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Myokines:metabolic regulation in obesity and type 2 diabetes

Life Metabolism 2024年第3期3卷 21-45页

作者： zhi-Tian Chen zhi-Xuan Weng Jiandie D.Lin Zhuo-xian Meng Department of Pathology and Pathophysiology and Department of Cardiology of the Second Affiliated Hospital School of MedicineZhejiang UniversityHangzhouZhejiang 310058China Key Laboratory of Disease Proteomics of Zhejiang Province School of MedicineZhejiang UniversityHangzhouZhejiang 310058China Zhejiang University-University of Edinburgh Institute(ZJE) School of MedicineZhejiang UniversityHainingZhejiang 314400China Life Sciences Institute and Department of Cell and Developmental Biology University of MichiganAnn ArborMI 48109United States Department of Geriatrics Affiliated Hangzhou First People’s HospitalHangzhouZhejiang 310006China

Skeletal muscle plays a vital role in the regulation of systemic metabolism,partly through its secretion of endocrine factors which are collectively known as *** myokine levels are associated with metabolic diseases,such as type 2 diabetes(T2D).The significance of interorgan crosstalk,particularly through myokines,has emerged as a fundamental aspect of nutrient and energy ***,a comprehensive understanding of myokine biology in the setting of obesity and T2D remains a major chal*** this review,we discuss the regulation and biological functions of key myokines that have been extensively studied during the past two decades,namely interleukin 6(IL-6),irisin,myostatin(MSTN),growth differentiation factor 11(GDF11),fibroblast growth factor 21(FGF21),apelin,brain-derived neurotrophic factor(BDNF),meteorin-like(Metrnl),secreted protein acidic and rich in cysteine(SPARC),β-aminoisobutyric acid(BAIBA),Musclin,and Dickkopf 3(Dkk3).Related to these,we detail the role of exercise in myokine expression and secretion together with their contributions to metabolic physiology and *** significant advancements in myokine research,many myokines remain challenging to measure accurately and investigate ***,new research techniques and detection methods should be developed and rigorously ***,developing a comprehensive perspective on myokine biology is crucial,as this will likely offer new insights into the pathophysiological mechanisms underlying obesity and T2D and may reveal novel targets for therapeutic interventions.

关键词： myokines skeletal muscle obesity type 2 diabetes metabolism

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基于动力学分析的大重合度直齿圆柱齿轮强度计算

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工程设计学报 2020年第6期27卷 729-734页

作者：何芝仙陈曦时培成安徽工程大学力学重点实验室安徽芜湖241000

为了探索大重合度直齿圆柱齿轮的承载能力,以2排交错布置、具有纵向重合度的直齿圆柱齿轮为研究对象,基于由动力学分析得到的轮齿间动态法向力的变化规律和齿轮的啮合点位置,采用有限元分析法计算其齿根弯曲应力,利用hertz公式计算其齿... 详细信息

为了探索大重合度直齿圆柱齿轮的承载能力,以2排交错布置、具有纵向重合度的直齿圆柱齿轮为研究对象,基于由动力学分析得到的轮齿间动态法向力的变化规律和齿轮的啮合点位置,采用有限元分析法计算其齿根弯曲应力,利用hertz公式计算其齿面接触应力。通过计算可知:与静态工况相比,考虑齿轮传动系统动力学效应时,大重合度直齿圆柱齿轮的最大齿根弯曲应力增大了22.49%,最大齿面接触应力增大了10.94%;与渐开线标准直齿圆柱齿轮相比,大重合度直齿圆柱齿轮的最大齿根弯曲应力减小了17.08%,最大齿面接触应力减小了43.79%。结果表明,大重合度直齿圆柱齿轮的强度大幅提升,应用潜力巨大。

