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Contragestazol (DL111-IT) inhibits proliferation of human androgen-independent prostate cancer cell line PC3 in vitro and in vivo

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Asian Journal of Andrology 2005年第4期7卷 389-393,页

作者： Qiao-Jun he bo yang Yi-Jia Lou Rui-Ying Fang Department of Pharmacology College of Pharmaceutical Science Zhejiang University Hangzhou 310031 China

Aim： To evaluate the antiproliferative activity of contragestazol （DL111-IT） on the human prostate cancer cell line PC3 in vitro and in vivo and to elucidate its potential molecular mechanisms. Methods： The cell killing ability of DL111-IT was measured by the 3-（4,5-dimethylthia-zol,2-yl）-2,5-diphenyltetrazolium bromide （MTT） reagent assay method and the tumor xenograft model. The cell cycle was analyzed by flow cytometry and protein expression, including retinoblastoma （pRb）, cyclin-dependent kinase 4 （CDK4） and cyclin D 1, was detected by Western blotting. Results： DL111-IT exhibited high efficiency on cell growth inhibition of the human androgen-independent prostate cancer cell line PC3. The drug concentration that yielded 50 % cell inhibition （IC50 value） was 9.9 mg/mL. In the PC3 tumor xenograft study, DL111-IT （1.25 mg/kg-20.0 mg/kg） given once a day for 10 days significantly inhibited tumor growth, with the inhibition rate ranging from 21% to 50 %. Flow cytometric analysis indicated that DL111-IT could cause GI arrest in the PC3 cell line, but not apoptosis. DL111-IT enhanced pRb expression and down-regulated CDK4 and cyclin D 1 expression, suggesting that cell cycle regulation might contribute to the anticancer property of DL 111- IT. Conclusion： DL111-1T inhibits the proliferation of human androgen-independent prostate cancer cell line PC3 in vitro and in vivo by a cell cycle regulation pathway.

关键词： DL111-IT prostate cancer pRb cyclin-dependent kinase 4 cyclin D 1 PC3 cell line

Catheter ablation of paroxysmal atrial fibrillation in a young patient with a partial anomalous pulmonary venous connection

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Chinese Medical Journal 2010年第16期123卷 2284-2286页

作者： HUANG he yang bo JIANG Hong WU Gang HUANG Cong-xin Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan Hubei 430060 China

It has been demonstrated that pulmonary veins （PV）play an important role in the initiation and perpetuation of paroxysmal atrial fibrillation （PAF）.1-5 Therefore, PV isolation has become the cornerstone for catheter ablation in the majority of these AF patients.3-5 In addition, ectopic foci in the non-PVs areas, such as superior vena cava（SVC）,

关键词： catheter ablation atrial fibrillation anomalous pulmonary venous drainage pulmonary vein superior vena cava

Supercontinuum Generationin Normal-dispersion Photonic Crystal Fiber Using Picosecond Pulse

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Semiconductor Photonics and Technology 2007年第4期13卷 256-260页

作者： YAO Li he Li yang bo-jun Key Laboratory of Optical Communication and Lightwave Technologies Ministry of Education Beijing University of Posts and Telecommunications Beijing 100876 CHN

Studied is the Super-continuum(SC) generation of a normal-dispersion photonic crystal fiber(PCF) using picosecond pulse excitation. In experimental analyses, a 237 nm broadband infrared continuum was generated pumped at 1 550 nm(normal dispersion regime) by 1.6 ps pulses from an erbium-doped fiber laser. In addition, we conduct the numerical analyses of SC based on generalized nonlinear Schr dionger equation. The results have been applied to investigate the dominant physical processes underlie the generation of SC. We conclude that dispersion, self-phase modulation(SPM),four-wave-mixing(FWM) and Raman scattering are determinants of SC generation rather than fission of soliton in normal-dispersion PCF.

关键词： supercontinuum photonic crystal fiber picosecond

Study on fluoroalkylation and fluoroalkoxylation——***(Ⅰ)-catalyzed reaction of fluoroalkyl iodides with alkenes and alkynes

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Acta Chimica Sinica(English Edition) 1988年第2期 155-160页

作者： CheN Qing-Yun he Ya-bo yang Zhen-Yu Shanghai Institute of Organic Chemistry,Shanghai

Fluoroalkyl iodides reacted with alkenes in the presence of hydridocarbonyltris(tri-phenylphosphine)iridium (I) to give the corresponding adducts in excellent yields under the *** iodides reacted also with alkynes to afford E isomer of adducts *** of free radical inhibitor or single electron transfer scavenger to the reaction mix-ture partially suppressed the *** ether could trap the fluoroalkyl radical to affordtetrahydrofuran *** showed that the valence of Ir (I) rised at the end of the *** findings seem to indicate that the reaction involves a free radical chain mechanism initiated byIr (I).

