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Succession of bacteria communities during production and application of dairy bedding by membrane-covered aerobic fermentation

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International Journal of Agricultural and Biological Engineering 2024年第1期17卷 232-240页

作者： Hongjie Yin Jianfei Zeng Chen Fang Xueqin He Ya Su Jinpeng xiong Lujia han Guangqun Huang College of Engineering China Agricultural University Beijing 100083China Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing 100081China College of Agriculture Guizhou UniversityGuiyang 550025China

The cost of dairy manure treatment and bedding material purchase increases the operating cost of the dairy ***-covered aerobic fermentation system has been widely used for dealing with dairy manure and recycling the final product as bedding ***,the microbial safety in each processing step is still *** better understand the bacterial community dynamics during the whole bedding conversion process,a full-chain and large-scale experiment including 16-day membrane-covered aerobic fermentation and 11-day bedding material application was *** results showed that the pile temperatures in the fermentation stage rapidly increased to 80°C and maintained>50°C for more than 11 days and the use of fermentation product as bedding material provided cows with a stable and comfortable bedding *** Chao1 and Shannon index decreased at the end of the fermentation stage and remained stable in the application stage,indicating that membrane-covered aerobic fermentation effectively killed some pathogenic bacteria and guaranteed both the maturity and stability of the final *** dominant bacteria in the fermentation stage were Acinetobacter,Thermus,and Rhodothermus at genus *** common potential pathogens of mastitis(Staphylococcus,Enterococcus,Serratia,Pseudomonas,Corynebacterium,Mycobacterium,and Bacillus)were found at the end of fermentation stage but the relative abundance was low(0.0025%-0.2727%).The dominant bacteria in the application stage mainly included Acinetobacter,Pseudomonas,and Flavobacterium at the genus *** relative abundance of Pseudomonas increased in the application stage,which was a reminder to the dairy farm to pay attention to the disinfection and timely replacement of bedding material to prevent the occurrence of dairy *** results of this study contributed deep understanding of the microorganism-driven bedding conversion process and provide practical guidance and cautions for the bedding

关键词： semi-permeable membrane dairy manure aerobic fermentation bedding material bacterial diversity

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水辅助注塑制件壁厚分析

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高分子材料科学与工程 2008年第7期24卷 20-23页

作者：曲杰黄汉雄华南理工大学汽车工程学院汽车研究中心华南理工大学工业装备与控制工程学院塑料橡胶装备及智能化研究中心广东广州510640

根据水辅助注塑技术应用短射法成型中空圆管制品的聚合物熔体流动的基本特征,把水辅助注塑充模阶段聚合物熔体流动行为简化为等温条件下幂率流体的稳态流动,应用流体力学理论,对圆管水辅助注塑中影响制件壁厚的因素进行分析。结果表明,... 详细信息

根据水辅助注塑技术应用短射法成型中空圆管制品的聚合物熔体流动的基本特征,把水辅助注塑充模阶段聚合物熔体流动行为简化为等温条件下幂率流体的稳态流动,应用流体力学理论,对圆管水辅助注塑中影响制件壁厚的因素进行分析。结果表明,制件的壁厚主要由水与熔体界面处的压力梯度和熔体前端压力梯度的比值确定,同时制件壁厚也受熔体的流变性能影响。

关键词：水辅注塑制件壁厚压力梯度流变性能

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Non-coding RNAs expression in SARS-CoV-2 infection:pathogenesis,clinical significance,and therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第1期9卷 55-78页

作者： Xiaoxing Liu Wandi xiong Maosen Ye Tangsheng Lu Kai Yuan Suhua Chang Ying han Yongxiang Wang Lin Lu Yanping Bao Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)100191 BeijingChina Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research Peking University100871 BeijingChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan University570228 HaikouChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of Sciences650204 KunmingYunnanChina National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Peking UniversityBeijing 100191China Institute of Brain Science and Brain-inspired Research Shandong First Medical University&Shandong Academy of Medical Sciences250117 JinanShandongChina Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina School of Public Health Peking University100191 BeijingChina

The coronavirus disease 2019(COVID-19)pandemic has been looming globally for three years,yet the diagnostic and treatment methods for COVID-19 are still undergoing extensive exploration,which holds paramount importance in mitigating future *** non-coding RNAs(ncRNAs)display aberrations in the context of ***,microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs)exhibit a close association with viral infection and disease *** this comprehensive review,an overview was presented of the expression profiles of host ncRNAs following SARS-CoV-2 invasion and of the potential functions in COVID-19 development,encompassing viral invasion,replication,immune response,and multiorgan deficits which include respiratory system,cardiac system,central nervous system,peripheral nervous system as well as long ***,we provide an overview of several promising host ncRNA biomarkers for diverse clinical scenarios related to COVID-19,such as stratification biomarkers,prognostic biomarkers,and predictive biomarkers for treatment *** addition,we also discuss the therapeutic potential of ncRNAs for COVID-19,presenting ncRNA-based strategies to facilitate the development of novel *** an in-depth analysis of the interplay between ncRNA and COVID-19 combined with our bioinformatic analysis,we hope to offer valuable insights into the stratification,prognosis,and treatment of COVID-19.

