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Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization

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Bone Research 2024年第2期12卷 372-389页

作者： Longqing Wang Wenhao jiang Siyuan Zhao Dong Xie Qing Chen Qi Zhao hao Wu Jian Luo lili Yang Spine Center Department of OrthopaedicsShanghai Changzheng HospitalSecond Affiliated Hospital of Naval Medical UniversityShanghai 200003PR China Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) Tongji University School of MedicineShanghaiPR China Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghaiPR China Department of Orthopaedics No.905 Hospital of PLA NavyShanghaiPR China

Ossification of the Posterior Longitudinal Ligament(OPLL)is a degenerative hyperostosis disease characterized by the transformation of the soft and elastic vertebral ligament into bone,resulting in limited spinal mobility and nerve *** both bulk and single-cell RNA sequencing,we elucidate the molecular characteristics,cellular components,and their evolution during the OPLL process at a single-cell resolution,and validate these findings in clinical *** study also uncovers the capability of ligament stem cells to exhibit endothelial cell-like phenotypes in vitro and in ***,our study identifies LOXL2 as a key regulator in this *** gain-and loss-of-function studies,we elucidate the role of LOXL2 in the endothelial-like differentiation of ligament *** acts via the HIF1A pathway,promoting the secretion of downstream VEGFA and *** function is not related to the enzymatic activity of ***,we identify sorafenib,a broad-spectrum tyrosine kinase inhibitor,as an effective suppressor of LOXL2-mediated vascular *** disrupting the coupling between vascularization and osteogenesis,sorafenib demonstrates significant inhibition of OPLL progression in both BMP-induced and enpp1 deficiency-induced animal models while having no discernible effect on normal bone *** findings underscore the potential of sorafenib as a therapeutic intervention for OPLL.

关键词： LOXL2 ligament finding

Efficient production of ligand-free microscintillators at gram-scale for high-resolution X-ray luminescence imaging

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Chinese Chemical Letters 2024年第3期35卷 554-558页

作者： hao jiang Qihao Chen Hongyu Wang Tingting Wu Jianwei Gong Zhenzhen Zhang Qiushui Chen Huanghao Yang lili Xie New Cornerstone Science Laboratory MOE Key Laboratory for Analytical Science of Food Safety and BiologyCollege of ChemistryFuzhou UniversityFuzhou 350108China School of Public Health Fujian Medical UniversityFuzhou 350108China Joint School of National University of Singapore and Tianjin University Fuzhou International Campus of Tianjin UniversityFuzhou 350207China Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

The efficient production of high-quality scintillators with long radioluminescence afterglow is crucial for high-performance X-ray luminescence extension ***,scaling-up the synthesis of ligand-free scintillators to fabricate large-area X-ray imaging screens for industrial applications remains a *** this study,we report an efficient method to synthesize ligand-free,lanthanide-doped microscintillators by a one-pot reaction via the concentrated hydrothermal *** as-synthesized microscintillators exhibit prolonged persistent radioluminescence for up to 30 days after X-ray exposure and remain high stability in air or water for more than 18 months without *** Carlo simulations indicate that the size effect is responsible for the excellent afterglow performance of the *** employ these high-quality lanthanide-doped microscintillators to fabricate a large-area X-ray imaging detector using a blade-coating method,a spatial resolution of 24.9 lp/mm for X-ray *** study offers a solution for scaling-up the synthesis of low-cost microscintillators for practical applications.

关键词： Microscintillators NaLuF_(4):Tb^(3+) Afterglow X-ray detector X-ray luminescence imaging

Photomediated core modification of diaryl dihydrophenzines through three-component alkylarylation of alkenes toward organocatalyzed ATRP

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Green Synthesis and Catalysis 2024年第1期5卷 35-41页

作者： Yajun Zhang hao Wang Dandan jiang Naixian Sun Wei He lili Zhao Ning Qin Ning Zhu Zheng Fang Kai Guo College of Biotechnology and Pharmaceutical Engineering State Key Laboratory of Materials-Oriented Chemical EngineeringNanjing Tech UniversityNanjing211800China Institute of Advanced Synthesis School of Chemistry and Molecular EngineeringNanjing Tech UniversityNanjing211800China Department of Mechanical Engineering The University of SheffieldSheffieldS13JDUnited Kingdom

