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排卵障碍性不孕的中医药治疗研究进展

中国当代医药 2024年第21期31卷 191-194页

作者：朱丹丹李程程郝晓园江苏省徐州矿务集团总医院妇产科江苏徐州221000

不孕症为比较常见的女性生殖健康问题,其不仅会对患者心理健康、生活质量产生影响,同时还可能导致家庭关系不和谐。排卵障碍性不孕为常见的不孕症类型,其发生率在近年来持续增长。该病的治疗关键在于促排卵,西药治疗该病能够促进排卵,... 详细信息

不孕症为比较常见的女性生殖健康问题,其不仅会对患者心理健康、生活质量产生影响,同时还可能导致家庭关系不和谐。排卵障碍性不孕为常见的不孕症类型,其发生率在近年来持续增长。该病的治疗关键在于促排卵,西药治疗该病能够促进排卵,但存在高排低孕的情况,治疗效果存在不确定性,长期用药还会导致卵巢综合征、子宫内膜癌等疾病发生风险增加。近年来中医在临床疾病诊治领域应用广泛并积累了比较丰富的经验,中医药治疗该病具有明显的优势,能够辨证论治。但中医药治疗方法较多,如辨证论治、中药调周序贯疗法、中医外治法等,临床应结合疾病诊断与治疗经验选择更加有效的治疗方案。本文就排卵障碍性不孕的病因病机、中医药治疗方法进行综述,以促进该病疗效的提升。

关键词：排卵障碍不孕中医药病因病机辨证论治

基于根因分析法的预见性护理在经阴道分娩产妇中的运用

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护理实践与研究 2024年第4期21卷 596-602页

作者：李敏马艳郝晓园周伟郭丽伟徐州矿务集团总医院产科江苏省徐州市221006

目的探讨基于根因分析法的预见性护理干预对经阴道分娩产妇产后出血情况、舒适度的影响。方法选取2022年6月—2023年4月医院收治的120例经阴道分娩产妇作为研究对象,按照组间资料均衡可比的原则将其分对照组和观察组,各60例。对照组... 详细信息

目的探讨基于根因分析法的预见性护理干预对经阴道分娩产妇产后出血情况、舒适度的影响。方法选取2022年6月—2023年4月医院收治的120例经阴道分娩产妇作为研究对象,按照组间资料均衡可比的原则将其分对照组和观察组,各60例。对照组接受常规护理,观察组接受基于根因分析法的预见性护理干预,比较两组产妇产后出血状况和出血相关指标[产后出血率、产后2 h和24 h出血量、血小板反应蛋白1(thrombospondin 1,THBS-1)、25-羟维生素D3[25-hydroxyvitamin D3,25(OH)D3]、一氧化氮合酶(nitric oxide synthase,NOS)]、舒适度[舒适状况量表(General Comfort Questionnaire,GCQ)]、心理情绪[焦虑自评量表(Self Rating Anxiety Seale,SAS)、抑郁自评量表(Self-Rating Depression Scale,SDS)]、妊娠结局指标[不良妊娠结局发生率、环氧合酶-2(cyclooxyge-nase-2,COX-2)、基质金属蛋白酶-1(matrix metalloproteinase-1,MMP-1)]。结果观察组产妇产后出血率低于对照组,产后2 h、24 h出血量低于对照组,组间比较差异均有统计学意义(P0.05);干预后,观察组产妇GCQ舒适度评分高于对照组,差异有统计学意义(P0.05);干预后,观察组产妇SAS评分、SDS评分低于对照组,差异有统计学意义(P<0.05)。观察组产妇不良妊娠结局发生率低于对照组,差异有统计学意义(P<0.05)。观察组产妇COX-2、MMP-1低于对照组,差异有统计学意义(P<0.05)。结论经阴道分娩产妇在分娩过程中接受基于根因分析法的预见性护理干预,能让产妇在分娩过程中保持良好情绪,提升分娩舒适度,降低产后出血量和不良妊娠结局。

关键词：阴道分娩根因分析法预见性护理干预出血舒适度妊娠结局

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几种诱抗剂对西瓜ZYMV的防治效果评价

中国蔬菜 2024年第1期 60-67页

作者：郝小苑刘卓文刘枫楠刘莉铭吴会杰古勤生康保珊中国农业科学院郑州果树研究所河南省果树瓜类生物学重点实验室河南郑州450009 中国农业科学院中原研究中心河南新乡453500

