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Measurement of the neutron total cross section of carbon at the Back-n white neutron beam of CSNS

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Nuclear Science and Techniques 2019年第9期30卷 73-82页

作者： Xing-Yan Liu Yi-wei Yang Rong Liu Jie Wen Zhong-wei Wen Zi-Jie Han Zhi-Zhou Ren Qi An Huai-{2..Bai Jie Bao Ping Cao Qi-Ping chen {2..Hao chen Pin-Jing cheng Zeng-Qi Cui Rui-Rui Fan Chang-Qing Feng Min-Hao Gu Feng-Qin Guo Chang-Cai Han Guo-Zhu he {2..cheng he Yue-Feng he Han-Xiong Huang wei-Ling Huang Xi-Ru Huang Xiao-Lu Ji Xu-Yang Ji Hao-Yu Jiang wei Jiang Han-Tao Jing Ling Kang Ming-Tao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Shu-Bin Liu Guang-Yuan Luan Ying-Lin Ma Chang-Jun Ning Bin-Bin Qi Jie Ren Xi-Chao Ruan Zhao-Hui Song Hong Sun Xiao-Yang Sun Zhi-Jia Sun Zhi-Xin Tan Hong-Qing Tang Jing-Yu Tang Peng-cheng Wang Qi Wang Tao-Feng Wang Yan-Feng Wang Zhao-Hui Wang Zheng Wang Qing-Biao Wu Xiao-Guang Wu Xuan Wu Li-Kun Xie Han Yi Li Yu Tao Yu {2..Ji Yu Guo-Hui Zhang Jing Zhang Lin-Hao Zhang Li-Ying Zhang Qing-Min Zhang Qi-wei Zhang Xian-Peng Zhang Yu-Liang Zhang Zhi-{2..Zhang Ying-Tan Zhao Liang Zhou Zu-Ying Zhou Dan-Yang Zhu Ke-Jun Zhu Peng Zhu Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics State Key Laboratory of Particle Detection and Electronics Chinese Academy of Sciences(CAS) Department of Modern Physics University of Science and Technology of China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking University Key Laboratory of Nuclear Data China Institute of Atomic Energy Institute of High Energy Physics Chinese Academy of Sciences(CAS) Spallation Neutron Source Science Center university of South china Northwest Institute of Nuclear Technology Department of Engineering and Applied Physics University of Science and Technology of China Beihang university Xi’an Jiaotong university

To verify the performance of the neutron total cross-sectional spectrometer, the neutron total cross section of carbon is initially measured in the energy range of 1 eV to 2..MeV using the time-of-flight method. The measurement is performed at the Back-n white neutron source with a 76-m time-of-flight path using the china Spallation Neutron Source. A multilayer fast fission chamber with 2..u and 2..u is employed as the neutron detector. The diameter and thickness of the natural graphite sample are 70 mm and 40 mm, respectively. Signal waveforms are collected using a data acquisition system. Off-line data processing was used to obtain the neutron time-of-flight spectra and transmissions. The uncertainty of the counting statistics is generally approximately 3% for each bin in the energy range of 1–2..MeV. It is determined that the results for the neutron total cross section of carbon obtained using ^2..u cells are in good agreement with the results obtained using 2..u cells within limits of statistical uncertainty. Moreover, the measured total cross sections show good agreement with the broadening evaluated data.

关键词： CSNS Back-n white neutron source NTOX Neutron total cross section Carbon Multilayer fast fission chamber

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直线易撕裂尼龙薄膜的直线撕裂性能研究

塑料工业 2019年第3期47卷 119-122页

作者：林新土陈曦李永泉廖贵何郑伟陈剑洪刘跃军厦门长塑实业有限公司福建厦门361028 厦门理工学院材料科学与工程学院福建厦门361024

尼龙薄膜具有优异的力学性能、透明性好、气体阻隔性高等优点,被广泛应用于食品包装、日用品包装等领域。对比测试了直线易撕裂尼龙薄膜和普通尼龙薄膜的力学性能,并采用一种简便的方法对直线易撕裂尼龙薄膜及其复合膜的直线撕裂性能进... 详细信息

