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Antiviral treatment standards for hepatitis B:An urgent need for expansion

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World Journal of Gastroenterology 2024年第4期30卷 418-420页

作者： Zi-Hong Bao zhi-Kun Dai Hao-xian Tang Department of Infectious Diseases The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Medical College Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of Cardiology The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The present letter to the editor is related to the review with the title“Past,present,and future of long-term treatment for hepatitis B virus.”Chronic hepatitis B(CHB)represents an important and pressing public health *** identification and effective antiviral therapy hold the potential to reduce liver-related mortality attributable to chronic infection with hepatitis B virus(HBV)***,the current global treatment rates for CHB remain conspicuously low,with the excessively stringent treatment criteria advocated by national CHB guidelines being a contributing factor to these low ***,recent strides in comprehending this malady and the emergence of novel antiviral agents prompt the imperative re-evaluation of treatment standards to extend the sphere of potential *** impending need arises for a novel paradigm for the classification of patients with CHB,the expansion of antiviral treatment eligibility for HBV-infected individuals,and even the streamlining of the diagnostic process for CHB to amplify cost-effectiveness and augment survival prospects.

关键词： hepatitis B virus Chronic hepatitis B Antiviral treatment criteria Serum alanine aminotransferase Liver-related mortality Letter to the Editor

Predicting dynamic compressive strength of frozen-thawed rocks by characteristic impedance and data-driven methods

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2591-2606页

作者： Shengtao Zhou Zong-xian Zhang Xuedong Luo Yifan Huang zhi Yu Xiaowei Yang Faculty of Engineering China University of GeosciencesWuhan430074China Oulu Mining School University of OuluOulu90570Finland Zijin School of Geology and Mining Fuzhou UniversityFuzhou350116China Department of Earth Science&Engineering Imperial College LondonLondonSW72AZUK

In cold regions,the dynamic compressive strength(DCS)of rock damaged by freeze-thaw weathering significantly influences the stability of rock ***,testing the dynamic strength under freeze-thaw weathering conditions is often both time-consuming and ***,this study considers the effect of characteristic impedance on DCS and aims to quickly determine the DCS of frozen-thawed rocks through the application of machine-learning ***,a database of DCS for frozen-thawed rocks,comprising 216 rock specimens,was *** external load parameters(freeze-thaw cycle number,confining pressure,and impact pressure)and two rock parameters(characteristic impedance and porosity)were selected as input variables,with DCS as the predicted *** research optimized the kernel scale,penalty factor,and insensitive loss coefficient of the support vector regression(SVR)model using five swarm intelligent optimization algorithms,leading to the development of five hybrid *** addition,a statistical DCS prediction equation using multiple linear regression techniques was *** performance of the prediction models was comprehensively evaluated using two error indexes and two trend indexes.A sensitivity analysis based on the cosine amplitude method has also been *** results demonstrate that the proposed hybrid SVR-based models consistently provided accurate DCS *** these models,the SVR model optimized with the chameleon swarm algorithm exhibited the best performance,with metrics indicating its effectiveness,including root mean square error(RMSE)﹦3.9675,mean absolute error(MAE)﹦2.9673,coefficient of determination(R^(2))﹦0.98631,and variance accounted for(VAF)﹦*** suggests that the chameleon swarm algorithm yielded the most optimal results for enhancing SVR ***,impact pressure and characteristic impedance emerged as the two most influential parameters in DCS *** research is

关键词： Freeze-thaw cycle Characteristic impedance Dynamic compressive strength Machine learning Support vector regression

Skyway:Accelerate Graph Applications with a Dual-Path Architecture and Fine-Grained Data Management

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Journal of Computer Science & Technology 2024年第4期39卷 871-894页

作者： Mo Zou Ming-Zhe Zhang Ru-Jia Wang xian-he Sun Xiao-Chun Ye Dong-Rui Fan zhi-Min Tang Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Institute of Information Engineering Chinese Academy of SciencesBeijing 100045China Department of Computer Science Illinois Institute of TechnologyChicagoIL 60616U.S.A.

Graph processing is a vital component of many AI and big data ***,due to its poor locality and complex data access patterns,graph processing is also a known performance killer of AI and big data *** this work,we propose to enhance graph processing applications by leveraging fine-grained memory access patterns with a dual-path architecture on top of existing software-based graph *** first identify that memory accesses to the offset,edge,and state array have distinct locality and impact on *** then introduce the Skyway architecture,which consists of two primary components:1)a dedicated direct data path between the core and memory to transfer state array elements efficiently,and 2)a data-type aware fine-grained memory-side row buffer hardware for both the newly designed direct data path and the regular memory hierarchy data *** proposed Skyway architecture is able to improve the overall performance by reducing the memory access interference and improving data access efficiency with a minimal *** evaluate Skyway on a set of diverse algorithms using large real-world *** a simulated fourcore system,Skyway improves the performance by 23%on average over the best-performing graph-specialized hardware optimizations.

