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MiRNAs and lncRNAs in NK cell biology and NK/T-cell lymphoma

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Genes & Diseases 2021年第5期8卷 590-602页

作者： Fengxia Gao Sirong he Aishun Jin Department of Immunology Chongqing Medical UniversityChongqing400010PR China Chongqing Key Laboratory of Tumor Immunology and Tumor Immunotherapy Chongqing Medical UniversityNo.1Medical School RoadYuzhong DistrictChongqing400010PR China

The important role of lncRNAs and miRNAs in directing immune responses has become increasingly *** evidence conforms that miRNAs and lncRNAs are involved in NK cell biology and diseases through RNAeprotein,RNAeRNA,or RNAeDNA *** this view,we summarize the contribution of miRNAs and lncRNAs to NK cell lineage devel-opment,activation and function,highlight the biological significance of functional miRNAs or lncRNAs in NKTL and discuss the potential of these miRNAs and lncRNAs as innovative bio-markers/targets for NKTL early diagnosis,target treatment and prognostic evaluations.

关键词： Activation Development Function lncRNAs miRNA NK cell Biology NK/T-cell lymphoma

Continuous-time System Identification with Nuclear Norm Minimization and GPMF-based Subspace Method

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IEEE/CAA Journal of Automatica Sinica 2016年第2期3卷 184-191页

作者： Mingxiang Dai Ying he Xinmin Yang the National Key Laboratory of Transient Physics Nanjing University of Science and Technology

To improve the accuracy and effectiveness of continuous-time (CT) system identification, this paper introduces a novel method that incorporates the nuclear norm minimization (NNM) with the generalized Poisson moment functional (GPMF) based subspace method. The GPMF algorithm provides a simple linear mapping for subspace identification without the timederivatives of the input and output measurements to avoid amplification of measurement noise, and the NNM is a heuristic convex relaxation of the rank minimization. The Hankel matrix with minimized nuclear norm is used to determine the model order and to avoid the over-parameterization in subspace identification method (SIM). Furthermore, the algorithm to solve the NNM problem in CT case is also deduced with alternating direction methods of multipliers (ADMM). Lastly, two numerical examples are presented to evaluate the performance of the proposed method and to show the advantages of the proposed method over the existing methods. © 2014 Chinese Association of Automation.

关键词： Identification (control systems) Matrix algebra Numerical methods Relaxation processes Religious buildings

Molecular variation and evolution of the tyrosine kinase domains of insulin receptor IRa and IRb genes in Cyprinidae

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Science China(Life Sciences) 2011年第7期54卷 626-633页

作者： KONG XiangHui WANG XuZhen he ShunPing College of Life Science Henan Normal University Xinxiang 453007 China Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 China

The insulin receptor （IR） gene plays an important role in regulating cell growth, differentiation and development. In the present study, DNA sequences of insulin receptor genes, IRa and IRb, were amplified and sequenced from 37 representative species of the Cyprinidae and from five outgroup species from non-cyprinid Cypriniformes. Based on coding sequences （CDS） of tyro- sine kinase regions of IRa and IRb, molecular evolution and phylogenetic relationships were analyzed to better understand the characteristics of IR gene divergence in the family Cyprinidae. 1Ra and IRb were clustered into one lineage in the gene tree of the IR gene family, reconstructed using the unweighted pair group method with arithmetic mean （UPGMA）. IRa and IRb have evolved into distinct genes after IR gene duplication in Cyprinidae. For each gene, molecular evolution analyses showed that there was no significant difference among different groups in the reconstructed maximum parsimony （MP） tree of Cyprinidae; IRa and 1Rb have been subjected to similar evolutionary pressure among different lineages. Although the amino acid sequences of IRa and IRb tyrosine kinase regions were highly conserved, our analyses showed that there were clear sequence variations between the tyrosine kinase regions of IRa and IRb proteins. This indicates that IRa and IRb proteins might play different roles in the insulin signaling pathway.

关键词： insulin receptor gene tyrosine kinase domain Cyprinidae

The influence of e-commerce live streaming affordance on consumer’s gift-giving and purchase intention

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Data Science and Management 2023年第1期6卷 13-20页

作者： Yunfan Lu Yucheng he Yifei Ke College of Economics and Management Huazhong Agricultural UniversityWuhan430070China

In e-commerce live streaming,sellers choose the most suitable streamers to endorse their *** streamer introduces the main functions of the goods,organizes marketing activities,improves the consumers’shopping experience,and finally facilitates transactions and obtains ***,the formation mechanism of guanxi between streamers and consumers remain *** on affordance theory,this study uses structural equations to empirically study the decision-making mechanism of consumer gift-giving and purchase behavior in ecommerce live *** study finds that affective affordance and cognitive affordance have positive impacts on swift guanxi;swift guanxi is an antecedent of consumers’purchase intention and gift-giving intention.

关键词： E-commerce live streaming Affordance theory Swift guanxi

Weighted gene co-expression network analysis identifies a novel immune-related gene signature and nomogram to predict the survival and immune infiltration status of breast cancer

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BIOCELL 2022年第7期46卷 1661-1673页

作者： JUNXIA LIU KE PANG FEI he Department of Oncology Yongchuan Hospital of Chongqing Medical UniversityChongqingChina Department of Geriatrics Yongchuan Hospital of Chongqing Medical UniversityChongqingChina

Breast cancer is one of the most common cancers in the world and seriously threatens the health of women *** models based on immune-related genes help to improve the prognosis prediction and clinical treatment of breast cancer *** the study,we used weighted gene co-expression network analysis to construct a co-expression network to screen out highly prognostic immune-related ***,the prognostic immunerelated gene signature was successfully constructed from highly immune-related genes through COX regression and LASSO COX *** analysis and time receiver operating characteristic curves indicate that the prognostic signature has strong predictive *** we developed a nomogram by combing the risk score with multiple clinical *** and TIMER algorithms confirmed that there are significant differences in tumorinfiltrating immune cells in different risk *** addition,gene set enrichment analysis shows 6 pathways that differ between high-and low-risk *** immune-related gene signature effectively predicts the survival and immune infiltration of breast cancer patients and is expected to provide more effective immunotherapy targets for the prognosis prediction of breast cancer.

