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Effects of Rapamycin on Clinical Manifestations and Blood Lipid Parameters in Different Preeclampsia-like Mouse Models

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Chinese Medical Journal 2017年第9期130卷 1033-1041页

作者： Yan-Hong yi Zi Yang yi-wei han Jing Huai Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China

Background： The pathogenesis of some types ofpreeclampsia is related to fatty acid oxidation disorders. Rapamycin can regulate fatty acid metabolism. This study aimed to investigate the effects of rapamycin on the clinical manifestations and blood lipid parameters in different preeclampsia-like mouse models. Methods： Two preeclampsia-like mouse models and a control group were established： L-NA （injected with Nco-nitro-L-arginine methyl ester）, LPS （injected with lipopolysaccharide）, and the control group with normal saline （NS）. The mouse models were established at preimplantation （PI）, early- and late-pregnancy （EP, LP） according to the time of pregnancy. The administration of rapamycin （RA; L-NA＋RA. LPS＋RA, and NS＋RA） or vehicle as controls （C; L-NA＋C, LPS＋C, NS＋C） were followed on the 2^nd day after the mouse models＇ establishment, Each subgroup consisted of eight pregnant mice. The mean arterial pressure （MAP）, 24-h urinary protein, blood lipid, fetus, and placental weight were measured. The histopathological changes and lipid deposition of the liver and placenta were observed. Student＇s t-test was used for comparing two groups. Repeated measures analysis of variance was used for blood pressure analysis. Qualitative data were compared by Chi-square test. Results： The MAP and 24-h urinary protein in the PI, EP, and LP subgroups of the L-NA＋C and LPS＋C groups were significantly higher compared with the respective variables in the NS＋C group （P 〈 0.05）. The preeclampsia-like mouse models were established successfully. There was no significant difference in the MAP between the PI, EP, and LP subgroups of the L-NA＋RA and L-NA＋C groups and the LPS＋RA and LPS＋C groups. The 24-h urine protein levels in the PI and EP subgroups of the L-NA＋RA group were significantly lower compared with the respective levels in the L-NA＋C groups （1037 ± 63 vs. 2127± 593 μg; 976 ±42 vs. 1238 ±72 μg; both P 〈 0.05）, also this effect appeared similar in the PI and EP subgroups of the LPS＋RA

关键词： Mouse Preeclampsia Rapamycin

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Differences in Liver Injury and Trophoblastic Mitochondrial Damage in Different Preeclampsia-like Mouse Models

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Chinese Medical Journal 2015年第12期128卷 1627-1635页

作者： yi-wei han Zi Yang Xiao-Yan Ding Huan Yu Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China

Background：Preeclampsia is a multifactorial disease during *** lipid metabolism may be related to some *** investigated the relationship between triglycerides （TGs） and liver injury in different preeclampsia-like mouse models and their potential common ***：Preeclampsia-like models （Nw-nitro-L-arginine-methyl ester [L-NAME],lipopolysaccharide [LPS],apolipoprotein C-Ⅲ [Apo] transgnic mice ＋ L-NAME,β2 glycoprotein Ⅰ [βGPI]） were used in four experimental groups：L-NAME （LN）,LPS,Apo-LN and βGPI,respectively,and controls received saline （LN-C,LPS-C,Apo-C,βGPI-C）.The first three models were established in preimplantation （PI）,early-,mid-and late-gestation （EG,MG and LG）.βGPI and controls were injected before *** arterial pressure （MAP）,24-hour urine protein,placental and fetal weight,serum TGs,total cholesterol （TC） and pathologic liver and trophocyte changes were ***：MAP and proteinuria were significantly increased in the experimental *** and fetal weight in PI,EP and MP subgroups were significantly lower than *** TGs significantly increased in most groups but *** was not different between experimental and control *** hepatic cell necrosis was observed in PI,EG,MG in LN,Apo-LN and βGPI,but no morphologic changes were observed in the LPS *** trophoblastic mitochondrial damage was observed in every experimental ***：Earlier preeclampsia onset causes a higher MAP and urine protein level,and more severe placental and fetal ***-like models generated by varied means lead to different changes in lipid metabolism and associated with liver *** mitochondrial damage may be the common terminal pathway in different preeclampsia-like models.

