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Whether Fire-Needle Therapy Bene?ts Plaque Psoriasis:A Multicenter,Randomized,and Controlled Trial

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Chinese Journal of Integrative Medicine 2019年第4期25卷 259-263页

作者： PAN Hu-dan QI Xiao-li WANG Lei he jing-yan LIU Jiu-li ZHANG Yun-bi TIAN Ye DUAN Xing-wu yanG Hao-yu BAI yan-ping Department of Dermatology China-Japan Friendship HospitalBeijing(100029)China Macao University of Science and Technology Macao(999078)China Department of Dermatology Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin(300120)China Department of Dermatology Shunyi District Branch of Beijing Hospital of Traditional Chinese MedicineBeijing(101300)China Department of Dermatology Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBeijing(100700)China Department of Dermatology Beijing Hospital of Traditional Chinese MedicineBeijing(100010)China

Objective: To observe the clinical effectiveness and safety of fire-needle therapy,an external approach of Chinese medicine in treating plaque ***: This study was a two-parallel-arm randomized controlled trial.A total of 151 participants with plaque psoriasis were randomly assigned to the ?re-needle therapy group(treatment group,76 cases) or the control group(75 cases) at a 1:1 allocation ratio using SAS *** participants received Oral Huoxue Jiedu Decoction(活血解毒汤,HXJDD) and applied externally vaseline cream twice a *** in the treatment group received ?re-needle therapy once weekly for 4 weeks plus HXJDD and vaseline cream applied the same as the control *** primary outcome measure was Psoriasis Area and Severity Index(PASI) score,and the secondary outcomes were Dermatology Life Quality Index(DLQL),and Hamilton Anxiety Rating Scale(HAMA),as well as Chinese medicine(CM) syndrome score and photos of target *** indices were evaluated before and after ***: Sixty-eight patients in each group completed the *** treatment group has not yet achieved signi?cant improvement in PASI score(P>0.05)compared to the control ***,signi?cant differences were found between the two groups in relieving CM syndrome(Phe short-term treatment and small sample size limit the conclusions of this *** rigorous randomized controlled trials with longer treatment are recommended.

关键词： fire-needle therapy Chinese medicine Huoxue Jiedu Decoction plaque psoriasis randomized controlled trial

Surgical treatment of interrupted aortic arch associated with ventricular septal defect and patent ductus arteriosus in patients over one year of age

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Chinese Medical Journal 2014年第9期127卷 1684-1690页

作者： Li Zhiqiang Li Bin Fan Xiangming Su Junwu Zhang jing he yan Liu Yinglong Department of Pediatric heart Center Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background Interrupted aortic arch （IAA） is a rare congenital anomaly affecting 1.5％ of infants with congenital heart *** repair of IAA is required to avoid irreversible pulmonary vascular ***,in China,patients with IAA associated with ventricular septal defect （VSD） and patent ductus arteriosus （PDA） over one year of age are *** we investigated the outcome of surgical treatment of IAA with VSD and PDA in patients over one year of *** From January 2009 to December 2012,19 patients with IAA have undergone complete single-stage *** patients＇ mean age was 4.4 years,ranging 1 to 15 years; and their mean weight was 12.8 kg,ranging 4.2 to 36.0 *** IAA were type A,four were type *** cardiac catheterization data were available from all *** pulmonary arterial pressure （mPAP） and pulmonary vascular resistance （PVR） were *** measurements of postoperative pulmonary artery pressure were taken in the operating room at the end of the *** patients underwent echocardiographic examinations before discharged from the *** addition,cardiac catheterization and echocardiographic examinations were performed during *** brain perfusion through the innominate artery during aortic arch reconstruction was used in all *** follow-up was （1.6±0.8） *** There were two hospital deaths （2/19,11％）.One patient died of pulmonary hypertension crisis,and another died of postoperative low cardiac *** cases had other main postoperative complications but no postoperative neurologic *** survivors were followed up,and there were no late deaths or *** cross-clamp duration was （85±22） minutes and selective brain perfusion duration was （34±11） *** patients required delayed sternal closure at two days *** care unit and hospital stays were （9±8） days and （47±24） days,*** gradients across the anastomo

关键词： interrupted aortic arch ventricular septal defect pulmonary hypertension

Midterm results of diagnostic treatment and repair strategy in older patients presenting with nonrestrictive ventricular septal defect and severe pulmonary artery hypertension

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Chinese Medical Journal 2014年第5期127卷 839-844页

作者： Liu Aijun Li Zhiqiang Li Xiaofeng Fan Xiangming Su Junwu Zhang jing he yan Liu Yinglong Department of Pediatric heart Center Beijing Anzhen HospitalCapital Medical University Beijing 100029 China

