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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng cong Jing-Jing Hu Yan Yu xiao-Li Li xiao-Ting Sun Li-Ting Wang xia Wu Ling-Jie Zhu xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： xia-Jie Quan hao Liang Yong-Hong Tang Li Jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

Real-time optimization power-split strategy for hybrid electric vehicles

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Science China(Technological Sciences) 2016年第5期59卷 814-824页

作者： xia Chao Ying ZHANG cong Institute of Electrical Engineering and Automation Tianjin University

Energy management strategies based on optimal control theory can achieve minimum fuel consumption for hybrid electric vehicles, but the requirement for driving cycles known in prior leads to a real-time problem. A real-time optimization power-split strategy is proposed based on linear quadratic optimal control. The battery state of charge sustainability and fuel economy are ensured by designing a quadratic performance index combined with two rules. The engine power and motor power of this strategy are calculated in real-time based on current system state and command, and not related to future driving conditions. The simulation results in ADVISOR demonstrate that, under the conditions of various driving cycles, road slopes and vehicle parameters, the proposed strategy significantly improves fuel economy, which is very close to that of the optimal control based on Pontryagin's minimum principle, and greatly reduces computation complexity.

关键词： hybrid electric vehicle (HEV) linear quadratic optimal control real-time control energy management strategy

A novel superhard tungsten nitride predicted by machine-learning accelerated crystal structure search

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Science Bulletin 2018年第13期63卷 817-824页

作者： Kang xia hao Gao cong Liu Jianan Yuan Jian Sun Hui-Tian Wang Dingyu Xing National Laboratory of Solid State Microstructures School of Physics and Collaborative Innovation Center of Advanced MicrostructuresNanjing University

Transition metal nitrides have been suggested to have both high hardness and good thermal stability with large potential application value, but so far stable superhard transition metal nitrides have not been synthesized. Here, with our newly developed machine-learning accelerated crystal structure searching method, we designed a superhard tungsten nitride, h-WN6, which can be synthesized at pressure around 65 GPa and quenchable to ambient pressure. This h-WN6 is constructed with single-bonded armchair-like N6 rings and presents ionic-like features, which can be formulated as W^2.4＋N^2.4-. It has a band gap of 1.6 eV at 0GPa and exhibits an abnormal gap broadening behavior under pressure. Excitingly, this h-WN6 is found to be the hardest among transition metal nitrides known so far （Vickers hardness around 57 GPa） and also has a very high melting temperature （around 1,900 K）. Additionally, the good gravimet- ric （3.1 kJ/g/and volumetric （28.0 kJ/cm3） energy densities make this nitrogen-rich compound a potential high-energy-density material, These predictions support the designing rules and may stimulate future experiments to synthesize superhard and high-energy-density material.

关键词： Tungsten nitride Transition metal nitrides Machine-learning accelerated crystal structure searching method Superhard tungsten nitride

Remote Sensing-based Spatiotemporal Distribution of Grassland Aboveground Biomass and Its Response to Climate Change in the Hindu Kush Himalayan Region

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Chinese Geographical Science 2022年第5期32卷 759-775页

作者： XU cong LIU Wenjun Zhao Dan hao Yanbin xia Anquan YAN Nana ZENG Yuan State Key Laboratory of Remote Sensing Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China School of Ecology and Environmental Sci-ences&Yunnan Key Laboratory for Plateau Mountain Ecology and Restoration of Degraded Environments Yunnan UniversityKun-ming 650091China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China CAS Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of SciencesBeijing 100101China Beijing Yanshan Earth Critical Zone National Research Station University of Chinese Academy of SciencesBeijing 101408China College of Resources and Envir-onment University of Chinese Academy of SciencesBeijing 100049China

The grassland in the Hindu Kush Himalayan(HKH) region is one of the large st and most biodiverse mountain grassland types in the world,and its ecosystem service functions have profound impacts on the sustainable development of the HKH *** the spatiotemporal distribution of grassland aboveground biomass(AGB) accurately and quantifying its response to climate change are indispensable sources of information for sustainably managing grassland ecosystems in the HKH *** this study,a pure vegetation index model(PVIM) was applied to estimate the long-term dynamics of grassland AGB in the HKH region during *** further quantified the response of grassland AGB to climate change(temperature and precipitation) by partial correlation and variance partitioning analyses and then compared their differences with *** results demonstrated that the grassland AGB predicted by the PVIM had a good linear relationship with the ground sampling *** grassland AGB distribution pattern showed a decreasing trend from east to west across the HKH region except in the southern *** 2000 to 2018,the mean AGB of the HKH region increased at a rate of 1.57 g/(m~2·yr) and ranged from 252.9(2000) to 307.8 g/m~2(2018).AGB had a positive correlation with precipitation in more than 80% of the grassland,and temperature was positively correlated with AGB in approximately half of the *** change in grassland AGB was more responsive to the cumulative effect of annual precipitation,while it was more sensitive to the change in temperature in the growing season;in addition,the influence of climate varied at different ***,compared with that of temperature,the contribution of precipitation to grassland AGB change was greater in approximately 60% of the grassland,but the differences in the contribution for each climate factor were small between the two temporal scales at elevations over 2000 *** accurate assessment of the temporal and spatial

