检索结果-南通市图书馆

genome-wide association study of complex traits in rice

在线全文

学校读者我要写书评

暂无评论

Genome-wide association study of complex traits in rice

genome-wide Association Mapping of Heading Date in Rice

第十三届全国植物基因组学大会

作者： Xuehui Huang~(1,2.,Bin han~(1*) 1 national {2. for Gene Research,Institute of Plant Physiology and Ecology,shanghai Institutes for Biological Sciences,chinese Academy of Sciences,shanghai 2.02.3,china 2.CAS key laboratory of genome Sciences and Information,Beijing Institute of genomics, chinese Academy of Sciences,Beijing 10002.,china

Rice(Oryza sativa L.) is the staple food for more than half of the world population. After thousands of years of cultivation,rice landraces have accumulated an enormous of important agronomic traits,which are invaluable genetic resources for breeding elite varieties for sustainable ***,rice has a high-quality reference genome sequence and the self-fertilization system that allows simplified haplotype identification and repeated phenotyping for *** direct

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Genome-wide Association Mapping of Heading Date in Rice

Isolation and annotation of 1082. putative full length cDNAs from indica rice

第十二届全国植物基因组学大会

作者： Canyang Li~1,Lizhen Si~1,Xuehui Huang~1,Yan Zhao~1,Qi Feng~1,Bin han~(1,2.) 1.national {2. For Gene Research,Institute of Plant Physiology and Ecology,shanghai Institutes For Biological Sciences, chinese Academy of Sciences,shanghai 2.02.3,china 2.Cas key laboratory of genome Sciences and Information,Beijing Institute of genomics,chinese Academy of Sciences,Beijing 10002.,china

The adaptation of plants to natural environments depends on the adaptation of flowering-time control at the appropriate season to set *** the genetic basis of flowering-time control is important for agriculture. Here,we performed genome-wide association studies(GWAS) for heading date trait in the population of Oryza sativa indica *** have identified 7 loci which were associated with heading *** order to further verify the possibility of these loci in controlling heading date,we also observed the heading date phenotype of the corresponding chromosome segment substitution lines(CSSLs) deriving from a back-

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Science china(Life Sciences) 2005年第5期48卷 445-451页

作者： XIE Kabin1, ZhanG Jianwei1, XIANG Yong1, FENG Qi2. han Bin2. CHU Zhaohui1, WANG Shiping1, ZhanG Qifa1 & XIONG Lizhong1 1. national key laboratory of Crop Genetic Improvement and national center of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan 430070, china 2. national center for Gene Research, chinese Academy of Sciences, shanghai 2.02.3, china 1. national key {2. of Crop Genetic Improvement and national center of Plant Gene Research (Wuhan) Huazhong Agricultural University 430070 Wuhan China 2. national center for Gene Research Chinese Academy of Sciences 200233 Shanghai China

We reported the isolation and identification of 1082. putative full-length cDNAs (FL-cDNA) from an indica rice cultivar, Minghui 63, with the long-term goal to isolate all full-length cDNAs from indica genome. Comparison with the databases showed that 780 of them are new rice cDNAs with no match in japonica cDNA database. Totally, 9078 of the FL-cDNAs contained predicted ORFs matching with japonica FL-cDNAs and 6543 could find homologous proteins with complete ORFs. 53% of the matched FL-cDNAs isolated in this study had longer 5′UTR than japonica FL-cDNAs. In silico mapping showed that 9776 (90.2.%) of the FL-cDNAs had matched genomic sequences in the japonica genome and 10046 (92.78%) had matched genomic se-quences in the indica genome. The average nucleotide sequence identity between the two sub-species is 99.2.. A majority of FL-cDNAs (90%) could be classified with GO (gene ontology) terms based on homology proteins. More than 60% of the new cDNAs isolated in this study had no homology to the known proteins. This set of FL-cDNAs should be useful for functional ge-nomics and proteomics studies.

关键词： Oryza sativa L., indica, functional genomics.

