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Gastric ulcer treated using an elastic traction ring combined with clip: A case report

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World Journal of Clinical Cases 2022年第31期10卷 11574-11578页

作者： Fei Pang Yan-Jun Song yin-he Sikong Ai-Jun Zhang Xiu-Li Zuo ru-Yuan Li Department of Gastroenterology Qilu Hospital(Qingdao)Cheeloo College of MedicineShangdong UniversityQingdao 266035Shandong ProvinceChina Department of hematology Qilu Hospital(Qingdao)Cheeloo College of MedicineShangdong UniversityQingdao 266035Shandong ProvinceChina Department of Gastroenterology Qilu HospitalCheeloo College of MedicineShangdong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND There is a high annual incidence of acute,nonvariceal upper gastrointestinal bleeding in Chinese *** endoscopic intervention can reduce rates of rebleeding,surgery,and *** metal clip is the most common method for establishing homeostasis;however,it possesses several *** patients with bleeding secondary to large gastric ulcers,the clip will often fail to stop the *** article highlights the use of an elastic traction ring as a novel hemostatic method for patients with upper gastrointestinal *** SUMMARY An elderly male presented to the emergency room with complaints of hematemesis and *** examination revealed an ulcer(Forrest IIa)in the lesser curvature of the gastric *** tissue clips and one elastic traction ring were inserted into the stomach cavity to suture the *** patient recovered quickly without postoperative gastrointestinal *** months later,the patient's ulcer was significantly *** To our best knowledge,this is the first report to demonstrate the safety and efficacy of elastic traction rings for upper gastrointestinal *** traction rings should be considered a routine therapeutic modality for patients with upper gastrointestinal bleeds.

关键词： Gastric ulcer Elastic traction ring Acute nonvariceal upper gastrointestinal bleeding Endoscopic hemostasia Tissue clips Case report

DENND1A desensitizes granulosa cells to FSH by arresting intracellular FSHR transportation

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Science China(Life Sciences) 2024年第8期67卷 1620-1634页

作者： Yunde Dou rusong Zhao Han Wu Zhiheng Yu Changjian yin Jie Yang Chaoyan Yang Xiaohua Luan Yixiao Cheng Tao Huang Yuehong Bian Shan Han Yuqing Zhang Xin Xu Zi-Jiang Chen Han Zhao Shigang Zhao Institute of Women Children and Reproductive HealthShandong UniversityJinan 250012China State Key Laboratory of Reproductive Medicine and Offspring health Jinan 250012China Key laboratory of Reproductive Endocrinology of Ministry of Education Shandong UniversityJinan 250012China Shandong Key Laboratory of Reproductive Medicine Shandong UniversityJinan 250012China Shandong Provincial Clinical Research Center for Reproductive health Jinan 250012China National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong UniversityJinan 250012China The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal HospitalNanjing Medical UniversitySuzhou 215008China Gusu School Nanjing Medical UniversitySuzhou 215000China Guangdong Provincial People’s Hospital Guangdong Academy of Medical SciencesGuangzhou 510080China Guangdong-Hong Kong Metabolism&Reproduction Joint Laboratory Guangdong Second Provincial General HospitalGuangzhou 510317China Reproductive Medicine Center Guangdong Second Provincial General HospitalGuangzhou 510317China Research Unit of Gametogenesis and health of ART-Offspring Chinese Academy of Medical Sciences(No.2021RU001)Jinan 250012China Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics Shanghai 200127China Center for Reproductive Medicine Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China

