检索结果-南通市图书馆

Plasma metabolites and risk of myocardial infarction:a bidirectional Mendelian randomization study

Journal of Geriatric Cardiology 2024年第2期21卷 219-231页

作者： Dong-Hua LI qiang WU Jing-Sheng LAN Shuo CHEN You-Yi HUANG Lan-Jin WU zhi-Qing QIN Ying HUANG Wan-Zhong HUANG Ting ZENG Xin HAO Hua-Bin SU qiang SU Department of Cardiovascular Medicine Minzu Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Senior Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Library of Graduate School Chinese PLA General HospitalBeijingChina Department of Cardiology Jiangbin Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Health Management Institute the Second Medical CenterChinese PLA General HospitalBeijingChina

BACKGROUND Myocardial infarction(MI)is a critical cardiovascular event with multifaceted etiology,involving several genetic and environmental *** is essential to understand the function of plasma metabolites in the development of MI and unravel its complex *** This study employed a bidirectional Mendelian randomization(MR)approach to investigate the causal relationships between plasma metabolites and MI *** used genetic instruments as proxies for plasma metabolites and MI and conducted MR analyses in both directions to assess the impact of metabolites on MI risk and vice *** addition,the large-scale genome-wide association studies datasets was used to identify genetic variants associated with plasma metabolite(1400 metabolites)and MI(20,917 individuals with MI and 440,906 individuals without MI)*** variance weighted was the primary method for estimating causal *** estimates are expressed as beta coefficients or odds ratio(OR)with 95%*** We identified 14 plasma metabolites associated with the occurrence of MI(P<0.05),among which 8 plasma metabolites[propionylglycine levels(OR=0.922,95%CI:0.881–0.965,P<0.001),gamma-glutamylglycine levels(OR=0.903,95%CI:0.861–0.948,P<0.001),hexadecanedioate(C16-DC)levels(OR=0.941,95%CI:0.911–0.973,P<0.001),pentose acid levels(OR=0.923,95%CI:0.877–0.972,P=0.002),X-24546 levels(OR=0.936,95%CI:0.902–0.971,P<0.001),glycine levels(OR=0.936,95%CI:0.909–0.964,P<0.001),glycine to serine ratio(OR=0.930,95%CI:0.888–0.974,P=0.002),and mannose to trans-4-hydroxyproline ratio(OR=0.912,95%CI:0.869–0.958,P<0.001)]were correlated with a decreased risk of MI,whereas the remaining 6 plasma metabolites[1-palmitoyl-2-arachidonoyl-GPE(16:0/20:4)levels(OR=1.051,95%CI:1.018–1.084,P=0.002),behenoyl dihydrosphingomyelin(d18:0/22:0)levels(OR=1.076,95%CI:1.027–1.128,P=0.002),1-stearoyl-2-docosahexaenoyl-GPE(18:0/22:6)levels(OR=1.067,95%CI:1.027–1.109,P=0.001),alpha-ketobutyrate levels(OR=1.108,95%

关键词： infarction alterations diagnosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In-situ SEM characterization of fracture mechanism of TiB/Ti-2Al-6Sn titanium matrix composites after electroshocking treatment

引用

Rare Metals 2024年第6期43卷 2805-2818页

作者： Ya-Ya Wu Jian Zhou Guo-Lei han Yan Wen Zhou Wang Li-qiang Wang Wei-Jie Lv Le-Chun Xie Lin Hua Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan 430070China Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing 100124China State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

