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Fabrication of corrosion inhibiting microcapsules functional coating and their high-efficiency corrosion resistance

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Rare Metals 2024年第2期43卷 842-848页

作者： hao-Ran yun Lu Lu Xue-Long hao Xing-Xiang Zhang School of Material Science and Engineering Tiangong UniversityTianjin300387China National Center of Analysis and Testing for Nonferrous Metals and Electronic Materials General Research Institute for Nonferrous MetalsBeijing100088China Guobiao(Beijing)Testing&Certification Co. Ltd.Beijing101407China

Benzotriazole(BTA)was loaded into calcium carbonate microsphere shell by self-assembly method and a new type of high-efficiency corrosion inhibiting microcapsules(CIMs)were fabricated,which were added and dispersed into epoxy resin coating to obtain a new corrosion resistance functional *** corrosion inhibition effect of benzotriazole on aluminum alloy matrix was verified by polarization curve *** effectiveness of the CIMs and their loading capacity on inhibitor were evaluated by scanning electron microscope,laser confocal Raman spectroscopy together with thermogravimetric analysis.

关键词： corrosion coating resistance

A robust genomic-based prognostic model for the assessment ofcancer stemness and survival for patients with hepatocellularcarcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 97-102页

作者： Cheng-Li Du Shen-Yu Wei yun-hao Chen Kang-Jie Chen Division of Thoracic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Zhejiang University School of Medicine Hangzhou 310003China Division of Hepatobiliary Pancreatic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

To the Editor:Hepatocellular carcinoma(HCC)is an aggressive malignancy with poor long-term prognosis[1].Liver cancer stem cell(CSC)can drive the metastasis,drug resistance,and recurrence of HCC[2].The regulatory mechanisms about liver cancer stemness have been investigated,which encouraged the identification and characterization of novel prognostic and therapeutic strategies for HCC[3].

关键词： cancer prognosis Liver

Random Subspace Sampling for Classification with Missing Data

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Journal of Computer Science & Technology 2024年第2期39卷 472-486页

作者：曹云浩吴建鑫 State Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210093China

Many real-world datasets suffer from the unavoidable issue of missing values,and therefore classification with missing data has to be carefully handled since inadequate treatment of missing values will cause large *** this paper,we propose a random subspace sampling method,RSS,by sampling missing items from the corresponding feature histogram distributions in random subspaces,which is effective and efficient at different levels of missing *** most established approaches,RSS does not train on fixed imputed ***,we design a dynamic training strategy where the filled values change dynamically by resampling during ***,thanks to the sampling strategy,we design an ensemble testing strategy where we combine the results of multiple runs of a single model,which is more efficient and resource-saving than previous ensemble ***,we combine these two strategies with the random subspace method,which makes our estimations more robust and *** effectiveness of the proposed RSS method is well validated by experimental studies.

关键词： missing data random subspace neural network ensemble learning

Causal relationship between feelings and cognitive decline:An univariable and multivariable Mendelian randomization study

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World Journal of Psychiatry 2024年第3期14卷 421-433页

作者： Juan Liu Lin Liu Yi-Xin Hu Jian-Hua Li Xiao Zou hao-yun Zhang Li Fan Department of Cardiology The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China Department of Pulmonary and Critical Care Medicine The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China The Fourth Department of Geriatric Health Care The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China Department of Anesthesiology First Medical Center of Chinese PLA General HospitalBeijing 100853China

BACKGROUND While the impact of depression on cognition is well-documented,the relationship between feelings and cognition has received limited *** To explore the potential association between feelings and cognition with a twosample Mendelian randomization(MR)*** Our analysis utilized genome-wide association data on various feelings(fed-up feelings,n=453071;worrier/anxious feelings,n=450765;guilty feelings,n=45-0704;nervous feelings,n=450700;sensitivity/hurt feelings,n=449419;miserableness,n=454982;loneliness/isolation,n=455364;happiness,n=152348)in the European population and their impact on cognitive functions(intelligence,n=269867).Conducting a univariable MR(UVMR)analysis to assess the relationship between feelings and *** this analysis,we applied the inverse variance weighting(IVW),weighted median,and MR Egger ***,we performed sensitivity analysis(leave-one-out analysis),assessed heterogeneity(using MR-PRESSO and Cochran’s Q test),and conducted multiple validity test(employing MR-Egger regression).Subsequently,a multivariable MR(MVMR)analysis was employed to examine the impact of feelings on *** served as the primary method in the multivariable analysis,complemented by median-based and MR-Egger *** In this study,UVMR indicated that sensitivity/hurt feelings may have a negative causal effect on cognition(OR=0.63,95%CI:0.43-0.92,P=0.017).After adjustment of other feelings using MVMR,a direct adverse causal effect on cognition was observed(OR_(MVMR)=0.39,95%CI:0.17-0.90,P_(MVMR)=0.027).While a potential increased risk of cognitive decline was observed for fed-up feelings in the UVMR analysis(ORUVMR=0.64,95%CI:0.42-0.97,PUVMR=0.037),this effect disappeared after adjusting for other feelings(OR_(MVMR)=1.42,95%CI:0.43-4.74,P_(MVMR)=0.569).These findings were generally consistent across MV-IVW,median-based,and MR-Egger ***-Egger regression revealed pleiotropy in the impact of worrier/anxious

