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楚雄师范学院学报 2022年第1期37卷 17-23页

作者：和雅迪李钢大理大学马克思主义学院云南大理671003

从生态治理现代化的视角出发,以问题为导向,聚焦洱海生态治理的实践。笔者在客观总结洱海生态治理现代化经验的基础上,找出当前洱海生态治理所面临的挑战与困难,力图揭示洱海生态治理现代化的本质和规律,探析今后洱海生态治理现代化的... 详细信息

从生态治理现代化的视角出发,以问题为导向,聚焦洱海生态治理的实践。笔者在客观总结洱海生态治理现代化经验的基础上,找出当前洱海生态治理所面临的挑战与困难,力图揭示洱海生态治理现代化的本质和规律,探析今后洱海生态治理现代化的路径。

关键词：生态治理现代化视域洱海路径

Absence of gender disparity in short-term clinical outcomes in patients with acute ST-segment elevation myocardial infarction undergoing irolimus-eluting stent based primary coronary intervention： a report from Shanghai Acute Coronary Event （SACE） Registry

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Chinese Medical Journal 2010年第7期123卷 782-788页

作者： ZHANG Qi QIU Jian-ping ZHANG Rui-yan LI Yi-gang he Ben JIN Hui-gen ZHANG Jun-feng WANG Xiao-long JIANG Li LIAO Min-lei HU Jian SheN Wei-feng Department of Cardiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Cardiology Gongli Hospital of Shanghai Pudong District Shanghai 200135 China Department of Cardiology Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200092 China Department of Cardiology Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200001 China Department of Cardiology Putuo District Center Hospital Shanghai University of Traditional Chinese Department of Cardiology No. 3 People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 201900 China Department of Cardiology Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai 201900China Department of Cardiology Center Hospital of Shanghai Changning District Shanghai 200336 China Department of Cardiology Baoshan Hospital Shanghai 201900China Department of Cardiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

Background Randomized, controlled trials have demonstrated the superiority of sirolimus-eluting stent （SES） implantation during primary percutaneous coronary intervention （PCI）, as opposed to bare-metal stents, in patients with ST-elevation myocardial infarction （STEMI）. This study aimed to test the hypothesis that clinical benefits of SES treatment were independent of gender in this *** A total of 2042 patients with STEMI undergoing SES-based primary PCI were prospectively enrolled into Shanghai Acute Coronary Event （SACE） registry （1574 men and 468 women）. Baseline demographics, angiographic and PCI features, and in-hospital and 30-day major adverse cardiac events （MACE） were analyzed as a function of gender. Results Compared with men, women were older and more frequently had hypertension, diabetes, and hypercholesterolemia. Use of platelet glycoprotein IIb/IIIa receptor inhibitor （GPI, 65.5% vs. 62.2%, P=0.10） and procedural success rate （95.0% vs. 94.2%, P=0.52） were similar in both genders. In-hospital death and MACE occurred in 3.8% and 7.6%, and 4.5% and 8.1% in the male and female patients, respectively （all P 〉0.05）. At 30-day follow-up, survival （94.3% vs. 93.8%, P=0.66） and MACE-free survival （90.2% vs. 89.3%, P=0.52） did not significantly differ between men and women. After adjustment for differences in patient demographics, angiographic and proceduralfeatures, there were no significant difference in either in-hospital （OR=0.77, 95%C/ of 0.48 to 1.22, P=0.30） or 30-day mortality （OR=1.28, 95%C/ of 0.73 to 2.23, P=0.38） between women and *** Despite more advanced age and clustering of risk factors in women, female patients with STEMI treated by SES-based primary PCI had similar in-hospital and short-term clinical outcomes as their male counterparts.

