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Efficacy and safety of modified medium-chain triglyceride ketogenic diet in patients with drug-resistant epilepsy

Acta Epileptologica 2024年第1期7卷 44-52页

作者： hua Li Yao Wang Jing Guo Peiqi Zhang Zheng Xu Kai Peng Xiaoli dong Liming Zhao Department of Neurology Guangdong Sanjiu Brain HospitalGuangzhou510510China

Background Medium-chain triglyceride ketogenic diet(MCTKD)is previously less commonly used in *** study was aimed to assess the efficacy and safety of the modified MCTKD in the treatment of drug-resistant epilepsy in Chinese *** Patients with drug-resistant epilepsy were enrolled to receive treatment with modified MCTKD in Guangdong Sanjiu Brain Hospital during December 2020 and September *** modified MCTKD contained fat that provided 50–70%of the total energy,as well as proteins and carbohydrates that provided 20–30%and 20%of energy,*** fat component was composed of 20–30%medium-chain triglycerides(MCTs)and 30–40%long-chain *** efficacy and safety of the diet were assessed at 1,3 and 6 *** A total of 123 patients aged 2.5 to 65 years,were included in this *** response rates at 1,3 and 6 months were 49.6%,43.1%,and 30.9%,*** seizure freedom rates at 1,3 and 6 months were 12.2%,10.6%,and 6.5%,*** retention rates at 1,3 and 6 months were 98.4%,65.0%and 33.3%*** effects occurred in 21.14%of patients,which were predominantly gastrointestinal symptoms such as abdominal pain,diarrhea,vomiting,and constipation,and most of them resolved after dietary adjustments.A total of 82 patients(66.7%)discontinued the treatment with the reason of refusing to eat(8.1%),poor efficacy(35.0%),poor compliance(4.9%),and inability to follow-up(9.8%).Only 4 patients(3.3%)withdrew the diet due to side *** The modified MCTKD with MCTs providing 20–30%of energy has a good safety in patients with drug-resistant epilepsy,but its effectiveness needs to be *** modifications of MCTKD with an optimal energy ratio are required to achieve a better efficacy and safety.

关键词： Medium-chain triglyceride ketogenic diet Ketogenic diet Drug-resistant epilepsy Efficacy Safety

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Bid蛋白在内质网和线粒体相关的凋亡过程中的作用

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中华血液学杂志 2007年第7期28卷 466-469页

作者：胡洁何冬花高良杨春虎蔡真浙江大学医学院附属第一医院血液科骨髓移植中心杭州310003 浙江大学医学院生物电磁学省重点实验室

目的研究 Bid 蛋白在内质网和线粒体相关的凋亡过程中的作用。方法以高三尖杉酯碱(HHT)诱导人骨髓增生异常综合征(MDS)细胞系 MUTZ-1细胞凋亡,用流式细胞术检测细胞凋亡率,RT-PCR 及 Western blot 法检测线粒体和内质网凋亡途径的相关... 详细信息

目的研究 Bid 蛋白在内质网和线粒体相关的凋亡过程中的作用。方法以高三尖杉酯碱(HHT)诱导人骨髓增生异常综合征(MDS)细胞系 MUTZ-1细胞凋亡,用流式细胞术检测细胞凋亡率,RT-PCR 及 Western blot 法检测线粒体和内质网凋亡途径的相关基因及蛋白表达,激光共聚焦显微镜观察用药前后钙离子浓度和线粒体膜电位的改变以及凋亡相关蛋白 Bid 的转位。结果 0.05μg/ml HHT 作用后4 h胞质内 Ca^(2+)浓度增高,12 h达高峰,其后开始下降。HHT 作用后线粒体膜电位持续下降。内质网应激相关因子基因及蛋白表达增强,12 h达到高峰,其后开始下降。激光共聚焦显微镜观察发现 Bid 蛋白用药前位于内质网,用药12 h后转位至线粒体。结论 HHT 可以诱导 MDS 细胞凋亡,内质网和线粒体相关的凋亡途径在其中发挥了重要的作用,Bid 蛋白可能是两种凋亡途径的交叉点。

关键词： Bid蛋白线粒体细胞凋亡 MUTZ-1细胞

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罗哌卡因复合瑞芬太尼腰麻-硬膜外麻醉在分娩镇痛中的价值

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医学信息 2022年第17期35卷 57-59页

作者：何华东东乡区人民医院麻醉科

目的探讨罗哌卡因复合瑞芬太尼腰麻-硬膜外麻醉（CSEA）在分娩镇痛中的应用价值。方法选取2020年1月-2021年6月东乡区人民医院行CSEA分娩镇痛的产妇84例为研究对象，随机分为镇痛A组和镇痛B组，每组42例。镇痛A组应用罗哌卡因麻醉，镇... 详细信息

