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A transcriptional cascade involving BBX22 and HY5 finely regulates both plant height and fruit pigmentation in citrus

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Journal of Integrative Plant Biology 2024年第8期66卷 1752-1768页

作者： Jialing Fu Li Liao Jiajing Jin Zhihao Lu Juan Sun Lizhi Song Yue Huang Shengjun Liu Ding Huang Yuantao Xu Jiaxian he bin Hu Yiqun Zhu Fangfang Wu Xia Wang xiuxin Deng Qiang Xu National Key Laboratory for Germplasm Innovation and Utilization of Horticultural Crops College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhan 430070P.R.China Hubei Hongshan Laboratory Wuhan 430070P.R.China Science and Technology Innovation Research Center of Majia Pomelo Shangrao 334000China

Dwarfing is a pivotal agronomic trait affecting both yield and *** species exhibit substantial variation in plant height,among which internode length is a core ***,the molecular mechanism governing internode elongation remains ***,we unveiled that the transcriptional cascade consisting of B-BOX DOMAIN PROTEIN 22(BBX22)and ELONGATED HYPOCOTYL 5(HY5)finely tunes plant height and internode elongation in ***-of-function mutations of BBX22 in an early-flowering citrus(Citrus hindsii“SJG”)promoted internode elongation and reduced pigment accumulation,whereas ectopic expression of BBX22 in SJG,sweet orange(***),pomelo(***)or heterologous expression of BBX22 in tomato(Solanum lycopersicum)significantly decreased internode ***,exogenous application of gibberellin A3(GA3)rescued the shortened internode and dwarf phenotype caused by *** experiments revealed that BBX22 played a dual role in regulation internode elongation and pigmentation in *** the one hand,it directly bound to and activated the expression of HY5,GA metabolism gene(GA2 OXIDASE 8,GA2ox8),carotenoid biosynthesis gene(PHYTOENE SYNTHASE 1,PSY1)and anthocyanin regulatory gene(Ruby1,a MYB DOMAIN PROTEIN).On the other hand,it acted as a cofactor of HY5,enhancing the ability of HY5 to regulate target genes ***,our results reveal the critical role of the transcriptional cascade consisting of BBX22 and HY5 in controlling internode elongation and pigment accumulation in *** the crosstalk regulatory mechanism between internode elongation and fruit pigmentation provides key genes for breeding of novel types with both dwarf and health-beneficial fortification in citrus.

关键词： anthocyanins BBX22 carotenoids citrus HY5 internode elongation plant height

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Iron accumulation and its impact on osteoporotic fractures in postmenopausal women

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第4期24卷 301-311页

作者： Hui CAI Huimei ZHANG Weiting he heng ZHANG Department of Pharmacy the First Affiliated Hospital of Bengbu Medical CollegeBengbu Medical CollegeBengbu 233004China School of Pharmacy Bengbu Medical CollegeBengbu 233030China School of Clinical Medicine Bengbu Medical CollegeBengbu 233030China Department of Orthopedics the First Affiliated Hospital of Bengbu Medical CollegeLaboratory of Tissue and Transplant in Anhui ProvinceBengbu Medical CollegeBengbu 233004China Department of Orthopedics Jinling HospitalSchool of MedicineNanjing UniversityNanjing 210002China

Postmenopausal osteoporosis is a kind of degenerative disease,also described as“invisible killer.”Estrogen is generally considered as the key hormone for women to maintain bone mineral content during their *** accumulation refers to a state of human serum ferritin that is higher than the normal value but less than 1000μg/*** has been found that iron accumulation and osteoporosis could occur simultaneously with the decrease in estrogen level after *** recent years,many studies indicated that iron accumulation plays a vital role in postmenopausal osteoporosis,and a significant correlation has been found between iron accumulation and fragility *** this review,we summarize and analyze the relevant literature including randomized controlled trials,systematic reviews,and meta-analyses between January 1996 and July *** investigate the mechanism of the effect of iron accumulation on bone metabolism and discuss the relationship of iron accumulation,osteoporosis,and postmenopausal fragility fractures,as well as the main clinical treatment *** conclude that it is necessary to pay attention to the phenomenon of iron accumulation in postmenopausal women with osteoporosis and explore the in-depth mechanism of abnormal bone metabolism caused by iron accumulation,in order to facilitate the discovery of effective therapeutic targets for postmenopausal osteoporosis.

