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Mechanisms of Dangua Fang(丹瓜方)in multi-target and multi-method regulation of glycolipid metabolism based on phosphoproteomics

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Journal of Traditional Chinese Medicine 2024年第2期44卷 334-344页

作者： heNG Xianpei WANG Zhita LI Liang YANG Liuqing HUANG Suping JIN Lang he weidong Department of Endocrinology People's Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhou 350004China Academy of Integrative Medicine Fujian University of Traditional Chinese MedicineFuzhou 350122China Faculty of Humanities and Management Fujian University of Traditional Chinese MedicineFuzhou 350122China Department of Geriatrics People's Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhou 350004China

OBJECTIVE:To explore the mechanism of Dangua Fang(丹瓜方,DGR)in multi-target and multi-method regulation of glycolipid metabolism based on phosphoproteomics.METHODS:Sprague-Dawley rats with normal glucose levels were randomly divided into three groups,including a conventional diet control group(Group A),high-fat-highsugar diet model group(Group B),and DGR group(Group C,high-fat-high-sugar diet containing 20.5 g DGR).After 10 weeks of intervention,the fasting blood glucose(FBG),2 h blood glucose[PBG;using the oral glucose tolerance test(OGTT)],hemoglobin A1c(HbA1c),plasma total cholesterol(TC),and triglycerides(TG)were tested,and the livers of rats were removed to calculate the liver index.Then,hepatic portal TG were tested using the Gross permanent optimization-participatiory action planning enzymatic method and phosphoproteomics was performed using liquid chromatography with tandem mass spectrometry(LC-MS/MS)analysis followed by database search and bioinformatics analysis.Finally,cell experiments were used to verify the results of phosphoproteomics.Phosphorylated mitogen-activated protein kinase kinase kinase kinase 4(MAP4k4)and phosphorylated adducin 1(ADD1)were detected using western blotting.RESULTS:DGR effectively reduced PBG,TG,and the liver index(Phepatic portal TG(Phematoxylin and eosin(he)staining,red oil O staining,and Masson staining of liver tissue.The total spectrum was 805334,matched spectrum was 260471,accounting for accounting 32.3%,peptides were 19995,modified peptides were 14671,identified proteins were 4601,quantifiable proteins were 4417,identified sites were 15749,and quantified sites were 14659.Based on the threshold of expression fold change(>1.2),DGR upregulated the modification of 228 phosphorylation sites involving 204 corresponding function proteins,and downregulated the modification of 358 phosphorylation sites involving 358 corresponding function proteins,which included correcting 75 phosphorylation sites involving

关键词： phosphoproteomics glycolipid metabolism therapeutic mechanism compound formula Dangua Fang

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Modification strategies for non-aqueous, highly proton-conductive benzimidazole-based high-temperature proton exchange membranes

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Chinese Chemical Letters 2024年第4期35卷 43-51页

作者： Yunfa Dong Shijie Zhong Yuhui he Zhezhi Liu Shengyu Zhou Qun Li Yashuai Pang Haodong Xie Yuanpeng Ji Yuanpeng Liu Jiecai Han weidong he National Key Laboratory of Science and Technology on Advanced Composites in Special Environments and Center for Composite Materials and StructuresHarbin Institute of TechnologyHarbin 150080China School of Petroleum Engineering Chongqing University of Science and TechnologyChongqing 401331China School of Physics University of Electronic Science and Technology of ChinaChengdu 610054China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China Chongqing Research Institute Harbin Institute of TechnologyChongqing 401151China School of Mechanical Engineering Chengdu UniversityChengdu 610106China