Improving flangeability of multiphase steel by increasing microstructural homogeneity

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第7期31卷 1736-1745页

作者： Xiao-yu Yang Yong-gang Yang Xing Fang han-long Zhang Zhen-li Mi Beijing Advanced Innovation center for Materials genome Engineering Institute of Engineering TechnologyUniversity of Science and Technology BeijingBeijing 100083China shanghai Baosteel Group Corp.Technology center Shanghai 201900China

Multiphase microstructure significantly increases the strength,usually at the expense of flangeability because of lacking microstructure *** further improve the strength-flangeability of multiphase steel,the microstructural homogeneity was advanced by adjusting the hard martensite/austenite(M/A)*** strength-flangeability was measured via uniaxial tensile tests and hole expansion *** microstructures were characterized using a scanning electron microscope equipped with an electron backscatter diffraction detector and a transmission electron *** tests were supplementally used to quantitatively reveal the microstructural homogeneity of the *** show that the adjusted multiphase steel achieves an excellent ultimate tensile strength(~800 MPa)and flangeability(~135%hole expansion ratio).A promising homogeneous multiphase microstructure was obtained by controlling undercooled austenite transformed at about 600℃.This microstructure consists of soft polygonal ferrite,blocky bainitic ferrite,and hard M/A *** volume fraction of M/A islands is around 5%,and the average size is less than l *** nanoindentation analysis indicated that the participation of M/A islands impressively influenced the microstructural *** strain partition and better mechanical compatibility were present in the adjusted multiphase steel since the plasticity initiation started late,which resulted in a positive ***,avoiding M/A islands distributed in the chain along the rolling direction on the matrix hindered the possibility of voids coalescing into cracks and stabilized the flanging performance.

关键词： Multiphase steel Flangeability Martensite/austenite island-Microstructural homogeneity-Microstructure Compact strip production process

The genetic load for hereditary hearing impairment in chinese population and its clinical implication

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Otology 2009年第2期4卷 98-105页

作者： WANG Qiu-ju 1,2. RAO Shao-qi 1, 3, GUO Yu-fen 4, LI Qing-zhong 5, ZHAO Hui 1, ZHAO Li-dong 1, YUAN Hu 1, ZONG Liang 1, LIU Qiong 1, ZHAO Ya-li 6, WANG Da-yong 1, han Ming-kun 1, JI Yu-bin 1, LI Jian-qiang 1, LAN Lan 1, YANG Wei-yan 1, SHEN Yan 2.6, han Dong-yi 1 1 Department of Otorhinolaryngology-Head and Neck Surgery, and Institute of Otolaryngology, {2. People’s Liberation Army General Hospital, Beijing, 100853 china 2.{2. national human genome center, Beijing, 100176 china 3 Department of Medical Statistics and Epidemiology, School of Public health, Sun Yat-Sen University, Guangzhou, 510080, china 4 Department of Otorhinolaryngology, Head and Neck Surgery, Second Hospital of Lanzhou University, Lanzhou 730030, china 5 Department of Otolaryngology, EYE & ENT hospital of Fudan University, shanghai, 2.0031,china 6 Institute of Basic Medical Sciences, {2. Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005 china Department of Otorhinolaryngology–Head and Neck Surgery and Institute of Otolaryngology Chinese People’s Liberation Army General Hospital Beijing 100853 China chinese national {2. genome center Beijing 100176 China Department of Medical Statistics and Epidemiology School of Public Health Sun Yat–Sen University Guangzhou 510080 China Department of Otorhinolaryngology Head and Neck Surgery Second Hospital of Lanzhou UniversityLanzhou 730030 China Department of Otolaryngology EYE & ENT hospital of Fudan University Shanghai 200031China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100005 China

