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Geochronology and Petrogenesis of Mafic-Intermediate Intrusions on the Northern Margin of the Central Tianshan(NW China): Implications for Tectonic Evolution

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Journal of Earth Science 2019年第2期30卷 323-334页

作者： hongming Cai he Yang Xiangkuan Gong School of Geology and Mining Engineering Xinjiang University Geography Postdoctoral Research Station Xinjiang University Xinjiang Research Center for Mineral Resources Xinjiang Institute of Ecology and GeographyChinese Academy of Sciences

Late Paleozoic mafic-intermediate intrusions are widespread in the central Tianshan belt, but their tectonic settings remain controversial. Petrogenesis of these intrusions can provide insights into the tectonic evolution of the belt and its adjacent areas. This study presents new whole-rock geochemical and zircon U-Pb geochronology and Hf isotopic data for the Yaxi diorite and Qianzishan gabbro on the northern margin of the central Tianshan(NW China). Zircon U-Pb dating yielded the magma crystallization ages of 313±4 and 295±4 Ma for the Yaxi diorite and Qianzishan gabbro, respectively. They have lower Mg# values, Ni and Cr contents than typical mantle-derived primary melt, with negative correlations between MgO, TFeO and SiO2 contents, indicating clinopyroxene and olivine fractionation during magma evolution. They are characterized by enrichment of large ion lithophile elements(e.g., Rb, Ba and Sr) and depletion of high field strength elements(e.g., Nb, Ta and Ti) with high Ba/Th and Rb/Y, suggesting that their mantle sources had been metasomatized by slab-derived fluids. In addition, the Qianzishan gabbro has high Al2 O3 contents(19.54 wt.%–20.88 wt.%) and positive Eu anomalies(Eu/Eu*=1.09–1.42), which can be attributed to accumulation of plagioclase. Geochemical and zircon Hf isotopic compositions reveal that both the Yaxi diorite and Qianzishan gabbro were derived from depleted lithospheric mantle in the spinel stability field with insignificant crustal contamination. In association with previous investigations, we suggest that the Yaxi and Qianzishan intrusions were emplaced in a subduction-related environment, which means that the subduction of the Junggar Ocean lasted at least to the earliest Permian.

关键词： mafic-intermediate intrusions geochemistry petrogenesis tectonic implication central Tianshan

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Development of a Poly(vinyl chloride)-based Nitrate Ion-selective Electrode

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Chemical Research in Chinese Universities 2012年第6期28卷 957-962页

作者： he Meng-meng YANG Hui-zhong Key Laboratory of Advanced Control in Light Industry Process Ministry of Education Jiangnan University Wuxi 214122 P. R. China

The authors developed a nitrate ion-selective electrode（ISE） based on poly（vinyl chloride）（PVC） membrane with methyltrioctylammonium nitrate as a carrier and 1-decanol as a *** performance of the nitrate-sensitive membranes was optimized by tuning the composition of *** electrode exhibits a linear response with a Nernstian slope of（52±1.0） mV per decade for the nitrate ion concentration ranging from 5.8×10-5 mol/L to 1.0 mol/*** electrode can be used to detect a low concentration of nitrate ions down to 3×10-5 mol/L in a pH range of 2.1―11.5 without any *** advantage of the electrode includes simple preparation,short response time and good *** detection performance of the novel electrode on nitrate ions has been tested for water samples.

关键词： Poly(vinyl chloride)(PVC) Methyltrioctylammonium nitrate Nitrate-selective electrode Potentiometric sensor

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G3DC:A Gene-Graph-Guided Selective Deep Clustering Method for Single Cell RNA-seq Data

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Big Data Mining and Analytics 2024年第3期7卷 809-827页

作者： Shuqing he Jicong Fan Tianwei Yu Department of Statistics University of MichiganAnn ArborMI 48109USA School of Data Science The Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China Shenzhen Research Institute of Big Data Shenzhen 518172China Warshel Institute for Computational Biology Shenzhen 518172China

Single-cell RNA sequencing(scRNA-seq)technology measures the expression of thousands of genes at the cellular *** single-cell transcriptome allows the identification of heterogeneous cell groups,cellular-level regulations,and the trajectory of cell *** important aspect in the analyses of scRNA-seq data is the clustering of cells,which is hampered by issues,such as high dimensionality,cell type imbalance,redundancy,and *** cells of each type are functionally consistent,incorporating biological relations among genes may improve the clustering *** light of this,we have developed a deep-embedded clustering method,*** method combines a graph regularization based on the pre-existing gene network and a feature selector based on the$l$2,1-norm regularization,along with a reconstruction loss,to generate a discriminatory and informative *** the gene interaction network bolsters the clustering performance and aids in selecting functionally coherent genes,consequently enriching the clustering *** experiments have shown that G3DC offers high clustering accuracy with regard to agreement with true cell types,outperforming other leading single-cell clustering *** addition,G3DC selects biologically relevant genes that contribute to the clustering,providing insight into biological functionality that differentiates cell groups.