尼龙薄膜具有优异的力学性能、透明性好、气体阻隔性高等优点,被广泛应用于食品包装、日用品包装等领域。对比测试了直线易撕裂尼龙薄膜和普通尼龙薄膜的力学性能,并采用一种简便的方法对直线易撕裂尼龙薄膜及其复合膜的直线撕裂性能进行评估。结果表明,直线易撕裂尼龙薄膜具有优异的直线撕裂性能和力学性能。

关键词：尼龙薄膜直线撕裂性能

Neutron-induced nuclear recoil background in the PandaX-4T experiment

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Chinese Physics C 2022年第11期46卷 262-274页

作者： Zhou Huang Guofang Shen Qiuhong Wang Abdusalam Abdukerim Zihao Bo wei chen Xun chen Yunhua chen chen cheng Yunshan cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo chencheng Han Ke Han Changda he Jinrong he Di Huang Yanlin Huang Ruquan Hou Xiangdong Ji yonglin Ju chenxiang Li Mingchuan Li Shu Li Shuaijie Li Qing Lin Jianglai Liu Xiaoying Lu Lingyin Luo Wenbo Ma Yugang Ma Yajun Mao Yue Meng Xuyang Ning Ningchun Qi Zhicheng Qian Xiangxiang Ren Nasir Shaheed Changsong Shang Lin Si Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Shaobo Wang Siguang Wang wei Wang Xiuli Wang Zhou Wang Mengmeng Wu weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Xiyu Yan Jijun Yang yong Yang Chunxu Yu Jumin Yuan Ying Yuan Dan Zhang Minzhen Zhang Peng Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou yong Zhou school of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China school of Physics Beihang UniversityBeijing 102206China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Jiao Tong university Sichuan Research Institute Chengdu 610213China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China school of Physics Sun Yat-Sen UniversityGuangzhou 510275China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary SciencShandong UniversityQingdao 266237China Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237China Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai200240China school of Physics Nankai UniversityTianjin 300071China school of Physics Peking UniversityBeijing 100871China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing102206China school of Physics and Microelectronics Zhengzhou UniversityZhengzhouHenan 450001China school of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Physics University of MarylandCollege ParkMaryland 20742USA school of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China SJTu Paris Elite Institute of Technology Shanghai Jiao Tong UniversityShanghai200240China

Neutron-induced nuclear recoil background is critical to dark matter searches in the PandaX-4T liquid xenon *** this study,we investigate the features of neutron background in liquid xenon and evaluate its contribution in single scattering nuclear recoil events using three *** first method is fully based on Monte Carlo *** last two are data-driven methods that also use multiple scattering signals and high energy signals in the *** the PandaX-4T commissioning data with an exposure of 0.63 tonne-year,all these methods give a consistent result,i.e.,there are 1.15±0.57 neutron-induced backgrounds in the dark matter signal region within an approximated nuclear recoil energy window between 5 and 100 keV.

关键词： dark matter neutron background multiple scattering high energy gamma

基于Nrf2..氧化应激研究麦味养肺汤对肺纤维化小鼠的保护作用及机制

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中国中药杂志 2023年第24期48卷 6682-6692页

作者：魏云王晶韩迪黄同杏柏乐陈立炜徐泳周贤梅南京中医药大学附属医院江苏南京210029 南京中医药大学第一临床医学院江苏南京210023 南京中医药大学中医学院·中西医结合学院江苏南京210023

探讨麦味养肺汤(Maiwei Yangfei Decoction,MWYF)对肺纤维化(pulmonary fibrosis,PF)小鼠的作用及其机制。制备MWYF水煎液,超高效液相色谱-三重四极杆串联质谱法(uPLC-MS/MS)检测其主要成分。雄性C57BL/6J小鼠随机分为对照组、模型组以... 详细信息