关键词： Mendelian randomization analysis Feelings Cognition Intelligence

Dual-functional microneedle with programmatic regulation of macrophage for autoimmune psoriasis treatment

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Nano Research 2024年第8期17卷 7436-7448页

作者： Ze Qiang Zhao Bo Zhi Chen Jia Li Gan yun hao Feng Ling Liang Lingyun Yu Zi Yi Wang Samin Abbaszadeh Mohammad-Ali Shahbazi Ruixing Yu Xin Dong Guo State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Beijing Laboratory of Biomedical Materials College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China China-Japan Friendship Hospital Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100029China Department of Dermatology China-Japan Friendship HospitalBeijing 100029China Department of Pharmaceutical Biomaterials School of PharmacyZanjan University of Medical SciencesZanjan 45139-56184Iran Department of Biomaterials and Biomedical Technology University Medical Center GroningenUniversity of GroningenAntonius Deusinglaan 19713 AV GroningenThe Netherlands W.J.Kolff Institute for Biomedical Engineering and Materials Science University of GroningenAntonius Deusinglaan 19713 AV GroningenThe Netherlands

Modulating the immune microenvironment to establish sustained positive feedback within immune pathways represents a promising avenue for the treatment of ***,the precise and efficient delivery of therapeutic systems to the subcutaneous basal layer to modulate immune disorders is a major challenge in the treatment of autoimmune *** this project,we introduce a dual-functional microneedle(DF-MN)designed to combine MNs with multiple release kinetics and immunotherapy,the programmed treatment is achieved through segmented design of the MN structure,realizing the unification of rapid and long-lasting treatment of autoimmune *** vivo imaging results showed that GelMA@M-CSF showed fluorescent signals after 5 days of delivery to subcutaneous tissues,whereas HA@IL-13 showed minimal fluorescent signals after 2 *** multistage release behavior of MNs and the diffusion mechanism of drugs were explained at the molecular level,in combination with coarse-grained molecular ***,DF-MN can successfully induce macrophage reprogramming in vitro and ameliorate overall symptoms in a psoriasis mice model,suggesting that it has the potential to be an effective strategy for the treatment of psoriasis and portends to be a transformative platform for the treatment of other autoimmune diseases.

关键词： microneedle psoriasis M2 macrophage immunoregulation

Rhodium(Ⅲ)-catalyzed diastereo-and enantioselective hydrosilylation/cyclization reaction of cyclohexadienone-tetheredα,β-unsaturated aldehydes

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Chinese Chemical Letters 2024年第9期35卷 160-164页

作者： Yi-Fan Wang hao-yun Yu hao Xu Ya-Jie Wang Xiaodi Yang Yu-Hui Wang Ping Tian Guo-Qiang Lin The Research Center of Chiral Drugs Shanghai Frontiers Science Center for TCM Chemical BiologyInnovation Research Institute of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China

A rhodium(Ⅲ)-catalyzed hydrosilylation/cyclization reaction of cyclohexadienone-tetheredα,β-unsaturated aldehydes(1,6-dienes)with triethylsilane is described,providing a series of cishydrobenzofurans,cis-hydroindoles,and cishydroindenes bearing silyl enol ether in good to excellent yields and excellent ***,the versatility of this method was demonstrated through a gram-scale experiment and various downstream transformations,highlighting its utility.