关键词：大重合度直齿圆柱齿轮动态法向力齿根弯曲应力齿面接触应力

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基于机电耦合的曲轴-滚动轴承系统动力学分析

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机械设计 2013年第6期30卷 48-52页

作者：陈磊何芝仙先进数控和伺服驱动技术安徽省重点实验室安徽芜湖241000 安徽工程大学机械与汽车工程学院安徽芜湖241000

以某W型压缩机的曲轴-滚动轴承系统为研究对象,利用动力学仿真软件ADAMS研究了压缩机从启动直至达到稳定转速这一动态过程的动力学行为。首先根据电动机的机械特性得到曲轴受到的转矩与转速间的关系曲线;再利用hertz公式和超静定问题的... 详细信息

以某W型压缩机的曲轴-滚动轴承系统为研究对象,利用动力学仿真软件ADAMS研究了压缩机从启动直至达到稳定转速这一动态过程的动力学行为。首先根据电动机的机械特性得到曲轴受到的转矩与转速间的关系曲线;再利用hertz公式和超静定问题的解法(力法)推导出滚动轴承受力与变形关系的计算公式并得到数值解;最后分别在ADAMS中建立电动机-刚性曲轴-滚动轴承耦合系统动力学仿真模型和电动机-柔性曲轴-滚动轴承耦合系统动力学仿真模型,分别仿真求解并得到相应的动力学响应。所得到的结论对提高压缩机的动力学性能具有指导意义。

关键词：机械特性超静定问题电动机-曲轴-滚动轴承耦合系统动力学仿真

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滚动轴承支承刚度计算

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机械设计 2016年第9期33卷 46-50页

作者：何芝仙刘喆安徽工程大学力学重点实验室安徽芜湖241000 安徽工程大学机械与汽车工程学院安徽芜湖241000

滚动轴承的支承刚度计算是研究轴-滚动轴承系统动力学的关键问题之一。文中以深沟球轴承为例,采用力法和hertz理论研究滚动轴承的受力与变形关系,在此基础上得到滚动轴承的支承刚度计算公式。着重探讨滚动体位置变化、离心力的作用、轴... 详细信息

滚动轴承的支承刚度计算是研究轴-滚动轴承系统动力学的关键问题之一。文中以深沟球轴承为例,采用力法和hertz理论研究滚动轴承的受力与变形关系,在此基础上得到滚动轴承的支承刚度计算公式。着重探讨滚动体位置变化、离心力的作用、轴承的游隙和预紧、径向力和轴向力作用等因素对滚动轴承支承刚度的影响。计算结果表明:离心力的作用、轴承的游隙和预紧、径向力和轴向力作用对滚动轴承的支承刚度影响较大,滚动体位置变化对滚动轴承的支承刚度影响较小。所得结果为准确计算轴-滚动轴承系统动力学问题提供了前提条件。

关键词：力法超静定问题 hertz理论

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PACS gene family-related neurological diseases: limited genotypes and diverse phenotypes

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World Journal of Pediatrics 2024年第1期20卷 82-91页

作者： Han Zhang Kai Gao Shuang Wang Yue-Hua Zhang zhi-xian Yang Ye Wu Yu-Wu Jiang Department of Pediatrics Peking University First Hospital.No.1 Xi'an Men StreetWest DistrictBeijing 100034China Bejing Key Laboratory of Molecular Diagnosis and Study on Pediatric Genetic Diseases BeijingChina Children Epilepsy Center Peking University First HospitalBeijingChina Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning CommissionPeking UniversityBeijingChina Center of Epilepsy Beijing Institute for Brain DisordersBeijingChina

Background The PACS gene family has been demonstrated to be related to intracellular vesicular *** phenotypic manifestations caused by the pathogenic variants of PACS include epilepsy,intellectual disability/developmental delay,and malformations,such as facial *** We identified seven new cases with pathogenic or likely pathogenic PACS variants using next-generation *** information obtained from these patients was analyzed along with that obtained from previously reported *** With the inclusion of the newly diagnosed cases in this study,103 cases with PACS gene family-related neurological diseases were reported,of which 43 were PACS2-related cases and the remaining were PACSI-related *** patients had seizures,which have been reported to be effectively controlled by several types of anti-seizure medications(ASMs).The most efficacious and frequently prescribed ASMs included sodium valproate(43.3%,13/30),oxcarbazepine/carbamazepine(26.7%,8/30),and levetiracetam(20%,6/30).Almost all patients had intellectual disability/developmental *** most common pathogenic missense variants were PACSI ***203Trp and PACS2 *** addition,we report a patient carrying a likely pathogenic copy number variation(CNV)(de novo heterozygous deletion of chr14:105821380-106107443,286 kilobase,destroyed part of the furin-binding region domain and the protein structure after it)with more severe and refractory late-onset *** The clinical phenotypes of the different PACS heterozygous missense variants were *** pathogenic variant sites of PACSI and PACS2 were quite limited but located in different regions.A CNV destroying part of the PACS2 gene might also be *** findings may provide an important clue for further functional studies on the pathogenic mechanism of neurological disorders related to the PACS gene family.