探讨麦味养肺汤(Maiwei Yangfei Decoction,MWYF)对肺纤维化(pulmonary fibrosis,PF)小鼠的作用及其机制。制备MWYF水煎液,超高效液相色谱-三重四极杆串联质谱法(uPLC-MS/MS)检测其主要成分。雄性C57BL/6J小鼠随机分为对照组、模型组以及MWYF低(MWYF-L)、中(MWYF-M)、高(MWYF-H)剂量组和吡非尼酮(PFD)组,每组10只。除对照组外,其余各组用博莱霉素(bleomycin,BLM)气管滴注法构建肺纤维化模型,次日起给予生理盐水或MWYF或PFD灌胃处理。每日观察小鼠饮水饮食、行动、毛发;苏木精-伊红(he)染色、马松(Masson)染色和CT观察肺组织病理改变;碱水解法检测肺组织中羟脯氨酸(HYP)水平;免疫组织化学法观察Ⅲ型胶原(COL3)、纤连蛋白(fibronectin)表达情况;反转录实时荧光定量PCR(RT-qPCR)检测α-平滑肌肌动蛋白(α-SMA)、Ⅰ型胶原α1(COL1α1)、COL3、波形蛋白(vimentin)mRNA表达水平;试剂盒检测肺组织和血清中氧化应激指标超氧化物歧化酶(SOD)、丙二醛(MDA);免疫荧光检测核因子E2..因子2..rf2..白入核情况;蛋白质免疫印迹法和RT-qPCR检测肺组织中Nrf2..氧化氢酶(CAT)、血红素加氧酶1(HO-1)蛋白及mRNA表达水平。uPLC-MS/MS共检测出12..学成分。动物实验显示,MWYF可以改善PF小鼠肺泡炎症、胶原沉积及纤维化,增加小鼠体质量,下调肺组织中HYP、α-SMA、COL1α1、COL3、fibronectin、vimentin等纤维化指标的表达。此外,MWYF可以提高PF小鼠肺组织和血清中SOD活力,上调Nrf2..水平并促进其向细胞核内转移,上调下游抗氧化靶基因CAT、HO-1水平,进而减少脂质代谢产物MDA的积累。综上,MWYF能够显著改善PF小鼠肺组织病理损伤和纤维化,其机制可能与激活Nrf2..调控氧化应激有关。

关键词：肺纤维化麦味养肺汤氧化应激 Nrf2

Optimization of performance of the KM2..full array using the Crab Nebula

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Chinese Physics C 2024年第6期48卷 169-178页

