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Target prediction and activity verification for the antidepressant action of Huangqin(Radix Scutellariae Baicalensis)

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Journal of Traditional Chinese Medicine 2021年第6期41卷 845-852页

作者： LI Ganggang LU Ye HE Pei ZHANG Shiyue CheNG Yating ZHANG Shaodan pei Lin School of Basic Medical Sciences Hebei University of Chinese MedicineShijiazhuang 050051China hebei Key Laboratory of Turbidity Hebei Academy of Chinese Medicine SciencesShijiazhuang 050011China Department of pediatrics Second Hospital of Hebei Medical UniversityShijiazhuang 050073China Department of Traditional Chinese Medicine Anyang Vocational and Technical CollegeAnyang 455000China

OBJECTIVE:To decipher the antidepressant targets and mechanisms of Huangqin(Radix Scutellariae Baicalensis)(RSB)by a novel computational system based on prediction and experimental verification.METHODS:The putative targets of RSB against depression were identified from Traditional Chinese Medicine Systems Pharmacology(TCMSP)and Drug Bank.Next,protein-protein interaction network of the anti-depression targets of RSB were identified,and differentially expressed genes(DEGs)of depression were mined from the NCBI database.Then,Kyoto Encyclopedia of Genes and Genomes and Gene Ontology were used to analysis the common targets.Finally,the selected pathways and functions were verified by experimentation.RESULTS:Thirty active compounds in RSB were predicted with high confidence by TCMSP and DrugBank,and seventy-one DEGs were identified in the GEO database.Besides,eight core target proteins were screened out by descending order of degree value,including AChe,IL6,SLC6A4,FOS,SLC6A3,MAOB,DPP4,and JUN.These target genes were further found to be associated with pathways involved in neuronal apoptosis,such as pathways in cancer,Toll-like receptor signaling pathway,and TNF signaling.The cell proliferation assay and wound-healing assay results showed that RSB does not affect PC12 cell proliferation and chemotaxis.Unexpectedly,RSB protected PC12 cells from oxidative stress induced by H2O2 via inhibiting autophagy and apoptosis.We revealed significant changes in mice treated with 400 mg/kg RSB compared with the lipopolysaccharide mice.The possible mechanism for the antidepressive action of RSB is by reducing the expression of LC3-B in CA1 neurons.CONCLUSIONS:Our research partially expounds the mechanism of the antidepressant effect of RSB by the combination of network pharmacology prediction and experimental verification.Furthermore,it is also conducive to the application of Traditional Chinese Medicine within modern medicine.

关键词： depression Huangqin(Radix Scutellariae Baicalensis) network pharmacology prediction and verification

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Characterization of CircRNA-Associated CeRNA Networks in Folate Deficiency-Induced Neural Tube Defects

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生物医学与环境科学:英文版 2023年第9期36卷 837-849页

作者： WANG Shan ZENG Yu Bing pei pei he Xue Jia LIU Fan WANG Yi ZHANG Ting Beijing Municipal Key Laboratory of Child Development and Nutriomics Capital Institute of PediatricsBeijing 100020China Capital Institute of Pediatrics-Peking University Teaching Hospital Beijing 100020China Children's Hospital Capital Institute of Pediatrics Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100020China

Objective Circular RNAs(circRNAs)participate in several important pathological processes and have been used in the diagnosis and treatment of various diseases.This study aimed to investigate the role of circRNAs in neural tube defects(NTDs).Method We characterized circRNA-associated competitive endogenous RNA(ceRNA)networks in brain tissue of low folate-induced NTDs mouse at embryonic day 13.5 by high-throughput sequencing.The expression levels of Circzfp644,miR-20-5p and Gas7 were detected by RT-PCR.Gas7 and Circzfp644functions were determined by miRNA-mimics and inhibitors in mouse teratocarcinoma cells(F9 cells),and luciferase gene reporter assay was assessed in the F9 cells.In addition,the expression levels of Circzfp644,miR-20-5p and Gas7 were determined by Nanostring in human NTDs tissues.Results We detected 57 circRNA transcripts,16 miRNAs,and 148 mRNAs that were significantly dysregulated in NTDs brain tissues compared with their expression levels in control(normal)tissues.Circzfp644 shared miRNA response elements with the growth arrest specific 7(Gas7)gene and competitively bound with miR-20-5p to increase the expression of Gas7.Downregulation of Circzfp644and Gas7 and upregulation of miR-20-5p were found in human NTD tissue.Conclusion This study provides new perspectives on the role of circRNAs in nervous system development and the pathogenesis of NTDs.