High-temperature proton exchange membranes(HT-PEMs) possess excellent thermal and outstanding electrochemical stability, providing an avenue to realize high-temperature proton exchange membranes fuel cells(HT-PEMFCs) with both superior power density and long-term durability. Unfortunately, polybenzimidazole(PBI), a typical material for conventional HT-PEMs, fails to compromise the high nonaqueous proton conductivity and high mechanical properties, thus hindering their practical applications.Achieving efficient nonaqueous proton conduction is crucial for HT-PEMFC, and many insightful research works have been done in this area. However, there still lacks a report that integrates the host-guest interactions of phosphoric acid doping and the structural stability of polymers to systematically illustrate modification strategies. here, we summarize recent advancements in enhancing the nonaqueous proton conduction of HT-PEMs. Various polymer structure modification strategies, including main chain and side group modification, cross-linking, blocking, and branching, are reviewed. Composite approaches of polymer, including compounding with organic porous polymers, filling the inorganic components and modifying with ionic liquids, etc., are also covered in this work. These strategies endow the HT-PEMs with more free volume, nanophase-separated structure, and multi-stage proton transfer channels, which can facilitate the proton transportation and improve their performance. Finally, current challenges and future directions for further enhancements are also outlined.

关键词： Benzimidazole Nonaqueous proton conduction Free volume Nanophase-separated structure Structure modification

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An anti-image interference quadrature IF architecture for satellite receivers

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Chinese Journal of Aeronautics 2014年第4期27卷 955-963页

作者： he weidong Lu Xiaochun he Chengyan James Torley National Time Service Center Chinese Academy of Science Key Laboratory of Precision Navigation and Timing Technology Academy of Sciences of China University of Colorado Denver

Since Global Navigation Satellite System（GNSS） signals span a wide range of frequency, wireless signals coming from other communication systems may be aliased and appear as image interference. In quadrature intermediate frequency（IF） receivers, image aliasing due to in-phase and quadrature（I/Q） channel mismatches is always a big problem. I/Q mismatches occur because of gain and phase imbalances between quadrature mixers and capacitor mismatches in analog-to-digital converters（ADC）. As a result, the dynamic range and performance of a receiver are severely degraded. In this paper, several popular receiver architectures are summarized and the image aliasing problem is investigated in detail. Based on this analysis, a low-IF architecture is proposed for a single-chip solution and a novel and feasible anti-image algorithm is investigated. With this anti-image digital processing, the image reject ratio（IRR） can reach approximately above50 dB, which relaxes image rejection specific in front-end circuit designs and allows cheap and highly flexible analog front-end solutions. Simulation and experimental data show that the antiimage algorithm can work effectively, robustly, and steadily.

关键词： Complex LMS Image reject Interferences I/Q mismatches Receiver architecture

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Dynamic Logic in Control

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Journal of Systems Engineering and Electronics 1994年第3期5卷 20-31页

作者： he, weidong Yu, Xinyao Chen, Zhongji Zhang, Minglian Beijing Univ of Aeronautics & Astronautics Beijing China

For the dynamic property in the control system, in this paper we advance dynamic logic to analyze and synthesize the control problems. This approach is similar to the way in which people always resolve such problems, and it can reflect the nature of the system. The dynamic logic combines the people's logic analysis with the dynamic property of the control system. On the basis of the dynamic logic qualitative model, the analyzing process and synthesizing process may go on. So there are many of the non-linear and logic factors which can be directly taken into consideration in the analyzing and designing process. The combination of the human intelligence and artificial intelligent techniques with the conventional methods of analysis and design, has provide an effective tool for the qualitative analysis and the qualitative design of the intelligent control system. We have successfully resolved the stabilizing problem of the inverted pendulum with dynamic logic.

关键词： Artificial intelligence Control system analysis Control system synthesis Intelligent control Mathematical models System stability

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基于几何接触算法的摆线针轮传动误差分析

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机械传动 2024年第3期48卷 10-17页

作者：黄岳磊张迎辉何卫东大连交通大学机械工程学院辽宁大连116028

在摆线针轮传动的轮齿接触分析(ToothContactAnalysis,TCA)模型中,通常将误差值设为一个定值,易造成计算结果不合理,且计算过程中常出现计算不收敛等问题。对此,建立了包含修形、加工误差等多因素综合作用下的摆线针轮传动误差分析模型... 详细信息

