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Multikinase inhibitor-based immunotherapy doublet for advanced hepatocellular carcinoma:its efficacy still needs to be determined

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 468-471页

作者： Heming Li Xiangjun Hao tao han Department of Medical Oncology the First Hospital of China Medical UniversityShenyangChina Department of Clinical Pharmacy Shenyang Pharmaceutical UniversityShenyangChina

The current landscape for advanced hepatocellular carcinoma(HCC)has evolved drastically in recent years,with the ever-increasing development of novel standard first-line therapeutic strategies(e.g.,the combination of atezolizumab and bevacizumab)and the approval of several new agents for second line strategies,such as regorafenib and cabozantinib(1,2).Although a large number of treatment options are available for advanced HCC patients,multikinase inhibitor(MKI)-based immunotherapy doublet has become notably complex,especially after the publication of the COSMIC-312 trial(3).This study evaluated the efficacy and safety of cabozantinib combined with atezolizumab versus sorafenib as the first-line treatment of patients with advanced *** the primary endpoint of progression-free survival(PFS)was significantly improved with treatment using cabozantinib combined with atezolizumab compared with sorafenib in the COSMIC-312 trial,the overall survival(OS)did not improve,and the response rate was lower than expected(3).Nevertheless,this was a crucial randomized controlled trial(RCT)evaluating the efficacy of MKI-based immunotherapy doublet as the first-line systemic therapy for advanced HCC,paving the way for future investigations to determine the underlying mechanism of these *** have several concerns with the interpretation of this study.

关键词： Advanced hepatocellular carcinoma(advanced HCC) multikinase inhibitor(MKI) immunotherapy hepatitis B virus(HBV) clinical trial

Modeling experimental study on weathering-leaching of Emeishan basalt and its relation with metallogenesis

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Chinese Journal Of Geochemistry 2010年第2期29卷 212-216页

作者： WANG Fudong ZHU Xiaoqing han tao LI Zengsheng State Key Laboratory of Ore Deposit Geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang 550002 China Postgraduate School of the ChineseAcademy of Sciences Beijing 100049 China

The Emeishan basalt has a high Cu background value (170×10-6 on average), and thus provides a ore-forming material source for copper ores. The collected samples were exposed in basalt lavas of the third segment of the Emeishan basalt eruptive cycle. By using a set of automatically cycling glass apparatuses, weathering-leaching experiments by three kinds of rainwater on the collected samples were carried out in the open system (at normal temperature and normal pressure). The analysis results showed that the most intensive export of Cu occurred under acidic rainwater-induced weathering-leaching conditions, almost 2-3 orders of magnitude the export of Cu by mod-ern air rainwater, and 1-2 orders of magnitude higher than the export of Cu by CO2 rainwater. In addition, the total amount of Zn, Cu, U, Ni and Sr exported by acidic rainwater are greater than 1%. All this indicates that copper in the Emeishan basalt provided the copper source for Cu mineralization at the contact between the basalt and the Maokou Formation limestone at the bottom.

关键词：峨眉山玄武岩成矿关系雨水收集实验建模淋溶试验调制解调器物质来源

Long-term photometric behavior of the eclipsing Z Cam-type dwarf nova AY Psc

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Research in Astronomy and Astrophysics 2017年第6期17卷 67-76页

作者： Zhong-tao han Sheng-Bang Qian Irina Voloshina Li-Ying Zhu Yunnan Observatories Chinese Academy of Sciences Kunming 650216 China Key Laboratory of the Structure and Evolution of Celestial Objects Chinese Academy of Sciences Kunming 650216 China University of Chinese Academy of Sciences Beijing 100049 China Sternberg Astronomical Institute Moscow State University Universitetskij prospect 13 Moscow 119992 Russia

New eclipse timings of the Z Cam-type dwarf nova AY Psc were measured and the orbital ephemeris was revised. In addition, based on long-term AAVSO data, the outburst behaviors were also explored. Our analysis suggests that normal outbursts are quasi-periodic, with an amplitude of 2.5（4-0.1） mag and a period of - 18.3（4-0.7） d. The amplitude vs. recurrence-time relation ofAY Psc is discussed, and we conclude that this relation may represent general properties of dwarf nova outbursts. The observed standstill ends with an outburst, which is inconsistent with the general picture of Z Cam- type stars. This unusual behavior was considered to be related to mass-transfer outbursts. Moreover, the average luminosity Is brighter during standstills than during outburst cycles. The changes in brightness mark variations in M2 due to the fact that the disk of AY Psc is nearly steady state.M2 value was limited to the range from 6.35 × 10-9 to 1.18 × 10-8 M yr-1. More detailed examination shows that there are a few small outbursts present during standstills. These events with amplitudes of - 0.5 - 0.9 mag are very similar to the stunted outbursts reported in some nova-like cataclysmic variables. We discussed several possible mechanisms and suggested that the most reasonable mechanism for these stunted outbursts is a changing mass-transfer rate.

