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Immobilization of hemoglobin on Cobalt Nanoparticles-modified Indium Tin Oxide Electrode： Direct Electrochemistry and Electrocatalytic Activity

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chemical Research in chinese Universities 2013年第3期29卷 563-567页

作者： LI Shuo-qi HU Jing-bo college of Materials Science and engineering Shandong University of Science and Technology Qingdao 266590 P. R. China college of chemistry Beijing Normal University Beijing 100875 P. R. China

A cobalt nanoparticles-attached indium tin oxide（CoNPs/ITO） electrode was applied to the immobilization of hemoglobin（Hb） and an Hb modified CoNPs/ITO electrode（Hb/CoNPs/ITO） was prepared. The direct electron transfer of Hb was shown by the well-behaved voltammetric responses for Hb/CoNPs/ITO electrode and the effects of scan rate and pH value were observed. Based on the catalytic activity of Hb immobilized on the CoNPs/ITO electrode toward the reduction of H2O2, a mediator-free H2O2 sensor was developed. A linear relationship existed between the catalytic current and the H2O2 concentration in a range of 1.0--100.0 μmol/L with a detection limit （S/N=3. of 0.2μmol/L.

关键词： Cobalt nanopartiele Indium tin oxide electrode Direct electron transfer hemoglobin Electrocatalysis Hydrogen peroxide

Mass Spectral Fragmentation of (S,S)-N,N′-Bis [1-(hydroxymethyl)alkyl]anthracene/Naphthalene-1,8-dicarboxamides under Electron Impact Ionization Conditions

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chemical Research in chinese Universities 2006年第6期22卷 756-759页

作者： JIAO Peng ZHANG qi-han XU Jia-xi Key Laboratory of Bioorganic chemistry and Molecular engineering of Ministry of Education College of Chemistry and Molecular Engineering Peking University Beijing 100871 China

The mass spectrometric fragmentation of （ S, S） -N, N＇-bis [ 1- （hydroxymethyl） alkyl] anthracene/naphthalene-1, 8-dicarboxamides was investigated with the aid of mass-analyzed ion kinetic energy spectrometry and the elemental compositions of important fragment ions were determined by accurate mass measurement under electron impact ionization conditions. All the compounds could eliminate formaldehyde. The [ M-CH2O] ions could also eliminate imine, aziridine, aziridinone, 2-amonoalkan-1-ol, water, and other fragments. Several cyclizations were observed under electron impact ionization.

关键词： Biscarboxamide EI-MS Fragmentation Cyclization

Thermo-sensitive Porous Polymer Membrane-immobilized Cellulose as a Switchable Enzyme Reactor for Tuning Its Enzymolysis via Variation Temperature

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chemical Research in chinese Universities 2023年第6期39卷 992-997页

作者： qiAO Juan ZHANG Xinya CheNG Cheng qi Li beijing National Laboratory for Molecular sciences Key Laboratory of Analytical Chemistry for Living BiosystemsInstitute of ChemistryChinese Academy of SciencesBeijing 100190P.R.China School of chemical sciences University of Chinese Academy of SciencesBeijing 100049P.R.China School of Pharmacy Xinxiang Medical UniversityXinxiang 453003P.R.China college of chemistry&Environmental Science Hebei UniversityBaoding 071002P.R.China

Immobilization of enzymes onto porous membranes has attracted considerable attention in recent ***,enhancing the enzymolysis efficiency of the resulting enzyme reactors by varying the environmental conditions poses a great *** this work,poly(styrene-maleic anhydride-N,N-dimethylacrylamide)was prepared and utilized to construct a thermo-sensitive porous polymer membrane-based enzyme reactor(TS-PPMER)after cellulase was immobilized onto the support by covalent *** catalytic activity of the nano-reactor was evaluated by measuring the yield of the product,glucose,at different temperatures with carboxymethylcellulose as the ***,the polymer chains coiled and formed numerous nano-pores at a high temperature,which induced the confine effect and greatly boosted the enzymolysis efficiency of ***,the proposed TS-PPMER was applied in the hydrolysis of green plant leaves in Epipremnum *** work shows great potential in obtaining biological resources by an environmentally friendly approach using smart polymer-based nano-reactors.

关键词： Thermo-sensitive porous polymer membrane Cellulase reactor Catalytic efficiency Glucose Plant leaf

Identification and semisynthesis of(-)-anisomelic acid as oral agent against SARS-CoV-2 in mice

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National Science Review 2022年第11期9卷 29-36页

作者： Hai-Xin Yu Nan Zheng Chi-Tai Yeh Chien-Ming Lee qi Zhang Wen-Lv Zheng qing Chang Yuan-he Li Yu-Jun Li Gui-Zhen Wu Jun-Min Quan Lin-qi Zhang Yew-Min Tzeng Zhen Yang Laboratory of chemical Genomics School of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Department of Medicinal Research and Education Taipei Medical University-Shuang Ho Hospital Department of Applied Science Taitung University Center for Global health and Infectious Diseases Comprehensive AIDS Research Center and Beijing Advanced Innovation Center for Structural Biology School of Medicine Tsinghua University Lanzhou Institute of Separation Science State Key Laboratory of Bioorganic chemistry and Molecular engineering of Ministry of Education and beijing National Laboratory for Molecular Science(BNLMS) College of Chemistry and Molecular EngineeringPeking University Shenzhen Bay Laboratory NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Department of Applied chemistry Chaoyang University of Technology

