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The zinc figure protein ZNF575 impairs colorectal cancer growth via promoting p53 transcription

Oncology Research 2023年第3期31卷 307-316页

作者： NING AN heqing peng MIN HOU DUOFENG SU LIU WANG XIAOGANG SHEN MING ZHANG Cancer Center Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduChina School of Medicine University of Electronic Science and Technology of ChinaChengduChina Department of Oncology Affiliated Hospital of North Sichuan Medical CollegeNanchong637000China Department of Oncology Chengdu Pidu District Hospital of traditional Chinese MedicineChengduChina Department of Gastrointestinal Surgery Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduChina

Zinc-finger proteins play different roles in cancer;however,the function of zinc-finger protein ZNF575 in cancer remains *** the present study,we aimed to determine the function and expression of ZNF575 in colorectal *** assay,colony formation assay,and tumor model in mice were used to investigate the function of ZNF575 after ectopic expression of ZNF575 in colorectal cancer(CRC)*** sequencing,ChIP,and luciferase assays were used to investigate the mechanism behind ZNF575 regulation of CRC cell *** expression of ZNF575 was determined by IHC staining in 150 pairs of malignant CRC tissues,followed by prognosis *** indicated that ectopic expression of ZNF575 inhibited CRC cell proliferation,colony formation and promoted cell apoptosis in *** growth in CRC was also impaired by ZNF575 in *** sequencing,follow-up western blotting,and qPCR results demonstrated the increase of p53,BAK,and PUMA in ZNF575-expressing CRC *** results indicated that ZNF575 directly targeted the p53 promoter and promoted the transcription of *** of ZNF575 was confirmed in malignant tissues,and ZNF575 expression was positively correlated with the prognosis of CRC *** present study demonstrated the function,underlying mechanism,expression,and the prognosis-predicting role of ZNF575 in CRC,which indicated that ZNF575 would be a potential prognostic predictor and therapeutic target for CRC and other cancers.

关键词： Colorectal Cancer ZNF-575 p53 Prognosis

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汽车遥控器注射模设计

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模具制造 2009年第6期9卷 53-56页

作者：彭和清中山市技师学院机械系广东中山528403

通过分析汽车遥控器的功能和塑件制品的结构工艺性,介绍了汽车遥控器注射模的设计,重点分析和阐述了抽芯机构和浇注系统的设计。经生产验证,本模具生产工艺和结构合理,操作方便,使用寿命长,对于同类产品的模具设计有一定的参考作用。

关键词：汽车遥控器注射模斜销潜伏式浇口侧向抽芯

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杨家矿区地质构造特征及找煤前景

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江西煤炭科技 2006年第2期 59-59,93页

作者：彭和清梁兴华江西省煤田地质局227队江西吉安343009

通过对杨家矿区构造特征的分析,确认了该矿区推覆断层的存在,指出了其下伏系统B煤组煤层保存较好,具有一定的找煤远景。

关键词：杨家矿区构造特征找煤

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江西晚三叠世安源煤系沉积特征及沉积环境探讨

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中国煤田地质 2005年第4期17卷 3-5,23页

作者：陈文华彭和清江西省煤田地质局227地质队江西吉安343000

江西省晚三叠世安源煤系,为江西省主要含煤地层之一,其煤种为烟煤,煤质好且为较好的动力用煤。然而,由于煤矿资源减少,造成我省乃至全国动力用煤的紧张状况,在一定程度上制约了经济的发展。通过对江西晚三叠世安源煤系(组)的沉积特征和... 详细信息

江西省晚三叠世安源煤系,为江西省主要含煤地层之一,其煤种为烟煤,煤质好且为较好的动力用煤。然而,由于煤矿资源减少,造成我省乃至全国动力用煤的紧张状况,在一定程度上制约了经济的发展。通过对江西晚三叠世安源煤系(组)的沉积特征和沉积环境的分析,指出了研究区安源煤系的分布状况和赋存特征,对寻找后续煤炭资源具有一定的指导意义。

关键词：沉积特征沉积环境安源煤系江西省晚三叠世煤系动力用煤含煤地层煤矿资源赋存特征

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对天河煤矿资源勘查的认识

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江西煤炭科技 2005年第4期 46-47页

作者：陈文华彭和清康道具刘援民江西省煤田地质局227队江西吉安343009

通过对含煤地层与赋煤特征的分析,认为以往那种认为“煤层厚度向深部变薄或尖灭,深部受断层F1、F2的切割破坏,找煤远景不大”的观点值得商榷,建议对本矿区进一步开展资源补勘工作。

