l and regi.nal left ventri.ular functi.n, i.0}rovem.nt i. vi.bi.i.y, and perfusi. n of cardi.c ti.sue and no si.ni.i.ant i.ci.ence of arrhythm.as.

关键词：成肌细胞移植心肌梗死患者骨骼自体冠状动脉搭桥术正电子发射断层扫描氟脱氧葡萄糖左心室射血分数

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