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Development of a diagnostic nomogram for alpha-fetoproteinnegative hepatocellular carcinoma based on serological biomarkers

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2463-2475页

作者： li he Cui Zhang Lan-Lan liu li-ping Huang Wen-Jing Lu Yuan-Yuan Zhang De-Yong Zou Yu-Fei Wang Qing Zhang Xiao-li Yang School of Clinical Medicine Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Organ Transplantation The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China Department of Laboratory Medicine The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China Department of Laboratory Medicine Jingyu County People’s HospitalBaishan 135200Jilin ProvinceChina School of Laboratory Medicine Weifang Medical UniversityWeifang 261053Shandong ProvinceChina

BACKGROUND hepatocellular carcinoma(HCC)is the third leading cause of cancer-related death *** biomarkers play an important role in the early diagnosis and prognosis of *** a certain percentage of HCC patients are negative for alpha-fetoprotein(AFP),the diagnosis of AFP-negative HCC is essential to improve the detection rate of *** To establish an effective model for diagnosing AFP-negative HCC based on serum tumour *** A total of 180 HCC patients were enrolled in this *** expression levels of GP73,des-γ-carboxyprothrombin(DCP),CK18-M65,and CK18-M30 were detected by a fully automated chemiluminescence *** variables were selected by logistic regression *** models were constructed using stepwise backward logistic *** performance of the models was compared using the C statistic,integrated discrimination improvement,net reclassification improvement,and calibration *** clinical utility of the nomogram was assessed using decision curve analysis(DCA).RESULTS The results showed that the expression levels of GP73,DCP,CK18-M65,and CK18-M30 were significantly greater in AFP-negative HCC patients than in healthy controls(Phe diagnostic performance of multiple models,we included GP73 and CK18-M65 as the model variables,and the model had good discrimination ability(area under the curve=0.946)and good goodness of *** DCA curves indicated the good clinical utility of the *** Our study identified GP73 and CK18-M65 as serum biomarkers with certain application value in the diagnosis of AFP-negative *** diagnostic nomogram based on CK18-M65 combined with GP73 demonstrated good performance and effectively identified high-risk groups of patients with HCC.

关键词： hepatocellular carcinoma Alpha-fetoprotein-negative Diagnostic Nomogram Biomarker

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Long Non-coding RNA PCED1B Antisense RNA 1 Promotes Cell Proliferation and Invasion in hepatocellular Carcinoma by Regulating the MicroRNA-34a/CD44 Axis

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Current Medical Science 2024年第3期44卷 503-511页

作者： Jian-gang BI Qi li Yu-sheng GUO li-ping liU Shi-yun BAO ping XU Department of hepatobiliary and Pancreatic Surgery Shenzhen People's HospitalThe Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Endocrinology Shenzhen People's HospitalThe Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China

Objective This study aimed to examine the role of long non-coding RNA PCED1B antisense RNA 1(PCED1B-AS1)in the development of hepatocellular carcinoma(HCC).Methods A total of 62 pairs of HCC tissues and adjacent non-tumor tissues were obtained from 62 HCC *** interactions of PCED1B-AS1 and microRNA-34a(miR-34a)were detected by dual luciferase activity assay and RNA pull-down *** RNA expression levels of PCED1B-AS1,miR-34a and CD44 were detected by RT-qPCR,and the protein expression level of CD44 was determined by Western *** cell proliferation was detected by cell proliferation assay,and the cell invasion and migration by transwell invasion *** HCC tumor growth after PCED1B-AS1 was downregulated was determined by in vivo animal *** PCED1B-AS1 was highly expressed in HCC tissues,which was associated with poor survival of HCC ***,PCED1B-AS1 interacted with miR-34a in HCC cells,but they did not regulate the expression of each ***,PCED1B-AS1 increased the expression level of CD44,which was targeted by *** cell proliferation and invasion assay revealed that miR-34a inhibited the proliferation and invasion of HCC in vitro,while CD44 exhibited the opposite ***,PCED1B-AS1 suppressed the role of ***,the knockdown of PCED1B-AS1 repressed the HCC tumor growth in nude mice in *** PCED1B-AS1 may play an oncogenic role by regulating the miR-34a/CD44 axis in HCC.