关键词： Developmental delay Epilepsy Intellectual disability PACSI PACS2

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Cardiomyocyte progenitors in canine pulmonary veins model of persistent atrial fibrillation

Cardiomyocyte progenitors in canine pulmonary veins model of...

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第十三次全国心血管病学术会议

作者： he xian-zhi Department of Cardiology,Longgang District Central Hospital of Shenzhen,Shenzhen 518116,China

Objective This study was aimed to discover the pathogenesis of focal atrial fibrillation(AF) originated from pulmonary *** observing the histological structure and special cells in canine pulmonary veins model of persistent atrial fibrillation. Methods The pulmonary veins and the sinus node were obtained from 20 mongrel dogs(10AF and 10control group) using light microscopy and transmission electron microscopy and the methods of immunohistochemistry on a transver-

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Sensitizing photoactive metal-organic frameworks via chromophore for significantly boosting photosynthesis

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Chinese Chemical Letters 2024年第5期35卷 519-522页

作者： Lihua Ma Song Guo zhi-Ming Zhang Jin-Zhong Wang Tong-Bu Lu xian-Shun Zeng School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China Institute for New Energy Materials and Low Carbon Technologies School of Material Science&EngineeringTianjin University of TechnologyTianjin 300384China

Photosensitization related to energy/electron transfer process is of great importance to natural ***,we proposed a promising strategy to improve the sensitizing ability of the typical photoactive MOFs(UiO-Ir)by engineering its metal coordination center with NBI(1,8-naphthalenebenzimidizole)*** resulting MOFs(UiO-Ir-NBI)exhibited a strong sensitizing ability for significantly boosting ***,the catalytic yield of 2-chloroethyl ethyl sulfoxide with UiO-Ir-NBI can reach 99%,over 6 times higher than that with UiO-Ir(16.4%).Moreover,UiO-Ir-NBI exhibited an excellent catalytic stability and a broad substrate tolerance,highlighting its great application *** investigations revealed that the strong visible light absorption,long excited state lifetime and efficient electron-hole separation of UiO-Ir-NBI greatly contributed to harvesting visible light and facilitating interface electron/energy transfer for efficient solar energy *** work provides a new horizon to boost photosythesis of MOFs by engineering their metal sensitizing centers at a molecular level.

关键词： Metal-organic framework Photocatalysis Excited state Strong visible absorption Iridium complex

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进水碳氮比对脱氮污泥羟胺氧化酶活性及N_2O产生的影响

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中国环境科学 2016年第5期36卷 1417-1425页

作者：魏旖旎何志仙袁林江西安建筑科技大学环境与市政工程学院陕西西安710055

在以A/O方式运行的SBR工艺中,研究了3种不同进水碳氮比下硝化与反硝化过程中污泥羟胺氧化酶(HAO)活性变化、N2O的产生/释放规律及两者之间的关联性.结果表明,当C/N=3.5与C/N=9.5时,HAO平均酶活性分别为(283.77±19.64),(348.87±17.94)U... 详细信息