Objective To understand the genetic load in the chinese population for improvement in diagnosis, prevention and rehabilitation of deafness. Methods DNA samples, immortalized cell lines as well as detailed clinical and audiometric data were collected through a national genetic resources collecting network. Two conventional genetic approaches were used in the studies. Linkage analysis in X chromosome and autosomes with microsatellite markers were performed in large families for gene mapping and positional cloning of novel genes. Candidate gene approach was used for screening the mtDNA 12.rRNA, GJB2.and SLC2.A4 mutations in population -based samples. Results A total of 2.572.chinese hearing loss families or sporadic cases were characterized in the reported studies, including seven X-linked, one Y-linked, 2. large and multiplex autosomal dominant hearing loss families, 607 simplex autosomal recessive hereditary hearing loss families, 100 mitochondrial inheritance families, 147 GJB2.induced hearing loss cases, 2.0 cases with enlarged vestibular aqueduct (EVA) syndrome, 169 sporadic cases with auditory neuropathy, and 1,2.3 sporadic sensorineural hearing loss cases. Through linkage analysis or sequence analysis, two X-linked families were found transmitting two novel mutations in the POU3F4 gene, while another X -linked family was mapped onto a novel locus, nominated as AUNX1 (auditory neuropathy, X-linked locus 1). The only Y-linked family was mapped onto the DFNY1 locus(Y-linked locus 1, DFNY1). Eight of the 2. autosomal dominant families were linked to various autosomal loci. In population genetics studies, 2.567 familial cases and sporadic patients were subjected to mutation screening for three common hearing loss genes: mtDNA 12. rRNA 1555G, GJB2.and SLC2.A4. The auditory neuropathy cases in our samples were screened for OTOF gene mutations. Conclusions These data show that the chinese population has a genetic load on hereditary hearing loss. Establishing personalize

关键词： Hereditary hea ring loss linkage analysis DFNY1 AUNX1 auditory neuropathy enlarged vestibular aqueduct senserineural hearing loss genetic epidemiology

genome-wide Analysis of Smad Targets Reveals the Role of BMP Signaling in Embryonic Stem Cell Fate Determination

在线全文

学校读者我要写书评

暂无评论

Genome-wide Analysis of Smad Targets Reveals the Role of BMP...

Computational tools for plant genomics and breeding

第十一次中国生物物理学术大会暨第九届全国会员代表大会

作者： Teng Fei 1# ,Kai Xia 2. ,Zhang Chen 2.,Hua Chen 1 ,Zhongwei Li 1 ,Jianping Zhang 1 ,Bing Zhou 2.,Huasheng Xiao 3 ,Jing-Dong J.han 2. ,Ye-Guang Chen 1* 1The State key laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology,Tsinghua University,Beijing 100084,china 2.AS key laboratory of Molecular Developmental Biology and center for Molecular Systems Biology,Institute of Genetics and Developmental Biology,the chinese Academy of Sciences,Beijing 100101,china 3national Engineering center for Biochip at shanghai,Zhangjiang Hi-Tech Park, shanghai,2.12.3,china

＜正＞Embryonic stem（ES）cells are under precise control of both intrinsic self-renewal gene regulatory network and extrinsic growth factor-triggered signaling *** external

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Science china(Life Sciences) 2024年第8期67卷 1579-1590页

作者： Hai Wang Mengjiao Chen Xin Wei Rui Xia Dong Pei Xuehui Huang Bin han State key laboratory of Maize Bio-breeding Frontiers Science Center for Molecular Design BreedingJoint International Research Laboratory of Crop Molecular BreedingNational Maize Improvement CenterCollege of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100193China Sanya Institute of china Agricultural University Sanya 572025China Hainan Yazhou Bay Seed laboratory Sanya 572025China State key laboratory of Tree Genetics and Breeding Key Laboratory of Tree Breeding and Cultivation of the State Forestry and Grassland AdministrationResearch Institute of ForestryChinese Academy of ForestryBeijing 100091China shanghai key {2. of Plant Molecular Sciences College of Life SciencesShanghai Normal UniversityShanghai 200234China College of Horticulture South China Agricultural UniversityGuangzhou 510640China national center for Gene Research CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200233China

Plant genomics and crop breeding are at the intersection of biotechnology and information *** by a combination of highthroughput sequencing,molecular biology and data science,great advances have been made in omics technologies at every step along the central dogma,especially in genome assembling,genome annotation,epigenomic profiling,and transcriptome *** advances further revolutionized three directions of *** is genetic dissection of complex traits in crops,along with genomic prediction and *** second is comparative genomics and evolution,which open up new opportunities to depict the evolutionary constraints of biological sequences for deleterious variant *** third direction is the development of deep learning approaches for the rational design of biological sequences,especially proteins,for synthetic *** three directions of development serve as the foundation for a new era of crop breeding where agronomic traits are enhanced by genome design.

