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Low-intensity pulsed ultrasound reduces alveolar bone resorption during orthodontic treatment via Lamin A/C-Yes-associated protein axis in stem cells

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World Journal of Stem Cells 2024年第3期16卷 267-286页

作者： Tong Wu fu Zheng Hong-Yi Tang Hua-Zhi Li Xin-Yu Cui Shuai Ding Duo Liu Cui-ying Li Jiu-Hui Jiang Rui-Li Yang Department of Orthodontics Peking University School and Hospital of StomatologyNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China Department of Central Laboratory Peking University School and Hospital of StomatologyNational Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China

BACKGROUND The bone remodeling during orthodontic treatment for malocclusion often requires a long duration of around two to three years,which also may lead to some complications such as alveolar bone resorption or tooth root ***-intensity pulsed ultrasound(LIPUS),a noninvasive physical therapy,has been shown to promote bone fracture *** is also reported that LIPUS could reduce the duration of orthodontic treatment;however,how LIPUS regulates the bone metabolism during the orthodontic treatment process is still *** To investigate the effects of LIPUS on bone remodeling in an orthodontic tooth movement(OTM)model and explore the underlying *** A rat model of OTM was established,and alveolar bone remodeling and tooth movement rate were evaluated via micro-computed tomography and staining of tissue *** vitro,human bone marrow mesenchymal stem cells(hBMSCs)were isolated to detect their osteogenic differentiation potential under compression and LIPUS stimulation by quantitative reverse transcription-polymerase chain reaction,Western blot,alkaline phosphatase(ALP)staining,and Alizarin red *** expression of Yes-associated protein(YAP1),the actin cytoskeleton,and the Lamin A/C nucleoskeleton were detected with or without YAP1 small interfering RNA(siRNA)application via *** The force treatment inhibited the osteogenic differentiation potential of hBMSCs;moreover,the expression of osteogenesis markers,such as type 1 collagen(COL1),runt-related transcription factor 2,ALP,and osteocalcin(OCN),*** could rescue the osteogenic differentiation of hBMSCs with increased expression of osteogenic marker inhibited by ***,the expression of LaminA/C,F-actin,and YAP1 was downregulated after force treatment,which could be rescued by ***,the osteogenic differentiation of hBMSCs increased by LIPUS could be attenuated by YAP siRNA ***,LIPUS increased alveolar

关键词： Low-intensity pulsed ultrasound Bone resorption Osteogenesis Cytoskeleton-Lamin A/C-Yes-associated protein axis Bone marrow mesenchymal stem cells Orthodontic tooth movement

Coupling coordination analysis of Mazu culture,socio-economy and ecological environment of Meizhou Island

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Ecological Economy 2024年第1期20卷 85-100页

作者： fu Wei-jia WU ying-qi LUO Zi-xuan YAO Jun-bing fu Li-jun College of International Management The University of SheffieldWestern BankSheffieldSouth YorkshireS102TNUK Faculty of Business Lingnan UniversityHongkong999077CHINA School of Business Administration Jimei UniversityXiamen 361021CHINA Putian Kelon Environmental Protection Technology Co. LTDPutian 351100CHINA

Taking the pilgrimage,tourism and cultural island of Meizhou Island as an example,the evaluation index system of the coupling and coordinated development of“Mazu culture,socio-economy,eco-environment”(MSE)compound system was *** index weights were determined by AHP-entropy method,and the coupling degree,coordinated degree,comprehensive evaluation index and grey correlation degree of MSE system of Mazu Island from 2012 to 2022 were *** results showed that:(1)the comprehensive evaluation indexes of the three subsystems was on the rise in general,but the evaluation index of the ecological subsystems increased relatively slowly.(2)The coupling degree was only in the running-in stage in 2012,and the other years were in the coordinated coupling stage.(3)The coupling coordination degree increased from 0.35 in 2012 to 0.82 in 2022,the coupling coordination level was changed from mild imbalance to good coordination.(4)Through the comparison of grey correlation degree,the 24 indexes in the evaluation index system had great influence on the coupling coordination degree of MSE *** coupling coordination degree was closely related to the development of socio-economy and the spread of Mazu *** the rapid development of tourism brought about by the spread of Mazu culture,the pressure on the ecological environment will be *** with the rapid growth of tourism and economy,it is equally important to strengthen environmental protection and pay attention to the quality of ecological environment development.