在摆线针轮传动的轮齿接触分析(ToothContactAnalysis,TCA)模型中,通常将误差值设为一个定值,易造成计算结果不合理,且计算过程中常出现计算不收敛等问题。对此,建立了包含修形、加工误差等多因素综合作用下的摆线针轮传动误差分析模型;在对啮合点矢量方程分析后,提出了一种解决数值不收敛等问题的方法,即在求得的摆线轮和针齿上纵横坐标相等的点中,找到法向量相等的啮合点。对回转体误差形式分析后,提出了一种解决计算结果不合理的方法,即令摆线轮周节误差、摆线轮齿廓径向跳动误差和针齿中心圆半径误差在公差带内呈周期性变化。以RV-80E减速器为试验对象,对比试验结果,验证了理论模型的正确性;研究各误差对传动误差的影响,开展了各误差灵敏度分析。结果表明,针齿半径误差和针齿与针齿壳间隙综合作用下的法向间隙是影响传动误差的主要因素。

关键词：轮齿接触分析几何接触法向间隙灵敏度

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机器人用精密行星摆线减速器主轴承预紧量对倾覆刚度影响研究

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机械传动 2024年第6期48卷 1-6页

作者：崔佳隽张迎辉何卫东大连交通大学机械工程学院辽宁大连116028

为掌握机器人用精密行星摆线减速器主轴承的受力状态,结合减速器的结构特点,建立了同时考虑外部负载与摆线齿轮啮合力的静力学模型,对额定工况下110E型减速器主轴承受力和内部接触状态进行分析,得到符合实际的受力结果;在此基础上,针对... 详细信息

为掌握机器人用精密行星摆线减速器主轴承的受力状态,结合减速器的结构特点,建立了同时考虑外部负载与摆线齿轮啮合力的静力学模型,对额定工况下110E型减速器主轴承受力和内部接触状态进行分析,得到符合实际的受力结果;在此基础上,针对精密减速器的高倾覆刚度要求,基于Romax Designer仿真分析软件建立减速器等效模型,分析了主轴承预紧量对倾覆刚度的影响规律。结果表明,主轴承的倾覆刚度随预紧量的增大而增大,同时满足倾覆刚度和疲劳寿命要求的最佳预紧量范围为5~20μm。研究结果对主轴承安装预紧量的选择具有一定的参考意义。

关键词：机器人用精密行星摆线减速器主轴承倾覆刚度预紧量

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住房公积金降费的稳就业效果及其解释

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管理世界 2024年第4期40卷 47-59,120页

作者：万海远朱志凯张尉贺伟东北京师范大学经济与工商管理学院

就业是最基本的民生,是经济发展的重要支撑。本文研究住房公积金改革的企业雇佣反应,分析公积金降费的稳就业作用,并逆向讨论公积金的制度属性问题。结果发现,下调公积金最低缴存比例会降低企业公积金支出,激励企业扩大雇佣需求,并达到... 详细信息

就业是最基本的民生,是经济发展的重要支撑。本文研究住房公积金改革的企业雇佣反应,分析公积金降费的稳就业作用,并逆向讨论公积金的制度属性问题。结果发现,下调公积金最低缴存比例会降低企业公积金支出,激励企业扩大雇佣需求,并达到稳定就业的效果。本文利用企业家主观调查数据发现,公积金降费让企业享受到实际优惠,这会提振企业发展预期,尤其是民营企业的预期改善效果更加明显,故带来更大的就业促进作用,体现民营企业将公积金作为成本而不是福利的可能性更大。劳动密集型与现金流缺乏的企业对缴存比例变动更加敏感,故公积金降费政策的企业预期改善和就业促进作用也更大。

关键词：公积金降费法定最低缴存比例预期改善稳就业制度属性

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“健商”理念融入高校体育教学改革研究

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冰雪体育创新研究 2024年第6期 149-151页

作者：翟洪军何卫东广西外国语学院体育教学部广西南宁530222 广西民族大学体育与健康科学学院广西南宁530006

高校教育正面临创新人才培养、提高教学质量、促进全面人才发展以及适应社会需求的时代挑战。在这一背景下,体育教育引人“健商”理念,成为改革的新亮点。研究表明,坚持以人为本、全面推动终身体育,树立“健康第一”的理念,能促进学生... 详细信息

