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Identification of serum immunoglobulin M(IgM)of crucian carp(Carassius auratus gibelio)and immune response to cyprinid herpesvirus 2 infection

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Aquaculture and Fisheries 2024年第2期9卷 172-180页

作者： Shuran wang haotian Wu Longlong wang Pinhua wang Liqun Lu Yousheng Jiang Ye Zhang Dan Xu National Pathogen Collection Center for Aquatic Animals Shanghai Ocean UniversityShanghai201306China Key Laboratory of Aquatic Genetic Resources of the Ministry of Agriculture Shanghai Ocean UniversityShanghai201306China National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean UniversityShanghai201306China

Crucian carp(Carassius auratus gibelio),an extensively cultivated freshwater fish,was one of the model species for the study of fish *** antibodies were advantageous molecular tools for studying teleost immune ***,polyclonal antibodies reacting with immunoglobulins(Ig)were used successfully in studies of the teleost *** the present study,we produced polyclonal antibody against CH2 domains of crucian carp IgM,and measured the in vivo dynamics of IgM mRNA caused by CyHV-2 *** recombinant protein IgM with relative molecular weight about 53 KD was correctly expressed in prokaryotic *** specificity of the polyclonal antibody was evaluated by Western blotting and results revealed that the antibody not only specifically recognized crucian carp serum but also cross-reacted with grass carp *** RT-PCR analysis demonstrated the expression of IgM mRNA changed significantly after CyHV-2 *** expression of IgM in the kidney increased and reached a maximum at 6 h post-infection(hpi),while dropped to a low level at 5 days post-infection(dpi).In conclusion,the expression of IgM was significantly upregulated in the kidney of crucian carp infected with CyHV-2,indicating that IgM played a potential role in systemic immunity against viral *** antibody against crucian carp IgM had certain clinical relevance,which might provide insight into the early stage of virus infection and prevention of the disease.

关键词： Immunoglobulin M Crucian carp Polyclonal antibody Cyprinid herpesvirus 2 Immunoprotection

Multifunctional properties of a polar spin chain compound[N(C_(3)H_(7))_(4)][Cu(C_(8)H_(4)NO_(4))]·H_(2)O exhibiting both one-dimensional magnetism and nonlinear optical activity

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Chinese Chemical Letters 2024年第2期35卷 622-625页

作者： Ang Li Yanhong wang haotian Tian Alimujiang Yalikun Yves Journaux Min Luo Hongcheng Lu Key Laboratory of Material Chemistry for Energy Conversion and Storage School of Chemistry and Chemical EngineeringHubei Key Laboratory of Bioinorganic Chemistry & Materia MedicaHuazhong University of Science and TechnologyWuhan 430074China Key Laboratory of optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 35002China Institut Parisien de Chimie Moléculaire IPCMSorbonne UniversitéCNRSParis F-75252France

Functional materials with multiple properties are urgent to be explored to reach high requirements for applications *** this work,a new multifunctional one-dimensional(1D)chain compound[N(C_(3)H_(7))_(4)][Cu(ohpma)]·H_(2)O 1(ohpma=deprotonated N-(2-hydoxyphenyl)oxamic acid)exhibiting both 1D antiferromagnetic and nonlinear optical properties,which are both originated from the same polar[Cu(C_(8)H_(4)NO_(4))]magnetic units,has been successfully synthesized by evaporation at room ***-polydentate nature of the(ohpma)3−ligand with constrained tridentate and bidentate coordination sites conducts Cu^(2+)ions coordinating in different geometries and forms 1D chains along the c axis,which are further separated by the[N(C_(3)H_(7))_(4)]+*** the 1D magnetic chains further exhibit noncentrosymmetric polar *** optical study shows polar compound 1 exhibits a discernible second-harmonic generation(SHG)efficiency and the calculation of the partial density of states indicates that the SHG efficiency of 1 is mainly originated from the polar[Cu(C_(8)H_(4)NO_(4))]magnetic ***,magnetic susceptibility shows a broad maximum around 70 K with strong intrachain interaction of J/k B=−113.0 K but no long-range order is observed down to 2 K,suggesting that 1 shows a good 1D *** good 1D magnetism and SHG activity suggest that 1 could be as a potential multifunctional material,particularly.