关键词： Liver Mitochondria Preeclampsia Triglyceride Trophoblast

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nfluence and mechanism of Xindakang on cardiac functions of isolated frog heart

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中国药理学与毒理学杂志 2021年第10期35卷 764-765页

作者： KONG Xiu-mei JIANG yi han yi-wei ZHAO Qin Engineering Research Center of Tibetan Medicine Testing Technology of Ministry of Education Tibetan Medicine Screening LaboratorySchool of MedicineTibet University for NationalitiesXianyang 712082China

OBJECTIVE To evaluate the effects of flavonoids from Xindakang(Hippophae Fructus flavone)on myocardial systolic and diastolic functions of isolated frog hearts and explore the possible mechanism,and provide experimental basis for improving the effect and efficacy of Xindakang on cardiac *** The isolated frog heart perfusion specimens were prepared by Yagi′s method,and the effects of different concentrations of Xindakang on myocardial contractility(0.0125,0.025,0.05,0.1 and 0.2 g·L^(-1)),heart rate and cardiac output of isolated frog heart were ***,atropine and epinephrine were administered successively to analyze the effects of Xindakang on cardiac systolic function of isolated frogs under the action of different drugs,and compared with *** effect of extracellular calcium ion concentration on the action of Xindakang was studied by using low calcium concentration,high calcium concentration and normal Ren′s *** study the effect and possible mechanism of Xindakang on cardiac systolic function of *** The concentration of Xindakang in the range of 0.0125-0.1 g·L^(-1)could weaken the contractility of isolated frog heart and increase the concentration of *** inhibitory effect of Xindakang on contractility of isolated frog heart was enhanced,and showed obvious dose-effect *** output was significantly decreased by Xindakang(Phannel on myocardial cell membrane and reducing the cal

关键词： Hippophae Fructus flavone Xindakang isolated frog heart cardiac function

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Dihydromyricetin Alleviates H9C2 Cell Apoptosis and Autophagy by Regulating CircHIPK3 Expression and PI3K/AKT/mTOR Pathway

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Chinese Journal of Integrative Medicine 2023年第5期29卷 434-440页

作者： ZhanG Zhi-ying LIU Chao WANG Peng-xiang han yi-wei ZhanG yi-wen HAO Mei-li SONG Zi-xu ZhanG Xiao-ying Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region School of MedicineXizang Minzu UniversityXianyangShaanxi Province(712082)China Key Laboratory of High Altitude Environment and Gene Related to Disease of Tibet Ministry of Education School of MedicineXizang Minzu UniversityXianyangShaanxi Province(712082)China School of Finance Economics Xizang Minzu UniversityXianyangShaanxi Province(712082)China School of Information Engineering Xizang Minzu UniversityXianyangShaanxi Province(712082)China

Objective: To investigate the effect and potential mechanism of dihydromyricetin(Dmy) on H9C2 cell proliferation, apoptosis, and autophagy. Methods: H9C2 cells were randomly divided into 7 groups, namely control, model, EV(empty p CDH-CMV-MCS-EF1-Cop GFP-T2A-Puro vector), IV(circHIPK3 interference), Dmy(50 μmol/L), Dmy+IV, and Dmy+EV groups. Cell proliferation and apoptosis were detected by cell counting kit-8 assay and flow cytometry, respectivley. Western blot was used to evaluate the levels of light chain 3 Ⅱ/Ⅰ(LC3Ⅱ/Ⅰ), phospho-phosphoinositide 3-kinase(p-PI3K), protein kinase B(p-AKT), and phospho-mammalian target of rapamycin(p-mTOR). The level of circHIPK3 was determined using reverse transcriptase polymerase chain reaction. Electron microscopy was used to observe autophagosomes in H9C2 cells. Results: Compared to H9C2 cells, the expression of circHIPK in H9C2 hypoxia model cells increased significantly(Phanism may be related to PI3K/AKT/mTOR pathway.

关键词： dihydromyricetin circHIPK autophagy cell apoptosis PI3K/AKT/mTOR

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High toughness and CMAS resistance of REAlO_(3)/RE_(2)Zr_(2)O_(7)(RE=La,Nd,Sm,Eu,Gd,and Dy)composites with eutectic composition for thermal barrier coatings

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Journal of Advanced Ceramics 2024年第6期13卷 800-809页

作者： Zijian Zhang Jian Sun Guanghua Liu yi han wei Liu yi Li wei Wang Xiangyang Liu Peng Zhang wei Pan Chunlei Wan State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China China United Gas Turbine Technology Co. Ltd.Beijing 100015China College of Mathematics and Physics Beijing University of Chemical TechnologyBeijing 100029China College of Materials Science and Engineering Beijing University of TechnologyBeijing 100124China

