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An N/4 fixed-point duality quantum search algorithm

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中国科学：物理学、力学、天文学英文版 2010年第9期53卷 1765-1768页

作者： hao liang1,liu {2.2.& LONG guilu1,3 1key laboratory for Atomic and molecular nanosciences and department of physics,tsinghua University,Beijing {{12.,china 2.chool of Sciences,Dalian Nationalities University,Dalian 116600,china 3tsinghua National laboratory for Information Science and Technology,Beijing {{12.,china 1. key laboratory for Atomic and {2. nanosciences and department of physics Tsinghua University Beijing 100084 China2. School of Sciences Dalian Nationalities University Dalian 116600 China3. Tsinghua National Laboratory for Information Science and Technology Beijing 100084 China

Here a fixed-point duality quantum search algorithm is *** algorithm uses iteratively non-unitary operations and measurements to search an unsorted *** the marked item is found,the algorithm stops *** algorithm uses a constant non-unitary operator,and requires N/4 steps on average(N is the number of data from the database) to locate the marked *** implementation of this algorithm in a usual quantum computer is also demonstrated.

关键词： fixed-point search algorithm duality quantum computing the N4 duality search algorithm

Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis

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World Journal of Gastroenterology 2024年第15期30卷 2143-2154页

作者： Sen Li Qian-Jun Ren Can-hao Xie Yang Cui Li-Tao Xu Yi-dan Wang Su Li Xing-Qiu {2. Bin Wen Ming-Kun {2. Xiao-Fang Zhao department of Basic Science Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina department of Science and Technology Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Traditional Chinese Medicine Specialty Office Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina

BACKGROUND Liver fibrosis is a compensatory response during the tissue repair process in chronic liver injury,and finally leads to liver cirrhosis or even hepatocellular *** pathogenesis of hepatic fibrosis is associated with the progressive accumulation of activated hepatic stellate cells(HSCs),which can transdiffer-entiate into myofibroblasts to produce an excess of the extracellular matrix(ECM).Myofibroblasts are the main source of the excessive ECM responsible for hepatic ***,activated hepatic stellate cells(aHSCs),the principal ECM producing cells in the injured liver,are a promising therapeutic target for the treatment of hepatic *** To explore the effect of taurine on aHSC proliferation and the mechanisms *** Human HSCs(LX-2.were randomly divided into five groups:Normal control group,platelet-derived growth factor-BB(PDGF-BB)(2. ng/mL)treated group,mmol/L,respectively)with PDGF-BB(2. ng/mL)treated *** Counting Kit-8 method was performed to evaluate the effect of taurine on the viability of ***-linked immunosorbent assay was used to estimate the effect of taurine on the levels of reactive oxygen species(ROS),malondialdehyde,glutathione,and iron *** electron microscopy was applied to observe the effect of taurine on the autophagosomes and ferroptosis features in *** real-time polymerase chain reaction and Western blot analysis were performed to detect the effect of taurine on the expression ofα-SMA,Collagen I,Fibronectin 1,LC3B,ATG5,Beclin 1,PTGS2.SLC7A11,and *** Taurine promoted the death of aHSCs and reduced the deposition of the *** with taurine could alleviate autophagy in HSCs to inhibit their activation,by decreasing autophagosome formation,downregulating LC3B and Beclin 1 protein expression,and upregulating p62.protein ***,treatment with taurine triggered ferroptosis and ferritinophagy to eliminate aHSCs characterized b

关键词： Hepatic stellate cells Autophagy Ferroptosis molecular docking Taurine

R11 peptides can promote the molecular imaging of spherical nucleic acids for bladder cancer margin identification

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Nano Research 2022年第3期15卷 2278-2287页

作者： Minghai Ma Pu Zhang Xiao liang Daxiang Cui Qiuya Shao Haibao Zhang Mengzhao Zhang Tao Yang Lu Wang Nan Zhang Minxuan Jing Lu Zhang Weichao dan Rundong Song Xi liu Jiatao hao Yuhang Chen Lijiang Gu Lei Wang Jinhai Fan department of Urology The First Affiliated HospitalXi’an Jiaotong UniversityXi’an 710061China department of Urology Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014China department of Thoracic Surgery Tangdu HospitalAir Force Medical UniversityXi’an 710038China department of Bio-Nano-Science and Engineering National Key Laboratory of Nano/Micro Fabrication TechnologyInstitute of Micro-Nano Science and TechnologyShanghai Jiao Tong UniversityShanghai 200240China

