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Recent updates on nano-phyto-formulations based therapeutic intervention for cancer treatment

Oncology Research 2024年第1期32卷 19-47页

作者： ABHISHEK WAHI MAMTA BISHNOI NEHA RAINA MEGHNA AMRITA singh PIYUSH VERMA PIYUSH KUMAR GUPTA GINPREET KAUR hardeep singh tuli MADHU GUPTA Department of Pharmaceutics School of Pharmaceutical SciencesDelhi Pharmaceutical Sciences and Research University(DPSRU)Pushp ViharNew Delhi110017India Department of Pharmaceutical Sciences Gurugram UniversityHaryana122003India Department of Life Sciences Sharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh201310India Department of Biotechnology Graphic Era(Deemed to be University)DehradunUttarakhand248002India Department of Pharmacology Shobhaben Pratapbhai Patel School of Pharmacy&Technology ManagementSVKM’s NMIMSVile Parle(West)Mumbai400056India Department of Bio-Sciences and Technology Maharishi Markandeshwar Engineering CollegeMaharishi Markandeshwar(Deemed to be University)MullanaAmbala133207India

Cancer is a leading cause of death globally,with limited treatment options and several *** agents often result in toxicity which long-term conventional *** are natural constituents that are more effective in treating various diseases with less toxicity than the chemotherapeutic agents providing alternative therapeutic approaches to minimize the *** phytoconstituents act in several ways and deliver optimum effectiveness against ***,the effectiveness of phyto-formulations in the management of cancers may be constrained due to challenges related to inadequate solubility,bioavailability,and *** presents a promising avenue for transforming current cancer treatment methods through the incorporation of phytochemicals into nanosystems,which possess a range of advantageous characteristics such as biocompatibility,targeted and sustained release capabilities,and enhanced protective *** holds significant potential for future advancements in cancer ***,this review aims to provide intensive literature on diverse nanocarriers,highlighting their applications as cargos for phytocompounds in ***,it offers an overview of the current advancements in the respective field,emphasizing the characteristics that contribute to favourable outcomes in both in vitro and in vivo ***,clinical development and regulatory concerns are also discussed to check on the transformation of the concept as a promising strategy for combination therapy of phytochemicals and chemotherapeutics that could lead to cancer management in the future.

关键词： Phyto-formulations Cancer Nanocarriers Nanotechnology Clinical development

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Experimental Investigation of Thermal Performance of Novel Finned Radiators for Automotive Cooling System

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Journal of Thermal Science 2024年第5期33卷 1726-1743页

作者： singh hardeep TING David S-K READER Graham ESHTIAGHI Nicky ICHIYANAGI Mitsuhisa SUZUKI Takashi Turbulence&Energy Laboratory University of WindsorWindsor N9B 3P4Canada Chemical and Environmental Engineering School of EngineeringRMIT UniversityMelbourneVictoria 3001Australia Department of Engineering and Applied Sciences Sophia UniversityTokyo 102-8554Japan

This research investigates innovative fin-type radiators for automobile engine cooling ***-channel and helical radiators,along with straight type,were analyzed for heat transfer characteristics under various *** uniqueness of this study is evident in the design of microchannel and helical *** helical radiators,the inner rod features 4/8 helical-shaped water galleries,while the outer tube frame with embedded fins remains *** contrast,the microchannel radiators have compact trapezoidal-shaped water galleries with separate fin ***,the novelty of the research is enhanced by the utilization of 3D printing technology in the manufacturing *** constant fin height analysis at varied water and air flow rate,Microchannel Water Air Radiator with fin height 10.5 mm(MCWAR10.5)depicted a higher heat transfer rate amongst the *** comparison to Straight Water Air Radiator with fin height 9.5 mm(SWAR9.5),the heat transfer rate is 30.3%and 1.3 times ***,in constant fin surface area analysis,microchannel radiator(MCWAR3.2)illustrates lower heat dissipation than Helical radiator(HWAR138)but higher than HWAR134 and Straight radiator(SWAR6).The examination of pumping loss indicated that the Micro-channel radiator outperformed helical radiators due to its lower pressure *** average pressure loss for Micro-channel radiators was 0.74 kPa,making it 1.2 times higher than that of a straight radiator(0.62 kPa),indicating a better trade-off.

