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Operational optimization of copper flotation process based on the weighted Gaussian process regression and index-oriented adaptive differential evolution algorithm

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Chinese Journal of Chemical Engineering 2024年第2期66卷 167-179页

作者： Zhiqiang Wang Dakuo he Haotian Nie College of Information Science and Engineering Northeastern UniversityShenyang 110004China State Key Laboratory of Synthetical Automation for Process Industries Northeastern UniversityShenyang 110004China

Concentrate copper grade(CCG)is one of the important production indicators of copper flotation processes,and keeping the CCG at the set value is of great significance to the economic benefit of copper flotation industrial *** paper addresses the fluctuation problem of CCG through an operational optimization ***,a density-based affinity propagationalgorithm is proposed so that more ideal working condition categories can be obtained for the complex raw ore ***,a Bayesian network(BN)is applied to explore the relationship between the operational variables and the *** on the analysis results of BN,a weighted Gaussian process regression model is constructed to predict the CCG that a higher prediction accuracy can be *** ensure the predicted CCG is close to the set value with a smaller magnitude of the operation adjustments and a smaller uncertainty of the prediction results,an index-oriented adaptive differential evolution(IOADE)algorithm is proposed,and the convergence performance of IOADE is superior to the traditional differential evolution and adaptive differential evolution ***,the effectiveness and feasibility of the proposed methods are verified by the experiments on a copper flotation industrial process.

关键词： Weighted Gaussian process regression Index-oriented adaptive differential evolution Operational optimization Copper flotation process

Experimental study on reactions between alkaline basaltic melt and orthopyroxenes: constraints on the evolution of lithospheric mantle in the North China Craton

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Acta Geochimica 2024年第2期43卷 354-365页

作者： Hanqi he Mingliang Wang Hongfeng Tang Key Laboratory for High Temperature and High Pressure Study of the Earth’s Interior Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China School of Resource and Civil Engineering Suzhou UniversitySuzhou 234000AnhuiChina

The experimental results of the reactions between an alkaline basaltic melt and mantle orthopyroxenes under high-temperature and high-pressure conditions of 1300–1400℃ and 2.0–3.0 GPa using a six-anvil apparatus are reported in this *** reactions are proposed to simulate the interactions between melts from the asthenospheric mantle and the lithospheric *** starting melt in the experiments was made from the alkaline basalt occurring in Fuxin,Liaoning Province,and the orthopyroxenes were separated from the mantle xenoliths in Damaping,hebei *** results show that clinopyroxenes were formed in all the reactions between the alkaline basaltic melt and orthopyroxenes under the studied P–T *** formation of clinopyroxene in the reaction zone is mainly controlled by dissolution–crystallization,and the chemical compositions of the reacted melt are primarily infl uenced by the diff usion eff *** is the most important parameter controlling the reactions between the melt and orthopyroxenes,which has a direct impact on the melting of orthopyroxenes and the diff usion of chemical components in the *** also directly controls the chemical compositions of the newly formed clinopyroxenes in the reaction zone and the reacted *** formation of clinopyroxenes from the reactions between the alkaline basaltic melt and orthopyroxenes can result in an increase of CaO and Al_(2)O_(3) contents in the rocks containing this ***,the reactions between the alkaline basaltic melt from the asthenospheric mantle and orthopyroxenes from the lithospheric mantle can lead to the evolution of lithospheric mantle in the North China Craton from refractory to fertile with relatively high CaO and Al 2 O 3 *** addition,the reacted melts in some runs were transformed from the starting alkaline basaltic into tholeiitic after reactions,indicating that tholeiitic magma could be generated from alkaline basaltic one via reactions betwe

关键词： Alkaline basaltic melt Orthopyroxene Melt–mineral reaction High-temperature and high-pressure experiment Genesis of basalt Evolution of lithospheric mantle in the North China Craton

From traditional Chinese medicine formulations to effective anticancer agents:Insights from Calculus bovis

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World Journal of Gastroenterology 2024年第35期30卷 4011-4013页

作者： he-Tong Zhao Department of Traditional Chinese Medicine Navy No.905 HospitalShanghai 200050China

This editorial examines the therapeutic potential of traditional Chinese medicine(TCM)for aggressive cancers,particularly liver *** highlights the study by Huang et al,which shows how Calculus bovis,a component of the TCM Pien Tze Huang,suppresses liver cancer by inhibiting M2 macrophage polarization via the Wnt/β-catenin *** research emphasizes the importance of transitioning from effective TCM formulations to isolating active components and understanding their *** the study provides valuable insights,it primarily focuses on the Wnt/β-catenin pathway and does not delve deeply into the mechanisms of individual *** research should aim to comprehensively study these components,explore their interactions,and validate findings through clinical *** approach will integrate traditional wisdom with modern scientific validation,advancing the development of innovative cancer treatments based on TCM formulations.

