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EjGASA6 promotes flowering and root elongation by enhancing gibberellin biosynthesis

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Journal of Integrative Agriculture 2024年第5期23卷 1568-1579页

作者： Qian Chen Shunyuan Yong Fan Xu Hao Fu Jiangbo Dang qiao he Danlong Jing Di Wu Guolu Liang Qigao Guo Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education)/College of Horticulture and Landscape Architecture Southwest UniversityChongqing 400715China State Cultivation Base of Crop Stress Biology for Southern Mountainous Land of Southwest University/Academy of Agricultural Sciences of Southwest University Chongqing 400715China College of Agronomy and Biotechnology Southwest UniversityChongqing 400715China

The Gibberellic Acid-stimulated Arabidopsis(GASA)gene family is involved in the regulation of gene expression and plant growth,development,and stress responses.To investigate the function of loquat GASA genes in the growth and developmental regulation of plants,a loquat EjGASA6 gene homologous to Arabidopsis AtGASA6 was cloned.EjGASA6 expression was induced by gibberellin,and ectopic transgenic plants containing this gene exhibited earlier bloom and longer primary roots since these phenotypic characteristics are related to higher gibberellin content.Transcriptome analysis and qRT-PCR results showed that the expression levels of GA3ox1 and GA20ox1,which encode key enzymes in gibberellin biosynthesis,were significantly increased.Furthermore,we confirmed that EjGASA6 could promote the expression of GA20ox1 via the luciferase reporter system.Overall,our results suggest that EjGASA6 promotes blooming and main-root elongation by positively regulating gibberellin biosynthesis.These findings broaden our understanding of the role of GASAs in plant development and growth,and lay the groundwork for future research into the functions of EjGASA6 in regulating loquat growth and development.

关键词： loquat EjGASA6 gibberellin synthesis biological function

Effects of Tanreqing Injection on ICU Mortality among ICU Patients Receiving Mechanical Ventilation: Time-Dependent Cox Regression Analysis of A Large Registry

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Chinese Journal of Integrative Medicine 2023年第9期29卷 782-790页

作者： WANG Wen he qiao WANG Ming-qi XU Jia-yue JI Peng ZHANG Rui ZOU Kang SUN Xin Chinese Evidence-Based Medicine Center West China HospitalSichuan UniversityChengdu610041China NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan Chengdu610041China Sichuan Center of Technology Innovation for Real World Data Chengdu610041China Intensive Care Unit West China HospitalSichuan UniversityChengdu610041China Information Center West China HospitalSichuan UniversityChengdu610041China

Objective To assess whether the use of Tanreqing(TRQ)Injection could show improvements in time to extubation,intensive care unit(ICU)mortality,ventilator-associated events(VAEs)and infection-related ventilator associated complication(IVAC)among patients receiving mechanical ventilation(MV).Methods A time-dependent cox-regression analysis was conducted using data from a well-established registry of healthcare-associated infections at ICUs in China.Patients receiving continuous MV for 3 days or more were included.A time-varying exposure definition was used for TRQ Injection,which were recorded on daily basis.The outcomes included time to extubation,ICU mortality,VAEs and IVAC.Time-dependent Cox models were used to compare the clinical outcomes between TRQ Injection and non-use,after controlling for the influence of comorbidities/conditions and other medications with both fixed and time-varying covariates.For the analyses of time to extubation and ICU mortality,Fine-Gray competing risk models were also used to measure competing risks and outcomes of interest.Results Overall,7,685 patients were included for the analyses of MV duration,and 7,273 patients for the analysis of ICU mortality.Compared to non-use,patients with TRQ Injection had a lower risk of ICU mortality(Hazards ratios(HR)0.761,95%CI,0.581–0.997),and was associated with a higher hazard for time to extubation(HR 1.105,95%CI,1.005–1.216),suggesting a beneficial effect on shortened time to extubation.No significant differences were observed between TRQ Injection and non-use regarding VAEs(HR 1.057,95%CI,0.912–1.225)and IVAC(HR 1.177,95%CI,0.929–1.491).The effect estimates were robust when using alternative statistic models,applying alternative inclusion and exclusion criteria,and handling missing data by alternative approaches.Conclusion Our findings suggested that the use of TRQ Injection might lower mortality and improve time to extubation among patients receiving MV,even after controlling for the factor that the use of TRQ changed over time.