关键词： Iron accumulation Postmenopausal osteoporosis Bone metabolism Osteoporotic fracture

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A necessary and sufficient condition for a surface sum of two handlebodies to be a handlebody

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Science China Mathematics 2020年第10期63卷 1997-2004页

作者： Fengchun Lei he Liu Fengling Li Andrei Vesnin School of Mathematical Sciences Dalian University of TechnologyDalian 116024China Regional Scientific and Educational Mathematical Center Department of Mechanics and MathematicsTomsk State UniversityTomsk 634050Russia

The main results of the paper are that we give a necessary and sufficient condition for a surface sum of two handlebodies along a connected surface to be a handlebody as follows:(1)The annulus sum H=H1∪AH2 of two handlebodies H1 and H2 is a handlebody if and only if the core curve of A is a longitude for either H1 or H2;(2)Let H=H1∪Sg,b H2 be a surface sum of two handlebodies H1 and H2 along a connected surface S=Sg,b,b 1,ni=g(Hi)2,i=1,*** that S is incompressible in both H1 and *** H is a handlebody if and only if there exists a basis J={J1,...,Jm}with a partition(J1,J2)of J such that J1 is primitive in H1 and J2 is primitive in H2.

关键词： handlebody surface sum of 3-manifolds free group

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Advanced Current Collectors for Alkali Metal Anodes

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Chemical Research in Chinese Universities 2020年第3期36卷 386-401页

作者： CheN Jianyu XU Xin he Qian MA Yanwen Kev Laboratory for Organic Electronics and Information Displays Jiangsu Key Laboratory for BiosensorsInstitute of Advanced Materials(LAM)Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAK1)Nanjing University of Posts&TelecommunicationsNanjing 210023P.R.China

High-energy-density batteries are in urgent need to solve the ever-increasing energy stroage demand for portable electronic devices,electric vehicles,and renewable solar and wind energy *** metals,typically lithium(Li),sodium(Na)and potassium(K),are considered as the promising anode materials owing to their low electrochemical potential,low density,and high theoretical gravimetric ***,the problem of dendrite growth of alkali metals during their plating/stripping process will lead to low Coulombic efficiencies,a short lifespan and huge volume expansion,eventually hindering their practical *** resolve this issue,a very effective approach is engineering the anodes on structured current *** review summarizes the development of the alkali metal batteries and discusses the recent advances in rational design of anode current ***,the challenges and strategies of suppressing alkali-metal dendrite growth are *** the special attention is paid to the novel current collector design for dendrite-free alkali metal ***,we give conclusions and perspective on the current challenges and future research directions toward advanced anode current collectors for alkali metal batteries.

关键词： High-energy-density battery Alkali metal anode Dendrite growth Growth mechanism Current collector

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Numerical reconstruction of microstructure of graphite anode of lithium-ion battery

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Science Bulletin 2016年第8期61卷 656-664页

作者： Shaoyang he Jianbang Zeng Bereket Tsegai Habte Fangming Jiang Laboratory of Advanced Energy Systems CAS Key Laboratory of Renewable Energy Guangzhou Institute of Energy Conversion Chinese Academy of Sciences (CAS)Guangzhou 510640 China University of Chinese Academy of Sciences Beijing 100049China

Due to the presence of graphite flake cascades, the real graphite anode of Li-ion battery shows non-iso- tropic characteristic. The present work developed an ellipsoid-based simulated annealing method and numeri- cally reconstructed the three-dimensional microstructure of a graphite anode. The reconstructed anode is a composite of three clearly distinguished phases： pore （or electrolyte）, graphite, and solid additives, well representing the non- isotropic heterogeneous characteristic of real graphite anode. Characterization analysis of the reconstructed electrode gives information such as the connectivity of individual phase, the specific interracial area between solid and pore phase, and the pore size distribution. The effects of the ellipsoid size on the structural characteristics of graphite anode were particularly studied. As the size of the ellipsoidal particle slightly increases, the average pore diameter increases and as a result the specific interfacial area between the solid and pore phase in the reconstructed area decreases; compared with the equatorial radius, the polar radius of ellipsoidal graphite particles has more sig- nificant influence on the characteristics of electrode microstructure.