关键词： Multifunctional properties Magnetic property Nonlinear optical property Evaporation One-dimensional chain

A Hybrid Parallel Strategy for Isogeometric Topology Optimization via CPU/GPU Heterogeneous Computing

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1103-1137页

作者： Zhaohui Xia Baichuan Gao Chen Yu haotian Han Haobo Zhang Shuting wang The State Key Lab of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan430074China School of Mathematics and Computer Science Wuhan Polytechnic UniversityWuhan430048China School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan430074China

This paper aims to solve large-scale and complex isogeometric topology optimization problems that consumesignificant computational resources. A novel isogeometric topology optimization method with a hybrid parallelstrategy of CPU/GPU is proposed, while the hybrid parallel strategies for stiffness matrix assembly, equationsolving, sensitivity analysis, and design variable update are discussed in detail. To ensure the high efficiency ofCPU/GPU computing, a workload balancing strategy is presented for optimally distributing the workload betweenCPU and GPU. To illustrate the advantages of the proposedmethod, three benchmark examples are tested to verifythe hybrid parallel strategy in this paper. The results show that the efficiency of the hybrid method is faster thanserial CPU and parallel GPU, while the speedups can be up to two orders of magnitude.

关键词： Topology optimization high-efficiency isogeometric analysis CPU/GPU parallel computing hybrid OpenMPCUDA

Optimising multi-vent module-based adaptive ventilation using a novel parameter for improved indoor air quality and health protection

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Building Simulation 2024年第1期17卷 113-130页

作者： haotian Zhang Xiaoxiao Ding Weirong Zhang Weijia Zhang Yingli Xuan Key Laboratory of Green Built Environment and Energy Efficient Technology Beijing University of TechnologyBeijing 100124China Department ofArchitecture TokyoPolytechnic UniversityTokyoJapan

As infectious respiratory diseases are highly transmissible through the air,researchers have improved traditional total volume air distribution systems to reduce infection ***-vent module-based adaptive ventilation(MAV)is a novel ventilation type that facilitates the switching of inlets and outlets to suit different indoor scenarios without changing ductwork ***,little research has evaluated MAV module sizing and air velocity selection,both related to MAV system efficiency in removing contaminants and the corresponding level of protection for occupants in the ventilated ***,the module-source offset ratio(MSOR)is proposed,based on the MAV module size and its distance from an infected occupant,to inform selection of optimal MAV module *** fluid dynamics simulations illustrated contaminant distribution in a two-person MAV equipped *** phase particles modelled respiratory contaminants from the infected occupant,and contaminant concentration distributions were compared under four MAV air distribution layouts,three air velocities,and three module sizes considered using the *** indicate that lower air velocities favour rising contaminant levels,provided the ventilation rate is *** contaminant discharge can be achieved when the line of outlets is located directly above the infected *** this parameter to guide MAV system design,85.7% of contaminants may be rendered harmless to the human body within 120 s using the default air vent layout.A more appropriate supply air velocity and air vent layout increases this value to 91.4%.These results are expected to inform the deployment of MAV systems to reduce airborne infection risk.

关键词： multi-vent module-based adaptive ventilation computational fluid dynamics indoor air quality infection control

An Adaptive Strategy-incorporated Integer Genetic Algorithm for Wind Farm Layout Optimization

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Journal of Bionic Engineering 2024年第3期21卷 1522-1540页

作者： Tao Zheng haotian Li Houtian He Zhenyu Lei Shangce Gao Faculty of Engineering University of ToyamaToyama9300887Japan

Energy issues have always been one of the most significant concerns for scientists *** the ongoing over exploitation and continued outbreaks of wars,traditional energy sources face the threat of *** energy is a readily available and sustainable energy *** farm layout optimization problem,through scientifically arranging wind turbines,significantly enhances the efficiency of harnessing wind ***-heuristic algorithms have been widely employed in wind farm layout *** paper introduces an Adaptive strategy-incorporated Integer Genetic Algorithm,referred to as AIGA,for optimizing wind farm layout *** adaptive strategy dynamically adjusts the placement of wind turbines,leading to a substantial improvement in energy utilization efficiency within the wind *** this study,AIGA is tested in four different wind conditions,alongside four other classical algorithms,to assess their energy conversion efficiency within the wind *** results demonstrate a notable advantage of AIGA.