关键词： Tanreqing critical care mechanical ventilation mortality ventilator-associated events

Synthesis and evaluation of bio-based elastomer based on diethyl itaconate for oil-resistance applications

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Science China Chemistry 2016年第11期59卷 1376-1383页

作者： Weiwei Lei he qiao Xinxin Zhou Wencai Wang Liqun Zhang Runguo Wang Kuo-Chih Hua State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology Key Laboratory of Beijing City for Preparation and Processing of Novel Polymer Materials Beijing University of Chemical Technology Engineering Center of Ministry of Education on Elastomer Materials Energy Saving and Resource Utilization Beijing University of Chemical Technology Goodyear Innovation Center Goodyear Tire & Rubber Co.

Bio-based elastomer poly(diethyl itaconate-co-isoprene)(PDEII) was designed and synthesized by redox-initiated emulsion polymerization from diethyl itaconate and isoprene with mass ratio of 20:80, 40:60, 60:40 and 80:20. The number-average molecular weights of PDEII exceeded 140000 with relatively high yields. The physical properties of PDEII, such as glass transition temperatures and thermostability, were comparable with conventional synthetic elastomers and can be readily tuned by varying the ratio of diethyl itaconate to isoprene. The interaction between silica and PDEII macromolecules was effectively enhanced with the increase of diethyl itaconate content by endowing high polarity. The oil-resistance relevant properties of silica/PDEII80(80% diethyl itaconate, 20% isoprene) such as retention of tensile strength, retention of elongation at break and change in volume even surpass those of silica/NBR 240 S after soaked in ASTM 3# oil at different temperatures.

关键词：基于简历的弹性体合成油抵抗

基于建筑信息模型数据驱动的铁路设备运维多模态知识图谱构建

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同济大学学报（自然科学版） 2024年第2期52卷 166-173页

作者：林海香胡娜娜何乔赵正祥白万胜兰州交通大学自动化与电气工程学院甘肃兰州730070 兰州交通大学四电建筑信息模型工程与智能应用铁路行业重点实验室甘肃兰州730070 贝尔福-蒙贝利亚技术大学信息学院法国贝尔福90000

铁路信号设备是保障行车安全、提高运输效率的核心装备,加强信号设备智能运维是降低铁路运行风险的必要基础保障。目前,针对我国基于建筑信息模型(BIM)的智能运维平台存在不能精准映射各设备的行为规律和相互之间互馈作用的机理,须同时... 详细信息

铁路信号设备是保障行车安全、提高运输效率的核心装备,加强信号设备智能运维是降低铁路运行风险的必要基础保障。目前,针对我国基于建筑信息模型(BIM)的智能运维平台存在不能精准映射各设备的行为规律和相互之间互馈作用的机理,须同时依靠经验知识进行推断等问题。首先构建了铁路设备运维文本知识图谱;其次构建卷积神经网络(CNN)-团组图卷积神经网络(cgGCN)模型对BIM图像模态数据进行处理,完成对20种铁路信号设备零件图信息的标注,实验结果表明模型准确率达到95.38%,精确率和召回率的调和平均值F1达到95.58%;最后将BIM图像信息以视觉模态嵌入运维文本知识图谱,利用Neo4j图数据库实现多模态知识图谱可视化展示,从而精准映射各信号设备相互之间互馈作用的机理,为后续现场铁路运维人员实施安全管理和运维决策提供在线服务和指导。