为探索对西瓜病毒病具有防效作用的植物免疫诱抗剂,以小西葫芦黄花叶病毒(zucchini yellow mosaic virus,ZYMV)为防治对象,植株的显症率及相对防效为指标,评价了6种不同浓度的哌啶酸(Pip)、N-羟基哌啶酸(NHP)、没食子酸、苯并噻二唑(BTH... 详细信息

为探索对西瓜病毒病具有防效作用的植物免疫诱抗剂,以小西葫芦黄花叶病毒(zucchini yellow mosaic virus,ZYMV)为防治对象,植株的显症率及相对防效为指标,评价了6种不同浓度的哌啶酸(Pip)、N-羟基哌啶酸(NHP)、没食子酸、苯并噻二唑(BTH)、壳寡糖、β–氨基丁酸(β-aminobutyric acid,BABA)及其2种药剂和3种药剂复配后对该病毒的防治效果。结果显示,单一药剂喷施后对西瓜ZYMV的防效从高到低依次为:NHP(0.5 mmol·L^(-1))、Pip(2 mmol·L^(-1))、壳寡糖(1 g·L^(-1))、没食子酸(0.5 g·L^(-1))、BABA(1 mmol·L^(-1))、BTH(0.1 mmol·L^(-1));复配药剂试验中,2种药剂复配防效最好的是2-Ⅶ(NHP 0.5 mmol·L^(-1)+Pip 2 mmol·L^(-1)),接种后11 d、无菌水对照植株显症率达到100.00%时,该组合处理的植株显症率为10.00%,相对防效达89.99%,但该复配药剂会影响植株生长;3种药剂复配防效较好的组合是3-Ⅰ(没食子酸0.5 g·L^(-1)+NHP 0.5 mmol·L^(-1)+BABA 1 mmol·L^(-1))和3-Ⅱ(没食子酸0.5 g·L^(-1)+NHP 0.5 mmol·L^(-1)+Pip 2 mmol·L^(-1)),显症率分别为27.27%、33.33%,相对防效分别为79.49%、68.27%,显著高于其他组合,其中3-Ⅱ处理的植株显症率增加缓慢,防病效果较其他处理持久,防治效果最优。综上,NHP、Pip和没食子酸3种诱抗剂在预防西瓜病毒病害中具有潜在的应用价值。

关键词：诱抗剂西瓜小西葫芦黄花叶病毒防效

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AHLs信号分子强化颗粒污泥系统性能的研究进展

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环境与发展 2024年第2期36卷 54-60页

作者：张瑞娜郝晓媛衣隆强刘长远韩蕊吴英海大连海洋大学海洋与土木工程学院辽宁大连116023 设施渔业教育部重点实验室(大连海洋大学) 辽宁大连116023

针对颗粒污泥系统性能强化的问题,介绍了酰基高丝氨酸内酯(acyl homoserine lactones,AHLs)信号分子强化颗粒污泥系统性能的研究进展,分析了外源AHLs对活性污泥颗粒聚集、稳定性以及微生物微生态的影响,探讨了基于AHLs的群体感应(quorum... 详细信息

针对颗粒污泥系统性能强化的问题,介绍了酰基高丝氨酸内酯(acyl homoserine lactones,AHLs)信号分子强化颗粒污泥系统性能的研究进展,分析了外源AHLs对活性污泥颗粒聚集、稳定性以及微生物微生态的影响,探讨了基于AHLs的群体感应(quorum sensing,QS)对颗粒污泥系统的强化效果,总结了溶解氧浓度、温度、盐度和pH值对外源AHLs效果的影响,梳理了近年来的主要研究方向和成果,指出了今后的研究方向。

关键词：群体感应微生物强化活性污泥处理效率污水处理

Tourists’ Perception of Celebrity Memorial Hall Under Red Tourism Back-ground:A Case Study of Wu Lanfu Memorial Hall

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Journal of Landscape Research 2019年第4期11卷 93-97,101页

作者： HAN Dong LI Meng hao xiaoyuan HAN Li College of History and Tourism Culture Inner Mongolia University Huhhot Inner Mongolia 010070 China Foreign Languages College Inner Mongolia University Huhhot Inner Mongolia 010070 China