关键词： long non-coding RNA PCED1B antisense RNA 1(PCED1B-AS1) hepatocellular carcinoma microRNA-34a(miR-34a) CD44 proliferation invasion

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A Coordinated Two-stage Decentralized Flexibility Trading in Distribution Grids with MGs

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Protection and Control of Modern Power Systems 2024年第5期9卷 54-69页

作者： Tao Xu Rujing Wang he Meng Mengchao li Hongru Wang Yu Ji Ying Zhang Qingrong Zheng ping Song Jiani Xiang Key Laboratory of Smart Grid of Ministry of Education Tianjin UniversityTianjin 300072China State Grid Shanghai Energy Interconnection Research Institute Co. Ltd.Shanghai 200031China Key Laboratory of Smart Grid Demand Response Shanghai 200030China State Grid Shanghai Municipal Electric Power Company Shanghai 200122China

Renewable energy dominated future power grids require enhanced system flexibility,in particular,activating the participation from various distributed en-ergy resources(DERs).A coordinated two-stage flexibility trading framework for distribution system with mi-crogrids(MGs)is proposed in this *** day-ahead stage,a peer to peer(P2P)trading mechanism and the associate leasing strategy of shared energy storage system are performed to solve the power variations caused by the wide spread integration of renewable resources,where asymmetric Nash bargaining is used to realize the fair revenue allocation according to the contribution of each MG in P2P *** intra-day stage,given the power imbalances from unexpected uncertainties,MGs exploit the adjustability of the DERs in responding to rapid flexibility requirements issued by distribution system *** particular,the average consensus based de-centralized Newton method with super linear convergence is utilized to meet the requirements of flexibility while maintaining the information *** feasibility,effectiveness and equity of the proposed trading strategies are verified through various simulation *** Terms—Microgrids,decentralized Newton,flexi-bility trading,asymmetric Nash bargaining,peer-to-peer.

关键词： Microgrids decentralized Newton flexibility trading asymmetric Nash bargaining peer-to-peer

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Synthesis of crystalline g-C_(3)N_(4) with rock/molten salts for efficient photocatalysis and piezocatalysis

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Green Energy & Environment 2024年第5期9卷 890-898页

作者： Tingting Xu Jung Hur ping Niu Shulan Wang Sangwook Lee Sang-Eun Chun li li Department of Chemistry College of ScienceNortheastern UniversityShenyang110819China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819China School of Metallurgy Northeastern UniversityShenyang110819China School of Materials Science and Engineering Kyungpook National UniversityDaegu41566Republic of Korea School of Industrial Technology Advances Kyungpook National UniversityDaegu41566Republic of Korea

Graphitic carbon nitride(g-C_(3)N_(4))is emerging as a promising visible-light photocatalyst while the low crystallinity with sluggish charge separation/migration dynamics signiﬁcantly restricts its practical ***,synthesizing highly crystalline g-C_(3)N_(4) with sufﬁcient surface activities still remains ***,different from using alkali molten salts which is commonly reported,we propose an approach for synthesis of highly crystalline g-C_(3)N_(4) with FeCl3/KCl rock/molten mixed *** rock salt can serve as the structure-directing template while molten salt provides the required liquid medium for ***,the synthesized photocatalyst showed further enhanced crystallinity and improved surface area along with high p/p*excitation compared with crystalline C_(3)N_(4) prepared from conventional molten-salt *** catalytically advantageous features lead to its superior photocatalytic and piezocatalytic activities with a high reactivity for overall water splitting that is not commonly reported for C_(3)N_(4).This work provides an effective strategy for structural optimization of organic semiconductor based materials and may inspire new ideas for the design of advanced photocatalysts.

关键词： High crystallinity Carbon nitride Photocatalysis Piezocatalysis Overall water splitting

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Dipeptidyl peptidase-4 inhibitors and the risk of infection: A systematic review and meta-analysis of cardiovascular outcome trials

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World Journal of Diabetes 2024年第5期15卷 1011-1020页

作者： Na Yang li-Yun he Peng liu Zi-Yi li Yu-Cheng Yang Fan ping ling-ling Xu Wei li Hua-Bing Zhang Yu-Xiu li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Endocrinology The First Affiliated Hospitaland College of Clinical Medicine of Henan University of Science and TechnologyLuoyang 471000Henan ProvinceChina