关键词： Calculus bovis Traditional Chinese medicine Liver cancer Tumor microenvironment M2 tumor-associated macrophages Wnt/β-catenin pathway

Stability behavior of the Lanxi ancient flood control levee after reinforcement with upside-down hanging wells and grouting curtain

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Journal of Mountain Science 2024年第1期21卷 84-99页

作者： QIN Zipeng TIAN Yan GAO Siyuan ZHOU Jianfen he Xiaohui he Weizhong GAO Jingquan School of Water Conservancy and Environment Engineering Zhejiang University of Water Resources and Electric PowerHangzhou 310018China Department of Civil Engineering Imperial College LondonLondonSW71BFEngland Lanxi Water Affairs Bureau Lanxi 321102China Zhejiang Water Conservancy Engineering Consulting Co. LtdHangzhou 310051China

The stability of the ancient flood control levees is mainly influenced by water level fluctuations, groundwater concentration and rainfalls. This paper takes the Lanxi ancient levee as a research object to study the evolution laws of its seepage, displacement and stability before and after reinforcement with the upside-down hanging wells and grouting curtain through numerical simulation methods combined with experiments and observations. The study results indicate that the filled soil is less affected by water level fluctuations and groundwater concentration after reinforcement. A high groundwater level is detrimental to the levee's long-term stability, and the drainage issues need to be fully considered. The deformation of the reinforced levee is effectively controlled since the fill deformation is mainly borne by the upside-down hanging wells. The safety factors of the levee before reinforcement vary significantly with the water level. The minimum value of the safety factors is 0.886 during the water level decreasing period, indicating a very high risk of the instability. While it reached 1.478 after reinforcement, the stability of the ancient levee is improved by a large margin.

关键词： Stability analysis Multiple factors Antiseepage reinforcement Upside-down hanging well Grouting curtain Ancient levee

Characterization of a Novel Esterase Belonging to Family V from Marinobacter flavimaris

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Journal of Ocean University of China 2024年第1期23卷 221-232页

作者： he Jingjing ZHANG Yunhui WU Leilei WANG Yaru ZHANG he LIU Zhengang SHI Xiaochong Frontiers Science Center for Deep Ocean Multispheres and Earth System and College of Marine Life SciencesOcean University of ChinaQingdao 266003China Laboratory for Marine Ecology and Environmental Science Laoshan LaboratoryQingdao 266237China Institute of Evolution&Marine Biodiversity Ocean University of ChinaQingdao 266003China

Lipolytic enzymes have attracted enormous attentions because of their ability in ester hydrolysis,ester synthesis,transesterification and other biochemical *** are important sources of lipolytic enzymes applied in ***,a novel lipolytic enzyme encoded by esterase gene est1347 was identified in Marinobacter flavimaris WLL162,and was purified and *** lipolytic enzyme Est1347 consisted of 312 amino acid residues and a 21-amino-acids N-terminal signal peptide with a predicted molecular weight of 34.2 *** belongs to family V of bacterial lipolytic enzymes based on the amino acid sequence homology ***1347 is a mesophilic and alkali-resistant enzyme with the highest activity at 45℃and pH 8.5;it is stable at temperatures below 50℃and pH 7.5–***1347 showed a preference for middle-length chain substrate p-NPC10 and a wide range of other *** Km,Vmax,Kcat and Kcat/Km values of Est1347 for p-NPC10 in pH 8.5 at 45℃were 0.9411 mmol L^(−1),1285μmol min^(−1)mg^(−1),698.91 s^(−1)and 743.65 s^(−1)(mmol L^(−1))^(−1),*** is also tolerant to the metal ions,organic solvents and *** conclusion,the esterase Est1347 laid a foundation for further study of bacterial lipolytic enzyme family V.

