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Ethnopharmacology,chemodiversity,and bioactivity of Cephalotaxus medicinal plants

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Chinese Journal of Natural Medicines 2021年第5期19卷 321-338页

作者： hao da-cheng HOU Xu-Dong GU Xiao-Jie XIAO Pei-Gen GE Guang-Bo Biotechnology Institute School of Environment and Chemical EngineeringDalian Jiaotong UniversityDalian 116028China Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Medicinal Plant Development Chinese Academy of Medical SciencesBeijing 100193China

Cephalotaxus is the only genus of Cephalotaxaceae family,and its natural resources are declining due to habitat fragmentation,excessive exploitation and *** many areas of China,folk herbal doctors traditionally use Cephalotaxus plants to treat innominate swollen poison,many of which are *** only among Han people,but also among minority ethnic groups,Cephalotaxus is used to treat various diseases,e.g.,cough,internal bleeding and cancer in Miao medicine,bruises,rheumatism and pain in Yao medicine,and ascariasis,hookworm disease,scrofula in She medicine,*** values of some Cephalotaxus species and compounds are acknowledged ***,there is a lack of comprehensive review summarizing the ethnomedicinal knowledge o f Cephalotaxus,relevant medicinal phytometabolites and their *** research progresses in ethnopharmacology,chemodiversity,and bioactivities of Cephalotaxus medicinal plants are reviewed and commented *** gaps are pinpointed and future research directions are *** medicinal books,folk medicine books,herbal manuals and ethnomedicinal publications were reviewed for the genus Cephalotaxus(Sanjianshan in Chinese).The relevant data about ethnobotany,phytochemistry,and pharmacology were collected as comprehensively as possible from online databases including Scopus,NCBI PubMed,Bing Scholar,and China National Knowledge Infrastructure(CNKI).44 Cephalotaxus"',and the respective species name were used as keywords in database *** obtained articles of the past six decades were collated and *** Cephalotaxus species are listed in the official medicinal book in *** are used as ethnomedicines by many ethnic groups such as Miao,Yao,Dong,She and *** are obtained from traditional applications,and Cephalotaxus phytometabolites are developed into anticancer ***-type alkaloids,homoerythrina-type alkaloids and homoharringtonine(HHT)are abundant in Cephalo

关键词： Cephalotaxus Ethnomedicine Chemodiversity Alkaloids Bioactivity Pharmacology

Mining chemodiversity from biodiversity:pharmacophylogeny of medicinal plants of Ranunculaceae

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Chinese Journal of Natural Medicines 2015年第7期13卷 507-520页

作者： hao da-cheng XIAO Pei-Gen MA Hong-Ying PENG Yong HE Chun-Nian Biotechnology Institute School of Environment and Chemical EngineeringDalian Jiaotong University Institute of Medicinal Plant Development Chinese Academy of Medical Sciences

This paper reports a pharmacophylogenetic study of a medicinal plant family,Ranunculaceae,investigating the correlations between their phylogeny,chemical constituents,and pharmaceutical ***,ethnopharmacological,and pharmacological data were integrated in the context of the systematics and molecular phylogeny of the *** chemical components of this family included several representative metabolic groups:benzylisoquinoline alkaloids,ranunculin,triterpenoid saponin,and diterpene alkaloids,among *** and magnoflorine were found to coexist in some *** pharmacophylogenetic analysis,integrated with therapeutic information,agreed with the taxonomy proposed previously,in which the family Ranunculaceae was divided into five sub-families:Ranunculoideae,Thalictroideae,Coptidoideae,Hydrastidoideae,and *** was plausible to organize the sub-family Ranunculoideae into ten *** chemical constituents and therapeutic efficacy of each taxonomic group were reviewed,revealing the underlying connections between phylogeny,chemical diversity,and clinical use,which should facilitate the conservation and sustainable utilization of the pharmaceutical resources derived from the Ranunculaceae.

关键词： Ranunculaceae Pharmacophylogeny Chemodiversity Ethnopharmacology Bioactivity Sustainability

Mining Therapeutic Efficacy from Treasure Chest of Biodiversity and Chemodiversity:Pharmacophylogeny of Ranunculales Medicinal Plants

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Chinese Journal of Integrative Medicine 2022年第12期28卷 1111-1126页

作者： hao da-cheng XU Li-jia ZHENG Yu-wei LYU Huai-yu XIAO Pei-gen Biotechnology Institute School of Environment and Chemical EngineeringDalian Jiaotong UniversityDalian 116028China Institute of Medicinal Plant Development Chinese Academy of Medical SciencesBeijing 100193China