Background Congenital heart disease with severe pulmonary arterial hypertension （SPAH）,previously thought to have irreversible pulmonary vascular disease （PVD）,has been recently successfully corrected using diagnostic treatment and repair strategy by our surgery *** study aimed to evaluate the midterm results of a selected cohort of older patients with nonrestrictive ventricular septal defect （VSD） and SPAH using diagnostic treatment and repair *** The records of 56 patients older than six years with nonrestrictive VSD and SPAH undergoing diagnostic treatment and repair strategy from 2006 to 2012 were retrospectively *** patients received advanced pulmonary arterial hypertension （PAH） therapy and radical repairs were performed when transcutaneous oxygen saturation （SPO2） increased up to 93％.Results There were no operative ***2 and baseline six-minute walk test （SMWT） distance of all selected patients increased significantly and mean pulmonary artery pressure （MPAP） regressed significantly after diagnostic treatment and at late follow-up （P ＜0.01）.The incidence of late postoperative PAH was seen in six （10.7％） patients and by Logistic regression analysis,early postoperative PAH was an independent risk factor related to late postoperative *** Diagnostic treatment and repair strategy was effective and safe for treatment of nonrestrictive VSD and SPAH and the midterm results were *** treatment strategy was effective in assessing the reversibility of SPAH in older patients associated with nonrestrictive VSD and the PVD in these selective patients is generally reversible.

关键词： pulmonary hypertension congenital heart disease ventricular septal defect therapy

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong jing-jing Hu yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia yang Qian-Ru he Fei Ding Hai-yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： jing Li Zixuan he Weitai Chai Meng Tian Huali Yu Xiaoxiao he Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

Multifunctional Nacre‑Like Nanocomposite Papers for Electromagnetic Interference Shielding via heterocyclic Aramid/MXene Template‑Assisted In‑Situ Polypyrrole Assembly

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Nano-Micro Letters 2025年第3期17卷 37-54页

作者： Jinhua Xiong Xu Zhao Zonglin Liu he Chen Qian yan Huanxin Lian Yunxiang Chen Qingyu Peng Xiaodong he National Key Laboratory of Science and Technology On Advanced Composites in Special Environments Center for Composite Materials and StructuresHarbin Institute of TechnologyHarbin 150080People’s Republic of China

Robust, ultra-flexible, and multifunctional MXene-basedelectromagnetic interference (EMI) shielding nanocomposite filmsexhibit enormous potential for applications in artificial intelligence,wireless telecommunication, and portable/wearable electronic *** this work, a nacre-inspired multifunctional heterocyclic aramid(HA)/MXene@polypyrrole (PPy) (HMP) nanocomposite paper withlarge-scale, high strength, super toughness, and excellent tolerance tocomplex conditions is fabricated through the strategy of HA/MXenehydrogel template-assisted in-situ assembly of PPy. Benefiting from the"brick-and-mortar" layered structure and the strong hydrogen-bondinginteractions among MXene, HA, and PPy, the paper exhibits remarkable mechanical performances, including high tensile strength (309.7 MPa),outstanding toughness (57.6 MJ m−3), exceptional foldability, and structural stability against ultrasonication. By using the template effect ofHA/MXene to guide the assembly of conductive polymers, the synthesized paper obtains excellent electronic conductivity. More importantly,the highly continuous conductive path enables the nanocomposite paper to achieve a splendid EMI shielding effectiveness (EMI SE) of 54.1 dBat an ultra-thin thickness (25.4 μm) and a high specific EMI SE of 17,204.7 dB cm2g−1. In addition, the papers also have excellent applicationsin electromagnetic protection, electro-/photothermal de-icing, thermal therapy, and fire safety. These findings broaden the ideas for developinghigh-performance and multifunctional MXene-based films with enormous application potential in EMI shielding and thermal management.

关键词： MXene Remarkable mechanical properties heterocyclic aramid Electromagnetic interference shielding Polypyrrole Multifunctionality

楼宇交直流混合供电模式下直流电压等级的研究

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中国电机工程学报 2017年第20期37卷 5840-5851页

作者：陈红坤何桂雄石晶闫华光武汉大学电气工程学院湖北省武汉市430072 中国电力科学研究院北京市海淀区100192

直流供电相比交流供电具有许多优点,但由于成本、直流开断技术、普通用户使用习惯等方面的限制,智能楼宇全面使用直流前,仍需经历交直流混合供电阶段。由楼宇配电的现状出发,探讨了未来楼宇交直流混合供电方式的整体结构及相应的交、直... 详细信息