Polycystic ovary syndrome(PCOS)is a complex ***-wide association studies(GWAS)have identified several genes associated with this condition,including ***1A encodes a clathrin-binding protein that functions as a guanine nucleotide exchange factor involved in vesicular ***,the specific role of DENND1A in reproductive hormone abnormalities and follicle development disorders in PCOS remain poorly *** this study,we investigated DENND1A expression in ovarian granulosa cells(GCs)from PCOS patients and its correlation with *** results revealed an upregulation of DENND1A expression in GCs from PCOS cases,which was positively correlated with testosterone *** further explore the functional implications of DENND1A,we generated a transgenic mouse model overexpressing Dennd1a(TG mice).These TG mice exhibited subfertility,irregular estrous cycles,and increased testosterone production following PMSG ***,the TG mice displayed diminished responsiveness to FSH,characterized by smaller ovary size,less well-developed follicles,and abnormal expressions of FSH-priming ***,we found that Dennd1a overexpression disrupted the intracellular trafficking of follicle stimulating hormone receptor(FSHR),promoting its internalization and inhibiting *** findings shed light on the reproductive role of DENND1A and uncover the underlying mechanisms,thereby contributing valuable insights into the pathogenesis of PCOS and providing potential avenues for drug design in PCOS treatment.

关键词： PCOS DENND1A FSHR ovarian granulosa cells

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后盖零件联动夹具的设计分析

模具制造 2024年第9期24卷 219-221页

作者：尹启彬王庆玲韩茹山东中润液压机械有限公司山东临沂276715

在机械加工领域,夹具的设计对于保证零件的加工质量和提高生产效率起着至关重要的作用。后盖零件作为一种常见的机械部件,其加工精度和生产效率的要求日益提高。传统的夹具设计往往存在装夹不便、定位不准确等问题,难以满足现代生产的... 详细信息

在机械加工领域,夹具的设计对于保证零件的加工质量和提高生产效率起着至关重要的作用。后盖零件作为一种常见的机械部件,其加工精度和生产效率的要求日益提高。传统的夹具设计往往存在装夹不便、定位不准确等问题,难以满足现代生产的需求。为此,通过对一种后盖零件在加工中出现的问题的分析,总结设计出一种联动夹紧的夹具方案,制作简单、夹持可靠、便于安装调试。

关键词：机加工夹具联动夹紧快速可靠

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保活运输应激对水产动物肌肉品质影响的研究进展

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广东海洋大学学报 2024年第1期44卷 35-43页

作者：张亮子黄泽南尤娟刘茹尹涛马华威武汉商学院湖北武汉430056 华中农业大学食品科学技术学院湖北武汉430070 国家大宗淡水鱼加工技术研发分中心湖北武汉430070 广西壮族自治区水产科学研究院广西南宁530021

【目的】揭示应激对水产动物肌肉品质的影响,以期为水产动物保活运输提供参考。【方法】将保活运输过程中的应激源分为温度、低氧、拥挤、振动、氨氮和空气暴露等,综述各种应激源对不同水产动物肌肉品质的影响;在此基础上,概括加盐、暂... 详细信息

【目的】揭示应激对水产动物肌肉品质的影响,以期为水产动物保活运输提供参考。【方法】将保活运输过程中的应激源分为温度、低氧、拥挤、振动、氨氮和空气暴露等,综述各种应激源对不同水产动物肌肉品质的影响;在此基础上,概括加盐、暂养、加抗氧化剂、休眠和冷驯化等减缓应激措施对水产动物肌肉品质的影响,总结组学技术在揭示应激影响水产动物肌肉品质机制的应用。【结果与结论】应激状态下,水产动物的生命活动中,如基因表达、代谢和免疫等都会进行适应性调控,使蛋白质、代谢物组成和细胞形态等发生改变,并最终影响肌肉品质。消除应激可提升水产动物肌肉品质,关于其对提升肌肉品质的机理方面研究是未来的研究方向。

关键词：保活运输应激源减缓应激措施肌肉品质组学技术

Spatial–temporal distribution and potential ecological risk assessment of nonylphenol and octylphenol in riverine outlets of Pearl River Delta, China

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Journal of Environmental Sciences 2014年第11期26卷 2340-2347页

