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Safety and efficacy of T-614 in the treatment of patients with active rheumatoid arthritis： a double blind, randomized, placebo-controlled and multicenter trial

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Chinese Medical Journal 2008年第7期121卷 615-619页

作者： Lu Liang-jing TENGJia-lin BAO Chun-de han xing-hai SUN Ling-yun XU Jiang-hua LI xing-fu WU Hua-xiang Department of Rheumatology Renji Hospital Shanghai Jiao TongUniversity Shanghai 200001 China Department of Rheumatology Changhai Hospital Second MilitaryUniversity Shanghai 200001 China Department of Rheumatology Gulou Hospital Nanjing UniversityNanjing Jiangsu 210000 China Department of Rlaeumatology Frist Alliliated Hospital AnlluiMedical University Hefei Anhui 230000 China Department of Rheumatology Qilu Hospital of ShandongUniversity Jinan Shandong 250012 China Department of Rheumatology Second Affiliated HospitalZhejiang University Hangzhou Zhejiang 510000 China

Background A novel anti-rheumatic drug, T-614, has been shown to have an anti-inflammatory effect and to improve abnormal immunological findings in rheumatoid arthritis （RA）. To assess the safety and efficacy of T-614 versus placebo in patients with active RA we conducted a 24-week clinical study in 280 Chinese patients. Methods In a multicenter, randomized, double blind, placebo controlled study, 280 patients were randomly assigned to receive placebo （n=95） or T-614 at 50 mg （n=93） or 25 mg （n=92） daily. Active disease was defined by 4 of the following 5 criteria：〉5 tender joints, 〉3 swollen joints, morning stiffness lasting for 〉60 minutes, and Westergren erythrocyte sedimentation rate （ESR）〉28 mm/h, the assessment of pain at the rest by patient as moderate or severe. Clinical and laboratory parameters were analyzed at baseline, 2, 4, 6, 12, 18 and 24 weeks. The primary efficacy variable at week 24 was the American College of Rheumatology （ACR） response rate using the intent-to-treat population. Results The ACR response rate was significantly higher in the T-614 treatment group compared with the placebo group within 8 weeks after the initiation of treatment. After 24 weeks, the 25 mg/d and 50 mg/d dosage groups and the placebo group showed 39.13%, 61.29% and 24.21% in ACR20 and 23.91%, 31.18% and 7.37% in ACR50, respectively. A time-response in ACR response was observed, with clear superiority for the 25 mg/d and 50 mg/d dosage groups compared to placebo （P〈0.0001）, and the 50 mg/d dose compared to the 25 mg/d dose （P〈0.05） when using the ACR response analyses after 24 weeks. ESR and c-reactive protein （CRP） were significantly different in the treatment groups after 24 weeks. The incidence of adverse events （AEs） was not significantly higher with T-614 than with placebo, but upper abdominal discomfort, leucopenia, elevated serum alanine aminotransferase （sALT）, skin rash and/or pruritus were more common in the 50 mg and 25 mg dosage groups. Conclusion T-614, a n

关键词： arthritis, rheumatoid T-614 randomized controlled trial

Pressure Effect on the Local Composition SurroundingEthyl Acetoacetate in Supercritical CO_2 - Ethanol Mixture

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Chinese Chemical Letters 1998年第2期9卷 191-196页

作者： Jie LU Guan Ying YANG Ling ZHAO Bu xing han and hai Ke YAN(Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080) Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

The keto-enol tautomerization of ethyl acetoacetate (EAA) in supercritical CO2-ethanol mixture has been investigated at 308.15 K and at different pressures using UV-Visspectroscopy. A method for calculating the local composition about EAA has been developed based on the relationship between the equilibrium constant and dielectric property of the mixing solvent. The results indicate that the local concentration of ethanol surrounding EAA is much higher than that in the bulk.