In this article,in-situ scanning electron microscope characterization of the tensile properties of TiB/Ti-2Al-6Sn titanium matrix composite(TMC)was conducted before and after electroshocking treatment(EST).After EST,the tensile strength increased by 113.2 *** effect of EST on the tensile strength and fracture behavior of TiB was investigated using in-situ characterization of the fracture morphology and crack propagation path of the matrix and *** EST,TiB fracture introduced cracks that extended into the matrix,resulting in material *** EST,the refined TiB improved the bearing capacity of the matrix,thereby improving TMC ***,after EST,the cracks were introduced into the matrix,and resulting the fracture of matrix *** an increase in the external load,cracks in the matrix were observed to propagate to TiB,and the refined TiB was fractured,detached,and pulled out,resulting in the formation of *** the propagation path of the main crack after EST showed that the deflection angle of the main crack *** micro structure of the fracture surface indicated that the fracture of the matrix was plastic,whereas that of TiB was *** EST,the size and area of the dimples increased,confirming the increase in *** results revealed that the comprehensive mechanical properties of TiB/Ti-2Al-6Sn improved after ***,EST is an efficient method for tailoring the micro structures and mechanical properties of TMCs.

关键词： TiB/Ti-2Al-6Sn In-situ microstructure characterization Tensile properties Reinforcement Electroshocking treatment(EST)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Coinfection of SARS-CoV-2 Omicron variant and other respiratory pathogens in children

引用

World Journal of Pediatrics 2024年第1期20卷 92-96页

作者： Wei Li Bing-han Wang Bao-Hai Chen Yi Sun Lin Li Wen-Qing Xiang Ahmed Faisal Ali Lin-Xuan Su Hai-Yan Mao Hong-qiang Shen qiang Shu Department of Clinical Laboratory Children's HospitalNational Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhouChina School of Public Health Zhejiang University School of MedicineHangzhouChina Department of Information Center Children's HospitalZhejiang University School of MedicineHangzhouChina Zhejiang Provincial Center for Disease Control and Prevention HangzhouChina Department of Thoracic&Cardiovascular Surgery Children's HospitalNational Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhouChina

Since the outbreak of coronavirus disease 2019(COVID-19),the entire world has been affected by the epidemic[1,2].On November 9,2021,a variant of the novel coronavirus B.1.1.529 was detected for the first time from case samples in South *** Omicron strain spread and mutated significantly *** variant has the characteristics of escape immunity,which can induce relatively extreme disease and reduce the neutralization of antibodies in vaccinators,and is more likely to be reinfected[3,4].The clinical presentation of severe acute respiratory syndrome coronavirus 2(SARSCoV-2)in children has mild symptoms and a lower risk of hospitalization and death.

关键词： respiratory immunity acute

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Towards an ultrafast 3D imaging scanning LiDAR system:a review

引用

Photonics Research 2024年第8期12卷 1709-1729页

作者： zhi LI YAQI han LICAN WU ZIhan ZANG MAOLIN DAI SZE YUN SET SHINJI YAMASHITA QIAN LI H.Y.FU Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China Department of Electrical Engineering and Information Systems The University of TokyoTokyo 113-8656Japan Research Center for Advanced Science and Technology The University of TokyoTokyo 153-8904Japan School of Electronic and Computer Engineering Peking UniversityShenzhen 518055China

Light detection and ranging(LiDAR),as a hot imaging technology in both industry and academia,has undergone rapid innovation and *** current mainstream direction is towards system miniaturization and *** are many metrics that can be used to evaluate the performance of a LiDAR system,such as lateral resolution,ranging accuracy,stability,size,and *** recently,with the continuous enrichment of LiDAR application scenarios,the pursuit of imaging speed has attracted tremendous research ***,for autonomous vehicles running on motorways or industrial automation applications,the imaging speed of LiDAR systems is a critical *** this review,we will focus on discussing the upper speed limit of the LiDAR *** on the working mechanism,the limitation of optical parts on the maximum imaging speed is *** beam scanner has the greatest impact on imaging *** provide the working principle of current popular beam scanners used in LiDAR systems and summarize the main constraints on the scanning ***,we highlight the spectral scanning LiDAR as a new paradigm of ultrafast ***,to further improve the imaging speed,we then review the parallel detection methods,which include multiple-detector schemes and multiplexing ***,we summarize the LiDAR systems with the fastest point acquisition rate reported *** the outlook,we address the current technical challenges for ultrafast LiDAR systems from different aspects and give a brief analysis of the feasibility of different approaches.