作者：曹臻 F.Aharonian 安琪阿西克古白云翔包逸炜 D.Bastieri 毕效军毕玉江蔡金庭曹晴曹文羽曹喆常进常劲帆陈尚明陈恩生陈亮陈林陈龙陈明君陈玛丽陈起辉陈素弘陈天禄陈阳程宁程耀东崔明阳崔树旺崔晓红崔昱东戴本忠代洪亮戴子高单增罗布 D.della Volpe 董绪强段凯凯樊军辉范一中方军方堃冯存峰封莉冯少辉丰晓婷冯有亮 S.Gabici 高博高川东高林青高启高卫高伟康葛茂茂耿利斯 G.Giacinti 龚光华苟全补顾旻皓郭福来郭晓磊郭义庆郭莹莹韩毅昂何会海贺昊宁何佳银何新波何钰 M.heller 贺远强侯博文侯超侯贤胡红波胡铨胡世聪黄代绘黄天奇黄文俊黄性涛黄晓渊黄勇黄志成季筱璐贾焕玉贾康江琨姜晓巍姜泽军金敏康明铭柯通 D.Kuleshov.K.Kurinov 李兵兵李澄李骢李丹李飞李海波李会财李华阳李军李剑李捷李凯李文龙李文莲李秀荣李昕李一卓李哲黎卓梁恩维梁云峰林苏杰刘冰刘成刘栋刘虎刘海东刘佳刘江来刘金艳刘茂元柳若愚刘四明刘伟刘怡刘以农鲁睿罗晴吕洪魁马伯强马玲玲马欣华毛基荣闵振 W.Mitthumsiri 穆慧君南云程 A.Neronov 区子维庞彬宇 P.Pattarakijwanich 裴致远齐孟尧祁业情乔冰强秦家军 D.Ruffolo A.Sáiz D.Semikoz 邵澄宇邵琅 O.Shchegolev 盛祥东舒富文宋慧超 Yu.V.Stenkin V.Stepanov 苏扬孙秦宁孙晓娜孙志斌谭柏轩唐庆文唐泽波田文武王超王昌贝王广威王洪光王惠惠王建成汪凯王利苹王玲玉王培汉王冉王为王祥高王祥玉王阳王玉东王岩谨王忠海王仲翔王振王铮韦大明魏俊杰魏永健文韬吴超勇吴含荣武莎吴雪峰吴雨生席邵强夏捷夏君集项光漫肖迪泫肖刚辛广广辛玉良邢祎熊峥徐东莲徐仁峰徐仁新徐伟立薛良闫大海颜景志颜田杨朝文杨帆杨冯帆杨何文杨佳盈杨莉莉杨明洁杨睿智杨深邦姚玉华姚志国叶一锰尹丽巧尹娜游晓浩游智勇于艳红袁强岳华曾厚敦曾婷轩曾玮查敏张彬彬张丰张海明张恒英张建立张丽霞张力张鹏飞张佩佩张瑞张少博张少如张寿山张潇张笑鹏张云峰张毅张勇赵兵赵静赵雷赵立志赵世平郑福周斌周浩周佳能周猛周平周荣周勋秀祝成光祝凤荣朱辉朱科军左雄 LHAASO Collaboration Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of Sciences Beijing 100049China Tianfu Cosmic Ray Research Center Chengdu 610000China Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 10398069029 HeidelbergGermany State Key Laboratory of Particle Detection and Electronics China university of Science and Technology of china Hefei 230026China school of Physical Science and Technology&school of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China school of Astronomy and Space Science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China hebei Normal university Shijiazhuang 050024China Key Laboratory of Dark Matter and Space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Tsung-Dao Lee Institute&school of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key Laboratory of Cosmic Rays(Tibet university) Ministry of EducationLhasa 850000TibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China school of Physics and Astronomy(Zhuhai)&school of Physics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275China school of Physics and Astronomy Yunnan UniversityKunming 650091China Département de Physique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde Genève24 Quai Ernest Ansermet1211 GenevaSwitzerland Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China APC Universit'e Paris Cit'eCNRS/IN2P3CEA/IRFUObservat

The full array of the Large High Altitude Air Shower Observatory(LHAASO)has been in operation since July *** its kilometer-square array(KM2..,we optimized the selection criteria for very high and ultrahigh energyγ-rays using data collected from August 2..1 to August 2..2..esulting in an improvement in significance of the detection in the Crab Nebula of approximately 15%,compared with that of previous *** the implementation of these new selection criteria,the angular resolution was also significantly improved by approximately 10%at tens of *** aspects of the full KM2..array performance,such as the pointing error,were also calibrated using the Crab *** resulting energy spectrum of the Crab Nebula in the energy range of 10-1000 TeV are well fitted by a log-parabola model,which is consistent with the previous results from LHAASO and other experiments.

关键词： γ-ray Crab Nebula significance

新形势·新策略--中药新药及健康产品研发与国际化发展

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中国药理学与毒理学杂志 2018年第1期32卷 1-50页

作者：蒋宁齐春会曹亮陈兰英顾金辉康永 Inkyeom KIM 连晓媛陆茵吕圭源聂克齐云 Valérie SCHINI-KERTH Michael SPEDDING Cherry WAINWRIGHT 王月华肖伟杨勇余林中张丹参张永鹤周文霞杜冠华张永祥北京药理毒理研究所北京100850 《中国药理学与毒理学杂志》编辑部北京100850 江苏康缘药业股份有限公司江苏连云港222001 江西中医药大学江西南昌330006 国家卫生和计划生育委员会科教司重大专项处北京100044 山西省中医药研究院山西太原030012 Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea 浙江大学药学院浙江杭州310058 南京中医药大学江苏南京210023 浙江中医药大学现代中药与健康产品研究所浙江杭州310053 广东药科大学中药学院广东广州510006 中国医学科学院药用植物研究所北京100094 university de Strasbourg StrasbourgFrance Spedding Research Solutions SAS ParisFrance Robert Gordon university AberdeenUK 中国医学科学院药物研究所北京100050 中国药科大学新药安全评价研究中心江苏南京211198 南方医科大学广东广州510515 河北科技大学河北石家庄050018 北京大学基础医学院北京100191