在以A/O方式运行的SBR工艺中,研究了3种不同进水碳氮比下硝化与反硝化过程中污泥羟胺氧化酶(HAO)活性变化、N2O的产生/释放规律及两者之间的关联性.结果表明,当C/N=3.5与C/N=9.5时,HAO平均酶活性分别为(283.77±19.64),(348.87±17.94)U/g MLSS,而C/N=6.5条件下的平均酶活性仅为(246.45±23.30)U/g MLSS,总体上3个条件下缺氧阶段HAO活性均较好氧阶段高;反应过程中HAO的活性变化趋势基本与气态N_2O释放速率、溶解态N_2O及亚硝氮的浓度变化趋势成正相关,在C/N=9.5下好氧段HAO活性与后三者呈现完全一致的变化规律.N_2O主要产生于好氧阶段进行的硝化过程,尤其是羟胺氧化是N_2O产生的主要环节;碳源相对不充分的条件下(如C/N=3.5),缺氧段N_2O的释放与HAO活性关系密切;碳源相对较充分的条件下,缺氧段N_2O的产生与HAO酶活性无明显关联.推测可能是因为缺乏电子受体NO_2^-而导致HAO酶未参与反应;在N_2O产生较多的条件下,HAO活性相对也较高.

关键词：碳氮比羟胺氧化酶 N2O SBR 硝化反硝化

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Dual-curvilinear beam enabled tunable manipulation of high-and low-refractive-index particles

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Photonics Research 2024年第7期12卷 1427-1436页

作者： ZheNG YUAN CheNCheN ZHANG YUAN GAO WENxianG YAN xian LONG zhi-CheNG REN XI-LIN WANG JIANPING DING HUI-TIAN WANG National Laboratory of Solid State Microstructures and School of Physics Nanjing UniversityNanjing 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China Collaborative Innovation Center of Solid-State Lighting and Energy-Saving Electronics Nanjing 210093China

We present an innovative approach for the simultaneous agile manipulation of high-refractive-index(HRI) and low-refractive-index(LRI) particles. Our method involves introducing a dual-curvilinear optical vortex beam(DC-OVB) generated by superimposing a pair of curved beams: HRI and LRI particles are controlled by the bright curve and the dark channel between the two curves, respectively. The proposed DC-OVB provides customizable motion paths and velocities for both LRI and HRI particles. Each curve of the DC-OVB can support a distinct orbital flow density(OFD), enabling the application of torques to HRI and LRI particles, guiding them to orbit along specified trajectories and prompting them to execute various curvilinear motions simultaneously,including curvilinear movement, revolution, and rotation.

关键词： tunable refractive beam

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Improvement of the nutritional support management system for patients in intensive care units

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World Journal of Psychiatry 2024年第1期14卷 44-52页

作者： Yuan-Yuan Zhang Chun-Yi Wang Dong-xian Guo Hai-Nu Gao xian-Shan Jin Yan-Li Wu Lu-Han Chen zhi-xian Feng Department of Critical Care Medicine Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Information Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Pharmacy Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Nutrition Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Administrative Office Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina

BACKGROUND Nutritional support for patients hospitalized in the intensive care unit(ICU)is an important part of clinical treatment and care,but there are significant implementation *** To introduce a modified nutritional support management system for ICU patients based on closed-loop information management and psychological *** The division of functions,personnel training,system construction,development of an intelligent decision-making software system,quality control,and improvement of the whole process were carried out to systematically manage nutritional support for ICU *** Following the implementation of the whole process management system,the scores of ICU medical staff’s knowledge,attitudes/beliefs,and practices regarding nutritional support were comprehensively *** proportion of hospital bed-days of total enteral nutrition(EN)in ICU patients increased from 5.58%to 11.46%,and the proportion of EN plus parenteral nutrition increased from 42.71%to 47.07%.The rate of EN initiation within 48 h of ICU admission increased from 37.50%to 48.28%,and the EN compliance rate within 72 h elevated from 20.59%to 31.72%.After the implementation of the project,the Self-rating Anxiety Scale score decreased from 61.07±9.91 points to 52.03±9.02 points,the Self-rating Depression Scale score reduced from 62.47±10.50 points to 56.34±9.83 points,and the ICU stay decreased from 5.76±2.77 d to 5.10±2.12 *** The nutritional support management system based on closed-loop information management and psychological counseling achieved remarkable results in clinical applications in ICU patients.

关键词： Closed-loop information Psychological counseling Intensive care unit patients Nutritional support Management system

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