关键词： Circzfp644 Gas7 miR-20-5p Folate deficiency NTDs

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Spatial-Temporal ConvLSTM for Vehicle Driving Intention Prediction

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Tsinghua Science and Technology 2022年第3期27卷 599-609页

作者： he Huang Zheni Zeng Danya Yao Xin pei Yi Zhang Department of Automation Tsinghua Universitywith National Laboratory for Information Science and Technology(TNList)Tsinghua UniversityBeijing 100084China National Laboratory for Information Science and Technology(TNList) Tsinghua UniversityBeijing 100084China

Driving intention prediction from a bird’s-eye view has always been an active research area. However,existing research, on one hand, has only focused on predicting lane change intention in highway scenarios and, on the other hand, has not modeled the influence and spatiotemporal relationship of surrounding vehicles. This study extends the application scenarios to urban road scenarios. A spatial-temporal convolutional long short-term memory(ConvLSTM) model is proposed to predict the vehicle’s lateral and longitudinal driving intentions simultaneously. This network includes two modules: the first module mines the information of the target vehicle using the long short-term memory(LSTM) network and the second module uses ConvLSTM to capture the spatial interactions and temporal evolution of surrounding vehicles simultaneously when modeling the influence of surrounding vehicles. The model is trained and verified on a real road dataset, and the results show that the spatial-temporal ConvLSTM model is superior to the traditional LSTM in terms of accuracy, precision, and recall, which helps improve the prediction accuracy at different time horizons.

关键词： driving intention prediction lane change intention ConvLSTM

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BDS B1I multipath channel statistical model comparison between static and dynamic scenarios in dense urban canyon environment

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Satellite Navigation 2020年第1期1卷 287-302页

作者： Xin Chen Di he Ling pei Shanghai Key Laboratory of Navigation and Location-based Service School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityDongchuan Road 800Shanghai 200240China

Global Navigation Satellite System(GNSS)multipath channel models are fundamental and critical for signal simulation and receiver performance evaluation.They also aid the designing of suitable multipath error mitigation algorithms when the properties of multipath channel are available.However,there is insufficient existing research on BeiDou Navigation Satellite System(BDS)signal multipath channel models.In this study,multipath channel statistical models are established on the basis of extensive datasets of the BDS B1I signal.A multipath parameter estimation algorithm is designed to extract information of multipath rays from the intermediate frequency data.The delay,power loss,Doppler fading frequency,and lifetime distribution models for static and dynamic vehicle platforms are established and compared,and the effects of the satellite orbit type and platform speed on the models are analyzed.The results reveal the detailed distribution and variation characteristics of the multipath parameters and are valuable for the development of accurate urban navigation systems.

关键词： Multipath channel statistical model Multipath delay Multipath power loss Multipath Doppler fading frequency Multipath lifetime

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Crustal Electrical Structure of the Wuwei Basin,Lower Yangtze Region of China,and Its Geological Implications

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Journal of Earth Science 2023年第6期34卷 1744-1757页

作者： Xiaobo Zhang Penghui Zhang Meixing he Dashuang he Fagen pei Yaoyang Zhang Yan Peng Institute of Geophysical and Geochemical Exploration Chinese Academy of Geological SciencesLangfang 065000China National Research Center for Geo-exploration Technology Langfang 065000China College of Earth Sciences Chengdu University of TechnologyChengdu 610059China

