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Pien Tze Huang Inhibits Proliferation of Colorectal Cancer Cells through Suppressing PNO1 Expression and Activating p53/p21 Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第6期30卷 515-524页

作者： CAO Liu-jing LIU Li-ya CHEN You-qin han yu-ying WEI Li-hui YAO Meng-ying FANG Yi WU Mei-zhu CHENG ying Thomas J.Sferra LIU Hui-xin LI Li PENG Jun SHEN A-ling Clinical Research Institute the Second Affiliated Hospital&Academy of Integrative MedicineFujian University of Traditional Chinese MedicineFuzhou350122China Fujian Key Laboratory of Integrative Medicine in Geriatrics Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Pediatrics Case Western Reserve University School of MedicineUH Rainbow Babies and Children’s HospitalClevelandOH44106USA Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Health Management Fujian Provincial HospitalShengli Clinical College of Fujian Medical UniversityFuzhou000000China

ObjectiveTo explore the regulatory effect of Pien Tze Huang (PZH) on targeting partner of NOB1 (PNO1) and it’s down-stream mediators in colorectal cancer (CRC) *** polymerase chain reaction was performed to determine mRNA levels of PNO1, TP53, and CDKN1A. Western blotting was performed to determine protein levels of PNO1, p53, and p21. HCT-8 cells were transduced with a lentivirus over-expressing PNO1. Colony formation assay was used to detect cell survival in PNO1 overexpression of HCT-8 cells after PZH treatment. Cell-cycle distribution, cell viability and cell apoptosis were performed to identify the effect of PNO1 overexpression on cell proliferation and apoptosis of HCT-8 cells after PZH treatment. Xenograft BALB/c nude mice bearing HCT116 cells transduced with sh-PNO1 or sh-Ctrl lentivirus were evaluated. Western blot assay was performed to detect PNO1, p53, p21 and PCNA expression in tumor sections. Terminal deoxynucleotidyl transferase dUTP nick end labling (TUNEL) assay was used to determine the apoptotic cells in *** treatment decreased cell viability, down-regulated PNO1 expression, and up-regulated p53 and p21 expressions in HCT-8 cells (Phanism by which PZH induces its CRC anti-proliferative effect is at least in part by regulating the expression of PNO1 and its downstream targets p53 and p21.

关键词： colorectal cancer Pien Tze Huang Chinese medicine partner of NOB1 proliferation p53/p21 pathway

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Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Enhance the Osteoblastic Differentiation of Periodontal Ligament Stem Cells Under High Glucose Conditions Through the PI3K/AKT Signaling Pathway

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Biomedical and Environmental Sciences 2022年第9期35卷 811-820页

作者： YANG Shuo ZHU Biao TIAN Xiao yu yu han ying QIAO Bo ZHAO Li Sheng ZhanG Bin Department of Stomatology The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Stomatology Fuxing HospitalCapital Medical UniversityBeijing 100038China

Objective High glucose(HG)can influence the osteogenic differentiation ability of periodontal ligament stem cells(PDLSCs).Human umbilical cord mesenchymal stem cell-derived exosomes(hUCMSC-exo)have broad application prospects in tissue *** current study aimed to explore whether hUCMSC-exo could promote the osteogenic differentiation of hPDLSCs under HG conditions and the underlying *** We used a 30 mmol/L glucose concentration to simulate HG ***-8 assay was performed to evaluate the effect of hUCMSC-exo on the proliferation of *** phosphatase(ALP)staining,ALP activity,and qRT-PCR were performed to evaluate the pro-osteogenic effect of hUCMSC-exo on *** blot analysis was conducted to evaluate the underlying *** The results of the CCK-8 assay,ALP staining,ALP activity,and qRT-PCR assay showed that hUCMSC-exo significantly promoted cell proliferation and osteogenic differentiation in a dosedependent *** Western blot results revealed that hUCMSC-exo significantly increased the levels of p-PI3K and p-AKT in cells,and the effect was inhibited by LY294002(PI3K inhibitor)or MK2206(AKT inhibitor),***,the increases in osteogenic indicators induced by hUCMSC-exo were significantly suppressed by LY294002 and *** hUCMSC-exo promote the osteogenic differentiation of hPDLSCs under HG conditions through the PI3K/AKT signaling pathway.