关键词： bioinformatics plant genomics breeding by design

DeepRisk:A deep learning approach for genome-wide assessment of common disease risk

在线全文

学校读者我要写书评

暂无评论

Fundamental Research 2024年第4期4卷 752-760页

作者： Jiajie Peng Zhijie Bao Jingyi Lia Ruijiang han Yuxian Wang Lu han Jinghao Peng Tao Wang Jianye Hao Zhongyu Wei Xuequn Shang AI for Science Interdisciplinary Research center Schoolof Computer ScienceNorthwestern Polyechnical UniversityXi'an 129China key laboratoryof Bg Data Sorage and Management Northwestern Polytechnical UniversityMinisty of Industy and Information TechnologyX'an 129Chin College of Intelligence and Computing Tianjin UniversityTianjin 300072China School of Data Science Fudan UniversityShanghai 200433China Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518000China

The potential for being able to identify individuals at high disease risk solely based on genotype data has garnered significant *** widely applied,traditional polygenic risk scoring methods fall short,as they are built on additive models that fail to capture the intricate associations among single nucleotide polymorphisms(SNPs).This presents a limitation,as genetic diseases often arise from complex interactions between multiple *** address this challenge,we developed DeepRisk,a biological knowledge-driven deep learning method for modeling these complex,nonlinear associations among SNPs,to provide a more effective method for scoring the risk of common diseases with genome-wide genotype *** demonstrated that DeepRisk outperforms existing PRs-based methods in identifying individuals at high risk for four common diseases:Alzheimer's disease,inflammatory bowel disease,type 2.iabetes,and breast cancer.

关键词： Disease risk prediction Deep learning Polygenic risk score Common disease risk Disease prevention

Interactive effect of thermal aging and proton irradiation on microstructural evolution and hardening ofδ-ferrite in 308L stainless steel weld metal

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2024年第3期170卷 140-155页

作者： Xiaodong Gao Xiaodong Lin Tao Guo Lining Xu Yaolei han Baolong Jiang Xingyuan Mei Qunjia Peng Lijie Qiao Beijing Advanced Innovation center for Materials genome Engineering Institute of Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Institute of Materials Shanghai UniversityShanghai 200072China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Suzhou Nuclear Power Research Institute Suzhou 215004China State key laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

In the harsh service environment of high temperature and intense neutron irradiation in water-cooled nuclear reactors,the austenitic stainless steel weld overlay cladding on the inner surface of the reactor pressure vessel suffers from thermal aging and irradiation damage simultaneously,which can induce microstructural evolution and hardening of the *** it is quite difficult to achieve this simul-taneous process out of the pile,two kinds of combined experiments,i.e.,post-irradiation thermal aging and post-aging irradiation were performed on 308 L stainless steel weld metals in this *** interactive effect of thermal aging and proton irradiation on microstructural evolution and hardening ofδ-ferrite in 308 L weld metal was investigated by combining atom probe tomography,transmission elec-tron microscopy and nanoindentation *** results revealed that thermal aging could eliminate the dislocation loops induced by irradiation and affect the phase transition process by accelerating spinodal decomposition and G-phase precipitation,thus enhancing hardening of irradiatedδ-*** the effect of irradiation on the microstructure and hardening of thermally agedδ-ferrite,however,intensive collision cascades can intensify G-phase precipitation and dislocation loop formation but decrease spinodal decomposition,leading to a limited effect on hardening of thermally agedδ-***,the interaction of thermal aging and irradiation can promote G-phase ***,the interaction can causeδ-ferrite hardening,which is mainly influenced by spinodal decomposition,followed by G-phase and dislocation loops,where spinodal decomposition and G-phase cause hardening by inducing strain fields.

关键词： Austenitic stainless steel weld metals Thermal aging Proton irradiation Interaction Microstructural evolution Hardening