One of the critical problems in bladder cancer(BC)management is the local recurrence of ***,achieving the accurate delineation of tumor margins intraoperatively remains extremely difficult due to the lack of effective tumor margin recognition ***,survivin molecular beacon(MB)and R11 peptide-linked spherical nucleic acids(SNAs)were synthesized as nanoprobes(AuNP-MB@R11)for sensitive detection of BC *** properties proved that R11 peptides and survivin MB were successfully loaded onto the surface of ***-MB@R11 had good stability against nuclease activity and high sensitivity and specificity to detect survivin single strand DNA(ssDNA)in *** to cytology,R11 peptides could increase the BC targeting ability and membrane penetrability of ***,R11 peptides significantly promoted the disintegration of lysosomes and the release of SNAs to enhance fluorescence imaging *** RNA sequencing proved that some genes and pathways related to endocytosis and lysosomes were significantly regulated,such as AGPAT5,GPD1L,and *** orthotopic BC models and a clinical sample from a patient with BC,AuNP-MB@R11 showed a more legible cancerous fluorescence margin and offered remarkably improved detection compared to those achieved by SNAs.R11 peptide-linked SNAs present promising potential to identify BC margin,which may help to improve the R0 resection rate in surgery and improve patients’quality of life.

关键词： R11 peptides molecular beacons spherical nucleic acids tumor targeting lysosome escape bladder cancer

Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2.transcription network

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Protein & Cell 2021年第7期12卷 557-577页

作者： Yu-Kun Xia Yi-Rong Zeng Meng-Li Zhang Peng liu Fang liu {2. Zhang Chen-Xi He Yi-Ping Sun Jin-Ye Zhang Cheng Zhang Lei Song Chen Ding Yu-Jie Tang Zhen Yang Chen Yang Pu Wang Kun-liang Guan Yue Xiong dan Ye Huashan Hospital Fudan Universityand Molecular and Cell Biology LabInstitutes of Biomedical Sciencesand the Shanghai Key Laboratory of Medical Epigeneticsand the Key Laboratory of Metabolism and MolecularMinistry of EducationShanghai 200032China The International Co-laboratory of Medical Epigenetics and Metabolism Ministry of Science and TechnologyShanghai 200032China department of Neurosurgery Huashan HospitalFudan UniversityShanghai 200032China key laboratory of Cell Differentiation and Apoptosis of National Ministry of Education Department of PathophysiologyShanghai Jiao Tong University School of MedicineShanghai 200025China key laboratory of Synthetic Biology Institute of Plant Physiology and EcologyShanghai 200032China Institutes for Biological Sciences Chinese Academy of SciencesShanghai 200032China State key laboratory of Proteomics Beijing Proteome Research CenterBeijing Institute of Radiation MedicineBeijing 102206China National Center for Protein Sciences(The PHOENIX Center Beijing)Beijing 102206China State key laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development School of Life SciencesInstitutes of Biomedical SciencesFudan UniversityShanghai 200032China department of Pharmacology and Moores Cancer Center University of California San DiegoLa JollaCAUSA Lineberger Comprehensive Cancer Center Department of Biochemistry and BiophysicsUniversity of North CarolinaChapel HillNCUSA department of General Surgery Huashan HospitalFudan UniversityShanghai 200032China

Additional sex combs-like 1(ASXL1)interacts with BRCA1-associated protein 1(BAP1)deubiquitinase to oppose the polycomb repressive complex 1(PRC1)-mediated histone H2. *** BAP1 mutations are found in a spectrum of human malignancies,while ASXL1 mutations recurrently occur in myeloid neoplasm and are associated with poor *** all ASXL1 mutations are heterozygous frameshift or nonsense mutations in the middle or to a less extent the C-terminal region,resulting in the production of C-terminally truncated mutant ASXL1 *** ASXL1 regulates specific target genes and how the C-terminal truncation of ASXL1 promotes leukemogen-esis are ***,we report that ASXL1 interacts with forkhead transcription factors FOXK1 and FOXK2.to regulate a subset of FOXK1/K2.target *** show that the C-terminally truncated mutant ASXL1 proteins are expressed at much higher levels than the wild-type protein in ASXL1 heterozygous leukemia cells,and lose the ability to interact with FOXK1/*** deletion of the mutant allele eliminates the expression of C-termi-nally truncated ASXL1 and increases the association of wild-type ASXL1 with BAP1,thereby restoring the expression of BAP1-ASXL1-FOXK1/K2.target genes,particularly those involved in glucose metabolism,oxygen sensing,and JAK-STAT3 signaling *** addition to FOXK1/K2.we also identify other DNA-bind-ing transcription regulators including transcription factors(TFs)which interact with wild-type ASXL1,but not C-terminally truncated *** results suggest that ASXL1 mutations result in neomorphic alleles that contribute to leukemogenesis at least in part through dominantly inhibiting the wild-type ASXL1 from interacting with BAP1 and thereby impairing the function of ASXL1-BAP1-TF in regulating target genes and leukemia cell growth.