关键词： Rhodium(Ⅲ)catalysis Hydrosilylation/cyclization 1,6-Dienes Silyl enol ether Diastereo-and enantioselectivity

流通业智能化与城乡均衡发展——基于城乡居民消费差距视角

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广东财经大学学报 2024年第3期39卷 79-94页

作者：孟昊芸张扬西安交通大学经济与金融学院陕西西安710061 生态环境部环境规划院战略规划研究所北京100041

新发展格局背景下,促进流通业智能化转型是畅通国内国际双循环体系、破解城乡发展不均衡难题的关键。从城乡居民消费差距视角切入,依托马克思社会资本再生产框架,梳理流通业智能化发展在生产、分配、交换和消费四个环节影响城乡均衡发... 详细信息

新发展格局背景下,促进流通业智能化转型是畅通国内国际双循环体系、破解城乡发展不均衡难题的关键。从城乡居民消费差距视角切入,依托马克思社会资本再生产框架,梳理流通业智能化发展在生产、分配、交换和消费四个环节影响城乡均衡发展的理论逻辑,并基于2002—2022年我国285个地级市的面板数据,分析流通业智能化对城乡居民消费差距的影响效果及作用机制。研究发现,城乡居民消费差距与流通业智能化程度均存在区域发展不平衡特征;流通业智能化在面对负向宏观冲击时具有增长韧性,面对正向宏观冲击时表现出发展潜力;流通业智能化发展通过促进区域产业结构升级、降低城乡居民收入差距和推动电子商务发展等渠道有效缩小城乡居民消费差距,且对西部地区的影响最大。因此,驱动产业智能化转型、弥合区域数字鸿沟、规范平台经济发展可为提振居民消费、促进城乡均衡发展提供强力支撑。

关键词：流通业智能化城乡居民消费差距城乡均衡发展马克思社会再生产理论

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明清鼎革期间明将毛文龙与朝鲜关系研究

西南大学学报（社会科学版） 2024年第4期50卷 232-242页

作者：张丹丹郝运吉林师范大学历史文化学院吉林四平136000

明清鼎革之际,明与后金之间的军事争夺时有发生,双方争夺的结果直接决定了谁将成为未来东亚宗藩体系的领导者。在看似明确的敌我对抗和表面的新旧交替背后,还潜藏着宗藩体系内部成员的观望与自保、多方勾连甚至待价而沽。毛文龙作为明... 详细信息

明清鼎革之际,明与后金之间的军事争夺时有发生,双方争夺的结果直接决定了谁将成为未来东亚宗藩体系的领导者。在看似明确的敌我对抗和表面的新旧交替背后,还潜藏着宗藩体系内部成员的观望与自保、多方勾连甚至待价而沽。毛文龙作为明将代表明朝在朝鲜履行保护朝鲜国家安全的义务,但却卷入了明、后金与朝鲜三方博弈的漩涡之中。朝鲜作为明朝宗藩体系最亲近的一员,一方面与毛文龙互相袒护与猜忌,一方面又与后金保持半臣属状态。无疑,明将毛文龙与朝鲜关系为我们提供了一个观察明清鼎革前夜东亚宗藩体系内部关系实态的理想视角。

关键词：明清鼎革宗藩体系两面外交

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基于脉冲受激布里渊散射光谱的非接触式黏弹性测量

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物理学报 2024年第12期73卷 367-376页

作者：李佳芮乐陶然尉昊赟李岩清华大学精密仪器系精密测试技术及仪器国家重点实验室北京100084

细胞和组织的力学特性在决定生物功能中起着至关重要的作用,布里渊光谱技术作为一种黏弹性显微成像方法,可以无标记、非接触地以高空间分辨率表征样品的力学特征变化.为了更加灵敏地识别生物系统的微小力学性质差异,在提高布里渊散射效... 详细信息

细胞和组织的力学特性在决定生物功能中起着至关重要的作用,布里渊光谱技术作为一种黏弹性显微成像方法,可以无标记、非接触地以高空间分辨率表征样品的力学特征变化.为了更加灵敏地识别生物系统的微小力学性质差异,在提高布里渊散射效率的同时,结合多种黏弹性对比机制进行测量是需要关注的问题.本文报道了基于脉冲受激布里渊散射的光谱测量方法,采用脉冲光激发、连续光时域探测的方式,通过一次时域测量即可得到完整光谱并根据光谱信息反演样品的多种黏弹性参数.得益于受激散射和时域探测,实验中以毫秒级的光谱积分时间即可得到信噪比为26 dB的光谱,弹性纵模的存储模量和损耗模量的平均测量精度分别达0.1%和1%.基于此方法,测量并对比了常见液体及聚合物材料的布里渊光谱,并研究了不同固化阶段的PDMS弹性变化,与琼脂糖凝胶进行了对比.最后,基于多种黏弹性对比机制对6种食用油进行鉴别,不仅为物质鉴别提供了新的思路,也拓展了布里渊光谱的测量能力,提高了黏弹性测量的灵敏性.

关键词：布里渊散射黏弹性生物力学