关键词： binaries close - stars cataclysmic variables - stars individual (AY Psc)

Luminescence properties of Eu^(2+) doped BaAl_2Si_2O_8 phosphor for white LEDs

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Science China(Physics,Mechanics & Astronomy) 2011年第10期54卷 1783-1786页

作者： MA MingXing ZHU DaChuan ZHAO Cong han tao TU MingJing College of Material Science and Engineering Sichuan University Chengdu 610065 China College of Chemistry and Environmental Technology Chongqing University of Arts and Sciences Chongqing 402160 China

The BaAl2Si2O8:Eu2+blue emitting phosphor was obtained through the one-step calcination process of precursors prepared bychemical co-precipitation method. The phase structure and luminescence propertied of the phosphor were investigated usingX-ray diffraction (XRD) and a fluorescence spectrophotometer. The excitation spectrum exhibited a broad band between 230nm and 400 nm and the emission peaking at about 470 nm was observed, which originated from the allowed f-d transition ofEu2+ions at Ba2+sites. Owing to the different optimal concentrations under different excitation wavelengths (254 nm and 365nm), the energy-transfer mechanism in this phosphor has changed from the dipole-dipole interaction to the exchange interac-tion of Eu2+ions.

关键词： phosphor BaAl2Si2O8:Eu2+ luminescence properties white LED

Effect of geometric shape of plate on residual stress and deformation distribution for butt-weld joint

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China Welding 2018年第3期27卷 20-26页

作者： Qiao Ling han tao College of Mechanical and Electronic Engineering China University of PetroleumQingdao 266580China

This paper presents a numerical simulation of deformation and residual stress in butt-weld joint for different shaped plates. Within the framework of numerical investigation, 3 types of models and a double ellipsoidal heat source were implemented in finite element simulation. As for an effect of geometric shape, the weld-induced deformation and residual stress should be taken into account during designing the welded structure. And for U-shape plates, the effect of curvature radius on the mechanical properties was also obtained, which is a significant factor affecting its service life. The simulation results revealed that the plate processed into U-shape could reduce the deformation and residual stress near the weld. And the deformation and residual stress in U-shape plate with circular arc transition were further reduced. Furthermore, the effect of curvature radius on the mechanical properties of plates was not general considered as the bigger curvature radius the better mechanical properties. The results concluded that the geometric shape significantly affects the mechanical properties, which provides prediction for structural design.

关键词： numerical simulation residual stress deformation processing shape

Structure and Evolution of Clay-Organic Nanocomposites in Three Leading Shales in China

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Journal of Earth Science 2023年第3期34卷 824-837页

作者： Yuantao Gu Quan Wan Xiaoxia Li tao han Shuguang Yang Qinhong Hu School of Resources and Environment Henan University of EngineeringZhengzhou 451191China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China Shandong Provincial Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao 266580China University of Texas at Arlington Arlington Texas 76019USA

Organic matter(OM)in shales occurs as nanometer-sized intercalations with clay minerals that are termed as clay-organic nanocomposites;however,the OM occurrence in nanocomposites at different stages of maturation is still unclear,and the co-evolution process of OM and clay under burial is not well *** reveal the variation of OM occurrence and clarify the relationship between petroleum generation of OM&transformation of clay minerals in nanocomposites as a function of maturity,this study investigates the structure and clay-OM association in 44 samples from three leading shales at different maturity stages from two basins in China.A total of 15 samples of lacustrine shale from upper Triassic Yanchang Formation,15 samples of marine shale from Lower Silurian Longmaxi Formation,and 14 samples of marine shale from Lower Cambrian Niutitang Formation were analyzed based on organic geochemistry,X-ray diffraction(XRD),and field emission-scan electron microscopy(FE-SEM),focused ion beam(FIB)sample preparation and consequent high resolution-transmission electron microscopy(HR-TEM)observations combined with energy dispersive spectroscopy(EDS).The results from this study show that most shale samples are organic-rich,and these three shales represent thermal evolutionary process from oil-window mature to overmature in a sequence of Triassic Yanchang,Silurian Longmaxi,and Cambrian Niutitang *** observations indicate that sub-parallel bands of clays and intermingling of detrital minerals(such as quartz)dominate the nanocomposites in the Yanchang *** for Longmaxi and Niutitang shales,abundant nanopores and pyrite nanoparticles are observed in nanocomposites with features of layered distributions of OM and clay *** structural investigation of nanocomposites shows that organic carbon between multi-layers dominates the OM occurrence in nanocomposites,which significantly extends the traditional opinion of OM-clay *** an oil-window ma