关键词： acute myocardial infarction gender angioplasty stent prognosis

K_2CdSnS_4的溶剂热合成与晶体结构(英文)

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无机化学学报 2014年第2期30卷 405-410页

作者：白音孟和刚刚娜仁吉如嘎内蒙古师范大学化学与环境科学学院呼和浩特010022 内蒙古自治区功能材料物理与化学重点实验室呼和浩特010022

利用溶剂热法合成了层状硫代锡(Ⅲ)酸镉(Ⅱ)化合物K2CdSnS4。单晶X-射线衍射分析结果表明,化合物属单斜晶系,C2/c空间群,a=1.102 1(5)nm,b=1.103 0(5)nm,c=1.515 1(10)nm,α=90°,β=100.416(12)°,γ=90°,V=1.811 4(17)nm3,Z=8,Dc=3.209 g·cm-3,Mr=437.60,μ=6.853 mm-1,F(000)=1 600,λ=0.071 073 nm,R=0.104 2,wR=0.200 8。该化合物由类金刚烷[Cd2Sn2S10]8-结构单元互相连接形成层状结构。紫外-可见漫反射光谱研究表明,化合物为半导体,带隙为2.2 eV。

关键词：溶剂热合成晶体结构四元硫代锡酸盐光学性质

Selective tropism of liver stem cells to hepatocellular carcinoma in vivo

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World Journal of Gastroenterology 2007年第28期13卷 3886-3891页

作者： Xiao-gang Zhong Sheng he Wu Yin Jing-Yu Deng Bo Cheng Department of General Surgery The People's Hospital of Guangxi Zhuang Autonomous Region Nanning 530021 Guangxi Zhuang Autonomous Region China Department of General Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Department of Pathology West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

AIM: To investigate the selective tropism of liver stem cells to hepatocellular carcinoma (HCC) in an animal model and its feasibility as a vector to deliver therapeutic genes for targeted therapy of HCC. METHODS: WB-F344, a kind of rat liver stem cell, was infected with recombinant virus to establish a cell line with stable, high-level expressing enhanced green fluorescent protein (EGFP). An animal model of HCC in Wistar rats was established by implanting HCC cells (CBRH7919) combined with an immunosuppressive drug. EGFP labeled liver stem cells were injected into caudal veins of the animals and distribution was observed at different time points after injection. SDF-1 and c-kit expression in non-tumor liver and tumor tissue were analysed by immunohistochemistry for the relationshiop between the expression and migration of liver stem cells. Furthermore, hepatic stem cells were injected via the portal vein, hepatic artery, caudal vein, or directly into the pericancerous liver tissue, respectively, and effects on migration, localization, and proliferation of the hepatic stem cells within the tumor tissue were observed and analyzed. RESULTS: Recombinant adenovirus could deliver the EGFP gene to hepatic stem cells. A new stem cell line, named WB-EGFP, was established that stably expressed EGFP. WB-EGFP cells still showed selective tropism towards HCC and EGFP expression was stable in vivo. According to immunohistochemistry results, SDF-1 may not be related to the mechanisms of tropism of hepatic stem cells. Different application sites affected the distribution of liver stem cells. Injection via the portalvein was superior with regard to selective migration, localization, and proliferation of the hepatic stem cells within the tumor tissue. CONCLUSION: Liver stem cells have the biological behavior of selective migration to HCC in vivo and they could localize and proliferate within HCC tissue stably expressing the target gene. Liver stem cells are a potential tool for a ta

关键词：肝细胞癌干细胞基因治疗选择性

hepatic portal cholangiocarcinoma:a clinical analysis of 70 cases

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hepatobiliary & Pancreatic Diseases International 2008年第4期7卷 418-421页

作者： Zhang, Hong-Yi Kong, Ya-Lin Zhang, Hong-Yi he, Xiao-Jun Zhang, Hui Liu, Cheng-Li Zhao, gang Xiao, Mei Zhang, Xi-Dong Feng, Zhi-Qiang Gen Hosp Air Force PLA Dept Hepatobiliary Surg Beijing 100036 Peoples R China

