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第三十届中国控制会议

作者： MUTOH Yasuhiko hara tomohiro Department of Engineering and Applied Sciences Sophia University.Tokyo 102-8554Japan

ISBN: (纸本)9789881725592

＜正＞It is well known that,the pole placement controller can be designing for linear time-varying systems using the Frobenius canonical form,as for the time invariant *** paper presents the new approach to the design of the pole placement controller for linear time-varying discrete multivariable *** concept of the relative degrees of multivariable system plays an important role,and the time-varying feedback gain can be simply calculated without transforming the system into any canonical form,which is regarded as a discrete Ackerman’s *** the pole placement for non-lexicographically fixed systems is considered.

关键词： Linear Time-Varying System Multivariable Discrete System Pole Placement Non-lexicographically-Fixed

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Biomarkers in autoimmune pancreatitis and immunoglobulin G4-related disease

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World Journal of Gastroenterology 2021年第19期27卷 2257-2269页

作者： Akane hara tomohiro Watanabe Kosuke Minaga Tomoe Yoshikawa Ken Kamata Masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka-Sayama 589-8511Japan

Solitary organ autoimmune disorders,formerly known as autoimmune pancreatitis(AIP),autoimmune sialadenitis,and autoimmune sclerosing cholangitis,are now considered organ-specific manifestations of systemic immunoglobulin G4-related disease(IgG4-RD).AIP and IgG4-RD are characterized by elevated serum concentration of IgG4 antibody(Ab),accumulation of IgG4-expressing plasmacytes in the affected organs,and involvement of multiple *** is well established that enhanced IgG4 Ab responses are a hallmark of AIP and IgG4-RD for diagnosis and monitoring disease ***,a significant fraction of patients with AIP and IgG4-RD who develop chronic fibroinflammatory responses have normal serum concentrations of this IgG *** addition,disease flare-up is sometimes seen even in the presence of normalized serum concentrations of IgG4 Ab after successful induction of remission by ***,it is necessary to identify new biomarkers based on the understanding of the pathophysiology of AIP and ***,we found that activation of plasmacytoid dendritic cells producing both interferon-α(IFN-α)and interleukin-33(IL-33)mediate murine AIP and human *** importantly,we provided evidence that serum concentrations of IFN-αand IL-33 could be useful biomarkers for the diagnosis and monitoring of AIP and IgG4-RD activity after induction of remission in these autoimmune *** this Frontier article,we have summarized and discussed biomarkers of AIP and IgG4-RD,including Igs,autoAbs,and cytokines to provide useful information not only for clinicians but also for researchers.

关键词： Biomarker Autoimmune pancreatitis Immunoglobulin G4-related disease Plasmacytoid dendritic cells Cytokine Chemokine

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Surface Force Analysis of Pyrite (FeS₂): Its Reactivity to Amino Acid Adsorption

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Advances in Materials Physics and Chemistry 2016年第7期6卷 167-176页

作者： Narangerel Ganbaatar Nina Matsuzaki Yuya Nakazawa Rehana Afrin Masashi Aono Taka-aki Yano tomohiro Hayashi Masahiko hara Chemical Evolution Lab Unit Earth-Life Science Institute (ELSI) Tokyo Institute of Technology Tokyo Japan Department of Electronic Chemistry Interdisciplinary Graduate School of Science and Engineering Tokyo Institute of Technology Tokyo Japan Global Research Cluster RIKEN Saitama Japan

It is well known that mineral surfaces play an important role as catalysts for abiotic polymerization of amino acids to form peptides, which are the main components of the first self-replicating system. Understanding the mechanism behind the adsorption of simple amino acids on mineral surfaces is a topic of great interest not only in field of prebiotic evolution and but also in many other branches of material sciences. Various clay minerals have been suggested for studying how organic molecules were first synthesized in a prebiotic “inorganic” environment. Among them, pyrite (FeS2) is one of the most potential minerals as it possesses a highly reactive surface to drive molecular adsorption in prebiotic chemistry reactions. Recent theoretical experiments suggest that amino acids are adsorbed on the pyrite surface depending on its surface structures. However, these results have not been tested experimentally, and the exact mechanism of the specific interactions on this mineral has not been fully resolved yet at the molecular level. In this work, through quantitative force analysis with atomic force microscope (AFM) in which a single amino acid residue was mounted on the tip apex of AFM probe, we were able to find the reaction sites and study the interaction forces between the amino acid and the pyrite surface. Our results of Raman spectroscopic studies and force measurements with a well-designed AFM probe demonstrated for the first time that pyrite provided higher adsorption probabilities of amino acid residues for the chemical reactions at surfaces.

关键词： Pyrite Mineral-Organic Interface Atomic Force Microscopy Amino Acid Adsorption

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单向碳/环氧和玻纤/环氧复合材料扭转疲劳性能

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钢结构(中英文) 2009年第10期 86-86页

作者： tomohiro Yokozeki Eiichi hara

提出碳/环氧复合材料作为柔性梁材料的可行性。对相同树脂基体的单向碳纤维复合材料和玻璃纤维/环氧复合材料的扭转疲劳性能进行研究。碳纤维复合材料的初始扭转刚度几乎与玻璃纤维复合材料相同。采用有限元计算的扭转刚度与试验结果吻... 详细信息

提出碳/环氧复合材料作为柔性梁材料的可行性。对相同树脂基体的单向碳纤维复合材料和玻璃纤维/环氧复合材料的扭转疲劳性能进行研究。碳纤维复合材料的初始扭转刚度几乎与玻璃纤维复合材料相同。采用有限元计算的扭转刚度与试验结果吻合:扭转刚度主要受控于材料的剪切刚度。通过控制正弦波扭转的角度,进行了恒定受拉轴向荷载下的扭转疲劳试验。尽管根据循环次数降低了扭矩和扭转刚度振幅,无论是碳纤维还是玻璃纤维复合材料都没出现严重的破坏现象。X-射线CT的检查结果以及有限元计算的结果显示:主要是沿着纤维方向裂缝扩展引起扭转刚度的退化,碳纤维扭转疲劳寿命高于玻璃纤维复合材料。因此,根据扭转刚度和张拉-扭转疲劳性能,证实碳纤维具有很好的性能,可作为柔性梁的抗扭材料。

关键词：碳纤维玻璃纤维疲劳基体开裂

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