The Wuwei Basin is one of the most important oil-and gas-bearing basins in the Meso-Cenozoic basin groups in the Lower Yangtze River region.It has great shale gas resource prospects.The formation mechanism of this basin is poorly studied for lack of constraining data for deep structures.In this paper,a crustal electrical structure model of the Wuwei Basin and the adjacent areas is constructed based on the two-dimensional inversion of a magnetotelluric(MT)sounding profile achieved with the nonlinear conjugate gradient method.The results show that large-scale low-resistance bodies have developed in the underlying middle and lower crust of the Wuwei Basin,and are different from the uplifts on the two sides according to their high-resistance electrical characteristics.The electrical structure and regional geological and geophysical data suggest that the peak zone of the Chuzhou-Chaohu foreland fold-and-thrust belt is located on the east bank of the Yangtze River(Wuhu Section),which,together with the main thrust fault belt in the east,forms a typical thrust structure belt.An early Yanshanian sinistral strike-slip fault developed in the deep part of the Wuwei Basin,which may have controlled the formation and evolution of the basin,whereas the tectonic inversion of the early-developed thrust faults is relatively weak.These findings provide a geophysical basis for future studies of basin tectonic evolution and regional tectonic frameworks.

关键词： Wuwei Basin Lower Yangtze deep structure electrical structure fold-and-thrust belt shale gas magnetotellurics geophysics

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Exact quantum query complexity of weight decision problems via Chebyshev polynomials

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Science China(Information Sciences) 2023年第2期66卷 297-298页

作者： Xiaoyu he Xiaoming SUN Guang YANG pei YUAN Institute of Computing Technology Chinese Academy of Sciences (CAS) University of Chinese Academy of Sciences

The weight decision problem, which requires determining the Hamming weight of a given binary string, is a natural and important problem with lots of applications, such as cryptanalysis [1] and coding theory. In this study, we investigate the exact quantum query complexity of weight decision problems, where the exact quantum algorithm must always output the correct answer within finite steps(see Appendix A for a detailed explanation).

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Parametric Resonance Analyses for Spar Platform in Irregular Waves

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China Ocean Engineering 2018年第2期32卷 236-244页

作者： YANG he-zhen XU pei-ji School of Engineering University of GlasgowGlasgow G128QQUnited Kingdom School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The parametric instability of a spar platform in irregular waves is analyzed. Parametric resonance is a phenomenon that may occur when a mechanical system parameter varies over time. When it occurs, a spar platform will have excessive pitch motion and may capsize. Therefore, avoiding parametric resonance is an important design requirement. The traditional methodology includes only a prediction of the Mathieu stability with harmonic excitation in regular waves. However, real sea conditions are irregular, and it has been observed that parametric resonance also occurs in non-harmonic excitations. Thus, it is imperative to predict the parametric resonance of a spar platform in irregular waves. A Hill equation is derived in this work, which can be used to analyze the parametric resonance under multi-frequency excitations. The derived Hill equation for predicting the instability of a spar can include non-harmonic excitation and random phases. The stability charts for multi-frequency excitation in irregular waves are given and compared with that for single frequency excitation in regular waves. Simulations of the pitch dynamic responses are carried out to check the stability. Three-dimensional stability charts with various damping coefficients for irregular waves are also investigated. The results show that the stability property in irregular waves has notable differences compared with that in case of regular waves. In addition, using the Hill equation to obtain the stability chart is an effective method to predict the parametric instability of spar platforms. Moreover, some suggestions for designing spar platforms to avoid parametric resonance are presented, such as increasing the damping coefficient, using an appropriate RAO and increasing the metacentric height.

关键词： spar platform instability parametric resonance Mathieu equation irregular waves dynamic responses

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Attention-based efficient robot grasp detection network

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Frontiers of Information Technology & Electronic Engineering 2023年第10期24卷 1430-1444页

作者： Xiaofei QIN Wenkai HU Chen XIAO Changxiang he Songwen pei Xuedian ZHANG School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China College of Science University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Key Laboratory of Modern Optical System Shanghai 200093China Key Laboratory of Biomedical Optical Technology and Devices of Ministry of Education Shanghai 200093China Shanghai Institute of Intelligent Science and Technology Tongji UniversityShanghai 201210China