关键词： Immune-related genes Prognostic model Breast cancer WGCNA Nomogram

Alternating Direction Method of Multipliers for Linear Programming

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Journal of the Operations Research Society of China 2016年第4期4卷 425-436页

作者： Bing-Sheng he Xiao-Ming Yuan Department of Mathematics South University of Science and Technology of ChinaShenzhen 518055China Department of Mathematics Nanjing UniversityNanjing 210023China Department of Mathematics Hong Kong Baptist UniversityHong KongChina

Linear programming is the core problem of various operational research *** dominant approaches for linear programming are simplex and interior point *** this paper,we showthat the alternating direction method of multipliers(ADMM),which was proposed long time ago while recently found more and more applications in a broad spectrum of areas,can also be easily used to solve the canonical linear programming *** resulting per-iteration complexity is O(mn)where m is the constraint number and n the variable *** each iteration,there are m subproblems that are eligible for parallel computation;each requiring only O(n)*** is no inner iteration as *** thus introduce the newADMMapproach to linear programming,which may inspire deeper research for more complicated scenarios with more sophisticated results.

关键词： Continuous optimization Linear programming Alternating direction method of multipliers

Numerical Simulation of Gas-Solid Flow Processes in an Ash Conveying Pipeline with Multiple Feeds

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Fluid Dynamics & Materials Processing 2024年第12期20卷 2721-2739页

作者： Kairuo Chen he Wang Xiangliang Wang College of Transportation Ludong UniversityYantai264025China School of Energy and Power Engineering Northeast Electric Power UniversityJilin132012China

Pneumatic conveying technology,as an efficient material transportation method,has been widely used in various industrial *** study the powder transportation in horizontal ash conveying pipes,this study relies on the Computational Particle Fluid Dynamics(CPFD)numerical *** characteristics of the gas-solid two-phase flow under continuous air supply conditions are analyzed,and the effects on particle movement of factors such as feed port spacing,inlet air velocity,and the number of discharge ports are explored *** research results show that when the inlet velocity is 5 m/s,adjacent discharged particles come into contact after 8 *** the inlet air velocity increases,the contact time between adjacent discharge ports is *** the feed port spacing increases from 0.5 to 2 m,the dust accumulation thickness decreases by about 0.6 ***,when the spacing reaches a certain value,the rate of decrease in dust accumulation thickness begins to diminish.

关键词： Pneumatic conveying CPFD gas-solid two-phase flow powder transport continuous gas supply

Solution set calculation of the Sun-perturbed optimal two-impulse trans-lunar orbits using continuation theory

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Astrodynamics 2020年第1期4卷 75-86页

作者： Bo-yong he Hong-xin Shen State Key Laboratory of Astronautic Dynamics Xi’an Satellite Control CenterXi’an710043China

The solution set of the Sun-perturbed optimal two-impulse trans-lunar orbit is helpful for overall optimization of the lunar exploration mission.A model for computing the two-impulse trans-lunar orbit,which strictly satisfies the boundary constraints,is *** solution set is computed first with a circular restricted three-body model using a generalized local gradient optimization algorithm and the strategy of design variable initial *** taking the solution set of a circular restricted three-body model as the initial values of the design variables,the Sun-perturbed solution set is calculated based on the dynamic model continuation theory and traversal search methodology.A comparative analysis shows that the fuel cost may be reduced to some extent by considering the Sun’s perturbation and choosing an appropriate transfer ***,there are several optimal two-impulse trans-lunar methods for supporting a lunar mission to select a scenario with a certain ground measurement and to control the time cost.A fitted linear dependence relationship between the Sun’s befitting phase and the trans-lunar duration could thus provide a reference to select a low-fuel-cost trans-lunar injection window in an engineering project.

关键词： trans-lunar orbit optimization optimal solution set continuation theory Sun-perturbed

Analysis on Landscape Ecological Risk of the Qinghai-Tibet Plateaus:A Case Study on Niyang River Basin

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Wuhan University Journal of Natural Sciences 2006年第4期11卷 977-983页

作者： he Xiaorong ZHONG Xianghao CheN Xinwu School of Resources and Environmental Engineering WuhanUniversity of Technology Wuhan 430070 Hubei China Institute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu 610041SichuanChina Department of Business Administration Hubei University of Economics Wuhan 430205 Hubei China

Taking Niyang River Basin as an example, applying with the indices of landscape pattern, the indices of ecological risk of ecosystems are calculated in this paper, which takes the value of ecological loss of main ecosystem as the evaluation standard and takes into account the impacts of probability or the velocity of main hazards and event of the ecosystem. And the grades of ecological risk are assessed. According to the results of assessment, the ecological risk grades of the basin are divided into five classes. From the first grade risk to the fifth grade risk, the values of regional risk indices gradually reduce. The first grade risk areas mainly distribute in Niyang river and its branches downstream and the surrounding areas of main towns. And the basin area of non-valley region and the headstream regions of the branches are the fifth grades risk areas. This evaluation results provide the basis to the regional sustainable development.

关键词： the Qinghai-Tibet Plateau Niyang River Basin ecological risk indices of ecological risk the value of ecological loss disaster