Wu Lanfu Memorial Hall is taken as research object. By combining web text analysis with questionnaire research, comprehensive analysis of tourist experience information (thematic background, scenic area services and hardware infrastructure) of research object is conducted under red tourism perspective. Via further correlation analysis, the dimensions that influence visitors’perception and experience of celebrity memorial hall are found, which attempts to contribute to the more comprehensive promotion of the tourism experience of red tourist attractions. Research results are as below. First, visitors are generally satisfied with the overall perception of celebrity memorial hall, and celebrity memorial hall occupies an indispensable position in the red tourism system. Second, visitors’ potential perception of memorial hall is quite different from their actual perception, and the quality of scenic spots does not match its potential perception. Third, celebrity effect plays a prominent role in red tourism attractions. Fourth, celebrity memorial hall play an important role in the inheritance and dissemination of red culture. Corresponding improvement suggestions are put forward in this paper based on above conclusions, and it aims to provide the reference for the development of red tourism and the spread of red culture in ethnic regions.

关键词： Red tourism Celebrity memorial hall Tourists' perception Wu Lanfu Memorial Hall

Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2936-2952页

作者： Liang Zhao Yizhen Pang Yangfan Zhou Jianhao Chen hao Fu Wei Guo Weizhi Xu Xin Xue Guoqiang Su Long Sun Hua Wu Jingjing Zhang Zhanxiang Wang Qin Lin xiaoyuan Chen haojun Chen Department of Nuclear Medicine and Minnan PET Center Xiamen Key Laboratory of RadiopharmaceuticalsThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingaporeSingapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Department of Radiation Oncology Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Colorectal Tumor Surgery Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Cardiothoracic Surgery Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingChina Nanomedicine Translational Research Program NUS Center for NanomedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Department of Neurosurgery and Department of Neuroscience Fujian Key Laboratory of Brain Tumors Diagnosis and Precision TreatmentXiamen Key Laboratory of Brain Centerthe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamenChina

Radiotherapy combined with immune checkpoint blockade holds great promise for synergistic antitumor *** radionuclide therapy delivers radiation directly to tumor ***1004 is a fibroblast activation protein(FAP)-targeting radiopharmaceutical,conjugated with the albumin binder Evans Blue,which has demonstrated enhanced tumor uptake and retention in previous preclinical and clinical ***,we demonstrate that^(68)Ga/^(177)Lu-labeled LNC1004 exhibits increased uptake and prolonged retention in MC38/NIH3T3-FAP and CT26/NIH3T3-FAP tumor *** therapy with^(177)Lu-LNC1004 induced a transient upregulation of PD-L1 expression in tumor *** combination of^(177)Lu-LNC1004 and anti-PD-L1 immunotherapy led to complete eradication of all tumors in MC38/NIH3T3-FAP tumor-bearing mice,with mice showing 100%tumor rejection upon ***,single-cell RNA sequencing(scRNA-seq),and TCR sequencing revealed that combination therapy reprogrammed the tumor microenvironment in mice to foster antitumor immunity by suppressing malignant progression and increasing cell-to-cell communication,CD8^(+)T-cell activation and expansion,M1 macrophage counts,antitumor activity of neutrophils,and T-cell receptor diversity.A preliminary clinical study demonstrated that^(177)Lu-LNC1004 was well-tolerated and effective in patients with refractory ***,scRNA-seq of peripheral blood mononuclear cells underscored the importance of addressing immune evasion through immune checkpoint blockade *** was emphasized by the observed increase in antigen processing and presentation juxtaposed with T cell *** conclusion,our data supported the efficacy of immunotherapy combined with^(177)Lu-LNC1004 for cancer patients with FAP-positive tumors.