BACKGROUND Since adverse events during treatment affect adherence and subsequent glycemic control,understanding the safety profile of oral anti-diabetic drugs is imperative for type 2 diabetes mellitus(T2DM)*** To evaluate the risk of infection in patients with T2DM treated with dipeptidyl-peptidase 4(DPP-4)*** Electronic databases were *** selection criteria included randomized controlled trials focused on cardiovascular *** these studies,the effects of DPP-4 inhibitors were directly compared to those of either other active anti-diabetic treatments or *** trials involving 53616 patients were deemed *** calculated aggregate relative risks employing both random-effects and fixed-effects approaches,contingent upon the *** The application of DPP-4 inhibitors showed no significant link to the overall infection risk[0.98(0.95,1.02)]or the risk of serious infections[0.96(0.85,1.08)],additionally,no significant associations were found with opportunistic infections[0.69(0.46,1.04)],site-specific infections[respiratory infection 0.99(0.96,1.03),urinary tract infections 1.02(0.95,1.10),abdominal and gastrointestinal infections 1.02(0.83,1.25),skin structure and soft tissue infections 0.81(0.60,1.09),bone infections 0.96(0.68,1.36),and bloodstream infections 0.97(0.80,1.18)].CONCLUSION This meta-analysis of data from cardiovascular outcome trials revealed no heightened infection risk in patients undergoing DPP-4 inhibitor therapy compared to control cohorts.

关键词： T2DM drugs treatment

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Hardness Measurement of (TiB_2-TiAl)/TiAl Symmetrically Function Gradient Materials

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Journal of Wuhan University of Technology(Materials Science) 2002年第1期17卷 1-3页

作者：梅炳初 WuhanUniversityofTechnology

( TiB2-TiAl)/TiAl symmetrically function gradient materials ( FGM) were prepared by spark plasma sintering ( SPS). Owing to the difference, of the thermal expansion coefficients between TiB2 and TiAl, a compressive surface stress was introduced to the FGM fry the thermal expansion mismatch. The hardness values of the uniform materials and the FGM were tested, respectively. For the FGM with a compressive surface stress, hardness is obviously superior to that of the uniform material. When the FGM was subjected to heat treatment, the hardness decreased due to a partial relaxation of the compressive surface stress.

关键词： hardness measurement function gradient materials composite

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螺栓联接的有限元建模方法研究

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北京理工大学学报 2020年第12期40卷 1275-1281页

作者：贺李平任雪梅北京无线电测量研究所北京100854 北京理工大学自动化学院北京100081

对螺栓联接的有限元建模方法进行研究和评估.以螺栓-法兰联接为例,基于有限元分析软件ANSYS,建立了3种螺栓联接的有限元模型,即实体螺栓联接模型、梁单元联接模型和刚性单元联接模型.模态试验和应力分析表明,实体螺栓联接模型和梁单元... 详细信息

对螺栓联接的有限元建模方法进行研究和评估.以螺栓-法兰联接为例,基于有限元分析软件ANSYS,建立了3种螺栓联接的有限元模型,即实体螺栓联接模型、梁单元联接模型和刚性单元联接模型.模态试验和应力分析表明,实体螺栓联接模型和梁单元联接模型具有广泛的适用性,可准确分析螺栓联接结构的静态特性和动态特性.相比实体螺栓联接模型,梁单元联接模型在保留了关键细节的同时提高了建模和计算效率.刚性单元联接模型不能模拟螺栓预紧和接触,只适用于模态分析.试验和仿真均表明,螺栓预紧力的大小对结构模态影响很小.仿真表明,螺栓联接表现出复杂的非线性特性,如应力的非线性变化、法兰之间接触状态的变化、螺栓总拉力的非线性变化等.

关键词：螺栓法兰预紧力有限元分析

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车辆半主动油气悬架模糊控制的建模与仿真

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北京理工大学学报 2013年第5期33卷 474-478,515页

作者：么鸣涛龙凯贺李平中国南方工业研究院北京100089 华北电力大学新能源电力系统国家重点实验室北京102206 汽车噪声振动和安全技术国家重点实验室重庆400039 北京无线电测量研究所北京100854

为对某工程车辆半主动悬架系统进行可靠控制,针对单筒式油气弹簧建立了数学模型,分析了其刚度特性和阻尼特性以及节流小孔面积的改变对阻尼的影响.提出在防止悬架频繁击穿前提下改善车辆平顺性要求的控制思想,以悬架动挠度及其随时间变... 详细信息

为对某工程车辆半主动悬架系统进行可靠控制,针对单筒式油气弹簧建立了数学模型,分析了其刚度特性和阻尼特性以及节流小孔面积的改变对阻尼的影响.提出在防止悬架频繁击穿前提下改善车辆平顺性要求的控制思想,以悬架动挠度及其随时间变化率为控制输入,建立控制模型,并制定模糊控制规则,设计了模糊控制器.分别针对正弦路面激励、积分白噪声随机路面激励以及瞬态阶跃路面激励进行仿真.仿真结果表明:模糊控制策略在悬架半主动控制的应用,不仅可减小悬架击穿的概率,也从统计角度改善了车辆平顺性.