关键词： Meizhou Island Mazu culture socio-economy ecological environment comprehensive evaluation index coupling coordination degree

Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children

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World Journal of Pediatrics 2024年第9期20卷 901-914页

作者： ying-Shuo Wang Yun-Lian Zhou Guan-Nan Bai Shu-Xian Li Dan Xu Li-Na Chen Xing Chen Xiao-Yan Dong Hong-Min fu Zhou fu Chuang-Li Hao Jian-Guo Hong En-Mei Liu Han-Min Liu Xiao-Xia Lu Zheng-Xiu Luo Lan-Fang Tang Man Tian Yong Yin Xiao-Bo Zhang Jian-Hua Zhang Hai-Lin Zhang De-Yu Zhao Shun-ying Zhao Guo-Hong Zhu ying-Xue Zou Quan Lu Yuan-Yuan Zhang Zhi-Min Chen Department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Child health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Pediatric Pulmonology and Immunology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Pediatrics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China Department of Pulmonology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Department of Pulmonary and Critical Care Medicine Kunming Children’s HospitalKunming 650034China Department of Respiratory Medicine Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Pulmonology Children’s Hospital of Soochow UniversitySuzhou 215003China Department of Pediatrics Shanghai General Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200080China Department of Respiratory Medicine Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Department of Respiratory Medicine Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Department of Respiratory Medicine Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Respiratory Medicine Children’s Hospital of Fudan UniversityShanghai 201102China Department of Pediatric Pulmonology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 201102China Department of Pediatric Respiratory Medicine The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027China National Clinical Research Center for Respiratory Diseases Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China Departmen

Background Mycoplasma pneumoniae(***)is a significant contributor to community-acquired pneumonia among *** 1968,when a strain of *** resistant to macrolide antibiotics was initially reported in Japan,macrolide-resistant ***(MRMP)has been documented in many countries worldwide,with varying incidence *** infections lead to a poor response to macrolide antibiotics,frequently resulting in prolonged fever,extended antibiotic treatment,increased hospitalization,intensive care unit admissions,and a significantly higher proportion of patients receiving glucocorticoids or second-line *** 2000,the global incidence of MRMP has gradually increased,especially in East Asia,which has posed a serious challenge to the treatment of *** infections in children and attracted widespread attention from ***,there is still no global consensus on the diagnosis and treatment of MRMP in *** We organized 29 Chinese experts majoring in pediatric pulmonology and epidemiology to write the world’s first consensus on the diagnosis and treatment of pediatric MRMP pneumonia,based on evidence *** evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,CNKI,Medline,and the Cochrane *** used variations in terms for“macrolide-resistant”,“Mycoplasma pneumoniae”,“MP”,“***”,“pneumonia”,“MRMP”,“lower respiratory tract infection”,“Mycoplasma pneumoniae infection”,“children”,and“pediatric”.Results Epidemiology,pathogenesis,clinical manifestations,early identification,laboratory examination,principles of antibiotic use,application of glucocorticoids and intravenous immunoglobulin,and precautions for bronchoscopy are *** and rapid identification of gene mutations associated with MRMP is now available by polymerase chain reaction and fluorescent probe techniques in respiratory *** the resistance rate to mac

关键词： Child Macrolide-resistant Mycoplasma pneumoniae Recommendation Diagnosis Treatment

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裂缝性低渗透油气藏压裂井压力动态特征

特种油气藏 2008年第4期15卷 63-65,69页

作者：韩福成何应付中油大庆油田有限责任公司黑龙江大庆163416 中油大庆油田博士后工作站黑龙江大庆163712 西南石油大学博士后流动站四川成都610500

裂缝性低渗透油气藏往往存在明显的应力敏感性,利用椭圆流动模型和平均质量守恒方法,建立考虑介质变形影响的双重介质油气藏有限导流垂直裂缝井不稳定渗流的数学模型,给出数学模型的试探解,绘制并分析了压力动态特征的典型曲线。分析结... 详细信息

裂缝性低渗透油气藏往往存在明显的应力敏感性,利用椭圆流动模型和平均质量守恒方法,建立考虑介质变形影响的双重介质油气藏有限导流垂直裂缝井不稳定渗流的数学模型,给出数学模型的试探解,绘制并分析了压力动态特征的典型曲线。分析结果表明,介质变形对典型曲线的中晚期形态存在影响,由于渗透率应力敏感性的存在,使得压力导数曲线偏离0.5水平线,后期拟径向流特征段消失,并且渗透率模数越大,压力及压力导数曲线上翘越大。

