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Transvenous embolization of cavernous dural arteriovenous fistula:report of 28 cases

Chinese Medical Journal 2007年第24期120卷 2229-2232页

作者： he hong-wei jiang chu-han wu zhong-xue li you-xiang wang zhong-cheng Department of Neuroradiosurgery Beijing Neurosurgery InstituteBeijing Tiantan Hospital Capital Medical University Beijing100050 China

Background Usually, cavernous dural arteriovenous fistula can be treated via transarterial approaches. However, in many complicated patients, transvenous approaches are superior to the transarterial ones because of the difficulties during a transarterial operation. In this study, we retrospectively analyzed the outcomes of 28 patients with cavernous dural arteriovenous fistula treated by transvenous embolization. Methods From September 2001 to December 2005, 28 patients with 31 cavernous dural arteriovenous fistulae were treated with transvenous embolization in Beijing Tiantan Hospital. The involved cavernous sinuses were catheterized via the femoral vein-inferior petrosal sinus approach or the femoral-facial-superior ophthalmic vein approach, and embolized with coils （GDC, EDC, Matrix, Orbit or free coil） or coils plus silk. The patients were followed up for 3 to 26 months. Results All the 31 cavernous sinuses in the 28 patients were successfully embolized. Complete angiographic obliteration of the fistulae was achieved immediately in 25 patients. Residual shunting was observed in the other 3, who had drainage through the pterygoid plexus （2 patients） or the inferior petrosal sinus （1） after the operation. headache and vomiting were the most common symptoms after the embolization. In 3 patients, who achieved complete angiographic obliteration immediately, the left oculomotor nerve palsy remained unchanged after the operation. Transient abducens nerve palsy was encountered in 1. In 1 patient, the occular symptoms were improved after the operation, but recurred 4 days later, and then disappeared spontaneously after 5 days. During the follow-up, no patient had recurrence. Three months after the operation, angiography was performed on the 3 patients with residual shunting. Two of them had angiographic cure, the other had residual drainage through the pterygoid plexus. Conclusions Transvenous catheterization and embolization of the cavernous sinus is a safe and ef

关键词： transvenous cavernous sinus dural arteriovenous fistula embolization

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Transvenous embolization with a combination of detachable coils and Onyx for a complicated cavernous dural arteriovenous fistula

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Chinese Medical Journal 2008年第17期121卷 1651-1655页

作者： he hong-wei jiang chu-han wu zhong-xue li you-xiang LU Xian-li wang zhong-cheng Department of Neuroradiosugery Beijing Neurosurgery Institute Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background Treatment of cavernous dural arteriovenous fistulas （DAVF） is usually made by a transarterial approach. However, in many complicated patients, treatments via transarterial approaches can not be achieved, and only an operation via a transvenous approach is feasible. We aimed to study the feasibility of transarterial embolization of cavernous dural arteriovenous fistulas with a combination detachable coils and Onyx to embolize a complicated cavernous DAVF via a transvenous approach. Methods From August 2006 to August 2007, six cases of complicated cavernous DAVF were embolized with a combination of detachable coils and Onyx via a transvenous approach. Three cases were male and the other three were female. Their ages ranged from 36 to 69 years old. The fistula was in the right lateral cavernous sinus in one case, in the left lateral cavernous sinus in another, and in the bilateral cavernous sinus in 4 cases. One fistula was fed by the right internal carotid artery and its meningohypophyseal trunk; one was fed by the branches of the left internal carotid artery and left external carotid artery; four were fed by the branches of the bilateral internal carotid artery and/or the bilateral external carotid artery. One case was drained via one lateral inferior petrosal sinus; three were drained via bilateral inferior petrosal sinuses; one was drained via one lateral ophthalmic and facial veins; one was drained via the inferior petrosal sinus and the ophthalmic and facial veins. Four were embolized via the inferior petrosal sinus, and two were embolized via the ophthalmic and facial veins. Results Among six cases of complicated cavernous DAVF, four were fully embolized with Onyx by a single operation, and two cases were fully embolized with Onyx following two operations. Transient headache was found after operation in all patients, but was cured after several days by the symptomatic treatments. In one case, the first operation via the inferior petrosal sinus was a f