关键词： invasion therapeutic infection

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Study on Air Film Formation Mechanism and Cooling in Large-Span Air-Conditioning Plant Rooms without Natural Wind

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Journal of Applied Mathematics and Physics 2018年第8期6卷 1596-1605页

作者： Xiaoyong Peng Yuan Zhang Weili Gu han xiong Yu Li School of Civil Engineering University of South China Hengyang China

Large-span air-conditioning plant rooms have a large roof area and suffer from serious solar radiation in summer. The outside roof surface temperature is very high, so cooling load of roof occupies a large proportion in the envelope structure cooling load of large-span air-conditioning plant rooms. Based on the Coanda airfoil air induction unit, the author combined with exhaust air in large-span air-conditioning plant rooms to design the roof air film cooling system of large-span air-conditioning plant rooms. The adherence air film formed on the outside surface takes away heat on the outside surface of the roof, so as to reduce outside roof surface temperature of the roof, decrease heat transfer temperature difference between inside and outside roof surfaces of, and reduce roof cooling cold. Furthermore, the mathematical model and numerical simulation method of considering fluid-structure interaction for heat transfer and influences of solar radiation on air film formation of outside surface and cooling were constructed. Moreover, the numerical simulation method was conducted the validation of effectiveness. Also, the author discussed the air film formation mechanism and air film cooling ability of outside surface in large-span air-conditioning plant rooms without natural wind, developed a new air film cooling technology for the roof of large-span air-conditioning plant rooms, and supplemented the existing roof cooling technology.

关键词： Air Film Numerical Simulation Coanda Effect Cooling

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双级微结构上二氧化硅粒子对微注压成型PP表面润湿特性的影响

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高分子学报 2016年第6期26卷 791-796页

作者：陈安伏黄汉雄华南理工大学塑料橡胶装备及智能化研究中心广州510640

提出一种柔性复制法,采用微注射压缩(μ-ICM)成型具有微拓扑结构的仿生聚丙烯(PP)表面.通过复制模板上的双级微结构,所成型的PP材料表面上呈现具有锥形顶面的双级微结构,即微棱和高纵横比的微锥体.由于微锥体之间的间隙较大,水滴浸润其... 详细信息

提出一种柔性复制法,采用微注射压缩(μ-ICM)成型具有微拓扑结构的仿生聚丙烯(PP)表面.通过复制模板上的双级微结构,所成型的PP材料表面上呈现具有锥形顶面的双级微结构,即微棱和高纵横比的微锥体.由于微锥体之间的间隙较大,水滴浸润其间隙的上方,这使该表面呈现中等黏附的超疏水特性.在μ-ICM过程中,涂覆在模板上的二氧化硅纳米粒子(SNPs)被转移到熔体中,并牢牢附着于微结构表层,赋予其表面亚微米或微米粗糙度,形成多层次微结构.在附着有亲水SNPs的微结构上,高表面自由能使水滴完全浸润微锥体之间的间隙,表面的水接触角为161.9°、滚动角大于90°,呈现极高黏附的超疏水特性(花瓣效应);在附着有疏水SNPs的微结构上,水滴受疏水SNPs的排斥而减弱与表面之间的黏附作用,表面的水接触角为163.5°、滚动角为3.5°,呈现极低黏附的超疏水特性(荷叶效应).