关键词： esterase Marinobacter flavimaris enzymatic properties lipolytic enzyme family V

A Fractional-Order Ultra-Local Model-Based Adaptive Neural Network Sliding Mode Control of n-DOF Upper-Limb Exoskeleton With Input Deadzone

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 760-781页

作者： Dingxin he HaoPing Wang Yang Tian Yida Guo the School of Automation Nanjing University of Science and TechnologyNanjing 210094China IEEE Norinco Group Institute of Navigation and Control Technology Beijing 100089China

This paper proposes an adaptive neural network sliding mode control based on fractional-order ultra-local model for n-DOF upper-limb exoskeleton in presence of uncertainties,external disturbances and input *** the model complexity and input deadzone,a fractional-order ultra-local model is proposed to formulate the original dynamic system for simple controller ***,the control gain of ultra-local model is considered as a *** fractional-order sliding mode technique is designed to stabilize the closed-loop system,while fractional-order time-delay estimation is combined with neural network to estimate the lumped ***,a fractional-order ultra-local model-based neural network sliding mode controller(FO-NNSMC) is ***,to avoid disadvantageous effect of improper gain selection on the control performance,the control gain of ultra-local model is considered as an unknown ***,the Nussbaum technique is introduced into the FO-NNSMC to deal with the stability problem with unknown ***,a fractional-order ultra-local model-based adaptive neural network sliding mode controller(FO-ANNSMC) is ***,the stability analysis of the closed-loop system with the proposed method is presented by using the Lyapunov ***,with the co-simulations on virtual prototype of 7-DOF iReHave upper-limb exoskeleton and experiments on 2-DOF upper-limb exoskeleton,the obtained compared results illustrate the effectiveness and superiority of the proposed method.

关键词： Adaptive control input deadzone model-free control n-DOF upper-limb exoskeleton neural network

Ballistic performances of the hourglass lattice sandwich structures under high-velocity fragments

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Defence Technology（防务技术） 2024年第1期31卷 312-325页

作者： he-xiang Wu Jia Qu Lin-zhi Wu Key Laboratory of Advanced Ship Materials and Mechanics College of Aerospace and Civil EngineeringHarbin Engineering UniversityHarbin150001China School of Civil Engineering Northeast Forestry UniversityHarbin150040China

In this paper,the numerical simulation method is used to study the ballistic performances of hourglass lattice sandwich structures with the same mass under the vertical incidence of *** is paid to elucidating the influences of rod cross-section dimensions,structure height,structure layer,and rod inclination angle on the deformation mode,ballistic performances,and ability to change the ballistic direction of *** results show that the ballistic performances of hourglass lattice sandwich structures are mainly affected by their structural *** this respect,structural parameters optimization of the hourglass lattice sandwich structures enable one to effectively improve their ballistic limit velocity and,consequently,ballistic performances.

关键词： Hourglass lattice sandwich structures Ballistic performances high-velocity Finite element analysis

Investigation on the Velocity-Dependent Adhesion Hysteresis via Molecular Dynamics Simulation

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Acta Mechanica Solida Sinica 2024年第3期37卷 423-429页

作者： Jinshan he Yiran Li Zhaoyang Ma Ganyun Huang Department of Mechanics School of Mechanical EngineeringTianjin UniversityTianjin300350China

Adhesion plays an important role in miniaturized devices and technologies,which depends not only on indentation depth but also on the history of contact making and breaking,giving rise to adhesion *** the present work,adhesion hysteresis has been investigated via molecular dynamics simulations on approaching and retracting a rigid tip to and from a *** results show that hysteresis in the force-displacement curve that depends on approaching and retraction velocities arises under both elastic and plastic *** underlying mechanisms have been *** implications of the results in friction have been discussed briefly.

关键词： Adhesion hysteresis Molecular dynamics simulation Contact instability Plastic deformation

TGF-βsignaling in health,disease,and therapeutics

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1466-1505页

作者： Ziqin Deng Tao Fan Chu Xiao he Tian Yujia Zheng Chunxiang Li Jie he Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

ransforming growth factor(TGF)-βis a multifunctional cytokine expressed by almost every tissue and cell *** signal transduction of TGF-βcan stimulate diverse cellular responses and is particularly critical to embryonic development,wound healing,tissue homeostasis,and immune homeostasis in *** dysfunction of TGF-βcan play key roles in many diseases,and numerous targeted therapies have been developed to rectify its pathogenic *** the past decades,a large number of studies on TGF-βsignaling have been carried out,covering a broad spectrum of topics in health,disease,and ***,a comprehensive overview of TGF-βsignaling is required for a general picture of the studies in this *** this review,we retrace the research history of TGF-βand introduce the molecular mechanisms regarding its biosynthesis,activation,and signal *** also provide deep insights into the functions of TGF-βsignaling in physiological conditions as well as in pathological ***-β-targeting therapies which have brought fresh hope to the treatment of relevant diseases are *** the summary of previous knowledge and recent updates,this review aims to provide a systematic understanding of TGF-βsignaling and to attract more attention and interest to this research area.

关键词： homeostasis healing wound