关键词： Lithium-ion battery Graphite anode Microstructure reconstruction Simulated annealingmethod Ellipsoid particles

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Management and implementation strategies of pre-screening triage in children during coronavirus disease 2019 pandemic in Guangzhou, China

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World Journal of Clinical Cases 2021年第12期9卷 2731-2738页

作者： Xuan Shi Yu-Tao Cai Xian Cai xiu-Lan Wen Jing-Yan Wang Wen-Cheng Ma Jun Shen Jin-Xia Wu Hai-Yan Liu Jing Sun Pei-Qin he Yan Lin Dan-Yang Zhao Pei-Qing Li Department of Pediatric Emergency Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Outpatient Department of Pediatrics Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Emergency General Ward Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Nursing Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Disease Control and Prevention Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Emerging infectious diseases are a constant threat to the public’s health and health care systems around the *** disease 2019(COVID-2019),which was defined by the World health Organization as pandemic,has rapidly emerged as a global health *** evolution and prevention of international implications require substantial flexibility of frontline health care facilities in their *** To explore the effect of the implementation and management strategy of prescreening triage in children during *** The standardized triage screening procedures included a standardized triage screening questionnaire,setup of pre-screening triage station,multi-point temperature monitoring,extensive screenings,and two-way *** order to ensure the implementation of the pre-screening triage,the prevention and control management strategies included training,emergency exercise,and staff *** analysis was performed on the data from all the children hospitalized from January 20,2020 to March 20,2020 at solstice during the pandemic *** were obtained from questionnaires and electronic medical record *** A total of 17561 children,including 2652 who met the criteria for screening,192 suspected cases,and two confirmed cases without omission,were screened from January 20,2020 to March 20,2020 at solstice during the pandemic *** was zero transmission of the infection to any medical *** The effective strategies for pre-screening triage have an essential role in the prevention and control of hospital infection.

关键词： COVID-19 Pre-screening triage Management Implementation Strategies Pandemic

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ZIKA virus isolated from mosquitoes:a field and laboratory investigation in China,2016

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Science China(Life Sciences) 2017年第12期60卷 1364-1371页

作者： Shihong Fu Song Song Hong Liu Yuanyuan Li Xiaolong Li Xiaoyan Gao Ziqian Xu Guoping Liu Dingming Wang Zhenzao Tian Jingzhu Zhou Ying he Wenwen Lei Huanyu Wang bin Wang Xiaoqing Lu Guodong Liang State Key Laboratory of Infectious Disease Prevention and Control National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310058China Qingdao University Qingdao 266071China Shandong Provincial Research Center for Bioinformatic Engineering and Technique School of Life SciencesShandong University of TechnologyZibo 255049China National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionKey Laboratory of Parasite and Vector BiologyMinistry of HealthWHO Collaborating Centre for Tropical DieasesShanghai 200025China Center for Disease Control and Prevention of Shenyang Command Shenyang 110034China Guizhou Province Center for Disease Control and Prevention Guiyang 550004China

A field investigation of arboviruses was conducted in Dejiang, Guizhou Province in the summer of 2016. A total of 8,795 mosquitoes, belonging to four species of three genera, and 1,300 midges were collected. The mosquito samples were identified on site according to their morphology, and the pooled samples were ground and centrifuged in the laboratory. The supernatant was incubated with mosquito tissue culture cells(C6/36) and mammalian cells(BHK-21) for virus isolation. The results indicated that 40%(3,540/8,795) were Anopheles sinensis, 30%(2,700/8,795) were Culex pipiens quinquefasciatus, and 29%(2,530/8,795)were Armigeres subbalbeatus. Furthermore, a total of eight virus isolates were obtained, and genome sequencing revealed two Zika viruses(ZIKVs) isolated from Culex pipiens quinquefasciatus and Armigeres subbalbeatus, respectively; three Japanese encephalitis viruses(JEVs) isolated from Culex pipiens quinquefasciatus; two Banna viruses(BAVs) isolated from Culex pipiens quinquefasciatus and Anopheles sinensis, respectively; and one densovirus(DNV) isolated from Culex pipiens *** ZIKVs isolated from the Culex pipiens quinquefasciatus and Armigeres subbalbeatus mosquitoes represent the first ZIKV isolates in China's Mainland. This discovery presents new challenges for the prevention and control of ZIKV in China, and prompts international cooperation on this global issue.