关键词： immunity retention holds

HBV pgRNA在慢性乙型肝炎进程中的可能意义

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临床肝胆病杂志 2018年第10期34卷 2221-2223页

作者：谭宁罗皓徐小元北京大学第一医院感染疾病科北京100034

HBV pgRNA是HBV cccDNA的直接转录产物,能够通过反映HBV cccDNA的转录活动状态进而反映慢性乙型肝炎病情进展,指导临床治疗和判断预后。与其他常用HBV感染血清标志物相比,HBV pgRNA在反映HBV复制活动和抗病毒治疗效果等方面更灵敏,对于... 详细信息

HBV pgRNA是HBV cccDNA的直接转录产物,能够通过反映HBV cccDNA的转录活动状态进而反映慢性乙型肝炎病情进展,指导临床治疗和判断预后。与其他常用HBV感染血清标志物相比,HBV pgRNA在反映HBV复制活动和抗病毒治疗效果等方面更灵敏,对于抗病毒治疗阶段终点有预测价值。通过综合HBV pgRNA与HBcrAg、HBV cccDNA的相关性来阐述HBV pgRNA在反映慢性乙型肝炎治疗过程中病情变化的可能意义。

关键词：肝炎,乙型,慢性 HBV pgRNA HBcrAg 综述

系统性红斑狼疮合并妊娠64例临床病例资料分析

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中国医学工程 2019年第2期27卷 20-26页

作者：郝晓圆内蒙古医科大学附属医院风湿科内蒙古呼和浩特010010

目的将系统性红斑狼疮患者中选择性妊娠与非选择性妊娠的母体病情及胎儿情况进行对比,以便更好指导临床。方法分为选择性妊娠组和非选择性妊娠组,对两组患者一般情况(年龄、病程)、怀孕后的系统性红斑狼疮(SLE)病情变化、是否发生妊娠... 详细信息

目的将系统性红斑狼疮患者中选择性妊娠与非选择性妊娠的母体病情及胎儿情况进行对比,以便更好指导临床。方法分为选择性妊娠组和非选择性妊娠组,对两组患者一般情况(年龄、病程)、怀孕后的系统性红斑狼疮(SLE)病情变化、是否发生妊娠并发症如妊娠高血压疾病、妊娠结局如流产早产及死胎、胎儿出生后Apgar评分、妊娠方式的选择以及预测怀孕过程中病情恶化的相关因素进行整理分析。结果①选择性妊娠组较非选择性妊娠组疾病活动率低,足月产率高,早产率、低体重儿及新生儿呼吸窘迫比例低,妊娠高血压发生比例低。②单因素分析发现妊娠前低补体、双链DNA(dsDNA)(+)及血沉快是狼疮病情恶化的危险因素。结论所有患者均面临病情复发、妊娠相关并发症及妊娠不良结局,但选择性妊娠组均优于非选择性妊娠组。

关键词：系统性红斑狼疮妊娠并发症选择性妊娠非选择性妊娠

Autocatalytic bifunctional supramolecular hydrogels for osteoporotic bone repair

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National Science Review 2024年第07期 263-278页

作者： Zhihui Han Xiang Gao Yuanjie Wang Cheng Huang hao Song Shuning Cheng xiaoyuan Yang Xiaoliang Cui Jie Wu Kailu Wei Liang Cheng Institute of Functional Nano&Soft Materials(FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow University Department of Orthopedics The Second Affiliated Hospital of Soochow University Macao Institute of Materials Science and Engineering Macau University of Science and Technology

Conventional bone scaffolds, which are mainly ascribed to highly active osteoclasts and an inflammatory microenvironment with high levels of reactive oxygen species and pro-inflammatory factors, barely satisfy osteoporotic defect repair. Herein, multifunctional self-assembled supramolecular fiber hydrogels(Ce–Aln gel) consisting of alendronate(Aln) and cerium(Ce) ions were constructed for osteoporotic bone defect repair. Based on the reversible interaction and polyvalent cerium ions, the Ce–Aln gel, which was mainly composed of ionic coordination and hydrogen bonds, displayed good injectability and autocatalytic amplification of the antioxidant effect. In vitro studies showed that the Ce–Aln gel effectively maintained the biological function of osteoblasts by regulating redox homeostasis and improved the inflammatory microenvironment to enhance the inhibitory effect on osteoclasts. Ribonucleic acid(RNA) sequencing further revealed significant downregulation of various metabolic pathways, including apoptosis signaling,hypoxia metabolism and tumor necrosis factor-alpha(TNF-α) signaling via the nuclear factor kappa-B pathway after treatment with the Ce–Aln gel. In vivo experiments showed that the clinical drug-based Ce–Aln gel effectively promoted the tissue repair of osteoporotic bone defects by improving inflammation and inhibiting osteoclast formation at the defect. Notably, in vivo systemic osteoporosis was significantly ameliorated, highlighting the strong potential of clinical translation for precise therapy of bone defects.

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