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World Journal of Gastroenterology 2008年第18期14卷 2882-2887页

作者： Dan Xu Bao-Ping yu he-sheng Luo Ling-Dan Chen Department of Gastroenterology Renmin Hospital of Wuhan University Wuhan 430060 Hubei Province China

AIM: To identify the cholecystokinin (CCK)-A receptors (CCK-AR) on the guniea pig gallbladder interstitial cells of cajal (ICC) and to study CCK-8 induced gallbladder muscle strip contractions through the CCK-AR. METHODS: The existence of CCK-AR was examined by immunohistofluorescence on sectioned tissue and cultured cells. In vitro contractile response of guinea pig gallbladder muscle strips and the strips with ICC removed were also studied with CCK-8 receptors added. RESULTS: In tissue sections, intensely CCKAR- immunoreactive interstitial cells were found mainly in the muscular layers. In cultured cell sections, distinctive double staining of C-kit and CCK-AR ICCs were found. When we removed the ICC of the gallbladder, CCK-8 induced muscle strip contraction dose response curve significantly shifted to the right. CONCLUSION: We proved that both the existence of CCK-AR on the guinea pig gallbladder ICC and CCK evoked contraction are mediated through direct action on CCK-AR on the gallbladder ICC.

关键词： Gallbladder Interstitial cells of cajal Cholecystokinin-A receptor C-kit Immunohistofluorescence

Magnetic Study on Kondo Semiconductor CeNiSn

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Chinese Physics Letters 1998年第2期15卷 131-133页

作者： HOU yu-min JIN Duo YANG Fu-ming RAN Qi-ze WANG yu-peng CheN Zhao-jia he yu-sheng Cryogenic Laboratory Chinese Academy of SciencesBeijing 100080 Institute of Physics Chinese Academy of SciencesBeijing 100080

There are two standpoints to explain the formation of the peak of magnetic susceptibility versus temperature in *** is the presence of the pseudo-gapped density of states(DOS)while the other is the development of an antiferromagnetic *** check which one is more reasonable,an experiment is designed on measuring magnetic susceptibility under different magnetic *** is found that magnetic field can shift the peak of the magnetic susceptibility to lower temperatures while by calculation the presence of the pseudo-gapped DOS cannot shift the peak,which gives another evidence of the existence of antiferromagnetic correlations and is discussed in the light of some recent theoretical model.

关键词： correlation. Kondo susceptibility

Role of VEGF and CD44v6 in differentiating benign from malignant ascites

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World Journal of Gastroenterology 2003年第11期9卷 2596-2600页

作者： Wei-Guo Dong Xiao-Min Sun Bao-Ping yu he-sheng Luo Jie-Ping yu, Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, Hubei Province, China Department of Gastroenterology Renmin Hospital Wuhan University Wuhan 430060 Hubei Province China. dongwg@***

AIM: To detect the vascular endothelial growth factor (VEGF)and soluble splice variant 6 of CD44 (sCD44v6) levels in ascites and to explore their role in differentiating benign from malignant ***: Cirrhotic ascites (n=36), tuberculosis ascites (n=8) and malignant ascites (n=23) were collected and studied. Concentrations of soluble VEGF and sCD44v6 in various kinds of ascites (n=67) were measured using a sandwich enzyme-linked immunoadsorbent ***: VEGF and sCD44v6 levels in malignant ascites were 640.74±264.81 pg/ml and 89.22±38.20 ng/ml,respectively, both of which were significantly higher than those in cirrhotic ascites and tuberculous ascites (q=18.98,11.89 and q=8.92, 5.09; Phe levels of VEGF and sCD44v6 in cirrhotic and tuberculous ascites had no significant difference (q=0.48, 0.75; P>0.05).Furthermore, VEGF levels in malignant ascites in patients with ovarian cancer were higher than those with gastric and colon cancer (q=5.03, 6.79; P0.05). Whereas, sCD44v6 levels in malignant ascites from patients with ovadan, gastric and colon cancer had no significant difference (q=0.06, 0.91,0.35;P>0.05, respectirely). In comparison with cirrhotic and tuberculous ascites, when the upper limit of its VEGF mean levels 119.44 pg/ml (70.90±48.54) and sCD44v6 mean levels 63.59 ng/ml (44.42±19.17) was taken as the minimum cutoff limit, the sensitivity and specificity of VEGF and sCD44v6 of this assay to the diagnos is of malignant ascites were 91.3 %, 90.9 % and 73.9 %, 88.7 % ***: Elevated levels of VEGF and sCD44v6 may be useful in differential diagnosis of benign and malignant ascites.

关键词：恶性腹水 VEGF CD44v6 晚期肿瘤肿瘤转移发病机制

Effect of Nimesulide on proliferation and apoptosis of human hepatoma SMMC-7721 cells

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World Journal of Gastroenterology 2002年第3期8卷 483-487页

作者： Geng Tian Jie-Ping yu he-sheng Luo Bao-Ping yu Hui yue Jian-Ying Li Oiao Mei,Gastroenterology department,Renmin hospital of Wuhan university,Wuhan 430060,Hubei Province,China Gastroenterology department. Renmin hospital of Wuhan university 238 Jie-fang RoadWuhan 430060Hubei ProvinceChina.