关键词： Exosomes Human umbilical cord mesenchymal stem cell Periodontal ligament stem cell Osteogenic differentiation High glucose PI3K/AKT

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Transfer force perception skills to robot‐assisted laminectomy via imitation learning from human demonstrations

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CAAI Transactions on Intelligence Technology 2024年第4期9卷 903-916页

作者： Meng Li Xiaozhi Qi Xiaoguang han ying Hu Bing Li yu Zhao Jianwei Zhang Harbin Institute of Technology ShenzhenChina Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhenChina Shenzhen Key Laboratory of Minimally Invasive Surgical Robotics and System Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina Beijing Jishuitan Hospital Capital Medical UniversityBeijingChina Department of Orthopedics Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina University of Hamburg Hamburg22527Germany

A comparative study of two force perception skill learning approaches for robot‐assisted spinal surgery,the impedance model method and the imitation learning(IL)method,is *** impedance model method develops separate models for the surgeon and patient,incorporating spring‐damper and bone‐grinding *** surgeons'feature parameters are collected and mapped using support vector regression and image navi-gation *** imitation learning approach utilises long short‐term memory networks(LSTM)and addresses accurate data labelling challenges with custom *** results demonstrate skill recognition rates of 63.61%-74.62%for the impedance model approach,relying on manual feature ***,the imitation learning approach achieves a force perception recognition rate of 91.06%,outperforming the impedance model on curved bone *** findings demonstrate the potential of imitation learning to enhance skill acquisition in robot‐assisted spinal surgery by eliminating the laborious process of manual feature extraction.

关键词： learning(artificial intelligence) medical applications medical signal processing robotics

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An axisymmetric characteristic model for enhancing prediction of centrifugal compressor characteristics

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Chinese Journal of Aeronautics 2024年第4期37卷 203-215页

作者： Peng REN Xiangjun FANG Zeyu JIAO ying han School of Energy and Power Engineering Beihang UniversityBeijing 100191China Guangdong Key Laboratory of Modern Control Technology Institute of Intelligent ManufacturingGuangdong Academy of SciencesGuangzhou 510070China

Rapid and accurate determination of compressor characteristic maps is essential for the initial design of centrifugal compressors in aircraft power systems. The accuracy of existing methodologies, which rely on combinations of loss models, varies significantly depending on the compressor's geometry and operational range. This variance necessitates substantial experimental or Computational Fluid Dynamics(CFD) data for coefficient calibration. To address this challenge, this study presents an axisymmetric characteristic model for compressor performance assessment. This model incorporates the factors of blade angle, meridional passage area, and the radial deflection angle of meridional streamlines of the compressor. These factors are derived from fundamental aerodynamic equations encompassing mass, momentum, and energy conservation of the compressor. In contrast to conventional one-dimensional approaches, the proposed method reduces the number of loss coefficients and more effectively accounts for the impact of geometric alterations on centrifugal compressor properties. Furthermore, the model reduces dependence on experimental and CFD data. Efficacy of the model is validated using experimental data from four distinct types of centrifugal compressors. Correlation analysis reveals that the model's coefficients can be expressed as functions of the ratio of the Reynolds number to the impeller tip speed. This ratio serves as a characteristic parameter for the design and optimization of centrifugal compressors. Consequently, the proposed method offers an efficient and accurate means for the quick computation of centrifugal compressor characteristics. This is of great significance for improving the efficiency of centrifugal compressors and reducing energy consumption.

关键词： Centrifugal compressor Positive problem Characteristic prediction Aerodynamic characteristic Axisymmetric model

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Micropulse transscleral laser therapy for secondary angle-closure glaucoma in nanophthalmos: a case report

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1381-1384页

作者： Ping yu Bai-yu Hu yu He Lin Jing han-ying Fan Jing Shu Liu-Zhi Zeng Chengdu First People’s Hospital Chengdu 610095Sichuan ProvinceChina Eye School of Chengdu University of TCM Chengdu 610075Sichuan ProvinceChina

Dear Editor,The choice of surgical intervention for nanophthalmos patients with secondary angle-closure glaucoma poses a challenging decision for *** nanophthalmos patients who have undergone filtration surgery or other intraocular procedures are more susceptible to severe complications,including choroidal effusion,malignant glaucoma,and explosive choroidal hemorrhage,all of which can lead to vision loss[1].This dilemma is particularly pronounced in patients with shorter axial *** transscleral laser therapy(M-TLT),also known as micropulse transscleral cyclophotocoagulation(MP-TSCPC),is a nonincisional laser therapy surgery for glaucoma[2].In 2015,Golan and Kurtz[3]were the first to report four patients with secondary angle-closure glaucoma in nanophthalmos with axial lengths ranging between 17 and 19 mm(mean 18 mm)who were successfully treated with M-TLT,and choroidal detachment was observed in all patients(recovery spontaneously in two patients and recovery after systemic steroid treatment in the other two),of which two had a slight decrease in visual acuity.