关键词： transvenous cavernous dural arteriovenous fistula embolization Onyx detachable coils

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Endovascular treatment of cerebral arteriovenous malformations with Onyx embolization

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Chinese Medical Journal 2005年第24期118卷 2041-2045页

作者： he hong-wei jiang chu-han liU hong-bing li you-xiang ZhanG Jing-bo wu zhong-xue Department of Neurosurgery Qilu Hospital Shandong UniversityJinan 250012 China Department of Neuroradiosugery Beijing Neurosurgery Institute Beijing 100050China

Background In the past 5 years, new treatment materials and techniques offering a different concept in endovascular treatment have been described for cerebral arteriovenous malformations （CAVMs）. The aim of this study was to assess the endovascular treatment of CAVMs by using a liquid embolic material, Onyx （ Micro Therapeutics. Inc. , Irvine, CA, USA）. Methods From September 2003 to September 2004, Onyx was used to treat 22 patients with CAVMs. Ten AVMS were located in functional areas, 8 in deep cerebral areas, and 4 in the cerebellar hemisphere. The size of CAVMs was about 3 cm in diameter in 5 patients, 3 -6 cm in 11, and more than 6 cm in 6. Results In the 22 patients, Onyx embolization was successful. Nidus occlusion was complete in 3 patients, 〉 90% in 8, 〉 80% and 〈 90% in 6, and 〉 50% and 〈 80% in 5. Complications included transient neurological deficits in 2 patients, and adherence of microcatheter to the site of injection in 2. Conclusions Being non-adhesiveness, Onyx is a safe and satisfactory embolic material in the treatment of CAVMs. But its long-term efficacy awaits further follow-up.

关键词： cerebral arteriovenous malformations embolization, therapeutic Onyx copolymer

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Endovascular Treatment of the Huge Dissecting Aneurysms Involving the Basilar Artery by the Internal Trapping Technique： Technical Note

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Chinese Medical Journal 2015年第14期128卷 1916-1921页

作者： Shi-Qing Mu Xin-Jian Yang you-xiang li chu-han jiang zhong-xue wu Department of Interventional Neuroradiology Beijing Neurosurgical Institute and Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background： The endovascular strategy of the huge dissecting aneurysms involving the basilar artery （BA） is controversial and challenging. This study was to investigate the clinical and angiographic outcomes of the treatment of the huge dissecting aneurysms involving the BA by the internal trapping （IT） technique. Methods： We retrospectively studied 15 patients with the huge dissecting aneurysms involving the BA treated by the IT technique between September 2005 and September 2014 in Department of Interventional Neuroradiology of Beijing Tiantan Hospital. Clinical and angiographic data were reviewed and evaluated. Results： All patients were treated by the IT technique. That meant the dissecting artery and aneurysm segments were completed occlusion. After the procedure, the angiography demonstrated that all the dissecting artery and aneurysm segments were completed occlusion. Follow-up angiography was performed at 3-6 months or 12-18 months alter the endovascular treatment （median 8 months）, 14 patients had a good recovery. Re-canalization occurred in one patient whose aneurysm involved in bilateral vertebral arteries and the two third of the middle-lower BA. After the second treatment, the patient died by the ventricular tachycardia. Conclusions： The IT technique is a technically feasible and safe alternative for the treatment of BA dissecting aneurysms, but it is not necessarily the safest or most definitive treatment modality. The ideal treatment of the huge dissecting aneurysms involving the BA remains debatable and must be investigated on a case-by-case basis.