AIM: Cyclooxygenase-2 (COX-2) has been suggested to be associated with carcinogenesis. We sought to investigate the effect of the selective COX-2 inhibitor, Nimesulide on proliferation and apoptosis of SMMC-7721 human hepatoma ***: This study was carried out on the culture of hepatic carcinoma SMMC-7721 cell line. Various concentrations of Nimesulide (0, 200 micromol/L, 300 micromol/L, 400 micromol/L) were added and incubated. Cell proliferation was detected with MTT colorimetric assay, cell apoptosis by electron microscopy, flow cytometry and ***: Nimesulide could significantly inhibit SMMC-7721 cells proliferation dose-dependent and in a dependent manner compared with that of the control group. The duration lowest inhibition rate produced by Nimesulide in SMMC-7721 cells was 19.06%, the highest inhibition rate was 58.49%. After incubation with Nimesulide for 72 h, the most highest apoptosis rate and apoptosis index of SMMC-7721 cells comparing with those of the control were 21.20%+/-1.62% vs 2.24%+/-0.26% and 21.23+/-1.78 vs 2.01+/-0.23 (Phe selective COX-2 inhibitor, Nimesulide can inhibit the proliferation of SMMC-7721 cells and increase apoptosis rate and apoptosis index of SMMC-7721 cells. The apoptosis rate and the apoptosis index are dose-dependent. Under electron microscope SMMC-7721 cells incubated with 300 micromol and 400 micromol Nimesulide show apoptotic characteristics. With the clarification of the mechanism of selective COX-2 inhibitors, These COX-2 selective inhibitors can become the choice of prevention and treatment of cancers.

关键词： Apoptosis Carcinoma, hepatocellular control Cell Division Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors Humans Isoenzymes inhibitors Liver Neoplasms Membrane Proteins Prostaglandin-Endoperoxide Synthases Sulfonamides Tumor Cells, Cultured

Expression of TFF2 and helicobacter pylori infection in carcinogenesis of gastric mucosa

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World Journal of Gastroenterology 2003年第5期9卷 910-914页

作者： Guo-Yong Hu Bao-Ping yu Wei-Guo Dong Mu-Qi Li Jie-Ping yu he-sheng Luo Zong-Xue Rang Gastroenterology Department,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei Province,China Gastroenterology Department Renmin Hospital of Wuhan University Hubei Province China.

AIM: To investigate the expression of TFF2 and helicobacter pyloriinfection in carcinogenesis of gastric ***: The expression of TFF2 was immunohistochemically analyzed in paraffin-embedded samples from 119 patients with endoscopic biopsy and subtotal gastrectomy specimens of gastric mucosal lesions, including 16 cases of chronic superficial gastritis (CSG), 20 chronic atrophic gastritis (CAG),35 intestinal metaplasia (IN), 23 gastric epithelial dysplasia (GED) and 25 gastric carcinoma (CA), and helicobacter pylori infection was detected by Warthin-Starry ***: 1:TFF2 was located in the cytoplasm of gastrk mucous neck cell. The expression of TFF2 was 100 %,100 %, 0, 56.5 % and 0 in CSGs, CAGs, INs, GEDs and CAs, respectively. 2: The value of TFF2 positive cell density in CSG with helicobacter pyloriinfection was higher than that without helicobacter pyloriinfection. (52.89±7.27vs46.49±13.04, P＞0.05); But the value of TFF2 positive cell density in CAG and GED with helicobacter pyloriinfection was significantly lower than that without helicobacter pylori infection (18.17±4.09 vs 37.93±13.80, P＜0.01 and 14.44±9.32 vs 24.84±10.22, P＜0.05).CONCLUSION: Increase of TFF2 expression in CSG is perhaps associated with the protective mechanism after gastric mucosal injury. Decrease of TFF2 expression in CAG possibly attributes to the decrease in the number of gastric gland cell expressing TFF2. Re-expression of TFF2 in gastric epithelial dysplasia implies that TFF2 possibly contributes to the initiation of gastric carcinoma. The effect of helicobacter pylori on the expression of TFF2 depends on the status of gastric mucosa.

关键词：胃粘膜癌肿瘤生成幽门螺杆菌 TFF2蛋白免疫组织化学

Detection of type Ⅳ collagenase activity in malignant ascites

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World Journal of Gastroenterology 2003年第11期9卷 2592-2595页

作者： Xiao-Min Sun Wei-Guo Dong Bao-Ping yu he-sheng Luo Jie-Ping yu, Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, Hubei Province, China Department of Gastroenterology Renmin Hospital Wuhan University Wuhan 430060 Hubei Province China