关键词：变形介质双重介质油藏垂直裂缝井有限导流压力动态

Investigation of the epidemiology,pathogenicity and immunogenicity of Bordetella bronchiseptica isolated from cats and dogs in China from 2021 to 2023

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Animal Diseases 2024年第3期4卷 156-172页

作者： Qinghua Shang Wenhui Gao Xiangting Zhang Jianqing Zhao ying Wu Haoqi Li Ming Zhou Zhen F.fu Chengguang Zhang Ling Zhao National Key Laboratory of Agricultural Microbiology Huazhong AgriculturalUniversityWuhan 430070China. Key Laboratory of Preventive VeterinaryMedicine of Hubei Province College of Veterinary MedicineHuazhongAgricultural UniversityWuhan 430070China. Hubei Hongshan Laboratory Wuhan 430070China.

Bordetella bronchiseptica(Bb)is recognized as a leading cause of respiratory diseases in dogs and ***,epidemiological data on Bb in dogs and cats in China are still limited,and there is no commercially available *** vaccines containing Bb that are widely used abroad are generally efective but can establish latency and potentially reactivate to cause illness in some immunodefcient vaccinated recipients,raising safety *** this study,34 canine-derived and two feline-derived Bb strains were isolated from 1809 canine and 113 feline nasopharyngeal swab samples collected from eight provinces in China from 2021 to *** PCR results showed that the percentage of positive Bb was 22.94%(441/1922),and more than 90%of the Bb isolates had four virulence factor-encoding genes(VFGs),namely,fhaB,prn,betA and *** the isolated strains displayed a multidrug-resistant *** virulence of 10 Bb strains isolated from dogs with respiratory symptoms was tested in mice,and we found that eight isolates were highly ***,the eight Bb isolates with high virulence were inactivated and intramuscularly injected into mice,and three Bb strains(WH1218,WH1203 and WH1224)with the best protective efcacy were *** immunized with these three strains exhibited strong protection against challenge with the Bb feld strain ***,the WH1218 strain with the greatest protection in dogs was selected as the vaccine *** and cats that received a vaccine containing 109 Cfu of the inactivated WH1218 strain showed complete protection against challenge with the Bb feld strain *** study revealed that Bb is an important pathogen that causes respiratory diseases in domestic dogs and cats in China,and all the isolates exhibited multidrug *** present work contributes to the current understanding of the prevalence,antimicrobial resistance,and virulence genes of Bb in domestic dogs and ***,our results suggest

关键词： Bordetella bronchiseptica Epidemiological investigation Pathogenicity Immunogenicity Inactivated vaccine

复杂断块致密油藏CO_(2)驱油和埋存可行性研究

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陕西科技大学学报 2022年第3期40卷 115-122,151页

作者：王欢季秉玉赵淑霞何应付中国石化石油勘探开发研究院北京100083

金南复杂断块致密油藏,经过多年的衰竭和注水开发,目前面临注水部位产油井含水率高,衰竭部位地层能量严重亏空,单井采油速度低,区块整体采出程度低等问题.针对这些开发问题,本文以金南复杂断块致密油藏为目标,进行了注CO_(2)驱油和埋存... 详细信息

金南复杂断块致密油藏,经过多年的衰竭和注水开发,目前面临注水部位产油井含水率高,衰竭部位地层能量严重亏空,单井采油速度低,区块整体采出程度低等问题.针对这些开发问题,本文以金南复杂断块致密油藏为目标,进行了注CO_(2)驱油和埋存的可行性研究.应用地质建模技术和油藏数值模拟技术,对油藏开发历史进行了拟合,并对剩余油进行了分析,在此基础上,进行了开发方式优选、井网完善分析和注气参数优化研究.研究结果表明:对于压裂投产的断块致密油藏,CO_(2)水气交替(WAG)驱可以有效的提高原油采收率;完善的井网是注气开发的保障,注入压力、段塞比、关井气油比、生产流压等参数是WAG驱的关键参数;WAG驱不仅能提高复杂断块致密油藏的原油采收率,还能实现CO_(2)的有效埋存,从而实现经济与环保的双重效益.