关键词： LiDAR scanner system

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microplastic exposure disturbs sleep structure,reduces lifespan,and decreases ovary size in Drosophila melanogaster

引用

Zoological Research 2024年第4期45卷 805-820页

作者： Wei Yan Zi-Jie Li Zi-Yi Lin Shu-Qin Ji William Ka Fai Tse zhi-qiang Meng Chang Liu Lei Li Shenzhen-Hong Kong Institute of Brain Science Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Laboratory of Developmental Disorders and Toxicology Center for Promotion of International Education and ResearchFaculty of AgricultureKyushu UniversityFukuokaFukuoka 819-0395Japan Shenzhen Key Laboratory of Drug Addiction the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Guangdong Provincial Key Laboratory of Brain Connectome and Behavior Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China

The organ-specific toxicity resulting from microplastic(MP)exposure has been extensively explored,particularly concerning the gut,liver,testis,and ***,under natural conditions,these effects are not restricted to specific organs or *** whether MP exposure presents a systemic threat to an entire organism,impacting factors such as lifespan,sleep,and fecundity,is *** this study,we investigated the effects of dietary exposure to two different doses of MPs(1–5μm)using the terrestrial model organism Drosophila *** indicated that the particles caused gut damage and remained within the digestive *** MP exposure significantly shortened the lifespan of adult *** short-term exposure disrupted sleep patterns,increasing the length of daytime sleep ***,one week of MP exposure reduced ovary size,with a trend towards decreased egg-laying in mated *** MPs did not penetrate the brain or ovaries,transcriptome analysis revealed altered gene expression in these *** the ovary,Gene Ontology(GO)analysis indicated genotoxic effects impacting inflammation,circadian regulation,and metabolic processes,with significant impacts on extracellular structure-related *** the brain,GO analysis identified changes in pathways associated with proteolysis and carbohydrate ***,this study provides compelling evidence of the systemic negative effects of MP exposure,highlighting the urgent need to address and mitigate environmental MP pollution.

关键词： Microplastics Sleep Lifespan Reproduction Risk assessment Drosophila melanogaster

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于基因组和转录组数据的甲壳类系统发育研究

引用

浙江海洋大学学报（自然科学版） 2019年第6期38卷 469-474页

作者：孙善肖韩志强浙江海洋大学水产学院浙江舟山316022

甲壳类是节肢动物的一个亚门,在水生环境中占主导地位,在生态学和渔业中具有重要的地位。在过去的十多年间,利用基因序列探讨甲壳纲深层次的系统发育关系已取得初步进展,但是大多数系统发育研究是基于线粒体基因和少量的核基因进行的。... 详细信息

甲壳类是节肢动物的一个亚门,在水生环境中占主导地位,在生态学和渔业中具有重要的地位。在过去的十多年间,利用基因序列探讨甲壳纲深层次的系统发育关系已取得初步进展,但是大多数系统发育研究是基于线粒体基因和少量的核基因进行的。随着高通量测序的普及,利用转录组和基因组数据研究物种间系统发育关系已成为可能。筛选足够的单拷贝基因是构建可信系统发育树的关键。本文根据BUSCO建立的节肢动物1 066个单拷贝的直系同源数据库,利用hmmsearch将甲壳纲的10个物种的氨基酸序列与之比对,最终筛选出346个直系同源单拷贝基因,并以此构建了系统发育树,讨论了等足目、端足目、哲水蚤目、枝角目和十足目的系统发育关系,包括十足目对虾科的亚属划分问题。本文建立的基于基因组和转录组构建系统发育树的方法为其他物种系统发育关系的讨论提供了重要的方法参考。

关键词：甲壳类基因组转录组直系同源系统发育

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Exosomes derived from microglia overexpressing miR-124-3p alleviate neuronal endoplasmic reticulum stress damage after repetitive mild traumatic brain injury