关键词： heat exchangers multi-channel helical heat exchanger heat transfer 3D printing

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Role of Nurses in the Management of Common Gynecological Diseases:Recent Advances

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Journal of Clinical and Nursing Research 2021年第5期5卷 1-11页

作者： hardeep singh tuli Department of Biotechnology Maharishi Markandeshwar(Deemed to be University)Mullana-Ambala 133207HaryanaIndia

In recent years the role of the specialist nurse with respect to gynecology and women 5s health has gained significant *** advancement in the nursing practice has provided an insight to interact with patients to explore their *** hysteroscopy procedures may not only give a better feel to the patient but also explore the need for doctor *** review updates about the ongoing advances in the field of nursing science to upgrade the life of patients with gynecological *** has suggested the promising role of nurses to motivate patients with improved health after the *** present review will cover the various health issues of women including menstrual dysfunction,fertility,and management of pregnancy 5s termination,uro-gynecological issues,and gyne-oncology,*** role of nurses during the above health issue will be discussed via various ***,the present review will conclude the significant importance of nurses in women's health issues to sustain happiness and to strengthen the need to bring advances in the curriculum of nurses to full fill the requirement of medical staff.

关键词： Gynecology Menstrual problems Papillomavirus Fertility issues Abortion Cancer

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Predictors of cerebrospinal fluid GeneXpert MTB/RIF positivity in patients with tuberculous meningitis:A prospective cohort study

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Asian Pacific Journal of Tropical Medicine 2024年第10期17卷 465-472页

作者： Priyanka Gupta Neeraj Kumar Ravindra Kumar Garg hardeep singh Malhotra Imran Rizvi Rajesh Verma Praveen Kumar Sharma Ravi Uniyal Shweta Pandey Amita Jain Parul Jain Department of Neurology King George’s Medical UniversityLucknowIndia Department of Microbiology King George’s Medical UniversityLucknowIndia

Objective:To identify the clinical,laboratory,and radiological markers that could predict a positive GeneXpert result in patients suspected of tuberculous ***:In this prospective,observational study,patients with tuberculous meningitis were systematically *** clinical,laboratory[including cerebrospinal fluid(CSF)microscopy,culture,and GeneXpert],and neuroimaging factors were *** participants were administered anti-tuberculous treatment and corticosteroids.A six-month follow-up was done to evaluate the ***:Of the 116 patients studied,54(46.6%)tested positive for GeneXpert,while 62(53.4%)were *** cranial nerve involvement(OR 3.71,95%CI 1.052-13.09,P=0.04)and the presence of basal exudates on neuroimaging(OR 5.22,95%CI 2.03-13.42,P=0.001)emerged as independent predictive factors for a positive GeneXpert result.A positive CSF GeneXpert result(P=0.002)and drug resistance(P=0.004)were significantly linked to adverse ***,a high score on the Medical Research Council stageⅢ(OR 5.64,95%CI 1.18-26.87,P=0.03)and elevated CSF cell counts(OR 1.002,95%CI 1.00-1.001,P=0.03)were identified as independent predictors of poor ***:Third cranial nerve involvement and the presence of basal exudates were significant indicators of a positive GeneXpert *** stageⅢdisability and elevated CSF cell counts predicted poor outcomes.

关键词： Tuberculous meningitis Mycobacterium tuberculosis Cerebrospinal fluid Ziehl-Neelsen staining GeneXpert

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Disseminated cysticercosis presenting with bilateral proptosis: A case report

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Asian Pacific Journal of Tropical Medicine 2019年第7期12卷 337-338页

作者： Ravindra Kumar Garg Neeraj Kumar Imran Rizvi hardeep singh Malhotra Department of Neurology King George’s Medical University Uttar Pradesh

Rationale: Disseminated cysticercosis is characterized by presence of cysts in multiple body organs, like brain, skin, eyes, muscles and rarely heart and *** concerns: A 22-year-old man presented with bilateral proptosis of 1-year duration. He also had two episodes of cysticercosis encephalitis. In the second episode of encephalopathy, the patient ***: Disseminated ***: Corticosteroids(Initially intravenous dexamethasone 0.4 mg/kg/day for 2 weeks, followed by oral prednisolone 1.0 mg/kg/day).Outcomes: The patient died of cysticercosis encephalitis approximately 2 months ***: Disseminated cysticercosis in our case presented only with proptosis as he had very heavy infestation of the brain and eyes. Heavy larval infestation in a patient with disseminated cysticercosis can be life-threatening.