高校教育正面临创新人才培养、提高教学质量、促进全面人才发展以及适应社会需求的时代挑战。在这一背景下,体育教育引人“健商”理念,成为改革的新亮点。研究表明,坚持以人为本、全面推动终身体育,树立“健康第一”的理念,能促进学生身心健康的全面发展。在这一基础上,研究建议充分利用现代信息技术和信息环境支持的新型教学模式,将“健商”理念融入高校公共体育教学中,以提高学生对“健商”理念的理解和能力的提高。通过这样的教学方式,更好地调动学生的学习积极性,培养学生对学习的浓厚兴趣,不仅有助于开创高校体育教育的新局面,还有助于实现体育健康教育的深刻改革要求。

关键词： “健商”理念高校体育教学改革

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何卫东主任论治老年糖尿病便秘临床经验

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福建中医药 2024年第2期55卷 43-45页

作者：曾钰惠何卫东(指导) 福建中医药大学附属人民医院福建福州350004

何卫东主任认为老年糖尿病便秘患者病机为气阴两虚兼瘀血,以气虚津亏为发病之本,肠道燥枯为发病之标,腑气不通为发病之理,瘀血内阻为发病之要,治疗上运用“益气、滋阴、理气、化瘀”四法辨治,方以黄芪汤合增液汤为基本方,加减化裁,灵活... 详细信息

何卫东主任认为老年糖尿病便秘患者病机为气阴两虚兼瘀血,以气虚津亏为发病之本,肠道燥枯为发病之标,腑气不通为发病之理,瘀血内阻为发病之要,治疗上运用“益气、滋阴、理气、化瘀”四法辨治,方以黄芪汤合增液汤为基本方,加减化裁,灵活运用,获得满意疗效。

关键词：便秘糖尿病老年学术经验何卫东

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Self-supported metal(Fe, Co, Ni)-embedded nitrogen-doping carbon nanorod framework as trifunctional electrode for flexible Zn-air batteries and switchable water electrolysis

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Green Energy & Environment 2023年第6期8卷 1644-1653页

作者： Qiuyan Jin Liping Xiao weidong he Hao Cui Chengxin Wang State Key Laboratory of Optoelectronic Materials and Technologies School of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou510275China The Key Laboratory of Low-Carbon Chemistry&Energy Conservation of Guangdong Province Sun Yat-sen UniversityGuangzhou510275China

To meet the practical demand of wearable/portable electronics, developing high-efficiency and durable multifunctional catalyst and in-situ assembling catalysts into electrodes with flexible features are urgently needed but challenging. herein, we report a simple route to fabricate bendable multifunctional electrodes by in-situ carbonization of metal ion absorbed polyaniline precursor. Alloy nanoparticles encapsulated in graphite layer are uniformly distributed in the N-doping carbon nanorod skeleton. Profiting from the favorable free-standing structure and the cooperative effect of metallic nanoparticles, graphitic layer and N doped-carbon architecture, the trifunctional electrodes exhibit prominent activities and stability toward heR, OER and ORR. Notably, due to the protection of carbon layer, the electrocatalysts show the reversible catalytic heR/OER properties. The overall water splitting device can continuously work for 12 h under frequent exchanges of cathode and anode. Importantly, the bendable metal air batteries fabricated by self-supported electrode not only displays the outstanding battery performance,achieving a decent peak power density(125 mW cm^(-2)) and exhibiting favorable charge-discharge durability of 22 h, but also holds superb flexible stability. Specially, a lightweight self-driven water splitting unit is demonstrated with stable hydrogen production.

关键词： Trifunctional catalysts Self-supported electrodes Switchable water splitting Flexible Zn-air battery Self-powered system

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