Ranunculales,comprising of 7families that are rich in medicinal species frequently utilized by traditional medicine and ethnomedicine,represents a treasure chest of biodiversity and *** phylogenetically related species often have similar chemical profile,which makes them often possess similar therapeutic *** been validatedby both ethnomedicinal experiences and pharmacological *** paper summarizes molecular phylogeny,chemical constituents,and therapeutic applications of Ranunculales,i.e.,a pharmacophylogeny study of this representative medicinal *** phytochemistryl metabolome,ethnomedicine and bioactivity/pharmacology data are incorporated within the phylogenetic framework of *** most studied compounds of this order include benzylisoquinoline alkaloid,flavonoid,terpenoid,saponin and lignan,*** are especially abundant in Berberidaceae and *** most frequent ethnomedicinal uses are arthritis,heat-clearing and detoxification,carbuncle-abscess and *** most studied bioactivities are anticancer/cytotoxic,antimicrobial,and anti-inflammatory activities,*** pharmacophylogeny analysis,integrated with both traditional and modern medicinal uses,agrees with the molecular phylogeny based on chloroplast and nuclear DNA sequences,in which Ranunculales is divided into Ranunculaceae,Berberidaceae,Menispermaceae,Lardizabalaceae,Circaeasteraceae,Papaveraceae,and *** constituents and therapeutic efficacy of each taxonomic group are reviewed and the underlying connection between phylogeny,chemodiversityand clinical uses is revealed,which facilitate the conservation and sustainable utilization of Ranunculales pharmaceutical resources,as well as developing novel plant-based pharmacotherapy.

关键词： Ranunculales chemical constituent bioactivity diversity pharmacophylogeny

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黄素单加氧酶3在药物代谢中的作用

中国药理学与毒理学杂志 2008年第5期22卷 391-395页

作者：郝大程杨凌中国科学院大连化学物理研究所药用资源开发研究组辽宁大连116023 中国科学院研究生院北京100083

黄素单加氧酶(FMO,E.C.1.***.13.8)是重要的Ⅰ相代谢酶,由于与细胞色素P450(CYP450,E.C.1.***.14.1)具有相同的单加氧药物和异物代谢功能,其重要性被明显低估。本文在与CYP450进行对比的基础上,重点对FMO3的功能、变异、调控及应用等方面... 详细信息

黄素单加氧酶(FMO,E.C.1.***.13.8)是重要的Ⅰ相代谢酶,由于与细胞色素P450(CYP450,E.C.1.***.14.1)具有相同的单加氧药物和异物代谢功能,其重要性被明显低估。本文在与CYP450进行对比的基础上,重点对FMO3的功能、变异、调控及应用等方面的最新进展进行了综述,并提出了进行FMO研究的未来策略。

关键词：黄素单加氧酶3 代谢变异(遗传学) 多态性,单核苷酸

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生物学和生物医学科学中的复杂性

医学与哲学（A） 2009年第3期30卷 7-9,12页

作者：郝大程大连交通大学环境学院生物技术教研室辽宁大连116028

自牛顿时代以来,经典力学和还原论一直是科学研究的基石。然而,还原论和决定论无法分析和恰当地解释复杂系统特征性的突现性质。以认识论的观点看,还原论和整体论结合起来才能综合评估复杂生物系统。突现,非线性和自组织等复杂性理论的... 详细信息

自牛顿时代以来,经典力学和还原论一直是科学研究的基石。然而,还原论和决定论无法分析和恰当地解释复杂系统特征性的突现性质。以认识论的观点看,还原论和整体论结合起来才能综合评估复杂生物系统。突现,非线性和自组织等复杂性理论的概念正改变和塑造着生物医学研究范式。还阐述了理解生物系统复杂性的重要价值。

关键词：复杂性还原论决定论整体论系统突现生物医学

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土建场地和建材的生物改良技术研究进展

生物技术通报 2019年第9期35卷 61-69页

作者：郝大程鲁兰兰大连交通大学环境化工学院生物技术研究所大连116028 大连交通大学土木工程学院大连116028

近年来,建造生物技术,尤其是建材和土建场地的生物改良技术的各个方面开始形成一个新的跨学科领域,涉及环境和工业微生物学、生物地球化学,以及生物技术在岩土工程和土木/环境工程中的多方面应用。概述土建场地和建材的微生物技术改良... 详细信息

近年来,建造生物技术,尤其是建材和土建场地的生物改良技术的各个方面开始形成一个新的跨学科领域,涉及环境和工业微生物学、生物地球化学,以及生物技术在岩土工程和土木/环境工程中的多方面应用。概述土建场地和建材的微生物技术改良研究和应用进展,讨论建造相关的生物地球化学过程:生物聚集可用于控制风土侵蚀和粉尘排放;生物结壳、生物堵塞和土壤生物黏固各自具有不同的机理和使用方式;其他新颖的土地改良方式,如水饱和无黏性土壤的生物去饱和,软土的生物胶囊化和土壤污染物的生物固定化等各自具有独特的机制和优点。目前绝大多数微生物岩土工程研究仍停留在实验室阶段,需要更多努力将科学理念转化为可行的技术。因此,撰写本文目的是概述土建场地和建材的微生物技术改良研究和应用进展,讨论相关研究者和工程师需要了解的建造相关微生物过程,简要讨论各种现场应用的设计原则和注意事项。