关键词： glaucoma surgery closure

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Engagement of N^(6)-methyladenisine methylation of Gng4 mRNA in astrocyte dysfunction regulated by CircHECW2

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1644-1660页

作者： ying Bai Di Chang Hui Ren Minzi Ju yu Wang Biling Chen han Li Xue Liu Daxing Li Xinchen Huo Xiaofei Guo Mengze Tong ying Tan Honghong Yao Bing han Department of Pharmacology Jiangsu Provincial Key Laboratory of Critical Care MedicineSchool of MedicineSoutheast UniversityNanjing 210009China Department of Radiology Zhongda HospitalJiangsu Key Laboratory of Molecular and Functional ImagingMedical School of Southeast UniversityNanjing 210009China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Institute of Life Sciences Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing 210096China Center for Global Health School of Public HealthNanjing Medical UniversityNanjing 211166China

The N^(6)-methyladenosine(m^(6)A)modification is the most prevalent modification of eukaryotic mRNAs and plays a crucial role in various physiological processes by regulating the stability or function of target *** evidence has suggested that m6A methylation may be involved in the pathological process of major depressive disorder(MDD),a common neuropsychiatric disorder with an unclear ***,we found that the levels of the circular RNA HECW2(circHECW2)were significantly increased in the plasma of both MDD patients and the chronic unpredictable stress(CUS)mouse ***,the downregulation of circHECW2 attenuated astrocyte dysfunction and depression-like behaviors induced by ***,we demonstrated that the downregulation of circHECW2 increased the expression of the methylase WTAP,leading to an increase in Gng4 expression via m^(6)A *** findings provide functional insight into the correlation between circHECW2 and m^(6)A methylation,suggesting that circHECW2 may represent a potential target for MDD treatment.

关键词： N^(6)-Methyladenosine Depression circHECW2 Astrocyte WTAP Ubiquitination GNG4 Dysfunction

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Insights into in-situ imbibition behavior of fracturing fluid in propped shale fractures based on nuclear magnetic resonance:A case study from Longmaxi Formation shale,Sichuan Basin,China

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Petroleum Science 2024年第1期21卷 410-429页

作者： Jing-Jing Guo Kai-Xiang Di Lie-Hui Zhang yu-Long Zhao Hui-ying Tang Rui-han Zhang Ye Tian National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500SichuanChina

Shale gas is an important component of unconventional oil and gas *** the imbibition behavior is helpful to optimize flowback parameters and enhance gas *** imbibition studies have focused on shale matrix,and the pressure conditions discussed were mostly *** initial imbibition behavior begins from propped fractures to matrix,but there are few studies working on explaining the imbibition behavior in propped fractures or the phenomenon of many shale wells exhibit higher productivity after a“soaking”***,propped fracture samples were designed for imbibition and migration *** order to accurately study the mechanism and main influencing factors of fracturing fluid imbibition and migration in propped and unpropped shale fractures under high temperature and high pressure,a series of experiments based on nuclear magnetic resonance(NMR)were carried *** showed that NMR T_(2) spectra of all samples exhibited a bimodal *** final imbibition volume of fracturing fluid was positively related to pressure and fracture *** imbibition effect of fracturing fluid was more evident in matrix pores under high *** the migration during soaking stage,the fracturing fluid gradually migrated from large pores to small pores and gradually displaced the shale gas from the matrix,thus allowing the water blocking in propped fractures to self-unlock to some *** permeability decreased in the imbibition stage,while it recovered in the migration stage to some extent.