关键词： gene graphs feature selection deep learning

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Dynamic Analysis and Optimization of Pneumatic Wedge-Shaped Launcher for UAV

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第5期35卷 866-873页

作者： Huang Min he Cheng Pei Jinhua College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics Key Laboratory of UAV’s Advanced Technology(Nanjing University of Aeronautics and Astronautics) Ministry of Industry and Information Technology

The constitution,structure,working principle and launching process of the wedge-shaped pneumatic launcher of an unmanned aerial vehicle(UAV)are *** simplifying its physical model,two dynamic models of the UAV launch system are established based on Lagrange equation and ***,*** curves of the acceleration and the velocity of UAV changing with time are *** simulation results are compared with the experimental results to verify the correctness of the ***,the influence of the parameters on the launch is ***,the system is *** maximum overload and the acceleration fluctuation are reduced.

关键词： unmanned aerial vehicle pneumatic launching dynamic simulation system optimization

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Plasticity of male germline stem cells and their applications in reproductive and regenerative medicine

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Asian Journal of Andrology 2015年第3期17卷 367-372页

作者： Zheng Chen Zheng Li Zuping he State Key Laboratory of Oncogenes and Related Genes Renji-Med X Clinical Stem Cell Research Center Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Institute of Cancer Shanghai 200127 China Department of Urology Shanghai Human Sperm Bank Shanghai Institute of Andrology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200001 China Shanghai Key Laboratory of Assisted Reproduction and Reproductive Genetics Shanghai 200127 China Shanghai Key Laboratory of Reproductive Medicine Shanghai 200025 China

Spermatogonial stem cells （SSCs）, also known as male germline stem cells, are a small subpopulation of type A spermatogonia with the potential of self-renewal to maintain stem cell pool and differentiation into spermatids in mammalian testis. SSCs are previously regarded as the unipotent stem cells since they can only give rise to sperm within the seminiferous tubules. However, this concept has recently been challenged because numerous studies have demonstrated that SSCs cultured with growth factors can acquire pluripotency to become embryonic stem-like cells. The in vivo and in vitro studies from peers and us have clearly revealed that SSCs can directly transdifferentiate into morphologic, phenotypic, and functional cells of other lineages. Direct conversion to the cells of other tissues has important significance for regenerative medicine. SSCs from azoospermia patients could be induced to differentiate into spermatids with fertilization and developmental potentials. As such, SSCs could have significant applications in both reproductive and regenerative medicine due to their unique and great potentials. In this review, we address the important plasticity of SSCs, with focuses on their self-renewal, differentiation, dedifferentiation, transdifferentiation, and translational medicine studies.

关键词： differentiation direct transdifferentiation pluripotency self-renewal spermatogonial stem cells

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Algorithm for 2D irregular-shaped nesting problem based on the NFP algorithm and lowest-gravity-center principle

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第4期7卷 570-576页

作者： LIU Hu-yao he Yuan-jun Department of Computer Science and Technology. Shanghai Jiao Tong University Shanghai 200030 China

The nesting problem involves arranging pieces on a plate to maximize use of material. A new scheme for 2D ir- regular-shaped nesting problem is proposed. The new scheme is based on the NFP (No Fit Polygon) algorithm and a new placement principle for pieces. The novel placement principle is to place a piece to the position with lowest gravity center based on NFP. In addition, genetic algorithm (GA) is adopted to find an efficient nesting sequence. The proposed scheme can deal with pieces with arbitrary rotation and containing region with holes, and achieves competitive results in experiment on benchmark datasets.

关键词： Nesting Cutting stock No Fit Polygon (NFP) Genetic algorithm (GA) Lowest gravity center

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Hypothermic machine perfusion with metformin-University of Wisconsin solution for ex vivo preservation of standard and marginal liver grafts in a rat model

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World Journal of Gastroenterology 2017年第40期23卷 7221-7231页

作者： Yi-Chao Chai Guo-Xin Dang Hai-Qi he Jian-Hua Shi hong-Ke Zhang Rui-Tao Zhang Bo Wang Liang-Shuo Hu Yi Lv Department of hepatobiliary Surgery First Affiliated Hospital of Xi'an Jiaotong University Institute of Advanced Surgical Techniques and Engineering Regenerative Medicine and Surgery Engineering Research Center of Shaanxi Province Xi'an Jiaotong University Department of hepatobiliary and Vascular Surgery the 521 Hospital of Ordnance Industry