作者： ru Chen Pinghe yin Ling Zhao Qiming Yu Aihua Hong Shunshan Duan Department of Chemistry College of Life Science and Technology Jinan University Center of Analysis and Test Department of Environmental Engineering Jinan University Griffith School of Engineering Griffith University Nathan Campus Brisbane Queensland 4111 Australia Center of Analysis and Test Guangzhou Research Center of Hydrobiology College of Life Science and TechnologyJinan University

The aquatic environments of the Pearl River Delta in Southern China are subjected to contamination with various industrial chemicals from local industries. In this paper, the occurrence, seasonal variation and spatial distribution of alkylphenol octylphenol （OP） and nonylphenol （NP） in fiver surface water and sediments in the runoff outlets of the Pearl River Delta were investigated. NP and OP were detected in all water and sediment samples and their mean concentrations in surface water during the dry season ranged from 810 to 3366 ng/L and 85.5 to 581 ng/L, respectively, and those in sediments ranged from 14.2 to 95.2 ng/g dw and 0.4 to 3.0 ng/g dw, respectively. In surface water, much higher concentrations were detected in the dry season than those in the wet season. In sediments, the concentrations in the dry season were also mostly higher. High concentrations of NP and OP were found in Humen outlet, likely due to high levels of domestic and industrial wastewater discharges. An ecological risk assessment with the use of hazard quotient （HQ） was also carried out and the HQvalues ranged from 3.6 × 10^-5 to 35 and 64% of samples gave a HQ 〉 1, indicating that the current levels of NP and OP pose a significant risk to the relevant aquatic organisms in the region.

关键词： Nonylphenol Octylphenol Environmental concentration Ecological risk assessment Pearl River Delta

基于CEEMD-BiLSTM-RFR的短期光伏功率预测

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科学技术与工程 2024年第5期24卷 1955-1962页

作者：冯沛儒江桂芬徐加银叶剑桥李生虎国网安徽省电力有限公司经济技术研究院合肥230061 合肥工业大学电气与自动化工程学院合肥230009

由于短期光伏预测中气象因素的时间尺度不同,直接分析其对光伏功率的相关性,易忽略时间尺度的影响,进而导致预测模型误差。为提高光伏功率预测精度,构建了预测模型。首先,利用互补集合经验模态分解(complementary empirical mode decomp... 详细信息

由于短期光伏预测中气象因素的时间尺度不同,直接分析其对光伏功率的相关性,易忽略时间尺度的影响,进而导致预测模型误差。为提高光伏功率预测精度,构建了预测模型。首先,利用互补集合经验模态分解(complementary empirical mode decomposition,CEEMD)将光伏序列进行分解,得到在不同时间尺度上的光伏分量;然后,通过Pearson相关系数分析各光伏分量与空气温度、太阳辐射度、风速、风向和空气湿度的关系,对于强相关分量建立关于气象因素的随机森林回归(random forest regression,RFR)预测模型,弱相关分量直接通过双向长短期记忆网络(bidirectional long short-term memory neural network,BiLSTM)进行预测;并将预测求和输出。通过安徽省蚌埠市光伏电站7月实测数据进行验证,实验结果表明,所提预测模型CEEMD-BiLSTM-RFR相比传统预测模型有较好的预测精度。

关键词：光伏功率预测互补集合经验模态分解相关性分析 BiLSTM 随机森林回归

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鱼类运输应激反应及其对存活率影响研究进展

广东海洋大学学报 2024年第2期44卷 24-31页

作者：张亮子黄泽南尤娟刘茹尹涛马华威武汉商学院湖北武汉430056 华中农业大学食品科学技术学院湖北武汉430070 国家大宗淡水鱼加工技术研发分中心湖北武汉430070 广西壮族自治区水产科学研究院广西南宁530021 广西壮族自治区优势特色水产品加工与贮藏工程研究中心广西南宁530021

【目的】探讨促进活鱼类运输产业中关注的提高存活率问题的解决方案。【方法】在理解鱼类应激生理反应的基础上,对适用于运输中的应激指标进行分类,分析其应用局限性和发展趋势;保活运输过程中的应激源可分为温度、拥挤、溶氧、氨氮、... 详细信息