引用

Neural Regeneration Research 2024年第9期19卷 2010-2018页

作者： Yan Wang Dai Li Lan Zhang Zhenyu Yin Zhaoli han Xintong Ge Meimei Li Jing Zhao Shishuang Zhang Yan Zuo Xiangyang Xiong han Gao qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institute Tianjin Medical University General HospitalTianjinChina

We previously reported that miR-124-3p is markedly upregulated in microglia-derived exosomes following repetitive mild traumatic brain ***,its impact on neuronal endoplasmic reticulum stress following repetitive mild traumatic brain injury remains *** this study,we first used an HT22 scratch injury model to mimic traumatic brain injury,then co-cultured the HT22 cells with BV2 microglia expressing high levels of *** found that exosomes containing high levels of miR-124-3p attenuated apoptosis and endoplasmic reticulum ***,luciferase reporter assay analysis confirmed that miR-124-3p bound specifically to the endoplasmic reticulum stress-related protein IRE1α,while an IRE1αfunctional salvage experiment confirmed that miR-124-3p targeted IRE1αand reduced its expression,thereby inhibiting endoplasmic reticulum stress in injured ***,we delivered microglia-derived exosomes containing miR-124-3p intranasally to a mouse model of repetitive mild traumatic brain injury and found that endoplasmic reticulum stress and apoptosis levels in hippocampal neurons were significantly *** findings suggest that,after repetitive mild traumatic brain injury,miR-124-3 can be transferred from microglia-derived exosomes to injured neurons,where it exerts a neuroprotective effect by inhibiting endoplasmic reticulum ***,microglia-derived exosomes containing miR-124-3p may represent a novel therapeutic strategy for repetitive mild traumatic brain injury.

关键词： apoptosis C/EBP homologous protein endoplasmic reticulum stress exosome inositol-requiring enzyme 1α microglia miR-124-3p neuron repetitive mild traumatic brain injury X-box binding protein 1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Olfactory Three-Needle Electroacupuncture Improved Synaptic Plasticity and Gut Microbiota of SAMP8 Mice by Stimulating Olfactory Nerve

引用

Chinese Journal of Integrative Medicine 2024年第8期30卷 729-741页

作者： WANG Yuan ZHENG A-ni YANG Huan WANG qiang DAI Biao WANG Jia-ju WAN Yi-tong LIU zhi-bin LIU Si-yang College of Acu-moxibustion and Massage Shaanxi University of Chinese MedicineXianyangShaanxi Province712046China Shaanxi Key Laboratory of Acupuncture and Medicine Shaanxi University of Chinese MedicineXianyangShaanxi Province712046China The Second Affiliated Hospital of Shaanxi University of Chinese Medicine XianyangShaanxi Province712000China Department of Traditional Chinese Medicine Baotou Medical CollegeBaotouInner Mongolia Autonomous Region014040China School of Basic Medical Sciences Xi’an Medical UniversityXi’an710021China

Objective To investigate the effects and mechanisms of olfactory three-needle(OTN)electroacupuncture(EA)stimulation of the olfactory system on cognitive dysfunction,synaptic plasticity,and the gut microbiota in senescence-accelerated mouse prone 8(SAMP8)*** Thirty-six SAMP8 mice were randomly divided into the SAMP8(P8),SAMP8+OTN(P8-OT),and SAMP8+nerve transection+OTN(P8-N-OT)groups according to a random number table(n=12 per group),and 12 accelerated senescence-resistant(SAMR1)mice were used as the control(R1)*** was performed at the Yintang(GV 29)and bilateral Yingxiang(LI 20)acupoints of SAMP8 mice for 4 *** Morris water maze test,transmission electron microscopy,terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling(TUNEL)staining,Nissl staining,Golgi staining,Western blot,and 16S rRNA sequencing were performed,*** Compared with the P8 group,OTN improved the cognitive behavior of SAMP8 mice,inhibited neuronal apoptosis,increased neuronal activity,and attenuated hippocampal synaptic dysfunction(Phanced the brain-derived neurotrophic factor(BDNF)/cAMP-response element binding(CREB)signaling and phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/AKT/mTOR)signaling compared with the P8 group(P<0.05 or P<0.01).However,the neuroprotective effect of OTN was attenuated by olfactory nerve *** with the P8 group,OTN had a very limited effect on the fecal microbial structure and composition of SAMP8 mice,while specifically increased the genera Oscillospira and Sutterella(P<0.05).Interestingly,the P8-N-OT group showed an abnormal fecal microbiota with higher microbialα-diversity,Firmicutes/Bacter