关键词： Neurocysticercosis Cysticercosis encephalitis Proptosis

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A Comprehensive Review of Animal Models for Coronaviruses: SARSCoV-2, SARS-CoV, and MERS-CoV

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Virologica Sinica 2020年第3期35卷 290-304页

作者： Ashutosh singh Rahul Soloman singh Phulen Sarma Gitika Batra Rupa Joshi hardeep Kaur Amit Raj Sharma Ajay Prakash Bikash Medhi Department of Pharmacology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India

The recent outbreak of coronavirus disease(COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) has already affected a large population of the world. SARS-CoV-2 belongs to the same family of severe acute respiratory syndrome coronavirus(SARS-CoV) and Middle East respiratory syndrome coronavirus(MERSCoV). COVID-19 has a complex pathology involving severe acute respiratory infection, hyper-immune response, and coagulopathy. At present, there is no therapeutic drug or vaccine approved for the disease. There is an urgent need for an ideal animal model that can reflect clinical symptoms and underlying etiopathogenesis similar to COVID-19 patients which can be further used for evaluation of underlying mechanisms, potential vaccines, and therapeutic strategies. The current review provides a paramount insight into the available animal models of SARS-CoV-2, SARS-CoV, and MERS-CoV for the management of the diseases.

关键词： Coronaviruses SARS MERS COVID-19 Animal model

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Biochar applications influence soil physical and chemical properties,microbial diversity,and crop productivity:a meta-analysis

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Biochar 2022年第1期4卷 1055-1071页

作者： hardeep singh Brian K.Northup Charles W.Rice P.V.Vara Prasad Department of Agronomy Kansas State University2002 Throckmorton Plant Sciences Center1712 Claflin RoadManhattanKS 66506USA United States Department of Agriculture-Agricultural Research Service Grazinglands Research LaboratoryEl-RenoOK 73036USA

Biochar is a widely known soil *** we synthesize the available information on influence of biochar application on different soil properties and crop productivity using *** data on influence of biochar applications on different soil physical,chemical,microbial properties,and crop productivity were extracted from literature and statistically *** on selection criteria,59 studies from the literature published between 2012 and 2021 were selected for the *** were developed between effect size of biochar application on different soil properties and crop *** of biochar increased soil pH,cation exchange capacity,and organic carbon by 46%,20%,and 27%,respectively,with greater effects in coarse and fine-textured *** on chemical properties were variable among biochar prepared from different *** physical properties,biochar application reduced bulk densities by 29%and increased porosity by 59%.Biochar prepared at higher pyrolytic temperatures(>500℃)improved bulk density and porosity to greater extents(31%and 66%,respectively).Biochar prepared at lower pyrolytic temperatures(<500℃)had a greater effect on microbial diversity(both bacterial and fungal),with more diverse bacterial populations in medium and coarse textured soils,while fungal diversity increased in fine textured *** applications increased crop productivity only in fine and coarse textured *** effect size of biochar application on crop productivity was correlated with responses to physical properties of *** meta-analysis highlighted the need to conduct long-term field experiments to provide better explanations for changes in biochar properties as it undergoes aging,its longer-term effects on soil properties,and timing of re-application of different biochars.

关键词： Biochar Crop productivity Microbial diversity Soil physical properties Soil chemical properties

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Exploring Design Level Class Cohesion Metrics

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Journal of Software Engineering and Applications 2010年第4期3卷 384-390页

作者： Kuljit Kaur hardeep singh Department of Computer Science and Engineering Guru Nanak Dev University Amritsar India.

