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加味旋覆代赭汤防治乳腺肿瘤化学治疗相关消化道反应的疗效观察

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中国临床实用医学 2017年第1期8卷 20-22页

作者：陈玲玲韩涛刘兆喆张冠中郑振东谢晓冬辽宁中医药大学 110847 解放军沈阳军区总医院肿瘤科 110016

目的探讨加味旋覆代赭汤防治乳腺肿瘤化学治疗出现的消化道反应的疗效.方法将78例接收乳腺肿瘤化学治疗的患者随机分为治疗组与对照组,每组39例.两组均给予帕洛诺司琼,治疗组化学治疗前1d加服加味旋覆代赭汤,连服7剂后比较疗效.结果 ... 详细信息

目的探讨加味旋覆代赭汤防治乳腺肿瘤化学治疗出现的消化道反应的疗效.方法将78例接收乳腺肿瘤化学治疗的患者随机分为治疗组与对照组,每组39例.两组均给予帕洛诺司琼,治疗组化学治疗前1d加服加味旋覆代赭汤,连服7剂后比较疗效.结果对照组未出现恶心及轻度恶心症状的患者共12例,治疗组未出现恶心及轻度恶心症状患者共24例,两组比较差异有统计学意义（P〈0.01）;对照组止呕有效率为35.9%（14/39）,治疗组为61.5%（24/39）,两组比较差异有统计学意义（P〈0.05）.结论加味旋覆代赭汤能有效防治乳腺肿瘤化学治疗出现的消化道反应.

关键词：乳腺肿瘤加味旋覆代赭汤化学治疗消化道反应

原发性输尿管癌的诊断与治疗——附21例报告

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临床泌尿外科杂志 2006年第6期21卷 426-427,429页

作者：王友宝陈长宜武宝通韩韬祝昌明徐向前鹿集成青岛大学医学院附属海慈医院泌尿外科山东青岛266033

目的：提高原发性输尿管癌的诊断和治疗水平。方法：回顾性分析21例原发性输尿管癌患者的临床表现、诊断及治疗方法。结果：随访20例(95．2%),随访时间4个月～8年3个月。死亡8例,其中7例死于盆腔、腹膜后或肺转移,1例死于膀胱肿瘤复发... 详细信息

目的：提高原发性输尿管癌的诊断和治疗水平。方法：回顾性分析21例原发性输尿管癌患者的临床表现、诊断及治疗方法。结果：随访20例(95．2%),随访时间4个月～8年3个月。死亡8例,其中7例死于盆腔、腹膜后或肺转移,1例死于膀胱肿瘤复发；生存12例,患肾、输尿管和膀胱袖套状切除9例,生存4个月～8年3个月。其中1例术后13个月发生膀胱肿瘤,作TURBt后已生存2年7个月；输尿管上段部分切除1例(T(?)G(?)),术后7年2个月无复发。输尿管下段加膀胱袖套状切除2例,已生存3年2个月和4年7个月。结论：间歇性全程肉眼血尿是原发性输尿管癌的典型症状。一侧腰部钝痛并肾、输尿管积水也常提示有该病存在(33(?)患肾、输尿管和膀胱袖套状切除仍是治疗原发性膀胱癌的金标准。预后主要取决于输尿管癌的分期和分级。

关键词：输尿管肿瘤癌诊断治疗

参芪扶正注射液联合CEF方案治疗乳腺肿瘤的临床分析

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中国临床实用医学 2017年第1期8卷 23-26页

作者：鞠伶伟韩涛刘兆喆刘永叶谢晓冬郑振东辽宁中医药大学 110032 解放军沈阳军区总医院肿瘤科 110016

目的观察乳腺肿瘤患者化学治疗期间配合参芪扶正注射液对免疫功能及造血功能的影响.方法收集2014年8月至2016年8月解放军沈阳军区总医院肿瘤科98例乳腺肿瘤患者术后采用CEF化学治疗方案（环磷酰胺、表阿霉素、氟尿嘧啶）的临床资料,... 详细信息