AIM To compare the effect of University of Wisconsin(UW) solution with or without metformin, an AMP-activated protein kinase(AMPK) activator, for preserving standard and marginal liver grafts of young and aged rats ex vivo by hypothermic machine perfusion(HMP).METHODS Eighteen young(4 mo old) and 18 aged(17 mo old)healthy male SD rats were selected and randomly divided into three groups: control group, UW solution perfusion group(UWP), and UW solution with metformin perfusion group(MUWP). Aspartate aminotransferase(AST), alanine aminotransferase(ALT), lactate dehydrogenase(LDH), interleukin-18(IL-18), and tumor necrosis factor-alpha(TNF-α) in the perfused liquid were tested. The expression levels of AMPK and endothelial nitric oxide synthase(e NOS) in liver sinusoidal endothelial cells were also ***, microscopic evaluation of the harvested perfused liver tissue samples was done. RESULTS AST, ALT, LDH, IL-18 and TNF-α levels in the young and aged liver-perfused liquid were, respectively,significantly lower in the MUWP group than in the UWP group(P he young and aged MUWP *** increased the expression of AMPK and e NOS protein levels, and promoted the extracellular release of nitric oxide through activation of the AMPK-e NOS mediated pathway. Histological examination revealed that in the MUWP group, the extent of liver cells and tissue damage was significantly reduced compared with the UWP *** The addition of metformin to the UW preservative solution for ex vivo HMP can reduce rat liver injury during cold ischemia, with significant protective effects on livers, especially of aged rats.

关键词： Metformin AMP-activated protein kinase Cold ischemia injury Hypothermic machine perfusion Liver Grafts

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PBNA: An Improved Probabilistic Biological Network Alignment Method

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Tsinghua Science and Technology 2014年第6期19卷 658-667页

作者： Muwei Zhao Wei Zhong Jieyue he School of Computer Science and Engineering and also with MOE Key Laboratory of Computer Network and Information IntegrationSoutheast University Division of Math and Computer Science University of South Carolina Upstate Spartanburg SC 29303USA

Biological network alignment is an important research topic in the field of bioinformatics. Nowadays almost every existing alignment method is designed to solve the deterministic biological network alignment ***, it is worth noting that interactions in biological networks, like many other processes in the biological realm,are probabilistic events. Therefore, more accurate and better results can be obtained if biological networks are characterized by probabilistic graphs. This probabilistic information, however, increases difficulties in analyzing networks and only few methods can handle the probabilistic information. Therefore, in this paper, an improved Probabilistic Biological Network Alignment（PBNA） is proposed. Based on Iso Rank, PBNA is able to use the probabilistic information. Furthermore, PBNA takes advantages of Contributor and Probability Generating Function（PGF） to improve the accuracy of node similarity value and reduce the computational complexity of random variables in similarity matrix. Experimental results on dataset of the Protein-Protein Interaction（PPI） networks provided by Todor demonstrate that PBNA can produce some alignment results that ignored by the deterministic methods, and produce more biologically meaningful alignment results than Iso Rank does in most of the cases based on the Gene Ontology Consistency（GOC） measure. Compared with Prob method, which is designed exactly to solve the probabilistic alignment problem, PBNA can obtain more biologically meaningful mappings in less time.

关键词： probabilistic biological network network alignment protein interaction network

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Catalytic enantioselective N-silylation of sulfoximine

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Chinese Chemical Letters 2024年第4期35卷 352-356页

作者： Xingfen Huang Jiefeng Zhu Chuan he Shenzhen Grubbs Institute and Department of Chemistry Guangdong Provincial Key Laboratory of CatalysisSouthern University of Science and TechnologyShenzhen 518055China Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education Hangzhou Normal UniversityHangzhou 311121China

A rhodium/diphosphine-catalyzed asymmetric cross-dehydrogenative coupling between sulfoximines and dihydrosilanes has been achieved. This is the first report on the enantioselective N-silylation of sulfoximines. The protocol gives access to a variety of Si-stereogenic N-silylated sulfoximines in decent yield(up to 99%) with excellent stereoselectivity(up to 99%), featuring high atom economy, and a cleaner manner with H2as the sole byproduct. The obtained bis-Si-stereogenic monohydrosilane product can be further converted into the corresponding chiral polymer with pendant sulfoximine groups.

关键词： N-Silylation of sulfoximine Chiral silylamine Si-stereogenic silanes Si-CADC Asymmetric catalysis

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miRNAs in non-alcoholic fatty liver disease

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Frontiers of Medicine 2016年第4期10卷 389-396页

作者： Zhen he Cheng Hu Weiping Jia Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus Shanghai Clinical Center for Diabetes Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 China

Non-alcoholic fatty liver disease （NAFLD） is a major cause of liver cirrhosis and hepatocellular carcinoma and is a considerable threat to public health, miRNAs are important post-transcriptional regulators of gene expression, and the dysregulation of miRNAs is involved in various biological processes in the liver, including lipid homeostasis, inflammation, apoptosis, and cell proliferation. Recently, a number of studies have described the association between miRNAs and NAFLD progression and have shown that circulating miRNAs reflect histological changes in the liver. Therefore, circulating miRNAs have potential use for the evaluation of NAFLD severity. In this review, we discuss the involvement of miRNAs in NAFLD pathogenesis and the key role of miRNAs in the screening, diagnosis, and staging of NAFLD.

关键词： nonalcoholic fatty liver disease nonalcoholic steatohepatitis hepatocellular carcinoma miRNA

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