目的探讨罗哌卡因复合瑞芬太尼腰麻-硬膜外麻醉（CSEA）在分娩镇痛中的应用价值。方法选取2020年1月-2021年6月东乡区人民医院行CSEA分娩镇痛的产妇84例为研究对象，随机分为镇痛A组和镇痛B组，每组42例。镇痛A组应用罗哌卡因麻醉，镇痛B组应用罗哌卡因联合瑞芬太尼麻醉。比较不同时间节点两组产妇心率、平均动脉压、疼痛评分，两组麻醉起效时间、麻醉起效后1 h Ramsay评分、产程及剖宫产率。结果麻醉镇痛后1 h，两组心率均低于麻醉镇痛前，镇痛B组高于镇痛A组，差异有统计学意义（P0.05）；分娩后1 h，镇痛A组心率高于镇痛前和镇痛B组，平均动脉压低于镇痛前和镇痛B组，差异有统计学意义（P<0.05）；麻醉镇痛后1 h、分娩后1 h，两组VAS评分低于麻醉镇痛前，镇痛B组低于镇痛A组，差异有统计学意义（P<0.05）；镇痛B组麻醉起效时间、产程短于镇痛A组，麻醉起效后1 h Ramsay评分高于镇痛A组，剖宫产率低于镇痛A组，差异有统计学意义（P<0.05）。结论罗哌卡因复合瑞芬太尼CSEA能够达到较好的分娩镇痛效果，能够促进产妇血流动力学稳定，缩短产程，减少剖宫产率。

关键词：罗哌卡因瑞芬太尼分娩镇痛

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Impact of metabolic syndrome components on clinical outcomes in hypertriglyceridemia-induced acute pancreatitis

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World Journal of Gastroenterology 2024年第35期30卷 3996-4010页

作者： Zhen-hua Fu Zi-Yue Zhao Yao-Bing Liang dong-Yu Cheng Jian-Ming Luo Hai-Xing Jiang Shan-Yu Qin Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND The incidence of hypertriglyceridemia(HTG)-induced acute pancreatitis(AP)is steadily increasing in China,becoming the second leading cause of *** complications and outcomes associated with HTG-AP are generally more severe than those seen in AP caused by other ***-AP is closely linked to metabolic dysfunction and frequently coexists with metabolic syndrome or its ***,the impact of metabolic syndrome components on HTGAP clinical outcomes remains *** To investigate the impact of metabolic syndrome component burden on clinical outcomes in *** In this retrospective study of 255 patients diagnosed with HTG-AP at the First Affiliated Hospital of Guangxi Medical University,we collected data on patient demographics,clinical scores,complications,and clinical ***,we analyzed the influence of the presence and number of individual metabolic syndrome components,including obesity,hyperglycemia,hypertension,and low high-density lipoprotein cholesterol(HDL-C),on the aforementioned parameters in HTG-AP *** This study found that metabolic syndrome components were associated with an increased risk of various complications in HTG-AP,with low HDL-C being the most significant risk factor for clinical *** risk of complications increased with the number of metabolic syndrome *** for age and sex,patients with highcomponent metabolic syndrome had significantly higher risks of renal failure[odds ratio(OR)=3.02,95%CI:1.12-8.11)],SAP(OR=5.05,95%CI:2.04-12.49),and intensive care unit admission(OR=6.41,95%CI:2.42-16.97)compared to those without metabolic *** The coexistence of multiple metabolic syndrome components can synergistically worsen the clinical course of HTGAP,making it crucial to monitor these components for effective disease management.

关键词： Hypertriglyceridemia-induced acute pancreatitis Metabolic syndrome High density lipoprotein cholesterol Obesity Hyperglycemia Hypertension Clinical outcomes

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SnO_(2)/metal organic complex composite derived from low-temperature activated metal organic complex for advanced lithium storage

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Rare Metals 2024年第7期43卷 3032-3043页

作者： Gui-Long Liu Zi-Han Zhao Jin-Ke Shen Zi-Bo Zhao Nai-Teng Wu dong-Lei Guo Wei-Wei Yuan Yong Liu Ye-hua Su Xian-Ming Liu Luoyang Key Laboratory of Green Energy Materials College of Chemistry and Chemical EngineeringLuoyang Normal UniversityLuoyang 471934China School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China Inner Mongolia Shijie Chemical Co. Ltd.Alxa League 737300

