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Science China Chemistry 2008年第8期51卷 705-708页

作者： JIM Cathy K W LAM Jacky W Y haeussler matthias Department of Chemistry The Hong Kong University of Science & TechnologyClear Water BayKowloonHong KongChina

This paper presents a new synthetic route to hyperbranched polymer. An arylene bipropiolate monomer,dimethylmethylenebis(1,4-phenylene) bipropiolate,was prepared by a one-step esterification reaction of bisphenol A with propiolic acid. Polycyclotrimrtization of the monomer was effected by reflux in dimethylformamide(DMF),producing a soluble hyperbranched poly(aroxycarbonylphenylene) in a good yield. The polymer was perfectly branched with a degree of branching of 100%.

关键词： cyclotrimerization regioselectivity hyperbranched polymer

Genome Editing with CRISPR-Cas9:Can It Get Any Better?

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Journal of Genetics and Genomics 2016年第5期43卷 239-250页

作者： Maximilian haeussler Jean-Paul Concordet Santa Cruz Genomics Institute MS CBSE1156 High StreetUniversity of California Laboratoire Structure et Instabilite des Genomes Inserm U1154CNRS UMR7196Museum national d'Histoire naturelle

The CRISPR-Cas revolution is taking place in virtually all fields of life *** DNA cleavage with the CRISPR-Cas9 system of Streptococcus pyogenes has proven to be extraordinarily simple and efficient,relying only on the design of a synthetic single guide RNA（sgRNA） and its co-expression with ***,we review the progress in the design of sgRNA from the original dual RNA guide for *** and Staphylococcus aureus Cas9（SpCas9 and SaCas9）.New assays for genome-wide identification of offtargets have provided important insights into the issue of cleavage specificity in *** the same time,the on-target activity of thousands of guides has been *** data have led to numerous online tools that facilitate the selection of guide RNAs in target *** appears that for most basic research applications,cleavage activity can be maximized and off-targets minimized by carefully choosing guide RNAs based on computational ***,recent studies of Cas proteins have further improved the flexibility and precision of the CRISPR-Cas toolkit for genome *** by the crystal structure of the complex of sgRNA-SpCas9 bound to target DNA,several variants of SpCas9 have recently been engineered,either with novel protospacer adjacent motifs（PAMs） or with drastically reduced *** Cas9 and Cas9-like proteins called Cpf 1 have also been characterized from other bacteria and will benefit from die insights obtained from *** editing with CRISPR-Cas9 may also progress with better understanding and control of cellular DNA repair pathways activated after Cas9-induced DNA cleavage.

关键词： Genome editing CRISPR-Cas9 system Guide RNA

Methods for measuring pre-,intra-,and postoperative skin thickness for cochlear implants

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Journal of Otology 2022年第2期17卷 72-77页

作者： Lena Zaubitzer Elena Schaefer Elisabeth Wallhaeuser-Franke Johannes Burkart Katrin Herrmann Beatrice Walter Angela Schell Claudia Scherl Jerome Servais Daniel haeussler Department of Otorhinolaryngology Head and Neck Surgery University Hospital MannheimMedical Faculty MannheimRuprecht-Karls-Universitat HeidelbergGermany Department of Neuroradiology University Hospital MannheimMedical Faculty MannheimRuprecht-Karls-Universitat HeidelbergGermany

Objective:This study was conducted to determine whether there is a reliable method for measuring the thickness of the retroauricular skin before,during,and after cochlear implantation,which allows the assessment of the optimal force of the external magnet of the cochlear implant(CI).Methods:The retroauricular skin thickness of 83 patients who received a CI was measured using three different *** thickness was measured on pre-and postoperative CT images,as well as *** magnet category chosen by the surgeon was recorded when the implant was switched on and during the first follow-up *** analyses were performed on the different skin thickness measurements and between the skin thickness and magnet strength ***:Only six patients required an exchange of the magnet until the *** the median absolute thickness differed significantly between the three measures(p<0.0001),their thickness values showed highly significant correlations(Pearson’s r=0.457-0.585;p<0.01).In addition,magnet strength,was significantly correlated with the flap thickness determined pre-,post-,and during *** lowest correlation with magnet strength was found in the intraoperative needle ***:All three measurements methods provided a suitable base for determining the ideal magnetic ***,of particular interest were the pre-and postoperative CT *** first enabled the early assessment of the required magnetic strength and thus a timely postoperative supply,whereas the latter helped to estimate the need for magnetic strength reduction during follow-up care and the feasibility of an early swith-on.