【目的】探讨促进活鱼类运输产业中关注的提高存活率问题的解决方案。【方法】在理解鱼类应激生理反应的基础上,对适用于运输中的应激指标进行分类,分析其应用局限性和发展趋势;保活运输过程中的应激源可分为温度、拥挤、溶氧、氨氮、盐离子、振动和噪声等,综述不同应激源对应激指标和存活率的影响。【结果与结论】在保活运输过程中,应当系统、全面地分析多项应激指标,总结其趋势和相互关联,以正确判定应激反应的强度;同时考虑鱼种、季节、鱼体大小、运输时间等因素的影响,进而制定适宜的保活方式,提高鱼的存活率。

关键词：运输应激反应存活率鱼类

Proteomic survey towards the tissue-specific proteins of mouse mitochondria

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Science China(Life Sciences) 2011年第1期54卷 3-15页

作者： WANG Yuan SUN HaiDan ru YaWei yin SongYue yin Liang LIU SiQi Beijing Institute of Genomics Chinese Academy of Sciences Beijing 101300 China

Mitochondrion plays the key functions in mammalian cells. It is believed that mitochondrion exerts the common biologic functions in many tissues, but also performs some specific functions correspondent with tissues where it is localized. To identify the tissue-specific mitochondrial proteins, we carried out a systematic survey towards mitochondrial proteins in the tissues of C57BL/6J mouse, such as liver, kidney and heart. The mitochondrial proteins were separated by 2DE and identified by MALDI-TOF/TOF MS. Total of 87 unique proteins were identified as the tissue-specific ones, and some representatives were further verified through ICPL quantification and Western blot. Because these issue-specific proteins are coded from nuclear genes, real-time PCR was employed to examine the mRNA status of six typical genes found in the *** combining of the expression data and the co-localization images obtained from confocal microscope, we came to the conclusion that the tissue-specifically mitochondrial proteins were widely distributed among the mouse tissues. Our investigation, therefore, indeed provides a solid base to further explore the biological significance of the mitochondrial proteins with tissue-orientation.

关键词： proteomics tissue-specific mitochondria

张掖-民乐盆地ZYDR3井地热流体氦同位素的指示

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甘肃地质 2024年第1期33卷 53-58页

作者：尹政何剑波张旭儒张玲汪嘉逸刘希尧甘肃省地矿局水文地质工程地质勘察院甘肃张掖734000 甘肃省地下水工程及地热资源重点实验室甘肃兰州730050

张掖—民乐盆地ZYDR3地热井地热流体中富含水溶性气体,其中氦气含量占水溶性气体含量的1.198%。通过对ZYDR3地热井地热流体氦同位素的分析测试,其3he/4he的值R(4.40×10^(-8))远小于大气3he/4he的值Ra(1.40×10^(-6)),认为该地热井地热... 详细信息

张掖—民乐盆地ZYDR3地热井地热流体中富含水溶性气体,其中氦气含量占水溶性气体含量的1.198%。通过对ZYDR3地热井地热流体氦同位素的分析测试,其3he/4he的值R(4.40×10^(-8))远小于大气3he/4he的值Ra(1.40×10^(-6)),认为该地热井地热流体中氦气以壳源氦为主,混合有微量的幔源氦。本文分析计算了热储层的热导率和井温梯度,并以此估算的大地热流值为69.23 mW/m^(2),略高于中国大陆地区平均热流值61.50 mW/m^(2),显示该地热井附近具有较好的热流状态;根据氦同位素4he、3he通量与壳、幔热流的相关关系,分析大地热流中主要为壳源热流,约占85.50%,幔源热流仅占14.50%。研究方法丰富了该区地热系统理论,同时为该区地热资源开发利用提供了一定的理论支撑。

关键词： he同位素壳幔热流比值热储温度地温梯度张掖—民乐盆地