Sn-based metal organic complexes with coordination bonds,multi-active sites,and high theoretical capacity have attracted much attention as promising anodes for lithium ion ***,the low electrical conductivity and huge volume changes restricted their electrochemical stability and practical ***,Snbased anode with superior electrochemical performance,including a high reversible capacity of 1050.1 mAh·g^(-1)at 2 A·g^(-1)and a stable capacity of 1105.5 mAh·g^(-1)after 500 cycles at 1 A·g^(-1),was fabricated via a low-temperature calcination strategy from Sn metal organic *** low-temperature calcination process regulates Sn-O bond and prevents the agglomeration of SnO_(2),generating highly dispersed SnO_(2) decorated metal organic complexes and providing sufficient active sites for ion *** situ characterizations expound that the undecomposed Sn-based metal organic complexes could be transformed into SnO_(2) during lithiation and delithiation,which enhances the electrical conductivity and induces a strong pseudo-capacitive behavior,accelerating the electrochemical kinetics;the multiple solid electrolyte interface with inflexible LiF and flexible ROCO_(2)Li buffers the volume variation of the electrode,resulting in its high electrochemical *** work provides a simple strategy for preparing excellent Sn-based anodes from metal organic complexes and reveals the lithium storage mechanism of the prepared Snbased anode.

关键词： Metal organic complex Lithium ion battery Electrochemical activation Low-temperature activation Partial decomposition

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碳化物特征对GH3536合金冷变形损伤的影响及控制

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金属学报 2024年第4期60卷 464-472页

作者：余华李昕江河姚志浩董建新北京科技大学材料科学与工程学院北京100083

为了研究碳化物对GH3536合金冷变形损伤的影响并加以控制,通过薄带材的冷轧变形和圆柱试样的压缩变形,观察了碳化物破裂以及基体局部开裂的现象,并结合有限元模拟结果,进一步探讨了碳化物形貌与分布特征对组织损伤的影响。结果表明,当... 详细信息

为了研究碳化物对GH3536合金冷变形损伤的影响并加以控制,通过薄带材的冷轧变形和圆柱试样的压缩变形,观察了碳化物破裂以及基体局部开裂的现象,并结合有限元模拟结果,进一步探讨了碳化物形貌与分布特征对组织损伤的影响。结果表明,当碳化物尺寸较大、形状不规则且呈团聚分布时,其内部应力与破裂倾向较大,而小尺寸圆形碳化物的情况与之相反。碳化物的团聚与条带状分布是引起基体应力和开裂倾向增加的主要原因。热处理结果表明,通过将热处理温度提高到1150℃以上,可以明显改善小尺寸碳化物的团聚和条带状分布特征,但对于10μm以上的大尺寸碳化物改善效果不明显。

关键词： GH3536合金冷变形热处理碳化物破裂

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Low RBC counts predict high on-treatment platelet reactivity in patients undergoing percutaneous coronary intervention and treated with clopidogrel

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The Journal of Biomedical Research 2024年第1期38卷 87-91页

作者： Qian Gu Qin Wang Rui hua Wenhao Zhang Jianzhen Teng Jiazheng Ma Zhou dong Xiaoxuan Gong Chunjian Li Department of Cardiology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

Dear Editor,Cardiovascular disease is the leading cause of deaths worldwide,with coronary artery disease(CAD)accounting for approximately 50%of its *** antiplatelet therapy,including aspirin and a P2Y12 inhibitor,is the most important treatment for CAD patients undergoing percutaneous coronary intervention(PCI)to prevent recurrent ischemic events and cardiac *** is one of the commonly used P2Y12 ***,up to 30%of patients treated with a standard dose of clopidogrel present with high on-treatment platelet reactivity(HOPR),which is associated with the increased ischemic risks[1].The causes of HOPR are multifactorial and complex.

关键词： coronary patients mortality

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Electroacupuncture with different waveforms for primary dysmenorrhea:A randomized controlled trial

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Journal of Traditional Chinese Medical Sciences 2024年第3期11卷 357-362页

作者： Xiaona Wu Jingxue Yuan Jinxia Ni Xiuli Ma Ziniu Zhang Yini hua Juwei dong Bob Peng Wang dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China New Zealand College of Chinese Medicine Auckland 17467New Zealand

Objective To observe and compare the clinical effects of different electroacupuncture waveforms on primary *** This was a prospective,randomized,three-group,parallel-controlled *** with primary dysmenorrhea were randomly divided into dense-sparse wave,continuous wave,and discontinuous wave groups in a 1:1:1 *** lateral Ciliao(BL 32)points were *** three groups started treatment 3–5 days before menstruation,once a day for six sessions per course of treatment,one course of treatment per menstrual cycle,and three menstrual *** primary outcome measure was the proportion with an average visual analog scale(VAS)score reduction of≥50%from baseline for dysmenorrhea in the third menstrual cycle during *** secondary outcome measures included changes in dysmenorrhea VAS scores,Cox Menstrual Symptom Scale scores and the proportion of patients taking analgesic *** The proportion of cases where the average VAS score for dysmenorrhea decreased by≥50%from baseline in the third menstrual cycle was not statistically significant(P>.05).Precisely 30 min after acupuncture and regarding immediate analgesia on the most severe day of dysmenorrhea,there was a statistically significant difference in the dense-sparse wave group compared with the other two groups during the third menstrual cycle(Phere was a statistically significant difference between the dense-sparse wave and discontinuous wave groups 24 h after acupuncture(Phea and its related symptoms in *** three groups showed similar results in terms of short-and long-term analgesic efficacy and a reduction in the number of patients taking analgesic *** achieving immediate analgesia,the dense-sparse wave group was slightly better than the other two groups.