目的观察乳腺肿瘤患者化学治疗期间配合参芪扶正注射液对免疫功能及造血功能的影响.方法收集2014年8月至2016年8月解放军沈阳军区总医院肿瘤科98例乳腺肿瘤患者术后采用CEF化学治疗方案（环磷酰胺、表阿霉素、氟尿嘧啶）的临床资料,分为观察组（50例）与对照组（48例）.对照组采用CEF方案治疗,观察组在对照组基础上,联合参芪扶正注射液治疗.比较两组患者化学治疗前后外周血血象及T细胞亚群的变化情况.结果观察组化学治疗后白细胞、血红蛋白及血小板均略降低,差异无统计学意义（P〉0.05）,而对照组化学治疗后白细胞、血红蛋白及血小板降低明显,差异有统计学意义（P〈0.05）;观察组与对照组化学治疗前后CD4、CD8及CD4/CD8变化明显,观察组均显著提升,而对照组均显著下降（均P〈0.05）.结论乳腺肿瘤患者化学治疗联合参芪扶正注射液可提高免疫功能、减轻骨髓抑制.

关键词：参芪扶正注射液乳腺肿瘤化学治疗免疫

西黄丸对乳腺癌荷瘤小鼠肿瘤组织凋亡及相关因子表达的影响

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中医药导报 2021年第6期27卷 1-4,9页

作者：张晓笛何丽娟陈会丛张瀚涛靳冉夏明钰沈阳药科大学生命科学与生物制药学院辽宁沈阳110016 北京同仁堂科技发展股份有限公司制药厂北京100079 北京中研同仁堂医药研发有限公司北京100079

目的:探讨西黄丸对乳腺癌细胞株MDA-MB-435移植瘤小鼠肿瘤生长及肿瘤组织凋亡的影响。方法:裸鼠皮下注射人乳腺癌细胞株MDA-MB-435建立肿瘤模型,35只荷瘤小鼠随机分为模型组、环磷酰胺组、西黄丸高剂量组、西黄丸中剂量组、西黄丸低剂量... 详细信息

目的:探讨西黄丸对乳腺癌细胞株MDA-MB-435移植瘤小鼠肿瘤生长及肿瘤组织凋亡的影响。方法:裸鼠皮下注射人乳腺癌细胞株MDA-MB-435建立肿瘤模型,35只荷瘤小鼠随机分为模型组、环磷酰胺组、西黄丸高剂量组、西黄丸中剂量组、西黄丸低剂量组,连续给药3周后脱颈椎处死,进行瘤体直径、瘤质量及脾脏指数的测定;采用HE染色、免疫组化染色及TUNEL染色方法观察肿瘤组织病理学变化、凋亡及相关蛋白表达的情况;采用RT-PCR方法检测肿瘤组织Bax mRNA、Bcl-2 mRNA及Caspase-3 mRNA表达。结果:与模型组比较,环磷酰胺组和西黄丸高剂量组小鼠肿瘤组织瘤质量显著降低(P<0.05);环磷酰胺组、西黄丸高剂量组和西黄丸中剂量组小鼠肿瘤组织凋亡区域明显增加(P<0.05);环磷酰胺组及西黄丸高剂量组小鼠肿瘤组织凋亡基因Bcl-2 mRNA和Bax mRNA的比率及Bcl-2 mRNA的表达显著下调(P<0.05),西黄丸低、中、高剂量组小鼠肿瘤组织凋亡基因Bax mRNA和Caspase-3 mRNA表达增加(P<0.05)。结论:西黄丸有抑制乳腺癌细胞株MDA-MB-435移植瘤裸鼠肿瘤生长的作用,可促进乳腺癌细胞株MDA-MB-435移植肿瘤组织凋亡,其机制可能是通过增加凋亡基因Bax mRNA和Caspase-3 mRNA的表达以促进肿瘤组织凋亡。

关键词：乳腺癌西黄丸细胞凋亡裸鼠抑瘤率环磷酰胺

Potential protective effects of red yeast rice in endothelial function against atherosclerotic cardiovascular disease

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Chinese Journal of Natural Medicines 2019年第1期17卷 50-58页

