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丁苯那嗪调节TH和突触囊泡转运改善hd的机制研究

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华东理工大学学报（自然科学版） 2023年第2期49卷 211-219页

作者：王如意范晶菁李洪林王蕊华东理工大学药学院上海市新药设计重点实验室上海200237

通过腹腔注射3-硝基丙酸(3-NP)建立亨廷顿舞蹈症(hd)大鼠模型,探究丁苯那嗪(TBZ)改善hd样症状的作用及机制。结果显示,TBZ缓解了3-NP诱导的hd大鼠体重下降和运动障碍,逆转了纹状体中亨廷顿蛋白(Htt)的表达和神经元丢失;同时TBZ调节了纹... 详细信息

通过腹腔注射3-硝基丙酸(3-NP)建立亨廷顿舞蹈症(hd)大鼠模型,探究丁苯那嗪(TBZ)改善hd样症状的作用及机制。结果显示,TBZ缓解了3-NP诱导的hd大鼠体重下降和运动障碍,逆转了纹状体中亨廷顿蛋白(Htt)的表达和神经元丢失;同时TBZ调节了纹状体中神经递质的含量,抑制酪氨酸羟化酶(TH)和囊泡单胺转运体2(VMAT2)的表达,并保护突触免受损伤;TBZ通过同时调控突触囊泡转运和TH的表达以降低纹状体中多巴胺(DA)的释放和合成,保护突触功能和神经元,从而减轻hd样症状。

关键词：亨廷顿舞蹈症 3-硝基丙酸丁苯那嗪多巴胺

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抗霉毒剂-hd乳化剂的抗真菌及抗细菌实验研究

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湖南医学院学报 1986年第1期 63-66页

作者：马恩庆罗成群戴贻亮张洪权湖南医学院第一附属医院烧伤研究室湖南医学院第一附属医院烧伤研究室

本文报告60％抗霉毒剂 hd的乳化剂对10种真菌和7种细菌的抗菌实验研究,以及薰蒸空气消毒,物表自然菌消毒,人工染菌木板消毒的效果。结果证明该乳剂易与水任意混合,使用方便;且具有较好的抗菌作用,作为消毒剂使用时,具有良好的细菌(真菌... 详细信息

本文报告60％抗霉毒剂 hd的乳化剂对10种真菌和7种细菌的抗菌实验研究,以及薰蒸空气消毒,物表自然菌消毒,人工染菌木板消毒的效果。结果证明该乳剂易与水任意混合,使用方便;且具有较好的抗菌作用,作为消毒剂使用时,具有良好的细菌(真菌)清除率。毒性试验,证明其具有较大安全系数。

关键词：抗生素抗霉毒剂hd 乳化剂消毒剂药效学投药与剂量

THE ARTIFICIAL BOUNDARY CONDITION FOR EXTERIOR OSEEN EQUATION IN 2-D SPACE

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Journal of Computational Mathematics 2002年第6期20卷 591-598页

作者： Zheng, CXO Han, hd Tsing Hua Univ Dept Math Sci Beijing 100084 Peoples R China

A finite element method for the solution of Oseen equation in exterior domain is proposed. In this method, a circular artificial boundary is introduced to make the computational domain finite. Then, the exact relation between the normal stress and the prescribed velocity field on the artificial boundary can be obtained analytically. This relation can serve as an boundary condition for the boundary value problem defined on the finite domain bounded by the artificial boundary. Numerical experiment is presented to demonstrate the performance of the method.

关键词： artificial boundary exterior domain Oseen equation

NUMERICAL SOLUTIONS OF PARABOLIC PROBLEMS ON UNBOUNDED 3-D SPATIAL DOMAIN

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Journal of Computational Mathematics 2005年第5期23卷 449-462页

作者： Han, hd Yin, DS Tsing Hua Univ Dept Mat Sci Beijing 100084 Peoples R China

In this paper, the numerical solutions of heat equation on 3-D unbounded spatial domain are considered. An artificial boundary F is introduced to finite the computational domain. On the artificial boundary F, the exact boundary condition and a series of approximating boundary conditions are derived, which are called artificial boundary conditions. By the exact or approximating boundary condition on the artificial boundary, the original problem is reduced to an initial-boundary value problem on the bounded computational domain, which is equivalent or approximating to the original problem. The finite difference method and finite element method are used to solve the reduced problems on the finite computational domain. The numerical results demonstrate that the method given in this paper is effective and feasible.