关键词： graph application computer architecture memory hierarchy

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论新民主主义文化的民族性和时代性

中央社会主义学院学报 2006年第2期 70-73页

作者：贺先志西南科技大学四川绵阳621002

把新民主主义社会或新民主主义国家当成一种总体的文化形态来研究,用真正文化学视角把新民主主义的文化定性与文化间关系的讨论转换成文化的民族性和时代性来具体分析,进而结合现代化理论加以拓展和深化,是本文分析毛泽东文化思想的基... 详细信息

把新民主主义社会或新民主主义国家当成一种总体的文化形态来研究,用真正文化学视角把新民主主义的文化定性与文化间关系的讨论转换成文化的民族性和时代性来具体分析,进而结合现代化理论加以拓展和深化,是本文分析毛泽东文化思想的基本概念依据。足见新民主主义文化是基于比较的中西文化观,体现了民族性表象下的时代性实质,具有世俗化时代走向的特征。

关键词：毛泽东新民主主义政治文化

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基于动力学和摩擦学分析的曲轴疲劳强度分析

内燃机学报 2008年第5期26卷 470-475页

作者：何芝仙桂长林李震孙军安徽工程科技学院机械工程系安徽芜湖241000 合肥工业大学机械与汽车学院安徽合肥230009

以某4缸柴油机曲轴为研究对象,根据曲轴的承载特点,提出了基于曲轴—轴承系统动力学和摩擦学分析的曲轴动应力计算方法,即在曲轴有限元分析时通过在曲轴轴颈表面动态施加包含曲轴—轴承系统动力学和摩擦学特性的动态油膜压力计算曲轴动... 详细信息

以某4缸柴油机曲轴为研究对象,根据曲轴的承载特点,提出了基于曲轴—轴承系统动力学和摩擦学分析的曲轴动应力计算方法,即在曲轴有限元分析时通过在曲轴轴颈表面动态施加包含曲轴—轴承系统动力学和摩擦学特性的动态油膜压力计算曲轴动应力,最后把损伤积累理论应用于曲轴疲劳强度计算。计算结果表明:动应力在曲轴轴颈表面的分布主要取决于油膜力对其弯曲和扭转作用以及应力集中效应,动应力随时间的变化与内燃机的发火次序密切相关。与传统方法相比,由损伤积累理论计算的曲轴安全系数下降了5.34%。

关键词：曲轴-轴承系统动态油膜压力动应力损伤积累理论雨流计数法

计入曲轴倾斜时曲轴-轴承系统动力学摩擦学和弹性力学耦合分析

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内燃机工程 2009年第3期30卷 86-92页

作者：何芝仙桂长林李震孙军安徽工程科技学院机械系芜湖241000 合肥工业大学机械与汽车学院合肥230009

采用动力学仿真软件ADAMS和有限元分析软件ANSYS,辅以手工编程相结合的方法,研究了计入曲轴倾斜时某4缸柴油机曲轴-轴承系统动力学、摩擦学和弹性力学(曲轴的刚度和强度)耦合分析问题。根据耦合特点,先解决曲轴-轴承系统动力学、摩擦学... 详细信息

采用动力学仿真软件ADAMS和有限元分析软件ANSYS,辅以手工编程相结合的方法,研究了计入曲轴倾斜时某4缸柴油机曲轴-轴承系统动力学、摩擦学和弹性力学(曲轴的刚度和强度)耦合分析问题。根据耦合特点,先解决曲轴-轴承系统动力学、摩擦学和刚度耦合析问题,再解决曲轴动应力计算问题的解耦方法。研究结果表明:计入曲轴颈倾斜,主轴承最小油膜厚度大幅度下降,最大油膜压力大幅度上升,曲轴动力学响应也发生变化,曲轴疲劳寿命下降23.24%。