(-)-Anisomelic acid, isolated from Anisomeles indica(L.) Kuntze(Labiatae) leaves, is a macrocyclic cembranolide with a trans-fused α-methylene-γ-lactone motif. Anisomelic acid effectively inhibits SARS-Co V-2 replication and viral-induced cytopathic effects with an EC50 of 1.1 and 4.3.μM, *** studies of SARS-CoV-2-infected K18-hACE2 mice showed that oral administration of anisomelic acid and subcutaneous dosing of remdesivir can both reduce the viral titers in the lung tissue at the same level. To facilitate drug discovery, we used a semisynthetic approach to shorten the project timelines. The enantioselective semisynthesis of anisomelic acid from the naturally enriched and commercially available starting material(+)-costunolide was achieved in five steps with a 27% overall *** developed chemistry provides opportunities for developing anisomelic-acid-based novel ligands for selectively targeting proteins involved in viral infections.

关键词： identification enantioselective semisynthesis (−)-anisomelic acid oral agent anti-SARS-CoV-2

Catalytic asymmetric oxidative sulfenylation of β-ketocarbonyls using a chiral primary amine

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Organic chemistry Frontiers 2022年第5期9卷 1276-1281页

作者： qi Zhang Mingying Shi Xueling Mi Sanzhong Luo Key Laboratory of Molecular Recognition and Function Institute of ChemistryChinese Academy of SciencesBeijing 100190China School of chemical Science University of Chinese Academy of SciencesBeijing 100490China college of chemistry Beijing Normal UniversityBeijing 100875China Center of Basic Molecular Science Department of ChemistryTsinghua UniversityBeijing100084China

Enantioselective oxidative construction of a C(sp^(3.)–S bond has been achieved using a chiral primary amine catalyst in the presence of tert-butyl hydroperoxide and a catalytic amount of tetrabutylammonium *** distinctive feature of the current reaction is coupling with nucleophilic sulfur reactants under oxidative *** protocol provides facile access to chiral thioethers bearing S-containing quaternary stereocenters with good chemo-and enantiocontrol.

关键词： oxidative chiral asymmetric

Enzyme immobilization on a pH-responsive porous polymer membrane for enzymatic kinetics study

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chinese chemical Letters 2021年第10期32卷 3195-3198页

作者： Juan qiao Lili Liu Ji Shen Li qi beijing National Laboratory of Molecular sciences Key Laboratory of Analytical Chemistry for Living Bio-systemsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of chemical sciences University of Chinese Academy of SciencesBeijing 100049China college of chemistry&Environmental Science Hebei UniversityBaoding 071002China

Immobilization of enzymes onto carriers is a rapidly growing research area aimed at increasing the stability,reusability and enzymolysis efficiency of free *** this work,the role of phaseseparation and a pH-responsive"hairy"brush,which greatly affected the topography of porous polymer membrane enzyme reactors(PMER),was *** porous polymer membrane was fabricated by phase-separation of poly(styrene-co-maleic anhydride-acrylic acid)and poly(styrene-ethylene glycol).Notably,the topography and pores size of the PMER could be controlled by phase-separation and a pHresponsive"hairy"*** evaluating the enzymolysis efficiency of D-amino acid oxidase(DAAO)immobilized carrier(DAAO@PMER),a chiral ligand exchange capillary electrophoresis method was developed with D-methionine as the *** DAAO@PMER showed good reusability and stability after five continuous ***,comparing with free DAAO in solution,the DAAO@PMER exhibited a17.7-folds increase in catalytic velocity,which was attributed to its tailorable topography and pHresponsive *** poly(acrylic acid)moiety of poly(styrene-co-maleic anhydride-acrylic acid)as the pH-responsive"hairy"brush generated topography changing domains upon adjusting the buffer pH,which enable the enzymolysis efficiency of DAAO@PMER to be tuned based upon the well-defined architectures of the *** approach demonstrated that the topographical changes formed by phaseseparation and the pH-responsive"hairy"brush indeed made the proposed porous polymer membrane as suitable supports for enzyme immobilization and fitting for enzymolysis applications,achieving high catalytic performance.

关键词： Enzyme immobilization Porous polymer membrane topography Phase separation pH-stimuli responsive hairy brush

Comparative Studies on Mass Spectrometric Fragmentation of Linear Chiral Secondary Alcohols (R)-1-(4-Alkylphenyl) and (R)-1-(4-Alkoxyphenyl/Alkylthiophenyl) Alcohols

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chemical Research in chinese Universities 2006年第3期22卷 347-350页

作者： ZHANG qi-han SU Xian-bin XU Jia-xi Key Laboratory of Bioorganic chemistry and Molecular engineering College of Chemistry and Molecular Engineering Peking University Beijing 100871 P.R. China

Mass spectrometric behaviour of （R） -1- （ 4-alkylphenyl ） alcohols, 1- （4-alkoxylphenyl） alcohols, and 1- （4-alkylthiophenyl） alcohols were studied with the aid of mass-analyzed ion kinetic energy spectrometry under electron impact ionization. All the title compounds show a tendency to eliminate a water molecule to form alkene ions and undergo an a-cleavago to produce protonated aldehyde ions by the loss of alkyl radicals. Except these two common fragment ions, they also show some different fragmentations due to with or without oxy/thioether-linkage.