关键词： ASXL1 BAP1 FOXK1/K2 leukemia epigenetics

口腔鳞癌中缺氧基因相关预后模型的构建与验证

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实用口腔医学杂志 2023年第2期39卷 198-202页

作者：梁丹卢浩复旦大学附属中山医院口腔科上海200032 上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科

目的:通过生物信息学筛选并建立与口腔鳞状细胞癌(OSCC)患者预后相关的缺氧基因预后模型。方法:通过癌症基因组图谱(TCGA)和GEO数据库下载OSCC患者的mRNA表达谱、临床数据和预后信息;通过蛋白互作网络(PPI)、Cox回归分析筛选和建立缺氧... 详细信息

目的:通过生物信息学筛选并建立与口腔鳞状细胞癌(OSCC)患者预后相关的缺氧基因预后模型。方法:通过癌症基因组图谱(TCGA)和GEO数据库下载OSCC患者的mRNA表达谱、临床数据和预后信息;通过蛋白互作网络(PPI)、Cox回归分析筛选和建立缺氧基因预后模型;生存分析(Kaplan-Meier, K-M)和受试者工作特征曲线(ROC)检验预后模型的准确性,单因素和多因素Cox回归评估模型作为独立预后因素的可行性;免疫相关性分析筛选差异表达的免疫检查点基因。结果:通过Cox回归分析构建了基于SLC2.3、GPI、PGK1三个缺氧基因的预后模型,将OSCC患者分为高风险组(n=173)、低风险组(n=172.。TCGA数据库中K-M生存曲线显示高风险组患者的生存率(OS)明显低于低风险组患者(P1),患者1、 3、 5年ROC曲线下面积分别为0.62., 0.677和0.713;GEO数据库中K-M生存曲线显示高风险组患者的生存率(OS)明显低于低风险组患者(P=0.02.),患者1、 3、 5年ROC曲线下面积分别为0.683、 0.705和0.690;单因素和多因素Cox回归分析显示,该预后模型可作为评估OSCC患者生存率的独立预后因素(P1);免疫相关性分析表明CD2.6等免疫检查点分子在不同风险组中表达具有显著性差异(P1)。结论:OSCC缺氧基因相关预后模型具有良好的预测性能,可为OSCC患者进行精准分组和靶向治疗提供参考。

关键词：口腔鳞状细胞癌缺氧基因预后模型免疫治疗

基于高效液相色谱-四级杆飞行时间质谱的硫酸多黏菌素E组分的结构分析

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中国药学杂志 2021年第1期56卷 54-62页

作者：张含智孙宁秦峰罗文燕赵敬丹闻宏亮裘亚刘浩李敏上海市食品药品检验所上海201203 上海科技大学免疫化学研究所上海201203 复旦大学化学系上海200438 复旦大学附属中山医院普外科上海200032

目的建立基于高效液相色谱-四级杆飞行时间质谱(HPLC-Q/TOF-MS)的分析方法,对硫酸多黏菌素E中的组分进行结构解析,结合光化学反应鉴定双键化组分。方法通过HPLC-Q/TOF-MS/MS对主要组分多黏菌素E1和E2.谱数据的分析,总结了多黏菌素类化... 详细信息

目的建立基于高效液相色谱-四级杆飞行时间质谱(HPLC-Q/TOF-MS)的分析方法,对硫酸多黏菌素E中的组分进行结构解析,结合光化学反应鉴定双键化组分。方法通过HPLC-Q/TOF-MS/MS对主要组分多黏菌素E1和E2.谱数据的分析,总结了多黏菌素类化合物结构解析的规律,采用精确分子质量、特征碎片离子确定组分结构,并选择氨基酸残基离子来辅助判断结构;多黏菌素E样品在2.4 nm紫外光灯下经照射发生光化学反应(帕特诺-比希反应),通过MS/MS验证多黏菌素E1双键化组分的环氧化产物。结果本实验首次总结了一条新的裂解途径。根据以上方法共解析了2.种组分的结构,包括2.多黏菌素E1和E2.双键化组分,结合光化学产物的二级质谱特征离子推断双键位于酰基脂肪链末端,将该组分命名为7'-烯基多黏菌素E1和6'-烯基多黏菌素E2.结论7'-烯基多黏菌素E1及其光反应环氧化产物、6'-烯基多黏菌素E2.为首次报道,本方法为多肽类抗生素组分包括含双键的未知杂质的结构分析提供了一种解决思路。

关键词：多黏菌素E组分液质联用光化学反应结构分析 7'-烯基多黏菌素E1