关键词：铁路信号设备建筑信息模型(BIM) 运维多模态知识图谱

Design and synthesis by redox polymerization of a bio-based carboxylic elastomer for green tire

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Science China Chemistry 2015年第10期58卷 1561-1569页

作者： Xinxin Zhou Runguo Wang Weiwei Lei he qiao Haoling Ji Liqun Zhang Kuo-Chih Hua Joseph Kulig State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology Key Laboratory of Beijing City for Preparation and Processing of Novel Polymer Materials Beijing Laboratory of Biomedical Materials Goodyear Innovation Center Goodyear Tire & Rubber Company

Poly(dibutyl itaconate-co-isoprene-co-methacrylic acid)(PDIM) elastomer was designed and synthesized by redox emulsion polymerization under mild conditions. PDIM has high molecular weight, relatively high yield, and low glass transition temperature(Tg). The structure of PDIM was determined by FTIR and NMR, and the carboxyl content was obtained by titration in a non-proton solvent. Tensile strength and elongation at break increased with increasing carboxyl content. In addition, the interaction between PDIM and silica was elucidated by rubber process analyzer(RPA) and TEM, and the results showed that the silica-PDIM interaction was strong, but the silica-silica interaction was weak.

关键词：还原聚合生物氧化绿色轮胎合成玻璃化转变温度橡胶加工分析仪设计二氧化硅

皮肤瘙痒的成因及其与昼夜节律关系的研究进展

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生命科学 2024年第3期36卷 381-387页

作者：何乔李丽高文红凌霄郭苗苗北京工商大学轻工科学与工程学院北京100048 润芳可(上海)生物科技有限公司上海201499 北京尚捷优蓝科技有限公司北京100872

瘙痒是皮肤常见的症状,包括由系统性基础疾病引起的全身性瘙痒,和皮肤疾病或外部条件导致的局部皮肤瘙痒。本文简要阐述了系统性基础疾病导致的全身性瘙痒以及皮肤疾病引起的局部皮肤瘙痒,并对不良生活条件(如空气污染、熬夜及不健康饮... 详细信息

瘙痒是皮肤常见的症状,包括由系统性基础疾病引起的全身性瘙痒,和皮肤疾病或外部条件导致的局部皮肤瘙痒。本文简要阐述了系统性基础疾病导致的全身性瘙痒以及皮肤疾病引起的局部皮肤瘙痒,并对不良生活条件(如空气污染、熬夜及不健康饮食)导致的皮肤局部瘙痒,及进而引起的昼夜节律紊乱进行总结分析,并从调节昼夜节律角度讨论缓解皮肤瘙痒的方法。

关键词：瘙痒系统性基础疾病空气污染睡眠不足不健康饮食昼夜节律

尿素对厚壳贻贝外套膜在酸化条件下贝壳损伤-修复过程的影响

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水生生物学报 2024年第7期48卷 1170-1182页

作者：何志巧范孝俊刘菲张晓林严小军申望廖智浙江海洋大学海洋科学与技术学院海洋生物资源与分子工程实验室舟山316022

为了解尿素对厚壳贻贝在海洋酸化条件下,其贝壳损伤-修复过程的影响,通过构建酸化条件下厚壳贻贝的壳损伤模型,结合外套膜转录组学技术,分析了厚壳贻贝外套膜在尿素添加前后的转录组学响应;进一步对两种条件下的厚壳贻贝外套膜开展了显... 详细信息

为了解尿素对厚壳贻贝在海洋酸化条件下,其贝壳损伤-修复过程的影响,通过构建酸化条件下厚壳贻贝的壳损伤模型,结合外套膜转录组学技术,分析了厚壳贻贝外套膜在尿素添加前后的转录组学响应;进一步对两种条件下的厚壳贻贝外套膜开展了显微观察、游离氨基酸组成变化及细胞内钙离子水平分析。结果表明,尿素的添加有助于贻贝外套膜在酸化背景下其细胞稳态维持、能量代谢水平提升、免疫平衡调节及钙离子募集等功能。上述研究有助于了解厚壳贻贝在海洋酸化背景下其贝壳的生物矿化过程及壳损伤-修复分子策略,从中判断尿素添加对贻贝在海洋酸化条件下的贝壳生物矿化过程的可能促进机制,也为在当前海洋酸化大背景下,海洋贝类养殖业的健康发展提供了新的思路。