关键词： arbovirus surveillance mosquito-borne arbovirus Japanese encephalitis virus Zika virus

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塑性变形类型与罗德系数的关系

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哈尔滨工业大学学报 2008年第1期40卷 61-64页

作者：苑世剑李峰何祝斌哈尔滨工业大学材料科学与工程学院哈尔滨工业大学材料科学与工程学院哈尔滨150001

为深入研究各应变参量间的内在联系,推导出应变增量与罗德系数间关系的表达式,直观地给出了不同应变增量间的定量变化关系.对塑性变形类型与罗德系数间的关系进行了定量表征,揭示了塑性变形类型与应力状态的内在联系.对典型工艺的研究... 详细信息

为深入研究各应变参量间的内在联系,推导出应变增量与罗德系数间关系的表达式,直观地给出了不同应变增量间的定量变化关系.对塑性变形类型与罗德系数间的关系进行了定量表征,揭示了塑性变形类型与应力状态的内在联系.对典型工艺的研究结果表明:随着高径比增加,圆环压缩过程中处于伸长类变形区域范围逐渐缩小;随着模角的增大,挤压过程中塑性区内应变类型由均一的伸长类变为3种共存,因此,材料流动的不均匀性也显著地增大.研究结果对塑性理论及其应用具有重要意义.

关键词：罗德系数塑性变形应变增量

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高填土涵洞相似材料的试验研究

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东北大学学报（自然科学版） 2007年第8期28卷 1194-1197页

作者：范鹤刘斌王成范泽东北大学资源与土木工程学院辽宁沈阳110004 辽宁地质工程职业学院资源系辽宁丹东118008

基于相似理论和量纲分析法,推导出相似指标,并作为试验相似与否的判定原则.以砂、石膏、硅藻土混合物为相似材料,进行相似材料模拟试验.用正交法设计初次试验,用抗压强度相似指标控制试验的相似程度.通过极差分析,得出材料力学指标4个... 详细信息

基于相似理论和量纲分析法,推导出相似指标,并作为试验相似与否的判定原则.以砂、石膏、硅藻土混合物为相似材料,进行相似材料模拟试验.用正交法设计初次试验,用抗压强度相似指标控制试验的相似程度.通过极差分析,得出材料力学指标4个影响因素的重要程度,并在此基础上小范围调整配比进行二次试验,得到符合力学相似指标要求的材料配比.用上述试验设计方法替代全面试验法,可以通过最少的试验次数得到符合相似指标要求的材料配比,大大减少试验次数和时间.试验得出的相似材料配比与力学指标的变化规律,对实际工程相似材料模拟具有一定的参考意义.

关键词：相似模拟相似材料相似指标正交设计涵洞力学指标

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NURBS曲线高速插补中的前瞻控制

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计算机辅助设计与图形学学报 2006年第5期18卷 625-629页

作者：彭芳瑜何莹李斌华中科技大学国家数控系统工程技术研究中心武汉430074

利用二次遗传算法对NURBS曲线进行预处理,找到曲线上的曲率极大值点集———刀具进给方向突变点集;建立机床动力学性能和曲线几何性能的混合约束条件,生成曲线插补的前瞻控制信息,包括进给方向突变点的安全进给速度与加速度,以及极大值... 详细信息

利用二次遗传算法对NURBS曲线进行预处理,找到曲线上的曲率极大值点集———刀具进给方向突变点集;建立机床动力学性能和曲线几何性能的混合约束条件,生成曲线插补的前瞻控制信息,包括进给方向突变点的安全进给速度与加速度,以及极大值降速点.在NURBS曲线的插补中,利用前瞻控制信息实时优化进给速度,以提高插补的精度、效率以及稳定性.

关键词： NURBS曲线前瞻控制遗传算法机床动力学

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