BACKGROUND: The incidence of hepatic portal cholangiocarcinoma is increasing and it is always associated with poor survival. This study analyzed an effective therapeutic method. METHODS: A retrospective analysis was made on 70 patients with hepatic portal cholangiocarcinoma admitted between January 2004 and February 2007 to the General Hospital of Air Force PLA. RESULTS: Forty-seven patients had hepatic ductjejunum anastomosis after resection of hepatic portal cholangiocarcinorna. Internal or external biliary drainage and canals for internal radiation were performed in those patients unfit for operation. Among the 70 patients, 5 died within 15 months, 27 survived more than 24 months, and the others survived 4-18 months. CONCLUSION: Surgery is the primary therapeutic method for hepatic portal cholangiocarcinoma. Internal or external biliary drainage can prolong the life-span.

关键词： hepatic portal cholangiocarcinoma drainage

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野生射干与栽培射干化学成分的定性比较

时珍国医国药 2001年第8期12卷 685-686页

作者：刘合刚赵亚汪建平湖北中医学院湖北武汉430061

目的 :对射干的栽培品与野生品的药用部位和非药用部位进行化学成分的定性分析比较。方法 :采用系统预试验、薄层层析法测定野生射干与栽培射干的根茎、根、茎、叶、花、果皮及种子的化学成分 ,并进行定性比较。结果 :栽培与野生射干根... 详细信息

目的 :对射干的栽培品与野生品的药用部位和非药用部位进行化学成分的定性分析比较。方法 :采用系统预试验、薄层层析法测定野生射干与栽培射干的根茎、根、茎、叶、花、果皮及种子的化学成分 ,并进行定性比较。结果 :栽培与野生射干根茎的成分基本一致 ;根与根茎的成分相近 ;其它部位与根茎的成分有所差异。结论 :射干非药用部位能否入药。

关键词：射干化学成分定性分析中药

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B(A)04等位基因的鉴定及相关分子机制

中国实验血液学杂志 2023年第5期31卷 1492-1495页

作者：徐明菊仇丰武沈钢何鸣镝武汉血液中心血型鉴定室湖北武汉430030

目的:探讨B(A)04等位基因的鉴定及相关分子生物学机制。方法:采用血型血清学法、基因测序法鉴定先证者及其9名亲属的ABO血型,分析血清学反应特点及家系遗传规律;构建突变体酶催化中心的局部空间模型,探索导致酶异常催化A抗原合成的可能... 详细信息

目的:探讨B(A)04等位基因的鉴定及相关分子生物学机制。方法:采用血型血清学法、基因测序法鉴定先证者及其9名亲属的ABO血型,分析血清学反应特点及家系遗传规律;构建突变体酶催化中心的局部空间模型,探索导致酶异常催化A抗原合成的可能分子机制。结果:血清学结果提示先证者及其哥哥、外祖母表型为A_(weak)B或B(A);其母亲表型为AB型,其舅舅及大姨为B型,其父亲为O型。ABO血型基因测序结果表明,该家系10名成员中,有6名携带B(A)04等位基因。分子结构模型显示,GTB突变体酶催化中心关键氨基酸残基的空间距离大于GTB,可能是引起酶异常催化A抗原合成的原因。结论:B(A)亚型血清学反应存在差异,其鉴定需与分子生物学及家系调查结合来判定。推测B(A)表现型可能与GTB突变体的催化中心容积变大有关。

关键词： ABO血型 B(A)亚型家系调查基因测序分子模型

E ect of Optical Depth on Study of Chemical Properties of Massive Star Forming Clumps

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Chinese Journal of Chemical Physics 2020年第1期33卷 114-118页