关键词： Basilar Artery Endovascular Treatment Huge Dissecting Aneurysms Internal Trapping Technique

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Comorbidity Burden of Dementia:A Hospital-Based Retrospective Study from 2003 to 2012 in Seven Cities in China

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Neuroscience Bulletin 2017年第6期33卷 703-710页

作者： Qing-Hua wang Xin wang Xian-Le Bu Yan lian Yang xiang hong-Bo Luo Hai-Qiang Zou Jie Pu zhong-he Zhou Xiao-Ping Cui Qing-Song wang xiang-Qun Shi wei han Qiang wu Hui-Sheng Chen hang lin Chang-Yue Gao li-li Zhang Zhi-Qiang Xu Meng Zhang Hua-Dong Zhou Yan-jiang wang Department of Neurology and Center for Clinical Neuroscience Daping HospitalThird Military Medical UniversityChongqingChina Department of Preventive Medicine Daping HospitalThird Military Medical UniversityChongqingChina Department of Neurology Chengdu General Hospital of the PLAChengduChina Department of Neurology Lanzhou General Hospital of the PLALanzhouChina Department of Neurology Guangzhou General Hospital of the PLAGuangzhouChina Department of Neurology Wuhan General Hospital of the PLAWuhanChina Department of Neurology Shenyang General Hospital of the PLAShenyangChina Department of Neurology Fuzhou General HospitalFujian Medical UniversityFuzhouChina Department of Prevention Medicine Guangzhou General Hospital of the PLAGuangzhouChina

Dementia is increasing dramatically and imposes a huge burden on society. To date, there is a lack of data on the health status of patients with dementia in China. In an attempt to investigate the comorbidity burden of dementia patients in China at the national level, we enrolled 2,938 patients with Alzheimer＇s disease（AD）, vascular dementia（Va D）, or other types of dementia, who were admitted to tertiary hospitals in seven regions of China from January2003 to December 2012. The Charlson Comorbidity Index（CCI） was used to evaluate the comorbidity burden of the patients with dementia. Among these patients, 53.4% had AD, 26.3% had Va D, and 20.3% had other types of dementia. The CCI was 3.0 ± 1.9 for all patients,3.4 ± 1.8 for those with Va D, and 3.0 ± 2.1 for those with AD. The CCI increased with age in all patients, andthe length of hospital stay and daily expenses rose with age and CCI. Males had a higher CCI and a longer stay than females. Moreover, patients admitted in the last 5 years of the study had a higher CCI than those admitted in the first 5 years. We found that the comorbidity burden of patients with dementia is heavy. These findings provide a better understanding of the overall health status of dementia patients, and help to increase the awareness of clinicians and policy-makers to improve medical care for patients.

关键词： Alzheimer’s disease Vascular dementia Prevalence Comorbidity Charlson comorbidity index

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经静脉入路栓塞治疗颈动脉海绵窦瘘

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中国医学科学院学报 2005年第1期27卷 35-37页

作者：李佑祥姜除寒吴中学中国医学科学院中国协和医科大学神经科学研究所血管内治疗研究室北京100050

目的评估经静脉入路栓塞治疗颈动脉海绵窦瘘(CCF)的方法。方法回顾性分析17例经静脉入路栓塞治疗颈动脉海绵窦瘘患者,其中女性14例,男3例;BarrowA型1例,B型1例,C型1例,D型14例。结果经岩下窦入路栓塞海绵窦9例,经眼静脉入路栓塞6例,经... 详细信息

目的评估经静脉入路栓塞治疗颈动脉海绵窦瘘(CCF)的方法。方法回顾性分析17例经静脉入路栓塞治疗颈动脉海绵窦瘘患者,其中女性14例,男3例;BarrowA型1例,B型1例,C型1例,D型14例。结果经岩下窦入路栓塞海绵窦9例,经眼静脉入路栓塞6例,经两种入路栓塞1例(双侧瘘)。12例治疗后即刻造影显示海绵窦和瘘口完全闭塞;4例虽海绵窦闭塞,但仍残留少许岩下窦的引流(2例为眼静脉入路者)和翼丛引流(2例)。1例面静脉-眼静脉入路,插管过程中面静脉痉挛,手术失败,患者在5d后自发症状缓解,7d后动脉造影显示CCF已自愈。结论经静脉入路栓塞颈动脉海绵窦瘘,特别是海绵窦区硬脑膜动静脉瘘(DAVF),效果确实,操作风险小。

关键词：颈动脉海绵窦瘘静脉入路栓塞

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A novel inhibitor of ARfl and ARv7 induces protein degradation to overcome enzalutamide resistance in advanced prostate cancer

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Acta Pharmaceutica Sinica B 2022年第11期12卷 4165-4179页