To balance the inference speed and detection accuracy of a grasp detection algorithm,which are both important for robot grasping tasks,we propose an encoder–decoder structured pixel-level grasp detection neural network named the attention-based efficient robot grasp detection network(AE-GDN).Three spatial attention modules are introduced in the encoder stages to enhance the detailed information,and three channel attention modules are introduced in the decoder stages to extract more semantic information.Several lightweight and efficient DenseBlocks are used to connect the encoder and decoder paths to improve the feature modeling capability of AE-GDN.A high intersection over union(IoU)value between the predicted grasp rectangle and the ground truth does not necessarily mean a high-quality grasp configuration,but might cause a collision.This is because traditional IoU loss calculation methods treat the center part of the predicted rectangle as having the same importance as the area around the grippers.We design a new IoU loss calculation method based on an hourglass box matching mechanism,which will create good correspondence between high IoUs and high-quality grasp configurations.AEGDN achieves the accuracy of 98.9%and 96.6%on the Cornell and Jacquard datasets,respectively.The inference speed reaches 43.5 frames per second with only about 1.2×10^(6)parameters.The proposed AE-GDN has also been deployed on a practical robotic arm grasping system and performs grasping well.Codes are available at https://***/robvincen/robot_gradet.

关键词： Robot grasp detection Attention mechanism Encoder-decoder Neural network

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Multi-Objective Sizing of Solar-Wind-Hydro Hybrid Power System with Doubled Energy Storages Under Optimal Coordinated Operational Strategy

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CSEE Journal of Power and Energy Systems 2023年第6期9卷 2144-2155页

作者： Su Guo Aynur Kurban Yi he Feng Wu Huanjin pei Guotao Song the School of Energy and Electricity Hohai UniversityNanjing 211100China

More and more attention has been paid to the high penetration of renewable energy in recent years.The randomness and intermittency of solar and wind energy make it an inevitable trend that renewables are coupled with energy storage technologies.Pumped hydro storage(PHS)is the most widelyused storage form in the power grid but the capacity is limited by geographic conditions.The concentrated solar power(CSP)plant with a thermal energy storage(TES)system can realize easier grid connections and effective peak shaving.Therefore,this paper proposes a solar-wind-hydro hybrid power system with PHS-TES double energy storages,and investigates the optimal coordinated operational strategy and multi-objective sizing.The optimal sizing problem which considers the minimum levelized cost of energy(LCOE)and loss of power supply probability(LPSP)as objectives is solved by multi-objective particle swarm optimization.Moreover,the seasonal uncertainties of renewables are considered by applying a scenario-based analysis using Kmeans clustering.Finally,a case study reveals the effectiveness of the coordinated operational strategy and double energy storages from the perspectives of economy and reliability.The comparisons of optimal sizing results show that the PV-WindCSP-PHS system decreases the LCOE by 19.1%compared to a PV-Wind-CSP system under the same LPSP,and reduces the LPSP compared to PV-Wind-PHS systems with limited reservoir capacity,which indicates that the proposed system with double energy storages has better economy and reliability performance compared to single storage.

关键词： Coordinated operation strategy double energy storages hybrid renewable energy system multi-objective sizing optimization solar-wind-hydro

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Transition-metal-free synthesis of 4-aminoisoquinolin-1(2H)-ones via a tandem reactionof arynes and oxazoles

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Organic Chemistry Frontiers 2022年第6期9卷 1550-1555页

作者： Shaojun Liu pei Xie Leifang Wu Jixing Zhao Zhihua Cai Lin he Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical EngineeringShihezi UniversityXinjiang Uygur Autonomous Region 832000People’s Republic of China Analysis and Testing Center of Shihezi University Xinjiang Uygur Autonomous Region832000China

A facile and transition-metal-free method for the synthesis of 4-amino isoquinolin-1(2H)-ones has beendeveloped. Arynes react with 4,5-disubstituted oxazoles through a tandem Diels–Alder reaction/dehydrogenation–aromatization/tautamerization process to produce 4-amino isoquinolin-1(2H)-ones in moderate to excellent yields. The reaction can be easily scaled up and the product can be transformed to isoquinoline derivatives efficiently.

关键词： synthesis Transition

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