直流供电相比交流供电具有许多优点,但由于成本、直流开断技术、普通用户使用习惯等方面的限制,智能楼宇全面使用直流前,仍需经历交直流混合供电阶段。由楼宇配电的现状出发,探讨了未来楼宇交直流混合供电方式的整体结构及相应的交、直流负荷分配情况,阐述了直流配电电压等级的选择原则。讨论了楼宇供电中超低压直流配电和低压直流配电电压等级的具体确定方法。综合各种因素,明确了超低压直流配电和低压直流配电中电压等级选择时可取范围的上限值和下限值,为我国楼宇直流供电中电压等级的最终确定提供依据。

关键词：混合交直流楼宇供电电压等级人体电流效应安全规定供电半径直流开断电应力

Unraveling post-growth mechanisms of monolayer CsPbBr3 nanocubes:Laser-enhanced transformations and cathodoluminescence-electron microscopy correlations

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Journal of Energy Chemistry 2025年第1期100卷 146-156页

作者： Mingxing Li Xiaoge Wang Xiaofan Cao Zhiqun he Chunjun Liang Mingxing Chen jing Ju Fangtian You Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronic Technology Beijing Jiaotong University Beijing National Laboratory for Molecular Sciences (BNLMS) College of Chemistry and Molecular Engineering Peking University

Lead-halide perovskite nanoparticles（LHP NPs） are highly promising materials for next-generation displays and solid-state lighting due to their exceptional optical properties. However, their inherent instability presents a significant challenge. Recent advances have demonstrated that optoelectronic devices based on monolayer nanoparticle films exhibit both high luminescence efficiency and long-term *** research demonstrates that mobility limitations and anisotropic alignments in CsPbBr3nanocube monolayer films are key to their stabilization, hindering spontaneous growth through face-to-face fusion and resulting in the formation of connecting necks in a diagonal direction. Introducing laser irradiation confirmed this by significantly accelerating nanocubes growth, increasing mobility, and enhancing local structural ordering, leading to larger and more regularly shaped nanosheets. Fourier transform infrared spectroscopy and energy dispersive spectroscopy line-scan analyses indicated that laser irradiation did not disrupt the ligand structure. Transmission electron microscopy and correlative cathodoluminescence electron microscopy revealed the effects of post-growth and heterogeneous structures, including enhanced luminescence and inhomogeneous intensity in the nanosheets. These findings deepen the understanding of the post-growth mechanism of monolayer nanoparticles and the structure-emission correlation and highlight the unique role of laser irradiation in directing the formation of well-defined and regular nanostructures.

关键词： Energy dispersive spectroscopy

Nano high-entropy oxide cathode with enhanced stability for direct borohydride fuel cells

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Journal of Energy Chemistry 2025年第1期100卷 309-316页

作者： Lei Zhang Lingfeng Kuang Lianke Zhang Wen Chu Haiying Qin jing Zhang Junjing he Hualiang Ni Hongzhong Chi New Energy Materials Research Center College of Materials and Environmental Engineering Hangzhou Dianzi University School of Materials Science and Engineering Zhejiang University Key Laboratory of MEMS of Ministry of Education School of Integrated Circuits Southeast University

High-entropy materials have become high-activity electrocatalysis owing to their high-entropy effect and multiple active ***,we synthesize a series of carbon-supported nano high-entropy oxides（heOs/C）,specifically （PtFeCoNiCu）O/C,using a carbothermal shock （CTS） method for application as a cathode catalyst in direct borohydride fuel cells （DBFCs）.The microstructure of the prepared catalysts was characterized by X-ray photoelectron spectroscopy,X-ray absorption fine structure,and transmission electron *** prepared （PtFeCoNiCu）O/C,with particle sizes ranging from 2 to 4 nm,demonstrates 3.94 transferred electrons towards the oxygen reduction reaction in an alkaline environment,resulting in a minimal H2O2yield of 2.6%.Additionally,it exhibits a Tafel slope of 61 mV dec-1,surpassing that of commercial Pt/C (82 mV dec-1).Furthermore,after 40,000 cycles of cyclic voltammetry（CV） testing,the half-wave potential of （PtFeCoNiCu）O/C shows a positive shift of 3 mV,with no notable decline in the limiting current *** （PtFeCoNiCu）O/C is used as a cathode catalyst in DBFCs,the DBFC achieves a maximum power density of 441 mW cm-2at 60°C and sustains a cell voltage of approximately 0.73 V after 52 h at 30°*** findings confirm that heO/C is a promising cathode catalyst for DBFCs.

关键词： Direct borohydride fuel cells (DBFC)