In object oriented paradigm, cohesion of a class refers to the degree to which members of the class are interrelated. Metrics have been defined to measure cohesiveness of a class both at design and source code levels. In comparison to source code level class cohesion metrics, only a few design level class cohesion metrics have been proposed. Design level class cohesion metrics are based on the assumption that if all the methods of a class have access to similar para-meter types then they all process closely related information. A class with a large number of parameter types common in its methods is more cohesive than a class with less number of parameter types common in its methods. In this paper, we review the design level class cohesion metrics with a special focus on metrics which use similarity of parameter types of methods of a class as the basis of its cohesiveness. Basically three metrics fall in this category: Cohesion among Methods of a Class (CAMC), Normalized Hamming Distance (NHD), and Scaled NHD (SNHD). Keeping in mind the anomalies in the definitions of the existing metrics, a variant of the existing metrics is introduced. It is named NHD Modified (NHDM). An automated metric collection tool is used to collect the metric data from an open source software program. The metric data is then subjected to statistical analysis.

关键词： Design Metrics Class Cohesion Metrics Cohesion among Methods of a Class Normalized Hamming Distance Scaled NHD

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Finite element modeling and analysis of powder mixed electric discharge machining process for temperature distribution and volume removal considering multiple craters

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International Journal of Modeling, Simulation, and Scientific Computing 2014年第3期5卷 115-135页

作者： hardeep singh Anirban Bhattacharya Ajay Batish Mechanical Engineering Department Thapar University Patiala–147004 India

Powder mixed electric discharge machining(PMEDM)is one of the modern developments in electric discharge machining(EDM)*** the present work,finite element modeling has been carried out considering randomly oriented multiple sparks during *** thermal analysis is done to obtain temperature distribution,volume removal,and proportion of volume removed by melting and evaporation at different current,pulse on time and fraction of heat that enters to work *** growing spark behavior and Gaussian distribution of heat source is used to simulate multiple *** distribution along radial direction shows peak temperature at center of spark and thereafter a gradual decrease with increase in radial *** depth direction temperature sharply decreases that forms wider craters with shallow depth in *** temperature and volume removal increases with current more *** removal by melting is much higher than evaporation at lower current settings and with higher current almost equal amount of material is removed by melting and evaporation thus reducing the re-solidification of melted *** plays a significant role behind the contribution of material removal by evaporation followed by fraction of *** in pulse on duration increases the total volume of material removal however does not significantly increase the proportion of volume removal by vaporization.

关键词： Finite element simulation powder mixed electric discharge machining temperature distribution volume removal multiple sparks

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实现优质诊断的五大策略

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英国医学杂志中文版 2022年第6期25卷 353-356页

作者： hardeep singh Denise M Connor Gurpreet Dhaliwal 蒋子涵(译) Center for Innovations in Quality Effectiveness and SafetyMichael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine HoustonTXUSA Department of Medicine University of California San FranciscoSan FranciscoCAUSA Medical Service San Francisco Veterans Affairs Medical CenterSan FranciscoCAUSA 中国医学科学院阜外医院心内科

优质的诊断是衡量高水平医疗的重要指标。然而,诊断错误(diagnostic errors)仍是全世界共同的医疗问题,损害着全球患者的健康1-2。诊断错误的定义为:未能准确且及时地做出诊断,或未能将这些疾病信息充分、有效地与患者沟通。英国最近的... 详细信息

优质的诊断是衡量高水平医疗的重要指标。然而,诊断错误(diagnostic errors)仍是全世界共同的医疗问题,损害着全球患者的健康1-2。诊断错误的定义为:未能准确且及时地做出诊断,或未能将这些疾病信息充分、有效地与患者沟通。英国最近的一项研究显示,4.3%的基层诊疗过程中会出现诊断错误3。而另一项meta分析显示,在美国每年有近25万起诊断错误事件对住院的成人患者造成了伤害4。美国国家科学、工程与医学研究院在报告《改进医疗保健中的诊断质量》中强调,大多数人一生中会至少经历一次诊断错误1。世界卫生组织也已将减少诊断错误作为提高全球患者安全的优先事项5。

关键词：诊断错误 meta分析诊断质量医学研究院医疗保健五大策略成人患者疾病信息

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