关键词：外套膜海洋酸化尿素生物矿化厚壳贻贝

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Investigations of the dynamical behaviors of a millimeter-scale cavitation bubble near the rigid wall

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Journal of Hydrodynamics 2023年第6期35卷 1064-1076页

作者： Dan Zi Dong-qiao he Zhi-feng Yao Fu-jun Wang Qiang Zhong Pin Lyu College of Water Resources and Civil Engineering China Agricultural UniversityBeijing100083China Beijing Engineering Research Center of Safety and Energy Saving Technology for Water Supply Network System Beijing100083China Yichang Testing Technology Research Institute Yichang443000China

The collapse of the cavitation bubble near the rigid wall emits shock waves and creates micro-jet,causing cavitation damage and operation instability of the hydraulic machinery.In this paper,the millimeter-scale bubble near the rigid wall was investigated experimentally and numerically with the help of a laser photogrammetry system with nanosecond-micron space-time resolution and the open source package OpenFOAM-2212.The morphological characteristics of the bubble during its growth phase,collapse phase and rebound phase were observed by experiment and numerical simulation,and characteristics of the accompanying phenomena including the shock wave propagation and micro-jet evolution were well elucidated.The numerical results agree well with the experimental data.The bubble starts from a tiny small size with high internal pressure and expands into a sphere with a radius of 1.07 mm forγ=d/R_(max)=1.78.The bubble collapses into a heart shape and moves towards to the rigid wall during its collapse phase,resulting in a higher pressure load for the rigid wall in the second collapse.The maximum pressure of the shock wave of the first bubble collapse phase reaches 5.4 MPa,and the velocity of the micro-jet reaches approximately 100 m/s.This study enriches the existing experimental and numerical results of the dynamics of the near-wall cavitation bubble.

关键词： Cavitation bubble collapse shock wave micro jet the rigid wall

Ultra-highly sensitive dual gases detection based on photoacoustic spectroscopy by exploiting a long-wave,high-power,wide-tunable,singlelongitudinal-mode solid-state laser

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Light(Science & Applications) 2024年第5期13卷 941-956页

作者： Shunda qiao Ying he Haiyue Sun Pietro Patimisco Angelo Sampaolo Vincenzo Spagnolo Yufei Ma National Key Laboratory of Laser Spatial Information Harbin Institute of TechnologyHarbinChina PolySense Lab Dipartimento Interateneo di FisicaUniversity and Politecnico of BariVia AmendolaBariItaly

Photoacoustic spectroscopy(PAS)as a highly sensitive and selective trace gas detection technique has extremely broad application in many fields.However,the laser sources currently used in PAS limit the sensing performance.Compared to diode laser and quantum cascade laser,the solid-state laser has the merits of high optical power,excellent beam quality,and wide tuning range.here we present a long-wave,high-power,wide-tunable,singlelongitudinal-mode solid-state laser used as light source in a PAS sensor for trace gas detection.The self-built solid-state laser had an emission wavelength of~2μm with Tm:YAP crystal as the gain material,with an excellent wavelength and optical power stability as well as a high beam quality.The wide wavelength tuning range of 9.44 nm covers the absorption spectra of water and ammonia,with a maximum optical power of~130 mW,allowing dual gas detection with a single laser source.The solid-state laser was used as light source in three different photoacoustic detection techniques:standard PAS with microphone,and external-and intra-cavity quartz-enhanced photoacoustic spectroscopy(QEPAS),proving that solid-state laser is an attractive excitation source in photoacoustic spectroscopy.

关键词： power tunable tuning