关键词：多层次微结构润湿特性聚丙烯二氧化硅纳米粒子微注射压缩成型

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Cmtm4 deficiency exacerbates colitis by inducing gut dysbiosis and S100a8/9 expression

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Journal of Genetics and Genomics 2024年第8期51卷 811-823页

作者： Qiao Meng Jing Ning Jingjing Lu Jing Zhang Ming Zu Jing Zhang Xiurui han Huiling Zheng Yueqing Gong Xinyu Hao Ying xiong Fang Gu Wenling han Weiwei Fu Jun Wang Shigang Ding Department of Gastroenterology Peking University Third HospitalBeijing 100191China Beijing Key Laboratory for Helicobacter Pylori Infection and Upper Gastrointestinal Diseases(BZ0371) Beijing 100191China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China Department of Immunology School of Basic Medical SciencesPeking University Health Science CenterNHC Key Laboratory of Medical Immunology(Peking University)Beijing 100191China Peking University Center for Human Disease Genomics Beijing 100191China

The dysfunction of innate immunity components is one of the major drivers for ulcerative colitis(UC),and increasing reports indicate that the gut microbiome serves as an intermediate between genetic mutations and UC ***,we find that the IL-17 receptor subunit,CMTM4,is reduced in UC patients and dextran sulfate sodium(DSS)-induced *** deletion of CMTM4(Cmtm4^(-/-))in mice leads to a higher susceptibility to DSS-induced colitis than in wild-type,and the gut microbiome significantly changes in *** causal role of the gut microbiome is confirmed with a cohousing *** further identify that S100a8/9 is significantly up-regulated in Cmtm4^(-/-)colitis,with the block of its receptor RAGE that reverses the phenotype associated with the CMTM4 ***4 deficiency rather suppresses S100a8/9 expression in vitro via the IL17 pathway,further supporting that the elevation of S100a8/9 in vivo is most likely a result of microbial *** together,the results suggest that CMTM4 is involved in the maintenance of intestinal homeostasis,suppression of S100a8/9,and prevention of colitis *** study further shows CMTM4 as a crucial innate immunity component,confirming its important role in UC development and providing insights into potential targets for the development of future therapies.

关键词： Ulcerative colitis CMTM4 Gut microbiota IL-17 receptor C(IL-17RC) S100a8/9

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Exosomes derived from microglia overexpressing miR-124-3p alleviate neuronal endoplasmic reticulum stress damage after repetitive mild traumatic brain injury

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Neural Regeneration Research 2024年第9期19卷 2010-2018页

作者： Yan Wang Dai Li Lan Zhang Zhenyu Yin Zhaoli han Xintong Ge Meimei Li Jing Zhao Shishuang Zhang Yan Zuo Xiangyang xiong han Gao Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institute Tianjin Medical University General HospitalTianjinChina

We previously reported that miR-124-3p is markedly upregulated in microglia-derived exosomes following repetitive mild traumatic brain ***,its impact on neuronal endoplasmic reticulum stress following repetitive mild traumatic brain injury remains *** this study,we first used an HT22 scratch injury model to mimic traumatic brain injury,then co-cultured the HT22 cells with BV2 microglia expressing high levels of *** found that exosomes containing high levels of miR-124-3p attenuated apoptosis and endoplasmic reticulum ***,luciferase reporter assay analysis confirmed that miR-124-3p bound specifically to the endoplasmic reticulum stress-related protein IRE1α,while an IRE1αfunctional salvage experiment confirmed that miR-124-3p targeted IRE1αand reduced its expression,thereby inhibiting endoplasmic reticulum stress in injured ***,we delivered microglia-derived exosomes containing miR-124-3p intranasally to a mouse model of repetitive mild traumatic brain injury and found that endoplasmic reticulum stress and apoptosis levels in hippocampal neurons were significantly *** findings suggest that,after repetitive mild traumatic brain injury,miR-124-3 can be transferred from microglia-derived exosomes to injured neurons,where it exerts a neuroprotective effect by inhibiting endoplasmic reticulum ***,microglia-derived exosomes containing miR-124-3p may represent a novel therapeutic strategy for repetitive mild traumatic brain injury.

关键词： apoptosis C/EBP homologous protein endoplasmic reticulum stress exosome inositol-requiring enzyme 1α microglia miR-124-3p neuron repetitive mild traumatic brain injury X-box binding protein 1

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Exponential Stabilization of Nonlinear Parabolic PDE Systems via Sampled-Data Fuzzy Control Approach

Exponential Stabilization of Nonlinear Parabolic PDE Systems...

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第36届中国控制会议

作者： Zi-Peng Wang Huai-Ning Wu han-xiong Li School of Electrical Engineering University of Jinan Science and Technology on Aircraft Control Laboratory School of Automation Science and Electrical EngineeringBeihang University Department of Systems Engineering and Engineering Management City University of Hong Kong

ISBN: (纸本)9781538629185

This paper investigates the exponential stabilization problem of nonlinear parabolic partial differential equation(PDE)systems via sampled-data fuzzy control approach. Initially, the nonlinear PDE system is accurately represented by the TakagiSugeno(T-S) fuzzy PDE model. Then, based on the fuzzy PDE model, a novel time-dependent Lyapunov functional is used to design a sampled-data fuzzy controller such that the closed-loop fuzzy PDE system is exponentially stable with a given decay rate. The stabilization condition is presented in terms of a set of linear matrix inequalities(LMIs). Finally, simulation results on the temperature profile of a catalytic rod show that the proposed design method is effective.