关键词： Waveforms Ciliao(BL 32) Electroacupuncture Primary dysmenorrhea Randomized controlled trial Dense-sparse waves Continuous waves Discontinuous waves

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Plastid phylogenomics provides new insights into the systematics,diversification,and biogeography of Cymbidium(Orchidaceae)

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Plant Diversity 2024年第4期46卷 448-461页

作者： Hai-Yao Chen Zhi-Rong Zhang Xin Yao Ji-dong Ya Xiao-hua Jin Lin Wang Lu Lu De-Zhu Li Jun-Bo Yang Wen-Bin Yu Center for Integrative Conservation&Yunnan Key Laboratory for the Conservation of Tropical Rainforests and Asian Elephants Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnan 666303China University of Chinese Academy of Sciences Huairou DistrictBeijing 101408China Plant Germplasm and Genomics Center Germplasm Bank of Wild SpeciesKunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China State Key Laboratory of Plant Diversity and Specility Crops Institute of BotanyChinese Academy of SciencesHaidian DistrictBeijing 100093China School of Pharmaceutical Sciences Yunnan Key Laboratory of Pharmacology for Natural Productsand Yunnan College of Modern Biomedical IndustryKunming Medical UniversityKunmingYunnan 650500China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar

Cymbidium(Orchidaceae:Epidendroideae),with around 60 species,is widely-distributed across Southeast Asia,providing a nice system for studying the processes that underlie patterns of biodiversity in the ***,phylogenetic relationships of Cymbidium have not been well resolved,hampering investigations of species diversification and the biogeographical history of this *** this study,we construct a plastome phylogeny of 56 Cymbidium species,with four well-resolved major clades,which provides a framework for biogeographical and diversification rate *** dating and biogeographical analyses show that Cymbidium likely originated in the region spanning northern IndoBurma to the eastern Himalayas during the early Miocene(~21.10 Ma).It then rapidly diversified into four major clades in East Asia within approximately a million years during the middle *** *** to the adjacent regions(Borneo,Philippines,and Sulawesi)primarily occurred during the Pliocene-Pleistocene *** analyses indicate that the net diversification rate of Cymbidium has decreased since its origin,and is positively associated with changes in temperature and monsoon *** hydrothermal conditions brought by monsoon intensification in the early Miocene possibly contributed to the initial rapid diversification,after which the net diversification rate was reduced with the cooling climate after the middle *** transition from epiphytic to terrestrial habits may have enabled adaptation to cooler environments and colonization of northern niches,yet without a significant effect on diversification *** study provides new insights into how monsoon activity and temperature changes affected the diversification dynamics of plants in Southeast Asia.

关键词： Cymbidium East Asia Asian monsoons Climate change Biogeographical patterns

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一种基于IGA的融合点云和影像的建筑物提取方法

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红外与毫米波学报 2024年第1期43卷 116-125页

作者：赖旭东骈蔚然薄立明何丽华武汉大学遥感信息工程学院湖北武汉430079 武汉大学中国发展与战略规划研究院湖北武汉430079 湖北省地理国情监测中心湖北武汉430000

针对精细化实景三维建筑物建模,提出一种基于改进遗传算法(IGA)的建筑物LiDAR点云与正射影像融合提取方法:计算并提取基于点云和影像的特征,实现点云特征空间的扩张;再改进遗传算法选择点云特征,构建并优化特征空间;最后使用SVM分类器... 详细信息

针对精细化实景三维建筑物建模,提出一种基于改进遗传算法(IGA)的建筑物LiDAR点云与正射影像融合提取方法:计算并提取基于点云和影像的特征,实现点云特征空间的扩张;再改进遗传算法选择点云特征,构建并优化特征空间;最后使用SVM分类器实现建筑物点云的精准提取。在ISPRS公开数据集Vaihingen测试数据的试验表明本文方法具有较高的建筑物提取精度;在实际生产数据的实验表明建筑物提取精度较高且稳定,证明了本文方法的先进性和普适性。

关键词：遥感信息工程 LiDAR点云特征选择建筑物提取

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