"2..7中国(连云港)国际医药技术大会"于2..7年11月15-17日在江苏省连云港市召开。会议期间,中国药理学会中药与天然药物药理专业委员会与江苏康缘药业股份有限公司共同举办了"中药新药及健康产品研发与国际化发展论坛"。中国药理学会理... 详细信息

"2..7中国(连云港)国际医药技术大会"于2..7年11月15-17日在江苏省连云港市召开。会议期间,中国药理学会中药与天然药物药理专业委员会与江苏康缘药业股份有限公司共同举办了"中药新药及健康产品研发与国际化发展论坛"。中国药理学会理事长兼中药与天然药物药理专业委员会主任委员、国际药理学联合会(IuPHAR)天然药物药理分会主席张永祥教授,中国药理学会前任理事长兼中药与天然药物药理专业委员会副主任委员杜冠华教授和江苏康缘药业股份有限公司董事长、中药与天然药物药理专业委员会副主任委员肖伟担任论坛共同主席。IuPHAR秘书长Michael SPEDDING教授、IuPHAR天然药物药理分会副主席Valérie SCHINI-KERTH教授、英国Robert Gordon大学天然产物研究中心主任Cherry WAINWRIGHT教授和韩国药理学会理事长金仁谦教授等外籍专家、中国药理学会中药与天然药物药理专业委员会委员以及江苏康缘药业股份有限公司主研人员70余人参加了本次论坛。国家卫生和计划生育委员会科技教育司重大专项处顾金辉处长应邀参会。论坛针对中药新药与健康产品研发与国际化发展等有关问题进行了综合讨论。为促进国内外学术交流,本文对部分专家的观点和意见进行了整理,以期为提高我国中药新药与健康产品研发水平及国际化发展起到积极的推动作用。

关键词：中药新药健康产品国际化

A Search for Solar Axions and Anomalous Neutrino Magnetic Moment with the Complete Panda X-Ⅱ Data

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Chinese Physics Letters 2021年第1期38卷 30-34页

作者： Xiaopeng Zhou Xinning Zeng Xuyang Ning Abdusalam Abdukerim wei chen Xun chen Yunhua chen chen cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda he Di Huang Yan Huang Yanlin Huang Zhou Huang Xiangdong Ji yonglin Ju Shuaijie Li Huaxuan Liu Jianglai Liu Xiaoying Lu Wenbo Ma Yugang Ma Yajun Mao Yue Meng Kaixiang Ni Jinhua Ning Xiangxiang Ren Changsong Shang Guofang Shen Lin Si Andi Tan Anqing Wang Hongwei Wang Meng Wang Qiuhong Wang Siguang Wang wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu weihao Wu Jingkai Xia Mengjiao Xiao Pengwei Xie Binbin Yan Jijun Yang yong Yang Chunxu Yu Jumin Yuan Ying Yuan Dan Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou INPAC School of Physics and AstronomyShanghai Jiao Tong Universityand Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China school of Physics Beihang UniversityBeijing 100191China Shanghai Jiao Tong university Sichuan Research Institute Chengdu 610213China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China school of Physics Sun Yat-Sen UniversityGuangzhou 510275China Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China school of Physics Nankai UniversityTianjin 300071China Key Laboratory of Nuclear Physics and Ion-Beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China school of Physics Peking UniversityBeijing 100871China International Research Center for Nuclei and Particles in the Cosmos&Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China school of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Physics University of MarylandCollege ParkMaryland 20742USA school of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China school of Physics and Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong UniversityJinan 250100China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Center for High Energy Physics Peking UniversityBeijing 100871China

We report a search for new physics signals using the low energy electron recoil events in the complete data set from PandaX-Ⅱ,in light of the recent event excess reported by XENON1 *** data correspond to a total exposure of 100.7 ton·day with liquid *** robust estimates of the dominant background spectra,we perform sensitive searches on solar axions and neutrinos with enhanced magnetic *** is found that the axionelectron coupling gAe10^(-12..for an axion mass less than 0.1 keV/c^(2..and the neutrino magnetic moment μv10^(-11)μB at 90%confidence *** observed excess from XENON1 T is within our experimental constraints.