作者： FENG Shu-Jun TANG Zhi-han WANG Ying TANG Xin-Ying LI tao-Hua TANG Wei KUANG Ze-Min Department of Cardiology The First People's Hospital of ChenzhouUniversity of South China Institute of Cardiovascular Disease Key Lab for Arteriosclerology of Hunan ProvinceUniversity of South China Department of Biochemistry and Molecular Biology The Libin Cardiovascular Institute of AlbertaThe University of CalgaryHealth Sciences Center3330 Hospital Drive NW Department of Cardiology The Second Affiliated Hospital of Henan University of Science and Technology Class 2014 Medical CollegeUniversity of South China Department of Hypertension Beijing Anzhen Hospital of Capital Medical University

Atherosclerotic cardiovascular disease(ASCVD) is the deadliest disease in the world, with endothelial injury occurring throughout the course of the disease. Therefore, improvement in endothelial function is of essential importance in the prevention of ASCVD. Red yeast rice(RYR), a healthy traditional Chinese food, has a lipid modulation function and also plays a vital role in the improvement of endothelial reactivity and cardiovascular protection; thus, it is significant in the prevention and treatment of ASCVD. This article reviews the molecular mechanisms of RYR and its related products in the improvement of endothelial function in terms of endothelial reactivity, anti-apoptosis of endothelial progenitor cells, oxidative stress alleviation and anti-inflammation.

关键词： Red yeast rice Xuezhikang Atherosclerotic cardiovascular disease Endothelial cells Molecular mechanism

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绵羊消化道线虫驱除效果试验

草食家畜 2020年第2期 61-64页

作者：楚高洁王杰沈辰峰韩涛哈力旦木参都哈西席浩陈世军新疆畜牧科学院兽医研究所乌鲁木齐830011 新疆农业大学乌鲁木齐830052

为探明常用驱虫药物对羊消化道线虫的驱除效果,本研究团队在焉耆县某羊场对32只绵羊进行了伊维菌素注射液和阿苯达唑片的驱虫效果对比试验,结果显示:伊维菌素组虫卵转阴率和虫卵减少率分别为75.0%和81.1%;阿苯达唑组虫分别为60.0%和66.... 详细信息

为探明常用驱虫药物对羊消化道线虫的驱除效果,本研究团队在焉耆县某羊场对32只绵羊进行了伊维菌素注射液和阿苯达唑片的驱虫效果对比试验,结果显示:伊维菌素组虫卵转阴率和虫卵减少率分别为75.0%和81.1%;阿苯达唑组虫分别为60.0%和66.7%;对照组则分别为0和-14.3%。绵羊应用这2种药物驱虫前后的线虫EPG差异极显著(P <0.01),绵羊投药后未发现明显临床异常。虽然两种药物均能较好地驱除绵羊消化道线虫,但根据用药效果、安全性、依从性和经济性等多方面综合分析,现阶段在焉耆盆地驱除绵羊消化道线虫应优先选择伊维菌素注射液。

关键词：绵羊消化道线虫伊维菌素注射液阿苯达唑片驱虫对比试验

Insecticidal Constructure and Bioactivities of Compounds from Ficus sarmentosa ***

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Agricultural Sciences in China 2011年第9期10卷 1402-1409页

作者： WANG Xue-gui WEI Xiao-yi HUANG King-yan SHEN Li-tao TIAN Yong-qing XU han-hong Key Laboratory of Natural Pesticide and Chemical Biology Ministry of Education/South China Agricultural University Guangzhou 510642 P.R.China Biorational Pesticide Research Laboratory Sichuan Agricultural University Chengdu 611130 PR.China South China Institute of Botany Chinese Academy of Sciences Guangzhou 510650 P.R.China

Insecticidal activities of the petroleum ether-, chloroform-, ethyl acetate-, and water-soluble fractions of the methanolic extract ofFicus sarmentosa var. henryi were assayed against Musca domestica adults. The chloroform- and ethyl acetate- soluble fractions were the most active with 92.6 and 88.9% mortalities （24 h after treatment） respectively. Therefore, the two fractions were combined and four compounds, isolated from the fractions by activity-guided fractionation, were elucidated as 7-hydroxycoumarin, apigenin, eriodictyol, and quercetin by spectroscopic method and displayed excellent insecticidal activities against adults of M. domestica and 4th instar larva of Aedes albopictus. Among those, 7- hydroxycoumarin showed the strongest insecticidal activities with lethal concentrations （LC50） values of 72.13 μg g^-1 sugar and 4.87 μg mL^-1 （48 h after treatment） against the test insects respectively. The cytoxicities of these compounds on BTI-Tn-5B 1-4 cell were also investigated for the insecticidal mechanism and found that quercetin represented superior inhibitory activity with MTT assay and reactive oxygen species （ROS） against BTI-Tn-5B 1-4 cell, but slightly weaker than that of the positive control （azadirachtin） and significantly greater than the negative control （DMSO only）. Meanwhile, eriodictyol demonstrated the strongest effect on the mitochondrial membrane potentials （MMP）. In conclusion, based on their comparative toxicities to commercial insecticides and their cytotoxic effects, some of the compounds from the F. sarmentosa have potential as botanical insecticides.