关键词： grassland aboveground biomass(AGB) climate change elevation spatiotemporal distribution Hindu Kush Himalayan(HKH)region

NGP_G-STABILITY OF LINEAR MULTISTEP METHODS FOR SYSTEMS OF GENERALIZED NEUTRAL DELAY DIFFERENTIAL EQUATIONS

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Applied Mathematics and Mechanics(English Edition) 2001年第7期22卷 827-835页

作者： cong Yu-hao(丛玉豪) Department of Mathematics Shanghai Normal University Shanghai 200234 P R China

The stability analysis of linear multistep methods for the numerical solutions of the systems of generalized neutral delay differential equations is discussed. The stability behaviour of linear multistep methods was analysed for the solution of the generalized system of linear neutral test equations, After the establishment of a sufficient condition for asymptotic stability of the solutions of the generalized system, it is shown that a linear multistep method is NGP(G)-stable if and only if it is A-stable.

关键词： generalized neutral delay differential system asymptotic stability linear multistep methods NGP(G)-stability

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从情景到情境的小学英语对话教学设计研究

教学与管理 2025年第2期 43-46页

作者：李海霞汤焱昊北京联合大学师范学院

《义务教育英语课程标准（2022年版）》提出英语课程目标是培养学生的核心素养，并主张围绕“情境”进行学习来实现目标。但是，教师往往难以区分“情景”和“情境”，在教学实践中用“情景”代替“情境”的做法比较普遍。针对这个问题... 详细信息

《义务教育英语课程标准（2022年版）》提出英语课程目标是培养学生的核心素养，并主张围绕“情境”进行学习来实现目标。但是，教师往往难以区分“情景”和“情境”，在教学实践中用“情景”代替“情境”的做法比较普遍。针对这个问题，结合小学具体教学案例，提出从创设前置情境、连贯情境和拓展性情境三个方面实现从“情景教学”到“情境教学”，从而培养学生核心素养，实现小学英语课程育人目标。

关键词：情景情境对话教学核心素养小学英语

Influence of Mechanical Activation on Acid Leaching Dephosphorization of High-phosphorus Iron Ore Concentrates

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Journal of Iron and Steel Research International 2016年第7期23卷 661-668页

作者： De-qing ZHU hao WANG Jian PAN cong-cong YANG School of Minerals Processing and Bioengineering Central South University

High pressure roll grinding（HPRG）and ball milling were compared to investigate the influence of mechanical activation on the acid leaching dephosphorization of a high-phosphorus iron ore concentrate,which was manufactured through magnetizing roasting-magnetic separation of high-phosphorus oolitic iron *** results indicated that when high-phosphorus iron ore concentrates containing 54.92 mass% iron and 0.76 mass% phosphorus were directly processed through acid leaching,iron ore concentrates containing 55.74mass%iron and 0.33mass%phosphorus with an iron recovery of 84.64%and dephosphorization of 63.79% were *** high-phosphorus iron ore concentrates activated by ball milling were processed by acid leaching,iron ore concentrates containing56.03mass%iron and 0.21mass% phosphorus with an iron recovery of 85.65% and dephosphorization of 77.49%were ***,when high-phosphorus iron ore concentrates activated by HPRG were processed by acid leaching,iron ore concentrates containing 58.02mass%iron and 0.10mass% phosphorus were obtained,with the iron recovery reaching 88.42% and the dephosphorization rate reaching 88.99%.Mechanistic studies demonstrated that ball milling can reduce the particle size,demonstrating aprominent reunion *** contrast,HPRG pretreatment contributes to the formation of more cracks within the particles and selective dissociation of iron and P bearing minerals,which can provide the favorable kinetic conditions to accelerate the solid-liquid reaction *** such,the crystal structure is destroyed and the surface energy of mineral particles is strengthened by mechanical activation,further strengthening the dephosphorization.

关键词： high-phosphorus iron ore concentrate high pressure roll grinding ball milling selective dissociation sulfuric acid leaching dephosphorization iron recovery

Identification algorithm of switched systems based on generalized auxiliary model

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Journal of Systems Engineering and Electronics 2019年第6期30卷 1224-1232页

作者： WANG Hongwei xia hao School of Control Science and Control Engineering Dalian University of TechnologyDalian 116024China School of Electrical Engineering Xinjiang UniversityUrumqi 830036China

For switched linear system with colored measurement noises,the identification difficulties of this system are that there exist unknown switching information,unknown middle variables and noise terms in the information *** the mentioned issues,the fuzzy clustering and the multi-innovation recursive identification algorithm are used to deal with these ***,the mode detection is transformed into the detection of membership degree values confirmed by the fuzzy clustering method,and the problem of mode detection is solved by judgment and decision of the fuzzy membership ***,the multi-innovation recursive identification algorithm based on the generalized auxiliary model is proposed to estimate the parameters of the switched linear system with colored ***,the effectiveness of the proposed method is verified by the results of the simulation example.

关键词： switched linear system fuzzy clustering parameter estimation multi-innovation.