关键词： catalyzed reaction of fluoroalkyl iodides with alkenes and alkynes Iridium

A cross-sectional survey on the prevalence of anxiety symptoms in Chinese patients with premature ventricular contractions without structural heart disease

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Chinese Medical Journal 2012年第14期125卷 2466-2471页

作者： LIANG Jin-jun HUANG he yang bo WAN Jun TANG Yan-hong BAO Ming-wei ZHAO Qin-yan wu Gang HUANG Cong-xin Department of Cardiology Renmin Hospital of Wuhan UniversityCardiovascular Research Institute of Wuhan University WuhanHubei 430060 China

Background Anxiety appears to be more common in patients with coronary artery disease （CHD） than in the general population, and anxiety symptoms may precede onset of CHD and play an important role in development of CHD. Little is known about the prevalence of anxiety symptoms in Chinese patients with premature ventricular contractions （PVCs）. Our objective was to study anxiety symptoms and potential risk factors in a Chinese population with PVCs but without structural heart disease. Methods The Zung self-rating anxiety scale （ZSAS） was used to assess anxiety symptoms. Correlation between anxiety symptoms and socio-demographics and medical factors were analyzed by Logistic regression. Results Of 1144 patients with PVCs （487 males and 657 females）, age （53＋23） years old, disease duration 1 month to 24 years, a total of 381 （33.3%） patients were categorized as having anxiety symptoms. Anxiety symptoms increased with age, low income, low education level, nationality, PVC count/24 hours, bad social support, village settlement type （P 〈0.05）. Multivariate Logistic regression indicated that six variablesmeducation level, ethnic minorities, dwelling place, age, PVC count/24 hours, and social support--significantly and independently related with anxiety symptoms （P 〈0.05）. Conclusions In the Chinese population, anxiety symptoms in subjects with PVCs were frequent. Education level, ethnic minorities, dwelling place, age, PVC count/24 hours, and social support were independent risk factors for anxiety symptoms. Further research on the relationship between PVCs and anxiety symptoms in China is necessary.

关键词： 'premature ventricular contractions " anxiety symptoms " risk factor

Comparisons of different radiofrequency ablation approaches for persistent atrial fibrillation:atrial fibrillation clinical trial in China

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Comparisons of different radiofrequency ablation approaches ...

中华医学会心电生理和起搏分会第十次全国学术年会

作者： Gang Wu,he Huang,bo yang,Hong Jiang,Congxin Huang Department of Cardiology,Renmin Hospital of Wuhan University 430060

Objective Several techniques based on circumferential pulmonary vein isolation(CPVI) have been successfully used in persistent atrial fibrillation(AF),but have not been adequately compared. Methods and Results This study included 315 patients registered in the Atrial Fibrillation Clinical Trial(AFCT) in *** patients had persistent AF and received CPVI,CPVI plus linear lesion(LL), or CPVI combined with ablation of complex fragmented atrial electrograms(CFAEs).Follow-up was conducted at 3,6 and 12 months after *** three protocols did not differ in efficacy at 3 months. At the 1-year follow-up,however,CPVI was inferior to CPVI + LL or CPVI + CFAEs(62.5%sinus rhythm vs.75.6%and 73.8%).CPVI + LL and CPVI + CFAEs were comparable to each *** three treatments increased left ventricle ejection fraction(EF),but did not affect left atrial diameter(LAD) or left ventricular end diastolic diameter(LVEDD).LL and ablation of CFAEs increased the total time of the procedure and the time of radiofrequency applications,but did not increase the time of *** patient in the CPVI arm had cardiac tamponade after ablation;there were no severe complications in any of the other groups. Conclusions CPVI combined with LL or CFAEs is superior to CPVI alone in maintaining sinus rhythm and is comparable in safety profile,but the benefits taked more than 6 months to *** significant difference can be detected between CPVI + LL and CPVI + CFAEs for at least 1 year after follow-up.

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加油控制盒过流烧毁故障研究

价值工程 2021年第13期40卷 175-177页

作者：贺阳博中航西安飞机工业集团股份有限公司西安710089

加油控制盒作为燃油系统加油控制的中心设备,接收地面压力加油信号,通过控制加油阀的开关,从而实现加油过程控制,并通过加油量计算飞机的重量重心。当加油控制盒故障时无法进行地面压力加油,并丧失重量重心计算功能,从而直接影响任务的... 详细信息

加油控制盒作为燃油系统加油控制的中心设备,接收地面压力加油信号,通过控制加油阀的开关,从而实现加油过程控制,并通过加油量计算飞机的重量重心。当加油控制盒故障时无法进行地面压力加油,并丧失重量重心计算功能,从而直接影响任务的完成。文章针对加油控制盒烧毁故障情况,对其烧毁故障原因进行分析,并根据分析结果对加油控制盒进行改进。

关键词：加油控制盒重量重心计算烧毁

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核电站新型应急柴油机排气温度巡检仪设计

核电子学与探测技术 2019年第6期39卷 796-804页

作者：黄勇王宇何伯阳李久锐中广核研究院有限公司北京分公司北京100086

设计了一种基于MSP430处理器和MAX6675温度采集芯片的应急柴油机(EDG)排气温度巡检仪,实现了多路温度测量、LCD显示、报警指示、定值参数设置等功能。本系统设计方案经基准实验、EMC实验验证了其可用性、稳定性。该设备的研制实现了EDG... 详细信息

设计了一种基于MSP430处理器和MAX6675温度采集芯片的应急柴油机(EDG)排气温度巡检仪,实现了多路温度测量、LCD显示、报警指示、定值参数设置等功能。本系统设计方案经基准实验、EMC实验验证了其可用性、稳定性。该设备的研制实现了EDG排气温度巡检仪的国产化,设备功能的完整性及各项性能指标满足使用要求。

关键词： MSP430 热电偶温度巡检仪应急柴油机

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以科学发展观指导和谐大学建设

湖南师范大学教育科学学报 2007年第6期6卷 44-45页

作者：何扬波湖南师范大学党委宣传部湖南长沙410081

和谐大学的根本特征是科学发展、和谐发展。构建和谐大学是大学以人为本的需要,是大学全面、协调、可持续发展的需要。以科学发展观统领和谐大学建设,必须促进大学发展与经济社会发展、师生利益、资源整合、结构调整、稳定等关系的和谐。

关键词：科学发展观和谐大学建设