关键词： Ficus sarmentosa var. henryi Musca domestica Aedes albopictus insecticidal activity 7-hydroxycoumarin quercetin

The neuroprotective efects of peracetylated chitosan oligosaccharides againstβ‑amyloid‑induced cognitive defcits in rats

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Marine Life Science & Technology 2023年第2期5卷 211-222页

作者： Cui Hao Minmin han Wei Wang Cheng Yang Jigang Wang Yunliang Guo tao Xu Lijuan Zhang Chunxia Li Medical Research Center Afliated Hospital of Qingdao UniversityQingdao 266003China Key Laboratory of Marine Drugs Ministry of EducationOcean University of ChinaQingdao 266003China Center of Integrated Traditional and Western Medicine Qingdao UniversityQingdao 266003China Qingdao Women’s and Children’s Hospital Qingdao 266003China Department of Pathology Afliated Hospital of Qingdao UniversityQingdao 266003China

Chitosan oligosaccharides(COSs)have been reported to possess a broad range of activities such as antitumor,antioxidant and neuroprotective *** this study,the protective efects and mechanisms of peracetylated chitosan oligosaccharides(PACOs)against Aβ-induced cognitive defcits were investigated in Sprague–Dawley(SD)*** treatment signifcantly improved the learning and memory function of Alzheimer’s disease(AD)rats and attenuated the neuron cell damage caused by Aβ.PACOs also markedly reduced the levels of lactate dehydrogenase(LDH)and Malondialdehyde(MDA)and decreased the phosphorylation of Tau protein to inhibit oxidative injury and infammatory responses in AD *** studies indicated that PACOs may promote the repair of Aβinduced nerve damage and inhibit neuronal apoptosis mainly through regulating PI3K/Akt/GSK3βsignaling ***,the transcriptome analysis verifed that the diferentially expressed genes(DEGs)were mainly involved in neuron development and the PI3K-Akt signaling *** together,peracetylated chitosan oligosaccharides(PACOs)have the potential to be developed into novel anti-AD agents targeting the cellular PI3K/Akt/GSK3βsignaling pathway.

关键词： Peracetylated chitosan oligosaccharides Neuroprotective Amyloid Cognitive defcit PI3K/Akt/GSK3βpathway

Evolution Toward the Observational Features of a Stripped Envelope TypeⅡb Supernova in a Binary System

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Research in Astronomy and Astrophysics 2022年第5期22卷 146-157页

作者： Gang Long han-Feng Song Rui-Yu Zhang Ying Qin Liu-Yan Zhao Shi-tao Qi Fang-Wen Wu College of Physics Guizhou UniversityGuiyang 550025China College of Physics Henan Normal UniversityXinxiang 453007China Department of Physics Anhui Normal UniversityWuhu 241000China

TypeⅡb supernovae(SNeⅡb)that have a thin layer of hydrogen left in their outer envelope have been believed to belong to core collapse *** transfer via Roche lobe overflow can significantly change the nucleosynthesis and surface chemical elements of the progenitors of SNeⅡ*** aim to explore what conditions a close binary can meet with the observational features of SNeⅡ*** find that an observed low mass SNⅡb cannot be produced by a low mass isolated star with M<20,M_(⊙)due to the existence of a thick hydrogen envelope regardless of *** dominate as progenitors in the mass interval(i.e.,M<20 M_(⊙))considered in this *** 16 M_(⊙),primary with a 14 M_(⊙) companion in a binary system with~10 days

关键词： (stars:)binaries(including multiple) close-stars evolution-stars rotation-stars abundances