关键词： organic matter shale clay-organic nanocomposites structure hydrocarbons

Numerical simulation of mechanical properties of straight pipe and elbow during in-service welding

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China Welding 2018年第4期27卷 33-40页

作者： Qiao Ling han tao College of Mechanical and Electronic Engineering China University of Petroleum

Elbows are the most vulnerable parts in pipeline network systems. The residual stress for in-service welding repair has significant impacts on the mechanical properties of straight pipes and elbows. In this paper,the thermal elastic-plastic finite element method is employed to investigate the mechanical field during the in-service welding. The prediction of residual stress and deformation in the straight pipe and elbow is performed based on the validation of the numerical models. And the effects of the curvature radius and defects on the elbow are investigated. The results show that the residual stress distribution is uneven along various directions after welding. And the mechanical properties of the elbow decrease when the curvature radius is small. Compared to the intact elbow,the residual stress of the elbow with defects concentrates in the defective area. The depth of defect is the main factors affecting the mechanical properties of the elbow. A systematic analysis of the mechanical properties of straight pipes and elbows is proposed to provide guidance to the in-service welding.

关键词： in-service welding elbow residual stress curvature radius pressure defects

Constrained polynomial fit-based k-domain interpolation in swept-source optical coherence tomography

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Journal of Innovative Optical Health Sciences 2021年第1期4卷 83-90页

作者： tao han Jianrong Qiu Di Wang Jia Meng Zhiyi Liu Zhihua Ding State Key Lab of Modern Optical Instrumentation College of Optical Science and Engineering Zhejiang University Hangzhou 310027P.R.China

We propose a k-domain spline interpolation method with constrained polynomial fit based on spectral phase in swept-source optical coherence tomography(SS-OCT).A Mach-Zehnder interferometer(MZI)unit is connected *** swept-source of the SS-OCT system to generate calibration signal in sync with the fetching of interference *** spectral phase of the calibration signal is extracted by Hilbert *** fitted phase-time relationship is obtained by polynomial fitting with the constraint of passing through the central spectral *** fitting curve is then adopted for k-domain uniform interpolation based on evenly spaced *** comparison with conventional k-domain spline interpolation,the proposed method leads to improved axial resolution and peak response of the axial point spread function(PSF)of the SS-OCT *** performance resulting from the proposed method is further verified by OCT imaging of a home-constructed microspheres-agar sample and a fresh *** SS-OCT,the proposed method is believed to be applicable to spectral domain OCT as well.

关键词： Optical coherence tomography interpolation constrained polynomial fit

Effect of groove shapes on mechanical properties of welded joints of ASTM4130 steel

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China Welding 2016年第2期25卷 40-46页

作者： Li Liying han tao College of Mechanical and Electronic Engineering China University of Petroleum Qingdao 26658

The 30 mm thick ASTM4130 steel pipe was fabricated by gas tungsten arc welding and shielded metal arc welding under quenched and tempered conditions. Whereafier, the mechanical properties of welded joints of both V groove and combination double V groove were measured, while the microstructure feature and fracture morphology of both welded joints were investigated. Moreover, the effect of groove shapes on the properties of welded joints was explored. The results show that the welding efficiency of the combination double V groove joint is as two times as that of the V groove joint. But the hardness and toughness of the heat-affected zone （HAZ） with combination double V groove can not satisfy the requirements. Also, the coarse grain heat-affected zone （CGHAZ） of the cap layer is mainly composed of granular bainite, tempered martensite and a small amount of carbon-free bainite, and the fractured swface of the fusion line is entirely dominated by the quasi-cleavage mode. That the mechanical properties of the combination double V groove are lower than that of the V groove lie in the penetration ratio, welding heat input, and the areas and distribution feature of brittle zones. The combination double V groove is not suitable for the fabricating of ASTM4130 steel.

关键词： ASTM4130 steel groove shape mechanical properties microstructure