关键词：危机矿山资源勘探认识

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3D打印乳腺托架增加乳腺癌调强放疗摆位准确度研究

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四川医学 2023年第4期44卷 400-404页

作者：彭荷情张明苏铎峰唐晓燕叶荣电子科技大学医学院四川成都610054 四川省人民医院肿瘤科·电子科技大学附属医院四川成都610072

目的探讨3D打印乳腺托架和普通头枕两种固定方式在乳腺癌调强放疗中摆位准确度。从摆位误差分析3D打印乳腺托架和普通头枕两种固定装置的效果。方法选取四川省人民医院2022年3月至8月接受调强放疗的80例乳腺癌患者,随机分为两组,3D乳腺... 详细信息

目的探讨3D打印乳腺托架和普通头枕两种固定方式在乳腺癌调强放疗中摆位准确度。从摆位误差分析3D打印乳腺托架和普通头枕两种固定装置的效果。方法选取四川省人民医院2022年3月至8月接受调强放疗的80例乳腺癌患者,随机分为两组,3D乳腺托架组和普通头枕组各40例。两组患者每周都进行锥体束CT(CBCT)扫描,用热塑膜固定胸部和下颌,将验证图像和计划图像配准,测量治疗中心坐标误差。用SPSS 27.0统计软件分析两组患者在乳腺/胸壁部位、锁骨上下部位、腋窝部位的左右(Lat)、头脚(Lng)以及腹背(Vrt)3个方向的摆位误差。结果两组患者基本资料差异无统计学意义。3D乳腺托架组在乳腺/胸壁部位的Lat、Lng、Vrt 3个方向摆位误差分别是(1.79±1.52)mm、(1.91±1.67)mm、(1.89±1.27)mm;锁骨上下部位:(1.72±1.38)mm、(1.95±1.53)mm、(1.68±1.31)mm;腋窝部位:(1.92±1.31)mm、(2.21±1.66)mm、(1.85±1.38)mm;普通头枕组在乳腺/胸壁部位的Lat、Lng、Vrt 3个方向摆位误差分别是(2.71±1.89)mm、(2.97±2.14)mm、(2.95±2.31)mm;锁骨上下部位:(2.92±2.00)mm、(2.90±1.66)mm,(2.86±1.61)mm;腋窝部位:(3.10±1.74)mm、(3.19±1.72)mm、(3.14±1.81)mm。3D乳腺托架组准确度高,误差小于普通头枕组,两组摆位误差比较差异有统计学意义(P<0.05)。结论3D打印乳腺托架固定摆位准确度更高,3个测量位置的摆位误差均小于普通头枕固定。

关键词：乳腺癌 3D打印乳腺托架放疗质控调强放射治疗摆位误差

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浅谈小煤矿资源/储量的核查工作

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江西煤炭科技 2006年第4期 30-30页

作者：彭和清江西省煤田地质局227地质队江西吉安343009

本文总结了小煤矿资源/储量核查工作的难点,提出了对策,对加强矿产资源保护和合理利用将起到积极作用。

关键词：资源储量难点对策

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Data-driven modeling of power system dynamics:Challenges,state of the art,and future work

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iEnergy 2023年第3期2卷 200-221页

作者： heqing Huang Yuzhang Lin Yifan Zhou Yue Zhao peng Zhang Lingling Fan Department of Electrical and Computer Engineering University of Massachusetts LowellLowellMA 01852USA Department of Electrical and Computer Engineering Stony Brook UniversityStony BrookNY 11794USA Interdisciplinary Science Department Brookhaven National LaboratoryUptonNY 11973USA Department of Electrical and Computer Engineering University of South FloridaTampaFL 33620USA

With the continual deployment of power-electronics-interfaced renewable energy resources,increasing privacy concerns due to deregulation of electricity markets,and the diversification of demand-side activities,traditional knowledge-based power system dynamic modeling methods are faced with unprecedented ***-driven modeling has been increasingly studied in recent years because of its lesser need for prior knowledge,higher capability of handling large-scale systems,and better adaptability to variations of system operating *** paper discusses about the motivations and the generalized process of datadriven modeling,and provides a comprehensive overview of various state-of-the-art techniques and *** also comparatively presents the advantages and disadvantages of these methods and provides insight into outstanding challenges and possible research directions for the future.