关键词：土建场地建材微生物技术改良

Fanlian Huazhuo formula:A promising therapeutic approach for metabolic associated steatotic liver disease

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World Journal of Gastroenterology 2025年第1期31卷 167-171页

作者： Chun-Han cheng Wen-Rui hao Tzu-Hurng cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305Taiwan Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561Taiwan Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328Taiwan

This article reviews the study,“Fanlian huazhuo formula alleviates high-fat-dietinduced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway”published in the World Journal of *** study explores the therapeutic potential of Fanlian Huazhuo formula(FLHZF)in treating metabolic-associated steatotic liver disease(MASLD),demonstrating that FLHZF reduces lipid accumulation,oxidative stress,and liver injury in MASLD models by modulating key signaling pathways involved in lipid metabolism and *** editorial emphasizes the potential of FLHZF as a treatment for MASLD and calls for further research to verify its clinical efficacy.

关键词： Fanlian Huazhuo formula Metabolic associated steatotic liver disease Autophagy Lipid metabolism Oxidative stress

Recent Advance in Chemical and Biological Studies on Cimicifugeae Pharmaceutical Resources

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Chinese Herbal Medicines 2013年第2期5卷 81-95页

作者： hao da-cheng GU Xiao-jie XIAO Pei-gen LIANG Zhan-guo XU Li-jia PENG Yong Biotechnology Institute School of Environmental and Chemical EngineeringDalian Jiaotong University Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences

Cimicifugeae is one of the rich sources for various active components and the health promoting and therapeutic values of the components have been corroborated by long-term use in folk medicine and traditional Chinese *** interest in Cimicifugeae pharmaceutical resources has led to the further discoveries of triterpenoid saponins, phenolic compounds, chromones, and many other compounds in various species of Cimicifugeae, and to the investigations on their chemotaxonomy, molecular phylogeny, and bioactivities. Based on our pharmacophylogenetic studies, the progress in phytochemistry, chemotaxonomy, molecular biology, and phylogeny of Cimicifugeae had been summarized since 2007, especially Cimicifuga L. ex Wernisch. and Actaea L., and their relevance to therapeutic efficacy. An exhaustive literature survey is used to characterize the global scientific effort in the phytochemical and biological studies of Cimicifugeae. More triterpenoid saponins have been found in various species, among which the cimigenol type(type A) is predominant. The versatile bioactivities of saponins and extracts,as well as those of phenolics and other ingredients, were summarized and discussed. The morphology-based five-genus classification of Cimicifugeae is not supported by molecular phylogeny. Molecular phylogeny based on nuclear and chloroplast DNA sequences tends to merge Cimicifuga Wernisch., Souliea Franch., and Actaea L. into a single genus. It is indispensable to integrate the emerging technologies into Cimicifugeae research for both the sustainable utilization of Cimicifugeae pharmaceutical resources and finding novel compounds with potential clinical utility and less adverse effects. Systems biology and omics technologies would play an increasingly important role in booming pharmaceutical research involving bioactive compounds of Cimicifugeae.

关键词： biological activity chemotaxonomy Cimicifugeae pharmaceutical resource phylogeny phytochemistry

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人细胞色素P450在大肠杆菌中的功能表达

中国生物工程杂志 2009年第7期29卷 94-101页

作者：郝大程肖培根大连交通大学环境化工学院大连116028 中国医学科学院药用植物研究所北京100193

研究人细胞色素P450(P450,CYP)在大肠杆菌中的功能表达对新药研发,临床药物治疗和药物早期ADME/T性质研究均有重要意义。异源表达人P450使用最多的宿主是大肠杆菌***,然而要获得足量的有催化活性的P450仍是一个难题。结合作者近年研究,... 详细信息

研究人细胞色素P450(P450,CYP)在大肠杆菌中的功能表达对新药研发,临床药物治疗和药物早期ADME/T性质研究均有重要意义。异源表达人P450使用最多的宿主是大肠杆菌***,然而要获得足量的有催化活性的P450仍是一个难题。结合作者近年研究,对异源表达的研究意义,P450在***中功能表达的策略,高效表达的影响因素和共表达等方面做一评述,指出今后的研究应用方向。

关键词：细胞色素P450 NADPH-P450氧化还原酶异源表达大肠杆菌表达优化