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Time-scale separation and stochasticity conspire to impact phenotypic dynamics in the canonical and inverted Bacillus subtilis core genetic regulation circuits

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Frontiers of Electrical and Electronic Engineering in China 2019年第1期7卷 54-68页

作者： lijie hao Zhuoqin Yang Marc Turcotte School of Mathematics and Systems Science and LMIB Beihang UniversityBeijing 100191China University of Texas at Dallas RichardsonTX 75080USA

Backgrounds In this work, we study two seemingly unrelated aspects of core genetic nonlinear dynamical control of the competence phenotype in Bacillus subtilis, a common Gram-positive bacterium living in the soil. Methods: We focus on hitherto unchartered aspects of the dynamics by exploring the effect of time-scale separation between transcription and translation and, as well, the effect of intrinsic molecular stochasticity. We consider these aspects of regulatory control as two possible evolutionary handles. Results: Hence, using theory and computations, we study how the onset of oscillations breaks the excitability-based competence phenotype in two topologically close evolutionary-competing circuits: the canonical "wild-type" regulation circuit selected by Evolution and the corresponding indirect-feedback inverted circuit that failed to be selected by Evolution, as was shown elsewhere, due to dynamical reasons. Conclusions^ Relying on in-silico perturbation of the living state, we show that the canonical core genetic regulation of excitability-based competence is more robust against switching to phenotype-breaking oscillations than the inverted feedback organism. We show how this is due to time-scale separation and stochasticity.

关键词： Bacillus subtilis competence gene regulation deterministic dynamics stochastic dynamics

Effect of Sintering on the Magnetism and Magnetoresistance of La_(1/3)Nd_(1/3)Ca_(1/3) MnO_3

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Journal of Materials Science & Technology 2000年第2期16卷 161-162页

作者： Guoqing LI, lijie hao, Ze XIANYU, Deren LI, Ke SUN and Halving LI (Department of Physics, Northeastern University, Shenyang 110006, China) Department of Physics Northeastern University Shenyang 110006 China

Perovskite-like bulk La_1/3Nd_1/3Ca_1/3MnO_3 is prepared by solid phase reaction method. The temperature dependence of the magnetization and the relationship between CMR effect and sintering have been studied. The CMR is up to 673.9% under 1 T applied magnetic field and 100 K temperature, and that also reaches 93.5% in 0.2 T and 100 K.

关键词： MnO3 Effect of Sintering on the Magnetism and Magnetoresistance of La Nd Ca

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环境正义的现实困境及其保障机制

宁夏社会科学 2019年第3期 53-58页

作者：郝立杰南京邮电大学

环境正义是一种新的伦理世界观,在所处理的关系向度、遵循的基本原则和蕴含的思想内容等方面具有鲜明特征。现如今,环境正义面临种种现实困境,究其原因,人们在人类中心主义和自我中心主义价值观的指引下,为了一己私利而肆意破坏环境,具... 详细信息

环境正义是一种新的伦理世界观,在所处理的关系向度、遵循的基本原则和蕴含的思想内容等方面具有鲜明特征。现如今,环境正义面临种种现实困境,究其原因,人们在人类中心主义和自我中心主义价值观的指引下,为了一己私利而肆意破坏环境,具体看来主要包括:传统的发展观,人类中心主义的价值秩序,消费主义的价值形态和机械论的世界观。因此,实现环境正义,建立多层次的保障机制则显得尤为必要。

关键词：环境正义现实困境保障机制

黄炎培职业道德教育思想的内在逻辑与当代启示

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江苏高职教育 2023年第4期23卷 62-69页

作者：郝立杰南京工业职业技术大学马克思主义学院江苏南京210023

黄炎培职业道德教育思想是其职业教育思想的伦理底色和价值支撑。从方法论上看,体现为历史和现实相映、共性和个性贯通、理论和实践互融的道德图景。从内容上看,黄炎培以敬业乐群为建构原则和出发点,从道德原则、伦理地位、义利规范、... 详细信息

黄炎培职业道德教育思想是其职业教育思想的伦理底色和价值支撑。从方法论上看,体现为历史和现实相映、共性和个性贯通、理论和实践互融的道德图景。从内容上看,黄炎培以敬业乐群为建构原则和出发点,从道德原则、伦理地位、义利规范、道德品质等方面论述职业道德教育思想。从实践上看,他将做学合一作为道德品质养成的主要途径,主要关涉教师、学生、学校、榜样等因素。步入新时代,工匠精神则成为黄炎培职业道德教育思想的演进路向。

关键词：黄炎培职业道德教育思想传承创新敬业乐群做学合一工匠精神

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“六书”理论与对外汉字教学

科教文汇 2019年第7期 72-74页

作者：郝丽洁河南理工大学文法学院河南焦作454000

对外汉字教学是对外汉语教学的重难点。外国学生认为汉字结构杂乱,信息量大,非常难学。把"六书"理论用于对外汉字教学中,对汉字结构和理据进行分析,能够帮助外国学生把握汉字的形、音、义,加深外国学生对汉字的理解和记忆,从而推动对外... 详细信息

对外汉字教学是对外汉语教学的重难点。外国学生认为汉字结构杂乱,信息量大,非常难学。把"六书"理论用于对外汉字教学中,对汉字结构和理据进行分析,能够帮助外国学生把握汉字的形、音、义,加深外国学生对汉字的理解和记忆,从而推动对外汉字教学的发展,促进对外汉语教学事业的进步。