关键词： 1-(4-Alkylphenyl) alcohol 1-(4-Alkoxylphenyl) alcohol 1-(4-Alkylthiophenyl) alcohol Electron impact ionization Fragmentation mechanism Mass spectrometry

Comparable charge transport property based on S…S interactions with that of π-π stacking in a bis-fused tetrathiafulvalene compound

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Science china chemistry 2017年第4期60卷 510-515页

作者： Ke Zhou Hongfeng Chen Huanli Dong qi Fang Wenping Hu beijing National Laboratory for Molecular sciences Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China State Key Laboratory of Crystal Materials Shandong University Jinan 250100 China Collaborative Innovation Center of chemical Science and engineering (Tianjin) Department of Chemistry School of Science Tianjin University Tianjin 300072 China

Compact molecular packing with short π-π stacking and large π-overlap in organic semiconductors is desirable for efficient charge transport and high carrier mobility. Thus charge transport anisotropy along different directions is commonly observed in organic semiconductors. Interestingly, in this article, we found that comparable charge transport property were achieved based on the single crystals of a bis-fused tetrathiafulvalene derivative （EM-TTP） compound along two interaction directions, that is, the multiple strong S…S intermolecular interactions and the π-π stacking direction, with the measured electrical conductivity and hole mobility of 0.4 S cm-1, 0.94 cm2 V i s 1 and 0.2 S cm-1, 0.65 cm2 V-1 s-1, respectively. This finding provides us a new molecular design concept for developing novel organic semiconductors with isotropic charge transport property through the synergistic effect of multiple intermolecular interactions （such as π-π interactions） and π-π stacking.

关键词： bis-fused TTF derivative single crystal electrical conductivity hole carrier mobility

Modification of NASICON Electrolyte and Its Application in Real Na-Ion Cells

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engineering 2022年第1期8卷 170-180页

作者： qiangqiang Zhang Quan Zhou Yaxiang Lu Yuanjun Shao Yuruo qi Xingguo qi Guiming Zhong Yong Yang Liquan Chen Yong-Sheng Hu Key Laboratory for Renewable Energy Beijing Key Laboratory for New Energy Materials and DevicesBeijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing 100190China Center of Materials Science and Optoelectronics engineering University of Chinese Academy of SciencesBeijing 100049China Xiamen Institute of Rare-Earth Materials Haixi InstitutesChinese Academy of SciencesXiamen 361021China State Key Laboratory of Physical chemistry of Solid Surfaces&Department of chemistry College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China HiNa Battery Technology Co. Ltd.Liyang 213300China Yangtze River Delta Physics Research Center Co. Ltd.Liyang 213300China

The low ionic conductivity of solid-state electrolytes(SSEs)and the inferior interfacial reliability between SSEs and solid-state electrodes are two urgent challenges hindering the application of solid-state sodium batteries(SSSBs).herein,sodium(Na)super ionic conductor(NASICON)-type SSEs with a nominal composition of Na_(3.2x)Zr_(2-x)MgxSi_(2)PO_(12) were synthesized using a facile two-step solid-state method,among which Na_(3.3.Zr_(1.85)Mg_(0.15)Si_(2)PO_(12)(x=0.15,NZSP-Mg_(0.15))showed the highest ionic conductivity of 3.54mS∙cm^(-1) at 25℃.By means of a thorough investigation,it was verified that the composition of the grain boundary plays a crucial role in determining the total ionic conductivity of ***,due to a lack of examination in the literature regarding whether NASICON can provide enough anodic electro{13. stability to enable high-voltage SSSBs,we first adopted a high-voltage Na_(3.(VOPO_(4))2F(NVOPF)cathode to verify its compatibility with the optimized NZSP-Mg_(0.15) *** comparing the electro{13. performance of cells with different configurations(low-voltage cathode vs high-voltage cathode,liquid electrolytes vs SSEs),along with an X-ray photoelectron spectroscopy evaluation of the after-cycled NZSP-Mg_(0.15),it was demonstrated that the NASICON SSEs are not stable enough under high voltage,suggesting the importance of investigating the interface between the NASICON SSEs and high-voltage ***,by coating NZSP-Mg_(0.15) NASICON powder onto a polyethylene(PE)separator(PE@NASICON),a 2.42 A∙h non-aqueous Na-ion cell of carbon|PE@NASICON|NaNi_(2/9)Cu_(1/9)Fe_(1/3.Mn_(1/3.O_(2) was found to deliver an excellent cycling performance with an 88%capacity retention after 2000 cycles,thereby demonstrating the high reliability of SSEs with NASICON-coated separator.

关键词： Solid-state electrolytes Solid-state sodium batteries NASICON Interface Separator Coating