关键词： supercritical CO_2 ethanol cosolvent cluster local density enhancement

Etoricoxib versus indometacin in the treatment of Chinese patients with acute gouty arthritis： a randomized double-blind trial

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Chinese Medical Journal 2013年第10期126卷 1867-1871页

作者： LI Ting CHEN Shun-le DAI Qing han xing-hai LI Zhan-guo WU Dong-hai ZhanG Xiao GU Jie-ruo YANGNan-ping SUN Ling-yun ZhanG Miu-jia LI xing-fu and BAO Chun-de Department of Rheumatology Renji Hospital Shanghai JiaotongUniversity School of Medicine Shanghai 200001 China Department of Rheumatology Changhai Hospital Shanghai 200438China Department of Rheumatology Beijing University People's HospitalBeijing 100044 China Department of Rheumatology China-Japan Friendship HospitalBeijing 100029 China Department of Rheumatology Guangdong Provincial People'sHospital Guangzhou Guangdong 510120 China Department of Rheumatology Third Affiliated Hospital Sun Yat-SenUniversity Guangzhou Guangdong 510630 China Department of Rheumatology West China Hospitall SichuanUniversity Chengdu Sichuan 610041 China_ Department of Rheumatology Nanjing Drum Tower HospitalNanjing Jiangsu 210008 China Department of Rheumatology Jiangsu Province Hospital NanjingJiangsu 210029 China Department of Rheumatology Qilu Hospital Jinan Shandong250012 China

Background Acute gout is an intensely painful, inflammatory arthritis. Although the non-steroidal anti-inflammatory drugs （NSAIDs） are widely used for this condition, the efficacy is based on only a few studies, particularly in China. We tried to assess the safety and efficacy of etoricoxib in the treatment of acute gouty arthritis in China. Methods A randomized, double-blind, active comparator study was conducted at 10 sites in China. Patients （n=178; 〉18 years of age） with acute gouty attack （〈48 hours） were treated for 5 days with etoricoxib （120 mg/d; n=89） or indometacin （75 mg twice daily; n=89）. The primary efficacy end point was self-assessed pain in the affected joint （0-4 point Likert scale） from days 2-5. Secondary end points included investigator assessments of tenderness and swelling, patient/ investigator global assessments of response to therapy, and patients discontinuing treatment. Safety was assessed by adverse events （AEs）. Results Etoricoxib and indometacin had comparable primary and secondary end points. Mean change difference from baseline from days 2-5 was 0.03 （95% confidence interval （CI） -0.19 to 0.25; P=0.6364）, which fell within the prespecifled comparative bounds of -0.5 to 0.5. No severe AEs were associated with etoricoxib use. Non-severe AEs were mainly digestive and general, and most （73.7%） were mild, although they caused withdrawal of two subjects in the etoricoxib group, due to bilateral renal calculi and uronephrosis of the left kidney （unrelated to etoricoxib） and fever and chills （potentially etoricoxib-related）. Overall, AEs were similar, although the absolute number of AEs in the etoricoxib group （n=31） was less than the indometacin group （n=34）. Conclusions Etoricoxib （120 mg once daily） is effective in treating acute gout, is generally safe and well-tolerated, and is comparable in efficacy to indometacin （75 mg twice daily）.

关键词： gout, arthritis, etoricoxib, indometacin cyclooxygenase-2

Sparse Modal Decomposition Method Addressing Underdetermined Vortex-Induced Vibration Reconstruction Problem for Marine Risers

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China Ocean Engineering 2024年第2期38卷 285-296页

作者： DU Zun-feng ZHU hai-ming YU Jian-xing State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation School of Civil EngineeringTianjin UniversityTianjin 300350China

When investigating the vortex-induced vibration(VIV)of marine risers,extrapolating the dynamic response on the entire length based on limited sensor measurements is a crucial step in both laboratory experiments and fatigue monitoring of real *** problem is conventionally solved using the modal decomposition method,based on the principle that the response can be approximated by a weighted sum of limited vibration ***,the method is not valid when the problem is underdetermined,i.e.,the number of unknown mode weights is more than the number of known *** study proposed a sparse modal decomposition method based on the compressed sensing theory and the Compressive Sampling Matching Pursuit(Co Sa MP)algorithm,exploiting the sparsity of VIV in the modal *** the validation study based on high-order VIV experiment data,the proposed method successfully reconstructed the response using only seven acceleration measurements when the conventional methods failed.A primary advantage of the proposed method is that it offers a completely data-driven approach for the underdetermined VIV reconstruction problem,which is more favorable than existing model-dependent solutions for many practical applications such as riser structural health monitoring.