关键词： “六书”理论现代汉字对外汉字教学

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科技的价值之维

科教文汇 2017年第35期 163-164页

作者：郝立杰南京邮电大学江苏南京210023

科技的发展日新月异,科技的价值问题则是一个古老又年轻的话题,科技的价值中立论无论是从学理上还是从历史上看都是站不住脚的。本文在价值中立论分析的基础上对科技价值的合理性进行考察,对当今社会具体的伦理价值进行分析,最后得出结... 详细信息

科技的发展日新月异,科技的价值问题则是一个古老又年轻的话题,科技的价值中立论无论是从学理上还是从历史上看都是站不住脚的。本文在价值中立论分析的基础上对科技价值的合理性进行考察,对当今社会具体的伦理价值进行分析,最后得出结论:对科学活动主体(科学活动个体和科学共同体)提出了伦理上的要求并对科学的价值进行正确的评价。

关键词：价值中立科学价值内在价值外在价值

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实现中国梦必须坚持人民主体地位

科教导刊 2017年第12Z期 158-159页

作者：郝立杰南京邮电大学江苏南京210023

梦"有不同的范围和表现形式,"中国梦"是社会历史发展的结晶。国家富强、民族振兴和个人幸福是中国梦的有机组成部分,坚持人民主体地位是实现中国梦的题中应有之义。所以,坚持人民的主体地位,必须尊重人民的首创精神,发挥人民民主,维护... 详细信息

梦"有不同的范围和表现形式,"中国梦"是社会历史发展的结晶。国家富强、民族振兴和个人幸福是中国梦的有机组成部分,坚持人民主体地位是实现中国梦的题中应有之义。所以,坚持人民的主体地位,必须尊重人民的首创精神,发挥人民民主,维护人民的合法权益,保证国家权力有效实施。

关键词：中国梦人民主体地位

Design and implementation of the monochromator shielding for the cold neutron spectrometers XINGZHI and BOYA

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Chinese Physics B 2024年第5期33卷 96-102页

作者：汪晋辰刘娟娟徐大业 Florian Grünauer 郝丽杰刘蕴韬张红霞程鹏鲍威 Laboratory for Neutron Scattering and Beijing Key Laboratory of Optoelectronic Functional Materials and MicroNano Devices Department of PhysicsRenmin University of ChinaBeijing 100872China Physics Consulting Zorneding 85604Germany China Institute of Atomic Energy Beijing 102413China Department of Physics City University of Hong KongKowloon 999077China Center for Neutron Scattering City University of Hong KongKowloon 999077China

An innovative monochromator shielding is designed and implemented for the cold neutron spectrometers XINGZHI and BOYA operated by Renmin University of China at China Advanced Research *** Monte Carlo simulations and careful mechanical designs,a shielding configuration has been successfully developed to satisfy safety requirements of below 3μSv/h dose rate at its exterior,meanwhile fulfilling space,floor load and nonmagnetic *** materials are utilized to form the sandwich-type shielding walls:the inner layer of boron carbide rubber,the middle layer of steel-encased lead and the outer layer of borated ***-shaped liftable shielding blocks are incorporated to facilitate a continuous adjustment of the neutron energy while preventing radiation *** work has demonstrated that by utilizing composite shielding materials,along with the sandwich structure and liftable shielding blocks,a compact and lightweight shielding solution can be *** enables the realization of advanced neutron scattering instruments that provide expanded space of measurement,larger energy and momentum coverage,and higher flux on the *** shielding represents the first of its kind in neutron scattering instruments in *** its successful operation,it has been subsequently employed by other neutron instruments across the country.

关键词： neutron scattering cold neutron spectrometer monochromator shielding sandwich shielding structure

Preparation of Low Ratio Magnesium Ccement by Acid Leaching Treatment of Boron Mud

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 120-129页

作者： YANG Mei ZHANG Mingzhe CHEN hao School of Materials Science and Engineering Shenyang Jianzhu UniversityShenyang 110168China School of Physical Science and Technology Shenyang Normal UniversityShenyang 110168China

The effects of liquid-solid ratio and reaction time on the leaching rate of magnesium at room temperature were investigated,as well as the effects of the molar ratio of MgO/MgCl_(2),the amount of water added,and the amount of acid-impregnated slag dosed on the compressive strength and water resistance of *** results showed that the magnesium element in the boron mud could be maximally leached under the conditions of 1:1 concentration of hydrochloric acid at room temperature,liquid-solid ratio of 2.5 mL·g^(-1),and reaction time of 5 h,and the main products were amorphous SiO_(2) as well as a small amount of magnesium olivine which had not been completely *** LR-MOC prepared using the acid-soaked mixture could reach a softening coefficient of 0.85 for 28 d of water immersion when the molar ratio of MgO/MgCl_(2) was 2.2,the amount of water added was 0 g,and the acid-soaked slag dosing was 40 wt%,which also led to an appreciable late-strength,with an increase of 19.4%in compressive strength at 28 d compared to that at 7 *** previous studies,LR-MOC prepared in this way has a final strength phase that is not the more easily hydrolysed 3-phase but the lath-like *** this phenomenon,we analyzed the mechanism and found that,during the acid leaching process,a part of amorphous SiO_(2) dissolved in the acid leaching solution formed a silica sol,in which Mg^(2+)played a bridging role to make the silica sol more *** the addition and hydrolysis of MgO,the silica sol gel coagulation slows down,providing a capping layer to inhibit the hydrolysis of the 5-phase crystals and providing some strength after *** amorphous SiO_(2) in the other part of the acid-impregnated slag generated M-S-H gel with Mg^(2+)and OH-,which synergised with the dense structure composed of interlocking crystals to improve the water resistance of LR-MOC.

关键词： boron mud magnesium chloride-oxygen cement acid immersion water resistance silica sol