关键词： Exponential Stability Sampled-Data Control Fuzzy control Parabolic PDE Systems Linear Matrix Inequality(LMI)

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注压成型聚丙烯/碳纳米管材料表面的纳米结构和光热除冰/除霜

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高分子学报 2021年第11期52卷 1506-1513页

作者：朱军黄汉雄华南理工大学广东省高分子先进制造技术及装备重点实验室微/纳成型与流变学研究室广州510640

采用注射压缩成型(ICM)快速制备表面具有纳米丝状结构的聚丙烯/多壁碳纳米管(PP/MWCNTs)复合材料复制物.结果表明,密集分布的纳米丝使表面呈现超疏水、极低黏附的润湿状态;MWCNTs和纳米丝有效降低了复制物表面的反射率(在300~800 nm波... 详细信息

采用注射压缩成型(ICM)快速制备表面具有纳米丝状结构的聚丙烯/多壁碳纳米管(PP/MWCNTs)复合材料复制物.结果表明,密集分布的纳米丝使表面呈现超疏水、极低黏附的润湿状态;MWCNTs和纳米丝有效降低了复制物表面的反射率(在300~800 nm波长范围内平均反射率仅为5.5%),促进复制物对太阳光的吸收(在1 sun(1 kW/m^(2))模拟太阳光照射300 s后其表面平均温度从0℃快速升至77.4℃).复制物的这种润湿状态和高效的光热转换性能使其具有良好防冰和除冰/除霜性能.复制物表面上水滴的结冰时间得到明显延长,在1 sun模拟太阳光照射下冰滴可被快速清除.在光热融霜过程中,复制物表面上融霜碎片卷曲成球形融霜水滴,且融霜水滴自发滑移;融霜结束时,复制物表面上的融霜水滴覆盖率仅为7.5%.研究表明,采用ICM快速制备具有良好被动防冰和主动除冰功能的超疏水高分子纳米复合材料表面是可行的.

关键词：聚丙烯/碳纳米管复合材料注压成型纳米丝光热转换除冰/除霜

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不同参龄、坡向及根际土壤微生物对林下园参皂苷积累的影响

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中国食品添加剂 2024年第2期35卷 88-97页

作者：杜欣谢阿贵方新月江荣鑫熊涵窦少华王东明肖永坤刘春莹大连大学生命健康学院大连116622 大连市动物免疫重点实验室大连116622 片仔癀(上海)生物科技研发有限公司上海200030 三蚁科技(广州)有限公司广州510805 辽宁省海洋微生物工程技术研究中心大连116622

本研究通过高效液相色谱法同时测定林下园参中33种皂苷含量,分析不同参龄、坡向林下园参中皂苷组成与分布差异;通过高通量测序技术,分析不同坡向林下园参根际土壤微生物多样性特征及其与皂苷积累的关系。结果表明,3~5年生林下园参中均... 详细信息

本研究通过高效液相色谱法同时测定林下园参中33种皂苷含量,分析不同参龄、坡向林下园参中皂苷组成与分布差异;通过高通量测序技术,分析不同坡向林下园参根际土壤微生物多样性特征及其与皂苷积累的关系。结果表明,3~5年生林下园参中均含有皂苷Re、Rg1、Rf、Rb1、Rb2、Rc、Rb3、Rd、S,R-Rg2、R-Rh1、Rh4,皂苷含量随参龄增长而增加;阳坡5年生林下园参中人参皂苷Rg1、Rc、Rb2、Rb3、Rd质量分数高于阴坡,但Re、Rf、Rb1质量分数低于阴坡。阴坡林下园参根际土壤中细菌、真菌ACE、chao和Shannon值数值均高于阳坡,且PCA距离相差均大于阳坡,其根际微生物丰度更高,多样性更丰富。阳坡阴坡真菌属类最优势属均为被孢霉属,其余菌属种类与占比均存在较大差异;阳坡优势菌利于皂苷Rg1、Rc、Rb2、Rb3、Rd的积累,阴坡优势菌利于皂苷Re、Rf、Rb1的积累。

关键词：林下园参人参皂苷根际微生物 HPLC 高通量测序

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