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Prognostic values of serum cystatin C and β2 microglobulin, urinary β2 microglobulin and N-acetyl-β-D-glucosaminidase in early acute renal failure after liver transplantation

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Chinese Medical Journal 2008年第14期121卷 1251-1256页

作者： hei zi-qing li xiao-yun shen ning pang hong-yu zhou shao-li guan jian-qiang Department of Anesthesiology Third Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510630 China

Background Acute renal failure （ARF） after liver transplantation is associated with high mortality and morbidity. Early therapeutic or preventive intervention is hampered by the lack of early effective prognostic factors. Recent studies indicated that serum levels of cystatin C and β2-microglobulin （β2 MG） as well as urinary β2 MG and N-acetyI-β-D- glucosaminidase （NAG） would increase in patients with early and mild renal impairment. In this study, these factors were detected during the different stages in patients who accepted orthotopic liver transplantation （OLT）, and their feasibilities to predict early ARF after OLT were also analyzed. Methods Sixty patients with normal blood urea nitrogen （BUN） and serum creatinine （SCr） who received modified piggyback liver transplantation without veno-venous bypass were prospectively studied. Blood samples were drawn from patients for the determination of serum β2 MG（n=60）, SCr （n=60） and serum Cystatin C （n=39） at following 5 intervals： before operation （TO）, 20 minutes before anhepatic phase （T1）, 25 minutes in anhepatic （T2）, 60 minutes after reperfusion （T3） and at the end of operation（T4）. Urinary B2 MG （n=60） and NAG （n=60） were also examined at following 3 intervals： before operation （TO）, 60 minutes after reperfusion （T3） and at the end of operation （T4）. According to the Rimola A criteria of ARF in 24 hours after operation, all the patients were divided into two groups： ARF group and non-ARF group. The data were statistically analyzed to evaluate the feasibiliy of regarding these factors as prognostic factors for early ARF after liver transplantation in patients with normal SCr and BUN before operation. Results Ten of sixty cases showed ARF（16.7%）. The Logistic regression analysis showed that the levels of serum and urinary β2 MG as well as serum cystatin C before operation were correlated with early ARF after liver transplantation （P 〈0.05）, while only serum levels of cystatin C and Cr at the end of operation c

关键词： liver transplantation acute renal failure cystatin C β2-microglobulin

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术中应用乌司他丁对重型肝炎患者肝移植后急性肾功能衰竭的影响

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中华医学杂志 2010年第5期90卷 315-318页

作者：李晓芸关健强沈宁黑子清周少丽黎尚荣中山大学附属第三医院麻醉科广州510630

目的研究术中应用乌司他丁是否能减少重型肝炎患者肝移植术后急性肾功能衰竭的发生。方法31例术前血肌酐、尿素氮正常的重型肝炎患者行改良背驮式原位肝移植术，均未采用体外静脉．静脉转流。数字随机法分为2组：乌司他丁组（U组，n=15... 详细信息

目的研究术中应用乌司他丁是否能减少重型肝炎患者肝移植术后急性肾功能衰竭的发生。方法31例术前血肌酐、尿素氮正常的重型肝炎患者行改良背驮式原位肝移植术，均未采用体外静脉．静脉转流。数字随机法分为2组：乌司他丁组（U组，n=15例）和对照组（C组，n=16例），分别于术前、术后24h分别抽取桡动脉血测定β2-微球蛋白（β2-MG）值、肌酐、尿素氮及留取新鲜尿液测定尿β2-MG值，记录两组患者术后肝移植相关性肾功能衰竭的发生率以及术后转归等情况。结果术后24h乌司他丁组有4例而对照组有10例发生肝移植相关性肾衰（P〈0．05）。术后24h发生的急性肾功能衰竭（ARF）的患者乌司他丁组4例均不需要血透治疗，治愈出院；而对照组ARF有4例需要进行血透，2例死亡，3例病情未愈但自动出院，5例治愈出院；两组术后24h血、尿β2-MG、肌酐、尿素氮均较术前明显增高（分别为P〈0．05和P〈0．01），两组间比较，对照组术后24h血、尿β2 MG、尿素氮值均明显高于乌司他丁组（分别为P〈0．05和P〈0．01）。结论术中应用乌司他丁对重型肝炎患者肝移植围术期的肾功能具有保护作用，能减少肝移植相关性肾衰的发生率。

关键词：胰蛋白酶抑制剂肝炎,重型肝移植肾衰,急性

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo Yong-Heng Zhao Gang Zhao li-Cai Deng xiao-Wei liu Yi-Peng Jing Gang Wang Hao-Tong Zhang jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping li Zhong-Rui Bai yue Wu Yan Cai Shu-yun Cao zi-Huang Cao Jeffrey L.Carlin Hai-yuan Chen jian-Jun Chen Kun-Xin Chen li Chen Xue-Lei Chen xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng jian-ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-liang He Jin-liang Hou Yong-Hui Hou Wen Hou hong-Zhuan Hu ning-sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua jiang Xiang jiang Zhi-Bo jiang Ge Jin xiao Kong Xu Kong Ya-Juan Lei Ai-Hua li Chang-Hua li guang-Wei li Hai-ning li jian li Qi li Shuang li Sha-Sha li Xin-Nan li Yan li Yin-Bi li Ye-Ping li yuan liang Chien-Cheng lin Chao liu Gen-Rong liu guan-Qun liu Zhi-Gang liu Wen-Zhi Lu yu Luo Yin-Dun Mao heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin shen Huo-Ming Shi Jing Song Yi-Han Song Ding-qiang Su hong-Jun Su Zheng-hong Tang qing-sheng Tao yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang Hai Wang hong-Chi Wang jian Wang Jia-ning Wang jian-ling Wang jian-Ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-guan Wang Shu-qing Wang Xia Wang Ya-Nan Wang You Wang yue-Fei Wang You-Fen Wang Peng Wei Ming-Zhi Wei hong Wu Ke-Fei Wu Xue-Bing Wu yu-Zhong Wu xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-sheng Yan De-Hua Yang Hai-Feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong yu Hui yuan Hai-Bo yuan Hai-Long yuan Wei-Min yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang jian-Nan Zhang li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang zhou Xu zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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