关键词： motion reconstruction vortex-induced vibration(VIV) marine riser modal decomposition method compressed sensing

Learning topological defects formation with neural networks in a quantum phase transition

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Communications in Theoretical Physics 2024年第5期76卷 68-76页

作者： han-Qing Shi hai-Qing Zhang Center for Gravitational Physics Department of Space ScienceBeihang UniversityBeijing 100191China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China

Neural networks possess formidable representational power,rendering them invaluable in solving complex quantum many-body *** they excel at analyzing static solutions,nonequilibrium processes,including critical dynamics during a quantum phase transition,pose a greater challenge for neural *** address this,we utilize neural networks and machine learning algorithms to investigate time evolutions,universal statistics,and correlations of topological defects in a one-dimensional transverse-field quantum Ising ***,our analysis involves computing the energy of the system during a quantum phase transition following a linear quench of the transverse magnetic field *** excitation energies satisfy a power-law relation to the quench rate,indicating a proportional relationship between the excitation energy and the kink ***,we establish a universal power-law relationship between the first three cumulants of the kink numbers and the quench rate,indicating a binomial distribution of the ***,the normalized kink-kink correlations are also investigated and it is found that the numerical values are consistent with the analytic formula.

关键词： neural networks machine learning transverse-field quantum Ising model kibble-zurek mechanism

Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy

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Chinese Chemical Letters 2024年第4期35卷 316-320页

作者： Ling-Ling Wu Xiangchuan Meng Qingyang Zhang Xiaowan han Feiya Yang Qinghua Wang hai-Yu Hu Nianzeng xing Department of Urology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Bioactive Substances and Function of Natural Medicine Institute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100050China

Photoacoustic agents combining photodynamic therapy(PDT) and photothermal therapy(PTT) functions have emerged as potent theranostic agents for combating cancer. The molecular approaches for enhancing the near-infrared(NIR)-absorption and maximizing non-radiative energy transfer are essential for effective photoacoustic imaging(PAI) and therapy applications. In addition, such molecules with high specificity and affinity to cancer cells are urgently needed, which would further decrease the side effect during treatments. In this study, we applied a heavy-atom engineering strategy and introduced p-aminophenol,-thio, and-seleno moieties into NIR heptamethine cyanine(Cy7) skeleton(Cy7-X-NH_(2), X = O, S, Se) to significantly increase photothermal conversion efficiency for PTT and promote intersystem crossing for ***, we designed a series of nitroreductase(NTR)-activated photoacoustic probes(Cy7-X-NO_(2),X = O, S, Se), and target hypoxic tumors with NTR overexpression. Our prostate cancer targeting probe,Cy7-Se-NO_(2)-KUE, exhibited specific tumor photoacoustic signals and effective tumor killing through outstanding synergistic PTT/PDT in vivo. These findings highlighted a versatile strategy for cancer photoacoustic diagnosis and enhanced phototherapy.