关键词： Cochlear implant Headpiece Magnet strength Flap thickness

加拿大海达瓜伊M_W7.8地震期间同震沉降的潮间带生物指示物

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世界地震译丛 2017年第4期48卷 326-348页

作者： Peter J.haeussler Robert C.Witter Kelin Wang 徐勇不详中国地震局地球物理勘探中心

2012年10月28日海达瓜伊M_W7.8地震是沿加拿大不列颠哥伦比省大倾斜汇聚的夏洛特皇后边缘的大型逆冲区地震。由于在250km的破裂区域内只有6个全球定位系统(GPS)测点和2个检潮仪台站,大地测量没有很好约束同震变形。为了更好地约束垂直... 详细信息

2012年10月28日海达瓜伊M_W7.8地震是沿加拿大不列颠哥伦比省大倾斜汇聚的夏洛特皇后边缘的大型逆冲区地震。由于在250km的破裂区域内只有6个全球定位系统(GPS)测点和2个检潮仪台站,大地测量没有很好约束同震变形。为了更好地约束垂直同震变形,我们测量了相对于震后5个月、25个测点海平面由自然条件控制的两个固着潮间带生物的生长上限。测量了岩藻(双列藻属,617个测点)和常见的橡子藤壶(藤壶属,686个测点)的位置。本研究重点探讨了该群岛的西侧,破裂模型表明有大规模垂直位移,同时也调查了远离推断破裂区的场点,以对照不受垂直位移影响的生物的上限。同时还做了322次海平面测量,以使用TPXO7.2潮汐模型,而不是使用全球定位系统确定的椭圆高度将生长极限与潮汐基准面相关联。用3种方法检查该数据都表明莫尔兹比岛西海岸由于2012年10月28日的海达瓜伊地震而出现了0.4~0.6m的沉降。我们的数据,在误差范围内,与海达瓜伊西海岸两个全球定位系统测点的数据一致,且与该群岛近海而非之下的大型逆冲破裂的破裂模型一致。

关键词：同震全球定位系统 MW7.8 生物指示物潮汐基准面潮间带潮汐模型藤壶破裂区潮汐变化

生物医用器件用Zr55.8Al19.4(Co1-xCux)24.8(x=0-0.8)块体金属玻璃研究

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生物医用器件用Zr55.8Al19.4(Co1-xCux)24.8(x=0-0.8)块体金属玻...

第十一届中国钢铁年会

作者：韩凯明羌建兵王英敏 haeussler Peter 大连理工大学三束材料改性教育部重点实验室

不含有毒元素Zr-Al-Co-Cu系金属玻璃有望用作生物医用器件材料。本文从Zr

关键词： Zr-Al-Co-Cu 金属玻璃力学性能生物医用器件材料

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Cu-Ni-P非晶钎料及其钎焊行为研究

Cu-Ni-P非晶钎料及其钎焊行为研究

第十一届中国钢铁年会

作者：张明海羌建兵王英敏 haeussler Peter 王建豹大连理工大学三束材料改性教育部重点实验室核工业西南物理研究院聚变所

Cu-Ni-P合金常用作Cu/CuCrZr材料连接钎料,但其钎焊接头中易出现CuP脆性相连续析出,导致相关接头性能不佳。针对这一问题,本文基于Cu-Ni-P三元相图特征,利用非晶合金团簇理论设计出CuNiP成分,利用感应熔炼法和急冷甩带技术制备了上述成... 详细信息

Cu-Ni-P合金常用作Cu/CuCrZr材料连接钎料,但其钎焊接头中易出现CuP脆性相连续析出,导致相关接头性能不佳。针对这一问题,本文基于Cu-Ni-P三元相图特征,利用非晶合金团簇理论设计出CuNiP成分,利用感应熔炼法和急冷甩带技术制备了上述成分的合金铸锭与箔带,分析了两种合金样品的凝固组织和熔化行为,并研究了CuNiP箔带钎焊Cu/CuCrZr合金的接头组织与性能。结果表明:通过急冷甩带技术可以获得完全非晶态的CuNiP箔带,由其钎焊获得的Cu/CuCrZr合金接头中的CuP相被Cu基固溶体所割裂,钎缝性能大为改善。

关键词： Cu-Ni-P合金非晶态 Cu/CuCrZr连接钎焊

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钨/低活化钢钎焊用Fe基非晶钎料研究

钨/低活化钢钎焊用Fe基非晶钎料研究