关键词： Alzheimer's disease olfactory threeneedle electroacupuncture olfactory nerve synaptic plasticity gut microbiota Chinese medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

砷在氮化-碳化法制备超细碳化钨粉过程中的细化机理

引用

Transactions of Nonferrous Metals Society of China 2024年第3期34卷 966-976页

作者：易志强谭敦强南昌大学物理与材料学院南昌330031 南昌大学国际材料创新研究院南昌330031

为了简化工艺制备超细WC粉末,在伸钨酸铵前驱体中添加一定量的As元素,采用氮化-碳化法系统研究As在超细WC粉制备过程中的作用机理。结果表明,当碳化温度均为1400℃,氮化温度从500℃升高到600℃,As含量从0增加到0.3%(质量分数)时,所制备... 详细信息

为了简化工艺制备超细WC粉末,在伸钨酸铵前驱体中添加一定量的As元素,采用氮化-碳化法系统研究As在超细WC粉制备过程中的作用机理。结果表明,当碳化温度均为1400℃,氮化温度从500℃升高到600℃,As含量从0增加到0.3%(质量分数)时,所制备的WC粉平均粒径从2.23μm减小到0.22μm,颗粒均匀性显著提高。As元素在氮化产物中以W_(2)O_(3)(AsO_(4))_(2)的形式存在,且容易在氮化产物(NH_(4))_(0.42)WC_(3)和WN表面富集或分布于两相之间,阻碍碳化过程中WC晶粒的长大,从而制备超细WC粉。

关键词：砷超细WC粉均匀性细化机理氮化碳化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Application of geophysical methods in fine detection of urban concealed karst:A case study of Wuhan City,China

引用

China Geology 2024年第3期7卷 517-532页

作者： Dao-han Liu Lei Wang Lei Liu Jun-jie Xu Jian-qiang Wu Pan Liu Wuhan Center China Geological SurveyWuhan430205China Central South China Center for Geoscience Innovation Wuhan430205China Geophysical Exploration Brigade of Hubei Geological Bureau Wuhan 430056China

The construction of modern livable cities faces challenges in karst areas,including ground collapse and engineering ***,with a population of 13.74×10^(6) and approximately 1161 km^(2)of soluble rocks in the urban area of 8569.15 km^(2),predominantly consists of concealed karst areas where occasional ground collapse events occur,posing significant threats to underground engineering *** address these challenges,a comprehensive geological survey was conducted in Wuhan,focusing on major karstrelated *** methods offer advantages over drilling in detecting concealed karst areas due to their efficiency,non-destructiveness,and *** paper reviewed the karst geological characteristics in Wuhan and the geophysical exploration methods for karst,selected eight effective geophysical methods for field experimentation,evaluated their suitability,and proposed method combinations for different karst *** results show that different geophysical methods have varying applicability for karst detection in Wuhan,and combining multiple methods enhances detection *** specific recommendations for method combinations provided in this study serve as a valuable reference for karst detection in Wuhan.

关键词： Ground Penetrating Radar(GPR) Electric Resistivity Tomography(ERT) Opposing-coils Transient Electromagnetic Method(OCTEM) Microtremor Array Measurements(MAM) Multi-channel Analysis of surface wave(MASW) Multi-source surface wave exploration(MSSW) Electromagnetic wave CT(EM CT) Surface Nuclear Magnetic Resonance(SNMR) Concealed karst Urban geological survey engineering

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：