关键词： Heavy-atom effect Phototherapy Photoacoustic imaging Hypoxia-responsive Prostate cancer

Recycling of spent lithium-ion batteries to resynthesize high-performance cathode materials for sodium-ion storage

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Tungsten 2024年第3期6卷 574-584页

作者： hai-Qiang Gong xing-Yuan Wang Long Ye Bao Zhang xing Ou National Engineering Laboratory for High-Efficiency Recovery of Refractory Nonferrous Metals School of Metallurgy and Environment Central South University

The spent lithium-ion batteries recovery has been brought into focus widely for its environmental imperatives and potential profits from the metal components,such as lithium,cobalt,nickel and ***,the weaker pollution and fewer profits of LiMn2O4cathode dispel the enthusiasm and responsibility of industry ***,a simplified and efncient method to regenerate the sodium-ion cathode materials and separate Li from spent LiMn2O4materials for the profit improvement is *** detail,adjusting the parameters of carbothermal reduction process appropriately,the LiMn2O4spinel structure is destroyed within a short period time and transformed into simple metal *** anticipated,nearly 95 wt.%lithium can be obtained and recovered during the water leaching,while 99 wt.% of manganese can be extracted in acid *** that the leaching residue can return to the carbothermic reduction,leading to a closed-loop economic recycling *** regenerated Na0.67Ni0.3Mn0.7O2cathode displays excellent electrochemical performance with superior cycling stability(the initial capacity reaches 95.9 mAh·g-1,and the retention rate reached 98.3% after 100 cycles at 1 C).The delicate strategy of sodium-ion cathode material regenerated from spent LiMn2O4aims to realize lithium separation and material utilization of manganese simultaneously,providing the instructive suggestion to rise up the recycling profits of spent batteries.

关键词： Manganese Spent battery LiMn 2 O 4 cathode Recycling Regenerated Na 0.67 Ni 0.3 Mn 0.7 O 2 Sodium-ion storage

Reinforcement Learning-Based MAS Interception in Antagonistic Environments

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 270-272页

作者： Siqing Sun Defu Cai hai-Tao Zhang Ning xing the School of Artificial Intelligence and Automation the MOE Engineering Research Center of Autonomous Intelligent Unmanned Systemsthe Guangdong Engineering Technology Research Center of Fully Autonomous Unmanned Surface VehiclesHuazhong University of Science and TechnologyWuhan 430074China the State Grid Hubei Electric Power Research Institute Wuhan 430074China IEEE

Dear Editor, As a promising multi-agent systems(MASs) operation, autonomous interception has attracted more and more attentions in these years, where defenders prevent intruders from reaching *** far, most of the relevant methods are applied in ideal environments without agent damages. As a remedy, this letter proposes a more realistic interception method for MASs suffered by damages.

关键词： agent MAS destination

Effect of low-speed waterjet pressure on the rock-breaking performance of unsubmerged cavitating abrasive waterjet

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Petroleum Science 2024年第4期21卷 2638-2649页

作者： Chen-xing Fan Deng Li Yong Kang hai-Tao Zhang Hubei Key Laboratory of Waterjet Theory and New Technology Wuhan University School of Power and Mechanical Engineering Wuhan University

Unsubmerged cavitating abrasive waterjet(UCAWJ) has been shown to artificially create a submerged environment that produces shear cavitation, which effectively enhances rock-breaking performance. The shear cavitation generation and collapse intensity depend on the pressure difference between the intermediate high-speed abrasive waterjet and the coaxial low-speed waterjet. However, the effect of the pressure of the coaxial low-speed waterjet is pending. For this purpose, the effect of low-speed waterjet pressure on rock-breaking performance at different standoff distances was experimentally investigated,and the effects of erosion time and ruby nozzle diameter on erosion performance were discussed. Finally,the micromorphology of the sandstone was observed at different locations. The results show that increased erosion time and ruby nozzle diameter can significantly improve the rock-breaking performance. At different standoff distances, the mass loss increases first and then decreases with the increase of low-speed waterjet pressure, the maximum mass loss is 10.4 g at a low-speed waterjet pressure of0.09 MPa. The surface morphology of cavitation erosion was measured using a 3D profiler, the increase in both erosion depth and surface roughness indicated a significant increase in the intensity of the shear cavitation collapse. At a low-speed waterjet pressure of 0.18 MPa, the cavitation erosion surface depth can reach 600 μm with a roughness of 127 μm.

关键词： Rock-breaking Coaxial low-speed waterjet pressure Abrasive waterjet Cavitation Unsubmerged environment