关键词：致密油藏 CO_(2)驱油 CO_(2)埋存数值模拟参数优化

World Federation of Acupuncture-Moxibustion Societies(WFAS)Technical Benchmark of Acupuncture and Moxibustion:Scalp Acupuncture

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World Journal of Acupuncture-Moxibustion 2024年第3期34卷 242-245页

作者： ying ZHOU fu-chun WANG Tie LI School of Acupuncture-Moxibustion Changchun University of Chinese MedicineChangchun 130117China

World Federation of Acupuncture-Moxibustion Societies(WFAS)Technical Benchmark of Acupuncture and Moxibustion:Scalp Acupuncture,was approved by WFAS,issued on October 9,2023,and officially implemented on December 31,*** technical benchmark specifies terms and definitions,scope of application,operation steps and requirements,security requirements,*** the development process,the actual clinical conditions of acupuncture and moxibustion in various countries have been fully *** technical benchmark is applicable to global acupuncture medical institutions,conducive to the standardized use of scalp acupuncture in clinical practice,and can promote the international dissemination of scalp acupuncture in a certain degree.

关键词： Technicalbenchmark Acupuncture and Moxibustion Scalpacupuncture World Federation of Acupuncture-Moxibustion Societies(WFAS) Standard

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颅脑损伤后脑水肿发病机制的研究进展

世界最新医学信息文摘 2019年第93期19卷 119-120页

作者：马西坤贺瑛福青海大学研究生院青海大学附属医院神经外科

脑水肿及由此引起的颅内压升高与创伤性颅脑损伤的不良预后有关。脑水肿发生率高,评估和处理继发性颅脑损伤过程及由此引起的颅内压升高是急性神经危重症治疗的重要内容。这篇综述主要通过描述导致脑水肿形成的关键分子,讲述颅脑损伤后... 详细信息

脑水肿及由此引起的颅内压升高与创伤性颅脑损伤的不良预后有关。脑水肿发生率高,评估和处理继发性颅脑损伤过程及由此引起的颅内压升高是急性神经危重症治疗的重要内容。这篇综述主要通过描述导致脑水肿形成的关键分子,讲述颅脑损伤后脑水肿的发病机制。

关键词：颅脑损伤脑水肿细胞毒性水肿血管源性水肿

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三重介质油藏压力动态分析的边界元法

西安石油大学学报（自然科学版） 2006年第6期21卷 35-39页

作者：张训华高慧梅刘先贵何应付中国科学院渗流流体力学研究所河北廊坊065007 中国石油大学石油工程学院北京102249

油藏形状对井底压力动态响应有着显著的影响,为了研究任意形状三重介质油藏的压力动态,本文首先建立了由基岩系统、裂缝系统和溶洞系统组成的任意形状的三重介质油藏试井解释模型.利用Laplace变换和边界元方法获得油藏内任意点的压力,... 详细信息

油藏形状对井底压力动态响应有着显著的影响,为了研究任意形状三重介质油藏的压力动态,本文首先建立了由基岩系统、裂缝系统和溶洞系统组成的任意形状的三重介质油藏试井解释模型.利用Laplace变换和边界元方法获得油藏内任意点的压力,进而由杜哈美原理得到了考虑井筒储存和表皮效应的井底压力.讨论了介质间窜流、弹性储容比、复杂边界以及油藏内存在不渗透区域等因素对压力响应的影响.分析表明,溶洞—裂缝窜流系数越大,半对数压力曲线上第一个过渡段出现得越早,双对数压力导数曲线上第一个下凹部分出现得越早;基岩—裂缝窜流系数和溶洞—裂缝窜流系数类似,只是其影响压力响应曲线的第二个过渡段;裂缝弹性储容比的大小控制着第一个过渡段持续时间的长短,表现为压力曲线上第一个过渡段台阶的宽窄和压力导数曲线上第一个凹兜的深浅;油藏的边界条件对油藏的压力动态存在明显影响,与定压边界条件相比,分段定压边界条件明显延迟了压力导数曲线下掉的时间;不渗透区域的存在使得压力导数曲线上第二个凹兜变浅,晚期径向流段抬升,偏离了0.5水平线.

关键词：三重介质油藏边界元方法压力动态