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Comparative study on glutathione transferases of rat brain and testis under the stress of phenobarbitol and β-methylcholanthrene

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Journal of Zhejiang University-Science b(biomedicine & biotechnology) 2005年第8期6卷 759-769页

作者： THYAGARAJU K hemavathi b VASUNDHARA K RAO A.D DEVI K.N Department of biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP India

A comparative study was made on the tissue specific expression of glutathione transferases (GST) in brain and testis after exposure of rat to phenobarbitol (Pb) and β-methylcholanthrene (MC). Glutathione transferases, a family of multifunctional proteins are involved in intracellular transport processes and in detoxication of electrophilic xenobiotics by catalyzing reactions such as conjugation, isomerization, reduction and thiolysis. On purification, the yield of GST proteins by affinity chromatography was 39% in testis and 32% in brain. The affinity purified testis GSTs were resolved by chromatofocusing into six anionic and four cationic isozymes, and in brain glutathione transferases were resolved into four anionic and three cationic isozymes, suggesting the presence of multiple isozymes with Yc, Yb, Yβ and Yδ in both of them. In testis and brain, these isozymes at identical pI values showed variable functions with a battery of substrates and the cationic isozymes of brain and testis showed identical properties in CHP (cumene hydroperoxide) at pH values of above 7.0. Substrate specificity studies and immunoblot analysis of testis and brain proteins revealed that they play a predominant role in the detoxication of phenobarbitol or β-methylcholanthrene. Expression of the isozymes in testis and brain on exposure to Pb and MC indicated elevated subunit variation. In both testis and brain, Yδ of π class was expressed on Pb treatment and Yc of α class and Yβ of μ class was expressed in MC treated testis and only Yc was predominantly expressed in MC treated brain. Thus these subunits expression is considered as markers for carcinogenesis and specific to chemical toxicity under phenobarbitol and β-methylcholanthrene stress.

关键词： Glutathione transferases Testis brain Phenobarbitol β-Methylcholanthrene

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Scalable blockchain Technology for Tracking the Provenance of the Agri-Food

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Computers, Materials & Continua 2023年第5期75卷 3339-3358页

作者： b.Subashini D.hemavathi Department of Data Science and business Systems School of ComputingSRM ISTKattankulathurTamilnadu603203India

Due to an increase in agricultural mislabeling and careless handling of non-perishable foods in recent years,consumers have been calling for the food sector to be more *** to information dispersion between divisions and the propensity to record inaccurate data,current traceability solutions typically fail to provide reliable farm-to-fork histories of *** threemost enticing characteristics of blockchain technology are openness,integrity,and traceability,which make it a potentially crucial tool for guaranteeing the integrity and correctness of *** this paper,we suggest a permissioned blockchain system run by organizations,such as regulatory bodies,to promote the origin-tracking of shelf-stable agricultural *** propose a four-tiered architecture,parallel side chains,Zero-Knowledge Proofs(ZKPs),and Interplanetary File Systems(IPFS).These ensure that information about where an item came from is shared,those commercial competitors cannot get to it,those big storage problems are handled,and the system can be scaled to handle many transactions at *** solution maintains the confidentiality of all transaction flows when provenance data is queried utilizing smart contracts and a consumer-grade reliance *** simulation testing using Ethereum Rinkeby and Polygon demonstrates reduced execution time,latency,and throughput overheads.

关键词： blockchain IPFS sidechain supply chain management traceability

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biological Monitoring of Urban Vehicular Pollution

Biological Monitoring of Urban Vehicular Pollution

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7th World Congress on Recovery, Recycling and Re-integration

作者： Shobha Jagannatha C.C.hemavathi Jagannatha Venkataramaiah DOS in botany University of Mysore "Sahana 437 A & b block Double Road Mysore 570023 Karnataka India Maharani's Science College "Sahana" 437 A & b block Double Road Mysore Karnataka India IObb "Sahana" 437 A & b block Double Road Mysore Karnataka India

Urban air quality management in developing countries due to vehicular pollution is a lowered priority. However, the health damages are significant. The implied pollution has three levels of impacts namely health, resources and ecological imbalances. Urban air pollution leading to irreversible damages at all three levels has been well documented in selected Indian cities. Irreversible reproductive health damage and increased degenerative type of diseases are few of the significant health impairments. This is happening despite rules providing emission standards for motor vehicles. While the pollution preventive strategies can reverse the damages leading to improved urban environmental quality, the monitoring has been a lowered priority. Dedicated monitoring facilities are either costly or unavailable. Thus, urban air quality even though very important is often neglected. biological monitoring of urban air quality is quite useful. Danish Urban Air Quality Monitoring using lichens is a well-known activity. An ultra structural response of leaf surface has been successfully used as bio-indication for vehicular pollution studies for the city of Mysore, India. The changes observed in the cutilar and epidermal features indicate the significance of bio-monitors of atmospheric pollution Results of an ongoing research showed that photograph and scanning electron microscopic studies revealed an increase in the number of stomata and narrowing of stomata aperture in the leaf

关键词： quality management, air pollution, biological monitoring, Samanea saman

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