作者： Yan li Ya chu Guangjiang Shi Xiaobin wang Wanli Ye chun Shan Dajia wang Di Zhang wei he Jingwei jiang Shuqian Ma Yuhong han Zhili Zhao Shijia Du Zhen Chen Zhiyu li Yong Yang Chen wang Xi Xu hongxi wu Center for New Drug Safety Evaluation and Research State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 211198China School of life Science and Technology China Pharmaceutical UniversityNanjing 211198China School of Pharmacy China Pharmaceutical UniversityNanjing 211198China jiangsu Key Lab of Drug Screening China Pharmaceutical UniversityNanjing 211198China

Enzalutamide(ENZ) is a second-generation androgen receptor(AR) antagonist used for the treatment of castration-resistant prostate cancer(CRPC) and reportedly prolongs survival time within a year of starting therapy. However, CRPC patients can develop ENZ resistance(ENZR), mainly driven by abnormal reactivation of AR signaling, involving increased expression of the full-length AR(ARfl)or dominantly active androgen receptor splice variant 7(ARv7) and ARfl/ARv7 heterodimers. There is currently no efficient treatment for ENZR in CRPC. herein, a small molecule LLU-206 was rationally designed based on the ENZ structure and exhibited potent inhibition of both ARfl and constitutively active ARv7 to inhibit PCa proliferation and suppress ENZR in CRPC. Mechanically, LLU-206 promoted ARfl/ARv7 protein degradation and decreased ARfl/ARv7 heterodimers through mouse double minute 2-mediated ubiquitination. Finally, LLU-206 exhibited favorable pharmacokinetic properties with poor permeability across the blood-brain barrier, leading to a lower prevalence of adverse effects, including seizure and neurotoxicity, than ENZ-based therapies. In a nutshell, our findings demonstrated that LLU-206 could effectively inhibit ARfl/ARv7-driven CRPC by dual-targeting of ARfl/ARv7 heterodimers and protein degradation, providing new insights for the design of new-generation AR inhibitors to overcome ARfl/ARv7-driven CRPC.

关键词： Drug resistance Enzalutamide Castration-resistant prostate cancer Androgen receptorsplice variant7 heterodimers Degradation

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo Yong-heng Zhao Gang Zhao li-Cai Deng Xiao-wei liu Yi-Peng Jing Gang wang Hao-Tong Zhang Jian-Rong Shi xiang-Qun Cui Yao-Quan chu Guo-Ping li zhong-Rui Bai Yue wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen li Chen xue-Lei Chen Xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-wei Fan Lei Feng Jian-Ning Fu Peng Gao xue-Fei Gong Bo-zhong Gu Yan-Xin Guo Zhan-Wen han Bo-liang he Jin-liang Hou Yong-Hui Hou Wen Hou hong-Zhuan Hu Ning-Sheng Hu zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua jiang xiang jiang Zhi-Bo jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua li Chang-Hua li Guang-wei li Hai-Ning li Jian li Qi li Shuang li Sha-Sha li Xin-Nan li Yan li Yin-Bi li Ye-Ping li Yuan liang Chien-cheng lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu Wen-Zhi Lu Yu Luo Yin-Dun Mao heidi Newberg Ji-Jun Ni Zhao-xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-han Song Ding-Qiang Su hong-Jun Su Zheng-hong Tang Qing-Sheng Tao Yuan Tian Dan wang Da-Qi wang Feng-Fei wang Guo-Min wang Hai wang hong-Chi wang Jian wang Jia-Ning wang Jian-ling wang Jian-Ping wang Jun-Xian wang Lei wang Meng-Xin wang Shou-Guan wang Shu-Qing wang Xia wang Ya-Nan wang you wang Yue-Fei wang you-Fen wang Peng wei Ming-Zhi wei hong wu Ke-Fei wu xue-Bing wu Yu-zhong wu Xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-Feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan wei-Min Yuan Chao Zhai En-Peng Zhang Hua-wei Zhang Jian-Nan Zhang li-Pin Zhang wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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Was chicken domesticated in northern China?New evidence from mitochondrial genomes

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Science Bulletin 2018年第12期63卷 743-746页