关键词： Data-driven modeling machine learning model construction parameter identification power system dynamics system identification

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A New Species of the Asian Leaf Litter Toad Genus Leptobrachella(Amphibia,Anura,Megophryidae)from Chongqing City,Southwest China

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Asian Herpetological Research 2022年第2期13卷 75-95页

作者： Tao LUO Weifeng WANG Dong peng Bo LEI Huaiqing DENG Shengnan JI heqing HUANG Jiang ZHOU School of life Sciences Guizhou Normal UniversityGuiyang 550001GuizhouChina School of Karst Science Guizhou Normal UniversityGuiyang 550001GuizhouChina Biodiversity Research Center Chinese Research Academy of Environmental SciencesBeijing 100012China Chongqing Academy of Environmental Science Chongqing 401147China

Herein we describe a new species,Leptobrachella yunyangensis ***.,from Yunyang County,Chongqing City,China,based on a combination of molecular and morphological *** analysis based on the mitochondrial 16 S rRNA gene and six nuclear genes indicated that this new species represented an independent evolutionary *** uncorrected genetic distance between the new species and its closest congener species,***,was 5.4 % for 16 S *** new species can be distinguished from its congeners by a combination of the following characters:(1) moderate body size(SVL28.3-30.6 mm in males);(2) rough dorsal skin,with sparse large granules and tubercles and short longitudinal ridges on the shoulder;(3) distinctly discernible tympanum with a diameter smaller than that of the eye(TMP/EYE ratio:0.51) and a distinct black supra tympanic line present;(4)an internasal distance almost equal to interorbital distance(IND/IOD ratio:1.05);(5) flanks with several dark spots arranged longitudinally in two rows;(6) distinctly visible supra-axilla ry,femoral,pectoral,a nd ventrola teral glands;(7) bicolored iris,with the upper 1/3 of the iris being copper orange and the lower 2/3 a light silvery grey;(8) relative finger lengths of Ⅰ <Ⅱ=Ⅳ <Ⅲ and relative toe lengths of Ⅰ <Ⅱ <Ⅴ <Ⅲ <Ⅳ;(9) absence of webbing and lateral fringes on fingers,and toes with rudimentary webbing and narrow lateral fringes;(10) heels overlapping when the thighs are positioned at right angles to the body;(11) tibiotarsal articulation reaching to the anterior corner of the eye when the leg is stretched forward;(12) ventral surfaces of the throat,chest,and belly greyish white with purple-brown speckling;(13) lacking distinct blackish dorsolateral markings;and(14) transverse dark brown bars on the surfaces of limbs and digits.

关键词： mitochondrial DNA morphology new species nuclear gene taxonomy

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Supercontinuum single-photon detector using multilayer superconducting nanowires

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Photonics Research 2019年第12期7卷 1425-1431页

作者： HAO LI YONG WANG LIXING YOU heqing WANG HUI ZHOU peng HU WEIJUN ZHANG XIAOYU LIU XIAOYAN YANG LU ZHANG ZHEN WANG XIAOMING XIE State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences(CAS)Shanghai 200050China CAS Center for Excellence in Superconducting Electronics Shanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

High-efficiency superconducting nanowire single-photon detectors(SNSPDs), which have numerous applications in quantum information systems, function by using the optical cavity and the ultrasensitive photon response of their ultra-thin superconducting nanowires. However, the wideband response of superconducting nanowires is limited due to the resonance of the traditional optical cavity. Here, we report on a supercontinuum SNSPD that can efficiently detect single photons over an ultra-broad spectral range from visible to mid-infrared light. Our detection approach relies on using multiple cavities with well-separated absorbed resonances formed by fabricating multilayer superconducting nanowires on metallic mirrors with silica acting as spacer layers. Thus, we are able to extend the absorption spectral bandwidth while maintaining considerable efficiency, as opposed to a conventional single-layer SNSPD. Our calculations show that the proposed supercontinuum SNSPD exhibits an extended absorption bandwidth with increased nanowire layers. Its absorption efficiency is greater than 70%over the entire range from 400 to 2500 nm(or 400 to 3000 nm), when using two-layer(or three-layer) *** a proof of principle, the SNSPD with bilayer nanowires is fabricated based on the proposed detector architecture with simplified geometrical parameters. The detector achieves broadband detection efficiency over 60%from 950 to 1650 nm. This type of detector may replace multiple narrow band detectors in a system and find uses in the emerging and rapidly advancing field of atomic and molecular broadband spectroscopy.

关键词： nanowires superconducting absorption

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