The design and synthesis of a novel organic photocatalyst(OPC)have attracted broad interest from both the organic chemistry and polymer ***,we presented a visible-light-induced alkylarylation of alkenes strategy for core modification of 5,10-diaryl-5,10-dihydrophenazines(DADHPs)under metal-and additive-free conditions,with the aim to develop powerful photocatalyst for organocatalyzed atom transfer radical polymerization(O-ATRP).Good tolerance for a wide variety of functional groups and affording the corresponding tetrasubstituted products in moderate to good yields were achieved in the batch and flow *** experimental and computational mechanistic study confirmed that DADHPs’radical cations andπ-πstacking interactions played important roles in the alkylarylation of alkenes.A series of the tetrasubstituted DADHPs were directly synthesized from the corresponding noncore-modified phenazines,which were demonstrated to be effective organic photoredox catalysts for *** responsive nature,controlled polymerization manner,and welldefined poly(methyl methacrylate)were achieved via tetrasubstituted DADHPs mediated O-ATRP.

关键词： Photoinduced Core modification Diaryl dihydrophenzine O-ATRP

Fe_3O_4 nano-whiskers by ultrasonic-aided reduction in concentrated NaOH solution

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Particuology 2011年第1期9卷 86-90页

作者： Chenglong Yu Xin hao Hongtao jiang lili Wang School of Materials Science and Engineering Shaanxi University of Science & Technology Xi'an 710021 China Research Laboratory of Hydrothermal Chemistry Faculty of Science Kochi University Kochi 7808520 Japan

Fe3O4 nano-whiskers were synthesized via ultrasonic-aided reduction of FeCl2.4H2O with N2H4-H2O in concentrated NaOH solution. Phase identification and morphology observation were conducted by X-ray diffraction （XRD） analysis, transmission electron microscopy （TEM） and field emission scanning electron microscopy （FE-SEM）. Face scanning energy dispersive spectrum （face scanning EDS） and twodimensional fast Fourier transform （2DFFF） for element distribution were carried out for confirming composition homogeneity. From XRD and TEIVI, the synthesized Fe304 nano-whiskers are of cubic phase with average dimension of 20 nm~ 200 nm （average aspect ratio of 10）. FE-SEM shows that the nanowhiskers without dispersion are interconnected into a network at a scale of 20μm. 2DFFT of the distribution of Fe and O from face scanning EDS confirms the composition homogeneity of the synthesized Fe3O4. Hydrazine hydrate determines the formation of the nano-whiskers, while the possible mechanism is the preferred growth along certain orientation with the aid of ultrasonic treatment.

关键词： Fe 3 O 4 nano-whiskers Morphology Homogeneity Two-dimensional fast Fourier transform

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高校课程思政与师德师风融合建设路径探析

西安电子科技大学学报（社会科学版） 2024年第1期34卷 131-136页

作者：姜莉莉卢毅石磊戴浩西安电子科技大学空间科学与技术学院陕西西安710126

高等院校的根本任务是立德树人,教师是立德树人的主体力量,课程是立德树人的基础环节和主渠道,课程思政是推动课程建设的积极因素,师德师风是教师为人师表的根本保障。近年来,随着立体化教师发展体系的构筑,高校课程思政与师德师风建设... 详细信息

高等院校的根本任务是立德树人,教师是立德树人的主体力量,课程是立德树人的基础环节和主渠道,课程思政是推动课程建设的积极因素,师德师风是教师为人师表的根本保障。近年来,随着立体化教师发展体系的构筑,高校课程思政与师德师风建设取得了长足发展。但客观而言,高校课程思政与师德师风建设还存在不少需要深入探究、回应解答的理论与实践问题,如何理解两者的关系,便是其中之一。本文从两者的内涵入手,分析两者内在联系及其建设中存在的问题,探讨高校课程思政与师德师风融合建设的若干路径。

关键词：课程思政师德师风融合

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Microstructure evolution of immiscible alloy solidified under the effect of composite electric and magnetic fields

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Journal of Materials Science & Technology 2023年第31期162卷 247-259页

作者： Yanqiang Li Hongxiang jiang hao Sun lili Zhang Jie He Jiuzhou Zhao Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

Solidification experiments were performed with Lead-Aluminum immiscible alloy under the effect of composite electric and magnetic fields(CEMFs).The results demonstrate that CEMFs not only decrease the size of minority phase particles(MPPs)but also promote a more uniform distribution of the MPPs.A theoretical model was built to describe the microstructure evolution during cooling the immiscible *** solidification process of Pb-0.4 wt.%Al alloy under the effect of the CEMFs was *** numerical results are well consistent with the experimental *** results demonstrate that CEMFs affect the solidification process through changing melt convection and the nucleation behavior of minority phase droplets(MPDs).On one hand,the CEMFs can inhibit the convection and lead to the homogeneous distribution of MPPs along the radial direction of the *** the other hand,the CEMFs can increase the nucleation driving force for the MPDs,which decreases the average radius of MPDs and boosts the formation of dispersed solidification *** research indicates that the application of CEMFs is a promising strategy for controlling the microstructure of immiscible alloys.