AIM: Type IV collagenase participates in invasion and metastasis of cancer cells. Malignant asdtes is a manifestation of advanced malignant disease that is associated with invasion and metastasis of the peritoneal cavity. Thus, it is reasonable to hypothesize that type IV collagenase is linked to malignant ascites. The purpose of our study was to detect type IV collagenase activity in malignant ascites so as to provide the scientific basis for clinic diagnosis and treatment of malignant ascites. METHODS: Cirrhotic ascites (n=36), tuberculous ascites (n=8) and malignant ascites (n=-23) from patients with gastric cancer (n=6), colon cancer (n=5), ovarian cancer (n=8) and other cancers (n=4), including 2 hepatocellular cancers, 1 pancreatic cancer, 1 primary peritoneal carcinoma were collected by paracentesis. The ascites were made cellfree by centrifugation and stored frozen at -70℃ before determination. Type IV collagenase activity was determined by gelatin zymography. RESULTS: The activity of matrix metalloproteinases-2 and -9 could not be detected in ascites of hepatic cirrhosis and tuberculous peritonitis but could be detected in 20 and 18 out of 23 malignant ascites respectively. The positive rate of type IV collagenase (MMP-2, 87.0% and MMP-9, 78.3%) was higher than that by routine ascites tests (Phermore, the activity of MMP-2 was higher than that of MMP-9 (P=0.022<0.05). CONCLUSION: Type IV collagenase is positive in malignant ascites. Detection of type IV collagenase activity is useful in qualitative diagnosis of ascites. Type IV collagenase may play an important role in malignant ascites formation.

关键词：恶性腹水 IV型胶原酶肿瘤转移恶性肿瘤发病机制

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中国玻璃钢/复合材料技术的兴起和发展

玻璃钢／复合材料 2014年第9期 5-8页

作者：何宇声中国复合材料工业协会北京100831

我国玻璃钢/复合材料技术源自1958年的七人研究小组,同年诞生第一块玻璃钢制品,依靠自力更生、艰苦奋斗、团结协作的精神,在国防工业的带动下,逐步形成和发展壮大起来。

关键词：玻璃钢复合材料兴起发展

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物流联盟协作机制应用实证研究

中国流通经济 2006年第3期20卷 16-19页

作者：贺盛瑜庞宇成都信息工程学院四川成都610225 西南交通大学经济管理学院四川成都610031

物流联盟是指为了取得比单独从事物流活动更好的效果,企业间形成的相互信任、共担风险、共享收益的物流伙伴关系。本文通过对物流联盟企业进行实证调查发现,建立联盟的企业收益与提高企业竞争力是两个最重要的选择因素,大多数企业愿意... 详细信息

物流联盟是指为了取得比单独从事物流活动更好的效果,企业间形成的相互信任、共担风险、共享收益的物流伙伴关系。本文通过对物流联盟企业进行实证调查发现,建立联盟的企业收益与提高企业竞争力是两个最重要的选择因素,大多数企业愿意建立相应的评判机制对绩效进行评估,对合作的满意度进行交互与测评。文章提出,物流联盟形式的出现、联盟内合作伙伴协作机制的建立是物流组织在物流联盟企业制度上的一次创新,它代表了今后流通组织发展的一个方向,也是物流业研究领域的一个发展方向。

关键词：物流联盟协作机制实证研究

MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self‑Powered Motion Sensing

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Nano-Micro Letters 2025年第3期17卷 265-279页

作者： yu‑Ze Wang yu‑Chang Wang Ting‑Ting Liu Quan‑Liang Zhao Chen‑Sha Li Mao‑sheng Cao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Materials Science and Engineering Peking UniversityBeijing 100871People’s Republic of China School of Mechanical and Material Engineering North China University of TechnologyBeijing 100144People’s Republic of China Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080People’s Republic of China

Polymeric microwave actuators combining tissue-like softness with programmablemicrowave-responsive deformation hold great promise for mobile intelligentdevices and bionic soft robots. However, their application is challenged by restricted electromagneticsensitivity and intricate sensing coupling. In this study, a sensitized polymericmicrowave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx(MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique spacechargepolarization and interfacial polarization, resulting in significant improvements of230% in the dielectric loss factor and 830% in the apparent efficiency of electromagneticenergy harvest. The sensitized microwave actuation demonstrates as the shortenedresponse time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (upto 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combinesdriving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of ~ 3 mV) duringactuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approachfor developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

2008年江苏电网并网机组发电设备可靠性分析

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中国电力 2009年第7期42卷 56-59页

作者：黄磊孙和泰何育生江苏方天电力技术有限公司江苏南京211102

以江苏电网并网发电机组2008年异常停机事件的调查和统计为基础,从机组容量分布、专业种类、事件起因、季节环境等多个角度,对设备故障和异常停运事件进行分类分析,就减少机组异常停运事件提出相应的预防措施:加强机组试运行期间的故障... 详细信息

以江苏电网并网发电机组2008年异常停机事件的调查和统计为基础,从机组容量分布、专业种类、事件起因、季节环境等多个角度,对设备故障和异常停运事件进行分类分析,就减少机组异常停运事件提出相应的预防措施:加强机组试运行期间的故障统计和原因分析,掌握安装和调试过程中的故障隐患点;大功率变频器改造前要做好选型工作,掌握常规的检修和维护技术,及时消缺;夏日雨季和严寒冬季到来前应细查严管,做好防雨、防冻、防雷等措施,为提高发电设备的运行可靠性提供借鉴。

关键词：江苏电网发电设备可靠性停机事件