Although rare earth zirconates(RE_(2)Zr_(2)O_(7))have garnered attention as viable candidates for thermal barrier coatings(TBCs),they suffer from low fracture toughness and accelerated calcium–magnesium–alumina–silicate(CMAS)melt corrosion at high service temperatures,which impedes their practical *** this work,we developed a series of REAlO_(3)/RE_(2)Zr_(2)O_(7)(RE=La,Nd,Sm,Eu,Gd,and Dy)composites with a eutectic composition that not only significantly enhanced the fracture toughness by more than 40%relative to that of RE_(2)Zr_(2)O_(7)but also exhibited improved resistance to CMAS *** increase in toughness arises from multiple mechanisms,such as ferroelastic toughening,fine-grain strengthening,and residual stress toughening,all of which trigger more crack defects and energy ***,the CMAS penetration depth of the REAlO_(3)/RE_(2)Zr_(2)O_(7)composites is approximately 36%lower than that of RE_(2)Zr_(2)O_(7).Al–O constituents in composites can capture CaO,SiO_(2),and MgO in CMAS melts and increase their viscosity,resulting in enhanced CMAS corrosion *** thermophysical properties of the REAlO_(3)/RE_(2)Zr_(2)O_(7)composites were also investigated,and their coefficient of thermal expansion and thermal conductivity are comparable to those of 7–8 wt%Y_(2)O_(3)partially stabilized ZrO2(YSZ),indicating their potential as TBC materials.

关键词： fracture toughness thermal property calcium-magnesium-alumina-silicate(CMAS)corrosion REAlO_(3)/RE_(2)Zr_(2)O_(7) eutectic composition

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Clinical characteristics of pulmonary cryptococcosis coexisting with lung adenocarcinoma:Three case reports

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World Journal of Clinical Cases 2020年第24期8卷 6444-6449页

作者： Gui-Xian Zheng Hai-Juan Tang Zhi-Ping Huang Hui-Ling Pan han-yi wei Jing Bai Department of Respiratory Medicine The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Pulmonary cryptococcosis (PC) is an invasive fungal disease caused mainly byCryptococcus (C.) neoformans or C. gattii. It may be present in immunocompetent orimmunocompromised patients. The radiographic features of PC vary, and themost common computed tomography manifestation is the presence of solitary ormultiple pulmonary nodules or masses distributed in the outer zone of the lungfield. The appearance of nodular or mass-like PC on computed tomography scansresembles that of primary or metastatic lung cancers, and differential diagnosis issometimes difficult. The coexistence of PC and malignant tumors is *** SUMMARY This paper reports three cases of PC combined with lung adenocarcinomadiagnosed by video-assisted thoracic surgery lung biopsy, which weresuccessfully managed by early diagnosis and *** The present case report might serve as a reminder not to neglect PC coexistingwith adenocarcinoma. Early diagnosis and treatment lead to a better prognosis.

关键词： Adenocarcinoma Coexistence Computed tomography Pulmonary cryptococcosis Respiratory medicine Case report

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Challenges and opportunities for battery health estimation:Bridging laboratory research and real-world applications

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Journal of Energy Chemistry 2024年第2期89卷 434-436,I0011页

作者： Te han Jinpeng Tian C.Y.Chung yi-Ming wei Center for Energy and Environmental Policy Research Beijing Institute of TechnologyBeijing 100081China School of Management and Economics Beijing Institute of TechnologyBeijing 100081China Department of Electrical and Electronic Engineering and Research Centre for Grid Modernization The Hong Kong Polytechnic UniversityKowloon 999077Hong KongChina

Addressing climate change demands a significant shift away from fossil fuels,with sectors like electricity and transportation relying heavily on renewable *** to this transition are energy storage systems,notably lithium-ion *** time,these batteries degrade,affecting their efficiency and posing safety *** and predicting battery aging is essential,especially estimating its state of health(SOH).Various SOH estimation methods exist,from traditional model-based approaches to machine learning approaches.

关键词： Energy storage systems State of health Multi-source data Scientific AI Data-sharing mechanism

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Redundant prepuce increases the odds of chronic prostatitis/chronic pelvic pain syndrome （CP/CPPS）

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Asian Journal of Andrology 2014年第5期16卷 774-777,I0011页

作者： Yu-Yang Zhao Dong-Liang Xu Fu-Jun Zhao Bang-Min han yi Shao wei Zhao Shu-Jie Xia Department of Urology Shanghai First People's Hospital Institute of Urology Shanghai Jiao Tong University Shanghai China