关键词： Forced imbibition Migration Soaking NMR T_(2)spectra Propped fracture Permeability recovery

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Degradation of Rhodamine B by MnFe-LDH/PMS/O_(3) three-phase catalytic system: performance, mechanism and ecotoxicity studies

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Frontiers of Environmental Science & Engineering 2024年第1期18卷 111-127页

作者： ying han ying Yang Weibao Liu Yilong Hou Ce Wang Jiangwei Shang Xiuwen Cheng Key Laboratory of Pollutant Chemistry and Environmental Treatment College of Chemistry and Environmental ScienceYili Normal UniversityYining 835000China Key Laboratory for Environmental Pollution Prediction and Control of Gansu Province College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China

This study developed a novel MnFe-LDH/PMS/O3 three-phase catalytic system to degrade the organic dye RhB, which was used to address the drawbacks of persulfate oxidation and ozonation techniques. The structure, ionic and elemental composition, specific surface area, and magnetic properties of the LDHs were investigated using a variety of physicochemical characterization tools. The results showed that MnFe-LDH had a large specific surface area, a rich crystalline phase composition, and a functional group structure. The RhB degradation rate of MnFe-LDH/PMS/O3 was 0.34 min−1, which was much higher than that of other comparative systems. RhB could be completely degraded in 10 min after optimization and had a significant effect on TOC removal. The system was found to be effective over a wide pH range. Common anions were largely unaffected and humic acid acted as an inhibitor. At the same time, the system had generally effective degradation performance for different dyes. Combined with quenching experiments and EPR, it was found that SO4•−, •OH, O_(2)•−, and 1O_(2) all participated in the reaction, and •OH contributed more. The degradation pathway of RhB was derived by LC-MS, and the T.E.S.T. evaluation found that the toxicity of the intermediate product was significantly reduced. Finally, the stability and availability of LDHs were verified using cycling experiments and metal ion leaching. This work provides a theoretical basis and data support for the synergistic catalysis of PMS/O3 and the deep treatment of dye wastewater.

关键词： Rhodamine B Layered double hydroxides Peroxymonosulfate Ozonation

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On Stability Discrimination of Limit Cycles for Piecewise Smooth Systems

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1785-1803页

作者： Mao An han Xia yu ZHOU School of Mathematical Sciences Zhejiang Normal UniversityJinhua321004P.R.China

This paper is concerned with the problem of stability discrimination of limit cycles for piecewise smooth *** first establish the Poincaré map near a periodic orbit,and deduce the first order derivative of the map for general piecewise smooth systems on the ***,we obtain a sufficient condition for determining the stability of limit cycles for these systems.

关键词： Piecewise smooth system limit cycle stability

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NHC-derived carbon-centered luminescent radicals with shortwavelength emission via suppression of Kasha's rule

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Science China Chemistry 2024年第8期67卷 2679-2685页

作者： Can Chen Xin Li Xinhua Ouyang ying-Feng han Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry and Materials ScienceNorthwest UniversityXi’an 710127China College of Material Engineering Fujian Agriculture and Forestry University Fuzhou 350108China

Luminescent organic radicals have garnered increasing attention owing to their versatile applications in sensing, imaging, and organic light-emitting diodes(OLEDs), attributed to their unique emission properties originating from the doublet spin ***, the natural narrow bandgap of organic free radicals typically limits their emission to the long-wavelength *** luminescent organic radicals with short-wavelength emission remains a significant challenge. Herein, a series of carbon-centered radicals with short-wavelength emission(383–476 nm) by combining N-heterocyclic carbenes with various polycyclic aromatic hydrocarbons(PAHs)(2-naphthyl, 2a~Ⅰ and 2b~Ⅰ;2-phenanthryl, 2a~Ⅱand 2b~Ⅱ;2-anthryl, 2a~Ⅲand 2b~Ⅲ;3-phenanthryl, 2a~Ⅳand 2b~Ⅳ). Theoretical calculations reveal that the introduction of PAHs significantly increases the ΔE_(D2-D1) in 2a^(Ⅰ–Ⅲ)and 2b^(Ⅰ–Ⅲ)compared to that in phenyl-derived radical congeners. Consequently, the internal transition from D2 to D1 is impeded, leading to a high yield of D2 emission and a suppressed Kasha's rule, thereby overcoming the limitations imposed by their narrow bandgap. For 2a~Ⅳ and 2b~Ⅳ, despite a moderately large ΔED2-D1value, the ΔED3-D1value exceeds 1 e V, indicating that their emission likely originates from the D3 state. Furthermore, we utilized 2a~Ⅲand 2b~Ⅲ as emissive materials in OLEDs,resulting in blue emissions with external quantum efficiencies of 7.5% and 6.5%, respectively.

关键词： N-heterocyclic carbenes luminescent organic molecules carbon-centered radicals short-wavelength emission

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