关键词： Wind farm layout optimization problem Meta-heuristic algorithms Adaptive Integer genetic algorithm

Learning to select the recombination operator for derivative-free optimization

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Science China Mathematics 2024年第6期67卷 1457-1480页

作者： haotian Zhang Jianyong Sun Thomas Back Zongben Xu School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an710049China Leiden Institute of Advanced Computer Science Leiden UniversityLeiden2333 CANetherlands

Extensive studies on selecting recombination operators adaptively,namely,adaptive operator selection(AOS),during the search process of an evolutionary algorithm(EA),have shown that AOS is promising for improving EA's performance.A variety of heuristic mechanisms for AOS have been proposed in recent decades,which usually contain two main components:the feature extraction and the policy *** feature extraction refers to as extracting relevant features from the information collected during the search *** policy setting means to set a strategy(or policy)on how to select an operator from a pool of operators based on the extracted *** components are designed by hand in existing studies,which may not be efficient for adapting optimization *** this paper,a generalized framework is proposed for learning the components of AOS for one of the main streams of EAs,namely,differential evolution(DE).In the framework,the feature extraction is parameterized as a deep neural network(DNN),while a Dirichlet distribution is considered to be the policy.A reinforcement learning method,named policy gradient,is used to train the *** case studies,the proposed framework is applied to two DEs including the classic DE and a recently-proposed DE,which result in two new algorithms named PG-DE and PG-MPEDE,*** on the Congress of Evolutionary Computation(CEC)2018 test suite show that the proposed new algorithms perform significantly better than their ***,we prove theoretically that the considered classic methods are the special cases of the proposed framework.

关键词： evolutionary algorithm differential evolution adaptive operator selection reinforcement learning deep learning

Deep insight into the B-cell associated tertiary lymphoid structure and tumor immunotherapy

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Cancer Biology & Medicine 2024年第2期21卷 125-131页

作者： Jilong Yang Jin Xu haotian Liu Wanyi Xiao Gengpu Zhang Department of Bone and Soft Tissue Tumor Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Molecular Cancer EpidemiologyTianjin 300060China Department of Anaesthesiology Tianjin University Tianjin HospitalTianjin 300211China

Bod et al.1 recently published a study in Nature that garnered attention to B cell-associated anti-tumor immunity and immunotherapy of melanoma and other *** a promising supplemental immunotherapy to mainstream method... 详细信息

关键词： immunotherapy immunity

Effect of annealing on the electrical performance of N-polarity GaN Schottky barrier diodes

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Journal of Semiconductors 2024年第4期45卷 48-55页

作者： Nuo Xu Gaoqiang Deng haotian Ma Shixu Yang Yunfei Niu Jiaqi Yu Yusen wang Jingkai Zhao Yuantao Zhang State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China

A nitrogen-polarity(N-polarity)GaN-based high electron mobility transistor(HEMT)shows great potential for high-fre-quency solid-state power amplifier applications because its two-dimensional electron gas(2DEG)density and mobility are mini-mally affected by device ***,the Schottky barrier height(SBH)of N-polarity GaN is *** leads to a large gate leakage in N-polarity GaN-based *** this work,we investigate the effect of annealing on the electrical characteristics of N-polarity GaN-based Schottky barrier diodes(SBDs)with Ni/Au *** results show that the annealing time and tem-perature have a large influence on the electrical properties of N-polarity GaN *** to the N-polarity SBD without annealing,the SBH and rectification ratio at±5 V of the SBD are increased from 0.51 eV and 30 to 0.77 eV and 7700,respec-tively,and the ideal factor of the SBD is decreased from 1.66 to 1.54 after an optimized annealing *** analysis results suggest that the improvement of the electrical properties of SBDs after annealing is mainly due to the reduction of the inter-face state density between Schottky contact metals and N-polarity GaN and the increase of barrier height for the electron emis-sion from the trap state at low reverse bias.

关键词： nitrogen polarity GaN Schottky barrier diodes annealing interface state

Autophagy promotes the stemness of pancreatic ductal adenocarcinoma by impairing the nuclear translocation of EHF

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Autophagy promotes the stemness of pancreatic ductal adenoca...