关键词： Heat equation Artificial boundary Exact boundary conditions Finite elementmethod

THE BOUNDARY INTEGRO-DIFFERENTIAL EQUATIONS OF A BIHARMONIC BOUNDARY VALUE PROBLEM

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Journal of Computational Mathematics 1999年第1期17卷 59-72页

作者： Ban, hd Tang, WJ Inst Appl Phys & Computat Math Lab Computat Phys Beijing 100088 Peoples R China Tsing Hua Univ Dept Appl Math Beijing 100084 Peoples R China

In this paper, a new method of boundary reduction is proposed, which reduces the biharmonic boundary value problem to a system of integro-differential equations on the boundary and preserves the self-adjointness of the original problem. Moreover, a boundary finite element method based on this integro-differential equations is presented and the error estimates of the numerical approximations are given. The numerical examples show that this new method is effective.

关键词： boundary integro-differential equations biharmonic boundary value problem

Studies on the diterpenoid constituents from Rabdosia angustifolia

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Chinese Journal of Chemistry 1997年第5期15卷 425-430页

作者： Zhang, RP Sun, hd Kunming Med Coll Kunming 650031 Yunnan Peoples R China Chinese Acad Sci Kunming Inst Bot Kunming 650204 Yunnan Peoples R China

Two new ent-kaurene diterpenoids, angustifolin B and natural hydrogen-bonded 1:1 complex, angustifolin C, as well as four known diterpenoids, angustifolin, isodonal, sodoponin, tri-chorabdal B, were isolated from the ... 详细信息

关键词： Rabdosia angustifolia angustifolin B angustifolin C diterpene

BOUNDARY ELEMENT APPROXIMATION OF STEKLOV EIGENVALUE PROBLEM FOR HELMHOLTZ EQUATION

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Journal of Computational Mathematics 1998年第2期16卷 165-178页

作者： Tang, WJ Guan, Z Han, hd Inst Appl Phys & Computat Math Lab Computat Phys Beijing 100088 Peoples R China Tsing Hua Univ Dept Appl Math Beijing 100084 Peoples R China

Steklov eigenvalue problem of Helmholtz equation is considered in the present paper. Steklov eigenvalue problem is reduced to a new variational formula on the boundary of a given domain, in which the self-adjoint property of the original differential operator is kept and the calculating of hyper-singular integral is avoided. A numerical example showing the efficiency of this method and an optimal error estimate are given.

关键词： Steklov eigenvalue problem differential operator error estimate boundary element approximation

Synthesis and Characterization of Fully-Functionalized Polysilanes for Photorefractive Materials

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Chinese Chemical Letters 2000年第8期11卷 675-676页

作者： Tang, hd Jin, JG Wuhan Univ Dept Chem Wuhan 430072 Peoples R China

Hydrogen-containing polysilanes and chromophore-containing polysilanes are prepared by traditional Wurtz coupling and subsequent hydrosilylation. They are characterized by (HNMR)-H-1, FT-IR, UV/VIS spectroscopies, dif... 详细信息

关键词： polysilanes synthesis characterization Wurtz coupling hydrosilylation

Joint Distribution of Wave Periods and Rate of Change of Wave Surface Elevation

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China Ocean Engineering 1999年第2期14卷 225-229页

作者： Shi, hd Sun, F Ocean Univ Qingdao Dept Civil Engn Qingdao 266003 Peoples R China

The rate of change of wave surface elevation is of much importance in ocean engineering, especially for the determination of the limitation of wave breaking. This paper gives a kind of joint distribution of wave periods and the rate of change of wave surface elevation by means of calculation of the two-order to four-order moment of the frequency spectrum based on the linear wave theory. For the first time, the distribution density function of wave periods determined by peaks is provided, and the conclusion is drawn that the rate of change of wave surface elevation obeys the Rayleigh distribution.

关键词： rate of change wave surface elevation joint distribution wave period