关键词：内燃机曲轴-轴承系统动态油膜压力轴倾斜耦合分析损伤积累理论

V型压缩机曲轴-滚动轴承系统动力学分析与优化设计

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机械设计 2012年第11期29卷 31-36页

作者：何芝仙李昂安徽工程大学建筑工程学院安徽芜湖241000 安徽工程大学纺织服装学院安徽芜湖241000

以某V型压缩机的曲轴-滚动轴承系统为研究对象,利用ADAMS动力学仿真软件,研究了额定工况作用下曲轴-滚动轴承系统的动力学行为和动力学优化设计问题。首先应用hertz公式和超静定问题的解法(力法)推导滚动轴承受力与变形关系的计算公式... 详细信息

以某V型压缩机的曲轴-滚动轴承系统为研究对象,利用ADAMS动力学仿真软件,研究了额定工况作用下曲轴-滚动轴承系统的动力学行为和动力学优化设计问题。首先应用hertz公式和超静定问题的解法(力法)推导滚动轴承受力与变形关系的计算公式并得到数值解,再以整个曲轴-滚动轴承系统为研究对象,在ADAMS中建立弹性曲轴-滚动轴承系统动力学仿真模型并求解,得到了额定工况下主轴承反力、曲轴轴颈中心径向振动响应。以此为基础,建立曲轴-滚动轴承系统动力学优化设计数学模型,该模型以两个主轴承曲轴轴颈中心径向振动响应振幅的加权平均值为目标函数,以压缩机气缸中心线夹角为设计变量。最后利用参数化建模技术建立ADAMS优化模型并进行设计研究,得到了设计变量与目标函数之间的关系和最优解。所得到的结论对压缩机动态设计有指导意义。

关键词：超静定问题曲轴-滚动轴承系统动力学仿真多目标优化隐函数

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基于损耗率和需求不确定情况下的订购批量

模糊系统与数学 2006年第5期20卷 151-157页

作者：徐鑫何先枝安徽大学数学与计算科学学院安徽合肥230039 合肥工业大学理学院数学系安徽合肥230009

库存管理模型在现实生活中有着广泛的运用。然而,在实际生活中,由于种种不确定性原因的影响,使得经典的确定型的EOQ模型的运用越来越不符合现实的需要;本文将需求和损耗率看成模糊数的同时,将物品的销售价格分成两部分来进行处理,即:没... 详细信息

库存管理模型在现实生活中有着广泛的运用。然而,在实际生活中,由于种种不确定性原因的影响,使得经典的确定型的EOQ模型的运用越来越不符合现实的需要;本文将需求和损耗率看成模糊数的同时,将物品的销售价格分成两部分来进行处理,即:没有损耗的产品以一种较高价格出售,对于有部分损耗的产品则按较低的价格出售;采用概率论置信区间估计的方法构建模糊变量的波动区间,构建使得总的利润达到最大的模糊库存模型,并利用三角模糊数、符号距离的方法以及最优化理论进行处理,得出满足条件的最优订购批量。最后,给出了模型分析和算例分析;通过分析,我们发现模糊库存模型的优点在于它自生所具有的不确定性;从数据上看,模糊库存模型比经典的库存模型更能反映出实际情况。

关键词：三角模糊数符号距离法模糊损耗率需求订购批量

A topology approach to overcome the pore size/volume trade-offs for autonomous indoor humidity control

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Science China Chemistry 2024年第9期67卷 2968-2974页

作者： zhi-Shuo Wang Xue-Wen Zhang Kai Zheng Xiao-xian Chen Dong-Dong Zhou Jie-Peng Zhang MOE Key Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular EngineeringSchool of ChemistryIGCMESun Yat-Sen UniversityGuangzhou 510275China Chemistry and Chemical Engineering Guangdong Laboratory Shantou 515021China

Autonomous indoor humidity control is gaining more and more attention but is limited by the trade-offs among pore volume,pore size and water stability of water *** solve this problem by using a unique coordination network topology combined with hydrolytically stable M(Ⅲ)carboxylate *** extending the ligand length from 9.0 to 11.2 and 13.7?,the pore volume significantly increases from 0.99 to 1.40 and 1.78 cm^(3)g^(-1),which proportionally increases the saturated water adsorption ***,the pore size slightly increases from 10.4 to 11.0 and 13.5A,which restricts the isotherm inflection pressure and hysteresis width to meet the requirement of indoor humidity *** single-crystals suitable for Xray diffraction studies were obtained by using Fe(Ⅲ)salts,while isostructural frameworks with sufficiently high water stabilities were synthesized by using Cr(Ⅲ)salts,which offer record working capacity of 0.90 and 1.10 g g^(-1)for indoor humidity control.

关键词： metal-organic frameworks water adsorption indoor humidity control water stability pore engineering