关键词：半主动悬架模糊控制油气弹簧动挠度悬架击穿平顺性

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The functions of exosomes targeting astrocytes and astrocyte-derived exosomes targeting other cell types

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Neural Regeneration Research 2024年第9期19卷 1947-1953页

作者： Hongye Xu he li ping Zhang Yuan Gao Hongyu Ma Tianxiang Gao Hanchen liu Weilong Hua Lei Zhang Xiaoxi Zhang Pengfei Yang Jianmin liu Neurovascular Center Changhai HospitalNaval Medical UniversityShanghaiChina Department of Emergency Naval Hospital of Eastern TheaterZhoushanZhejiang ProvinceChina

Astrocytes are the most abundant glial cells in the central nervous system;they participate in crucial biological processes,maintain brain structure,and regulate nervous system *** are cell-derived extracellular vesicles containing various bioactive molecules including proteins,peptides,nucleotides,and lipids secreted from their cellular *** evidence shows that exosomes participate in a communication network in the nervous system,in which astrocyte-derived exosomes play important *** this review,we have summarized the effects of exosomes targeting astrocytes and the astrocyte-derived exosomes targeting other cell types in the central nervous *** also discuss the potential research directions of the exosome-based communication network in the nervous *** exosome-based intercellular communication focused on astrocytes is of great significance to the biological and/or pathological processes in different conditions in the *** strategies may be developed for the diagnosis and treatment of neurological disorders by focusing on astrocytes as the central cells and utilizing exosomes as communication mediators.

关键词： astrocytes communication exosomes neurological disorders targeting mechanism

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Melittin analog p5RHH enhances recombinant adeno-associated virus transduction efficiency

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Journal of Integrative Medicine 2024年第1期22卷 72-82页

作者： Jing-shun Meng Yun he heng-bin Yang li-ping Zhou Si-yuan Wang Xi-lin Feng Omar Yahya Al-shargi Xiao-min Yu li-qing Zhu Chang-quan ling Shanghai University of Traditional Chinese Medicine Shanghai 201203China Oncology Department of Traditional Chinese Medicine Changhai HospitalNaval Medical UniversityShanghai 200433China Faculty of Traditional Chinese Medicine Naval Medical UniversityShanghai 200043China State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology(Ministry of Education) School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200438China Yantai Fuheng Biological Technology Co. Ltd.YantaiShandong Province 264006China. Department of Clinical Laboratory the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

Objective Melittin and its derivatives have been characterized to establish effective gene delivery *** capability of facilitating endosomal release enhances the nanoparticles-based gene ***,little investigation has been conducted to explore its potential application in the context of viral *** Various melittin-derived peptides were inserted into the loop VIII of the capsid proteins of recombinant adeno-associated virus *** vectors carrying either gfp or fluc genes were subjected to qPCR assays and transduction assays of heK293T cells to investigate the efficiency of vector production and gene *** addition,the ability of a specific p5RHH-rAAV vector to deliver genes was examined through in vitro transduction of different cultured cells and in vivo tail vein administration to C57BL/6 ***,the intricate details of the vector-mediated transduction mechanisms were revealed by specific pharmacological inhibitors of every stage of the rAAV2 intracellular life *** A total of 76 melittin-related peptides were compiled from existing *** them,cMA2,Melt13,p5RHH and aAR3 were found to significantly enhance the gene delivery efficiency of rAAV2 *** p5RHH-rAAV2 vectors efficiently transduced not only rAAV-potent cell lines but also cell lines previously considered resistant to ***,bafilomycin A1,a vacuolar endosome acidification inhibitor,completely inhibited the transgene expression mediated by the p5RHH-rAAV2 *** importantly,p5RHH-rAAV8 vectors also demonstrated increased hepatic transduction in vivo in C57BL/6 *** The incorporation of melittin analogues into the rAAV capsids results in a significant improvement in rAAV-mediated transgene *** further modifications remain an area of interest,our studies have substantially broadened the pharmacological prospects of melittin in the context of viral vector-mediated gene delivery.

关键词： Melittin Recombinant adeno-associated virus Capsid engineering Transduction efficiency

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