作者： Xun-he Huang Ya-jiang wu Yong-wang Miao Min-Sheng Peng Xing Chen Dan-lin he Chatmongkon Suwannapoom Bing-wang Du Xian-Yao li Zhuo-Xian Weng Si-Hua Jin Jiao-Jiao Song Ming-Shan wang Jie-Bo Chen wei-Na li Newton Otieno Otecko Zhao-Yu Geng xiang-Yong Qu Yan-Ping wu Xiu-Rong Yang Jie-Qiong Jin Jian-lin han Fu-Sheng zhong Xi-Quan Zhang Ya-Ping Zhang School of life Sciences.flaying University.Meizhou 514015.China State Key Laboratory for Conservation and Utilization of Bio-resources in Yunnan Yunnan UniversityKunming 650091China Faculty of Animal Science and Technology.Yunnan Agricultural University.Kunming 650201.China State Key Laboratory of Genetic Resources and Evolution and Yunnan Laboratory of Molecular Biology of Domestic Animals.kunming Institute of Zoology.Chinese Academy of Sciences.Kunming 650223.China College of Animal Sciences.South China Agricultural University.Guangzhou 510642.China School of Agriculture and Natural Resources.University of Phayao.Phayao 56000.Thailand College of Agriculture.Guangdong Ocean University.Zhanjiang 524088.China College of Animal Science and Technology.Shandong Agricultural University.Taian 271018.China College of Animal Science and Technology.Hunan Agricultural University.Changsha 410128.China College of Animal Science and Technology.Anhui Agricultural University.hefei 230036.China Institute of Animal Science.jiangxi Academy of Agricultural Sciences.Nanchang 330200.China College of Animal Science and Technology.Guangxi University.Nanning 530004.China Kunming College of life Science.University of Chinese Academy of Sciences.Kunming 650204.China Southeast Asia Biodiversity Research Institute.Chinese Academy of Sciences(CAS-SEABRI).Yezin 05282.Myanmar CAAS-ILRI Joint Laboratory on livestock and Forage Genetic Resources.Institute of Animal Science.Chinese Academy of Agricultural Sciences(CAAS).Beijing 100193.China International livestock Research Institute(ILRI).Nairobi 00100.Kenya

The timing and location of chicken(Gallus gallus domesticus)domestication have remained controversial for over a century[1].Several researchers have proposed China as one of the early centers for chicken domestication[2].This is based on a few archaeological‘‘chicken"remains discovered in China(Table S1).Recently,one investigation detected mitochondrial DNA(mt DNA)haplotypes

关键词：鸡肉中国染色体驯养证据研究人员职业人员 DNA

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Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang li li‑Jiao wang xiang‑Biao Qiu Jing‑Wen li wei Xu Tao li Ze‑Bin lin Chang‑Jun Ning Yong‑Hao Chen Rui‑Rui Fan Kang Sun Jing‑Yu Tang Rong Zhang han‑Tao Jing Bo Mei Qi An Hao‑Fan Bai jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen Zhen Chen Zeng‑Qi Cui An‑chuan Fan Chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing Gao Min‑Hao Gu Chang‑Cai han Zi‑Jie han Guo‑Zhu he Yong‑cheng he Yang hong Yi‑wei Hu han‑Xiong Huang wei‑Hua Jia Hao‑Yu jiang wei jiang Zhi‑Jie jiang Zheng‑Yao Jin ling Kang Bo li Chao li Gong li Jia‑Wen li Xiao li Yang li Jie liu Rong liu Shu‑Bin liu Guang‑Yuan Luan Bin‑Bin Qi Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑cheng wang Zhao‑Hui wang zhong‑wei Wen Xiao‑Guang wu Xuan wu li‑Kun Xie Yi‑wei Yang han Yi Yong‑Ji Yu Guo‑Hui Zhang lin‑Hao Zhang Mo‑han Zhang Qi‑wei Zhang Xian‑Peng Zhang Yu‑liang Zhang Yue Zhang Zhi‑Yong Zhang Mao‑Yuan Zhao Lu‑Ping Zhou Zhi‑Hao Zhou Ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

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