关键词： Phase separation Solidification Simulation Composite electric and magnetic fields

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防水卷材用隔离包装膜的制备及应用研究

化工新型材料 2024年第4期52卷 249-253页

作者：孙艳美马海霞陈丽莉姜欣家郝喜海湖南工业大学包装与材料工程学院株洲412007

以PVA为主要原料,纳米TiO_(2)和改性MMT为填料,采用溶液流延法制备具有免揭特性的防水卷材隔离包装膜。考察复合薄膜的性能以及对防水效果的影响,以最优配方制备包装隔离膜并采用剥离强度为指标来检测复合薄膜作为防水卷材隔离膜的应用... 详细信息

以PVA为主要原料,纳米TiO_(2)和改性MMT为填料,采用溶液流延法制备具有免揭特性的防水卷材隔离包装膜。考察复合薄膜的性能以及对防水效果的影响,以最优配方制备包装隔离膜并采用剥离强度为指标来检测复合薄膜作为防水卷材隔离膜的应用效果。并通过红外光谱(FT-IR)、X射线衍射(XRD)、扫描电镜(SEM)、热重(TG)、力学测试等手段对复合薄膜的结构、形貌、热稳定性、力学性能进行表征。结果表明:加入改性蒙脱土和纳米TiO_(2)制备的复合薄膜具有良好的热稳定性和力学性能,作为防水卷材隔离包装膜的效果良好,剥离强度可达到2.18N/mm,且该复合薄膜具有环保性、可简化施工流程、无需回收处理。

关键词：聚乙烯醇溶液流延法隔离包装膜免揭型

In-situ composite microstructure formation of immiscible alloy solidified in space

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National Science Review 2023年第2期10卷 88-90页

作者： Jiuzhou Zhao hao Sun lili Zhang Hongxiang jiang Linjie Yang Jie He Shi-changxu Innovation Center for Advanced Materials Institute of Metal Research Chinese Academy of Sciences School of Materials Science and Engineering University of Science and Technology of China

About one-third of alloys show a phase diagram with a miscibility gap in the liquid *** solidifications of these alloys proceed with a liquid-liquid decomposition and have great potential in the development of high-performance in-situ particulate composites,and composites with a core/shell ***,these alloys generally show a phase segregated microstructure when solidified on the *** the 1960s,

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Influence of rare earth cerium on the microstructures and performances of Al-Fe alloy

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Science China(Technological Sciences) 2023年第11期66卷 3317-3327页

作者： LI ShiXin jiang HongXiang LI YanQiang ZHANG lili SUN hao HE Jie jiang HaiCang Zhao JiuZhou Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Binzhou Institute of Technology Binzhou 256606China Shandong Key Laboratory of Advanced Aluminium Materials and Technology Binzhou 256606China

The effects of rare earth addition on the microstructures as well as the tensile performances and electrical conductivity of Al alloys have attracted increasing attention ***,little research has been carried out to investigate the influence of minor Ce(the Ce additive amount is below 0.1 wt.%).In this study,experiments have been performed to explore the effects of minor Ce on the microstructures as well as the tensile properties and the electrical conductivity of Al-Fe *** results demonstrate that minor rare earth Ce addition not only leads to the α-Al refinement and the modification of Al_(13)Fe_(4) minority phase,but also decreases the solid solubility of *** grain refinement induced by Ce addition has a negligible influence on the tensile strength and yield strength,while the ductility and conductivity can be simultaneously ascended by adding rare earth *** modification of Al_(13)Fe_(4) minority phase is responsible for the increment of ductility,and the diminution of Si solid solubility in the Al matrix leads to the increase of electrical *** work provides a strategy for concurrently improving the tensile performances and electrical conductivity of aluminum alloy.

关键词： aluminum alloy rare earth cerium microstructure conductivity property tensile performance