作者： Jian-jun Zhou Run-xia Li Donghui Quan Jarken Esimbek Yu-xin he Da-lei Li Xin-di Tang gang Wu Wei-guang Ji Zheng-xue Chang Xia Zhang Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of the Chinese Academy of Sciences Beijing 100080China Key Laboratory of Radio Astronomy Chinese Academy of SciencesUrumqi 830011China Department of Chemistry Eastern Kentucky UniversityRichmond KY 40475USA

here we present the study on chemical properties of massive star forming clumps using N2H^+(1-0),H^13CO+(1-0),HCN(1-0)and HN^13C(1-0)data from the literature[***.563,A97(2014)].We found that abundances of H^13CO+ and HN^13C are a ected by H2 column *** the median values of these two abundances increase by nearly 10 times from stages A to B,H^13CO+and HN^13C are suitable for tracing the evolution of massive star forming *** order of rapidity in growth of abundances of all the four studied molecules from stages A to B,is H^13CO^+,HCN,HN^13C,and N2H^+,from the highest to the *** results suggest that the observing optically thin molecular lines with high angular resolution are necessary to study the chemical evolution of massive star forming clumps.

关键词： Stars formation Clumps Molecules Radio lines

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正则Dirichlet形式的正则子空间

中国科学：数学 2019年第3期49卷 389-402页

作者：何萍应坚刚上海财经大学数学学院上海200433 复旦大学数学科学学院上海200433

正则Dirichlet形式的正则子空间问题,即存在性及其刻画等问题,是作者关注近20年的问题,该问题来自第二作者对于Markov过程的Killing变换的Dirichlet形式刻画问题的研究,这个问题是Dirichlet形式理论的一个基本问题,在最近10年中取得了... 详细信息

正则Dirichlet形式的正则子空间问题,即存在性及其刻画等问题,是作者关注近20年的问题,该问题来自第二作者对于Markov过程的Killing变换的Dirichlet形式刻画问题的研究,这个问题是Dirichlet形式理论的一个基本问题,在最近10年中取得了一点进展.本文将主要叙述问题及其背景,并介绍围绕该问题得到的一些结果与遗留的问题.

关键词： Dirichlet型 Markov过程正则子空间

下调MLAA-22基因对U937细胞增殖与分化的影响

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西安交通大学学报（医学版） 2018年第4期39卷 519-524页

作者：崔鹤张王刚内蒙古医科大学附属医院血液内科内蒙古呼和浩特010059 西安交通大学第二附属医院血液内科陕西西安710004

目的研究MLAA-22基因的表达下调对U937细胞增殖及分化的影响。方法采用规律成簇间隔短回文重复序列(CRISPR)/CRISPR相关核酸酶9(Cas9)系统下调U937细胞MLAA-22基因的表达;CruiserTM酶切法检测单链引导RNA(single guide RNA,sgRNA)的活性... 详细信息

目的研究MLAA-22基因的表达下调对U937细胞增殖及分化的影响。方法采用规律成簇间隔短回文重复序列(CRISPR)/CRISPR相关核酸酶9(Cas9)系统下调U937细胞MLAA-22基因的表达;CruiserTM酶切法检测单链引导RNA(single guide RNA,sgRNA)的活性;基因突变区PCR产物的TA克隆及测序法检测MLAA-22基因的突变率;细胞计数试剂盒-8(cell counting kit-8,CCK-8)检测细胞增殖;流式细胞仪检测CD11b的表达。结果CruiserTM酶切结果显示:所采用的CRISPR/Cas9系统的sgRNA序列能够高效地识别基因编辑靶点;TA克隆及测序结果显示:MLAA-22基因的突变率为61.3%;CCK-8检测结果显示:MLAA-22基因下调后,U937细胞的增殖明显受到抑制;流式细胞仪检测结果显示:MLAA-22基因下调后,CD11b阳性细胞率显著升高。结论 MLAA-22基因可能通过调控细胞分化而影响U937细胞增殖,从而促进急性单核细胞白血病的发生与发展。

关键词： MLAA-22基因细胞增殖细胞分化急性单核细胞白血病