Some published evidence has revealed that the dendritic cells can interact with pathogens that exist in the inner foreskin. This information provides a new vision that pathogens could play a role through the redundant prepuce; numerous studies have failed to find pathogens in prostates of patients who had chronic prostatitis/chronic pelvic pain syndrome （CP/CPPS）. However, no studies have reported an association between foreskin length and CP/CPPS. Hence, we conducted a retrospective case-control study of clinical data from 322 CP/CPPS patients （case group） and 341 nonCP/CPPS patients （control group）. Demographic characteristics, lifestyle factors, and foreskin lengths were collected and analyzed. Multivariate logistic regression was adopted to calculate the odds of foreskin length for CP/CPPS. According to the multivariate logistic regression results, when the foreskin length covered up more than half of the glans penis, the odds for CP/CPPS were higher with an increased foreskin （odds ratio （OR）： 1.66, 95% confidence interval （CI）： 1.04-2.66）. In comparison, when the glans penis was completely covered by the foreskin, the OR value increased to 1.86 （95% CI, 1.2-2.88）. The study results showed an association between foreskin length and the odds of CP/CPPS. When the foreskin length covered up more than half of the glans penis, there were greater odds for CP/CPPS. This possible mechanism might result from interaction between pathogens and DCs in the inner foreskin, consequently activating T-cells to mediate allergic inflammation in the prostate and producing the autoimmunizations causing CP/CPPS.

关键词： case control study chronic pelvic pain syndrome chronic prostatitis, prepuce

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Exogenous Hematin Alleviates Mercury-induced Oxidative Damage in the Roots of Medicago sativa

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Journal of Integrative Plant Biology 2007年第12期49卷 1703-1713页

作者： yi han wei Xuan Tian Yu Wen-Bing Fang Tian-Ling Lou yin Gao Xiao-Yue Chen XiaoXiao Wen-Biao Shen College of Life Sciences Laboratory of Nanjing Agricultural University and Carl Zeiss Far East Nanjing Agricultural University Nanjing 210095 China

In the present study, we evaluated the protective effect of exogenous heme oxygenase-1 （HO-1 EC 1.***.99.3） inducer hematin against mercury-induced oxidative damage in the roots of Alfalfa （Medicago sativa L.）. Plants exposed to mercury （HgCl2） exhibited a significant increase of lipid peroxidation, as well as inhibition of root elongation. However, hematin （50 μM） supplementation to HgCl2 （100 μmol/L） treated plants effectively reduced the lipid peroxidation and partially increased the root elongation. These responses were mimicked by the application of aqueous solution of carbon monoxide （CO） with 50% saturation. Also, treatment with hematin could result in the potent induction of HO-1 transcript in the root tissues, as detected 12h following treatment. Moreover, the activation of anti-oxidant enzyme, including glutathione reductase, monodehydroascorbate reductase and superoxide dismutase activities, and the decrease of lipoxygenase activity, were induced by hematin at 12h or 24h, which was further confirmed by histochemical staining for the detection of lipid peroxidation and loss of membrane integrity. Whereas, ascorbate peroxidase and guaiacol peroxidase isozyme activities or their transcripts were reduced, respectively, indicating that hydrogen peroxide might act as a signal to mediate Hg- tolerance at the beginning of treatment. The ameliorating effects of hematin were specific, since the CO scavenger hemoglobin differentially reversed the above actions. Taken together, our results suggested that hematin exhibits a vital role in protecting the plant against Hg-induced oxidative damage.

关键词： carbon monoxide hematin Medicago sativa mercury toxicity oxidative stress.

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Frequency-comb-linearized, widely tunable lasers for coherent ranging

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Photonics Research 2024年第4期12卷 663-681页

作者： BAOQI SHI yi-han LUO wei SUN YUE HU JINBAO LONG XUE BAI ANTING WANG JUNQIU LIU Department of Optics and Optical Engineering University of Science and Technology of ChinaHefei 230026China International Quantum Academy Shenzhen 518048China Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China

Tunable lasers,with the ability to continuously vary their emission wavelengths,have found widespread applications across various fields such as biomedical imaging,coherent ranging,optical communications,and *** these applications,a wide chirp range is advantageous for large spectral coverage and high frequency ***,the frequency accuracy and precision also depend critically on the chirp linearity of the *** extensive efforts have been made on the development of many kinds of frequency-agile,widely tunable,narrow-linewidth lasers,wideband yet precise methods to characterize and linearize laser chirp dynamics are also *** we present an approach to characterize laser chirp dynamics using an optical frequency *** instantaneous laser frequency is tracked over terahertz bandwidth at 1 MHz *** this approach we calibrate the chirp performance of 12 tunable lasers from Toptica,Santec,New Focus,EXFO,and NKT that are commonly used in fiber optics and integrated *** addition,with acquired knowledge of laser chirp dynamics,we demonstrate a simple frequency-linearization scheme that enables coherent ranging without any optical or electronic linearization *** approach not only presents novel wideband,highresolution laser spectroscopy,but is also critical for sensing applications with ever-increasing requirements on performance.

关键词： tunable Focus coherent

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