关键词： moment. excess estimates

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近玻尔速度不同离子碰撞产生Al的KX射线

物理学报 2023年第1期72卷 78-85页

作者：周贤明尉静程锐梁昌慧陈燕红赵永涛张小安咸阳师范学院离子束与光物理实验室咸阳712000 中国科学院近代物理研究所兰州730000 西安交通大学理学院西安710049

在玻尔速度附近能区,测量了H^(+),he^(2..和I^(2..),Xe^(2..)离子作用于Al靶时碰撞激发靶的K壳层X射线.得到了相应X射线的发射截面,并与不同理论模型进行对比.研究表明,单核子能量相同时,轻离子入射激发的X射线产生截面比高电荷态重离... 详细信息

在玻尔速度附近能区,测量了H^(+),he^(2..和I^(2..),Xe^(2..)离子作用于Al靶时碰撞激发靶的K壳层X射线.得到了相应X射线的发射截面,并与不同理论模型进行对比.研究表明,单核子能量相同时,轻离子入射激发的X射线产生截面比高电荷态重离子轰击时小了大约4个数量级.质子、he^(2..离子激发的实验截面可以由ECPSSR理论来很好的估算,而I^(2..),Xe^(2..)的实验结果与考虑有效电荷、低速库仑偏转修正的BEA理论计算符合较好.

关键词：离子 X射线截面 BEA ECPSSR

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奈诺沙星与磷霉素对万古霉素抗菌活性及防耐药突变能力影响的体外研究

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中国临床药理学杂志 2020年第24期36卷 3987-3991页

作者：黄珺晨郭思维何开大乔勇肖贵英曾白霜李昕湖南中医药大学研究生院湖南长沙410208 长沙市第三医院药学部湖南长沙410015 长沙市抗菌药物临床应用研究所湖南长沙410015

目的评价奈诺沙星与磷霉素对万古霉素抗耐甲氧西林金黄色葡萄球菌(MRSA)活性及防耐药突变能力的影响。方法收集万古霉素最低抑菌浓度(MIC)>1μg·mL-1的MRSA临床分离株共55株,用琼脂法和棋盘法测定万古霉素、奈诺沙星及磷霉素单药、万... 详细信息

目的评价奈诺沙星与磷霉素对万古霉素抗耐甲氧西林金黄色葡萄球菌(MRSA)活性及防耐药突变能力的影响。方法收集万古霉素最低抑菌浓度(MIC)>1μg·mL-1的MRSA临床分离株共55株,用琼脂法和棋盘法测定万古霉素、奈诺沙星及磷霉素单药、万古霉素联合奈诺沙星及万古霉素联合磷霉素的MIC与防耐药突变浓度(MPC),计算协同抗菌指数(FIC)和耐药突变选择窗(MSW),比较万古霉素单独用药和联合用药的体外抗菌活性及防细菌耐药突变能力。结果万古霉素与奈诺沙星或磷霉素的联合效应均为部分协同、相加或无关;奈诺沙星、磷霉素与万古霉素的部分协同效应分别为50.91%和40.00%,相加作用分别为14.55%和16.36%;联合后,万古霉素的MIC及MPC均有显著的下降。结论对于经梅里埃VITEK 2..ompact全自动细菌鉴定及药敏分析系统鉴定的万古霉素MIC>1μg·mL-1的临床分离MRSA,奈诺沙星与磷霉素可以增强万古霉素的体外抗菌活性和防耐药突变能力。

关键词：耐甲氧西林金黄色葡萄球菌联合用药万古霉素奈诺沙星磷霉素